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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

Atp1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication
Involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-210991 Basigin interactions
R-RNO-5578775 Ion homeostasis
R-RNO-936837 Ion transport by P-type ATPases
SABIO-RKP07340

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:Atp1b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2170 Atp1b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini63 – 304ExtracellularSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191001 – 304Sodium/potassium-transporting ATPase subunit beta-1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei101PhosphotyrosineBy similarity1
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158N-linked (GlcNAc...) asparagine; alternateBy similarity1
Glycosylationi158N-linked (HexNAc...) asparagine; alternateCombined sources1
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193N-linked (GlcNAc...) asparagine; alternateBy similarity1
Glycosylationi193N-linked (HexNAc...) asparagine; alternateCombined sources1
Disulfide bondi214 ↔ 277By similarity
Glycosylationi266N-linked (GlcNAc...) asparagineBy similarity1

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Disulfide bond, Glutathionylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07340
PRIDEiP07340

PTM databases

iPTMnetiP07340
PhosphoSitePlusiP07340
SwissPalmiP07340
UniCarbKBiP07340

Expressioni

Gene expression databases

BgeeiENSRNOG00000002934
ExpressionAtlasiP07340 baseline and differential
GenevisibleiP07340 RN

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit (By similarity). Interacts with regulatory subunit FXYD1 (PubMed:23532852). Interacts with regulatory subunit FXYD3 (PubMed:15743908). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1 (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity). Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247679, 2 interactors
IntActiP07340, 4 interactors
MINTiP07340
STRINGi10116.ENSRNOP00000003932

Structurei

3D structure databases

ProteinModelPortaliP07340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 304immunoglobulin-likeBy similarityAdd BLAST114

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP07340
KOiK01540
OMAiQVPQIQK
OrthoDBiEOG091G0DJ4
PhylomeDBiP07340
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR015565 Na/K_ATPase_sub_beta_chordates
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PTHR11523:SF10 PTHR11523:SF10, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISELKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA
110 120 130 140 150
YVLNIIRFLE KYKDSAQKDD MIFEDCGSMP SEPKERGEFN HERGERKVCR
160 170 180 190 200
FKLDWLGNCS GLNDESYGYK EGKPCIIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
LTMKYNPNVL PVQCTGKRDE DKDKVGNIEY FGMGGFYGFP LQYYPYYGKL
260 270 280 290 300
LQPKYLQPLL AVQFTNLTLD TEIRIECKAY GENIGYSEKD RFQGRFDVKI

EVKS
Length:304
Mass (Da):35,202
Last modified:April 1, 1988 - v1
Checksum:i86C3120F463B7B2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183V → M in AAA40780 (PubMed:3031033).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14137 mRNA Translation: AAA40781.1
J02701 mRNA Translation: AAA40780.1
BC078902 mRNA Translation: AAH78902.1
X63375 Genomic DNA No translation available.
PIRiA25082 PWRTNB
RefSeqiNP_037245.2, NM_013113.2
UniGeneiRn.8925

Genome annotation databases

EnsembliENSRNOT00000003932; ENSRNOP00000003932; ENSRNOG00000002934
GeneIDi25650
KEGGirno:25650
UCSCiRGD:2170 rat

Similar proteinsi

Entry informationi

Entry nameiAT1B1_RAT
AccessioniPrimary (citable) accession number: P07340
Secondary accession number(s): Q63062
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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