Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P07338 (CTRB1_RAT)

Last modified June 16, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Chymotrypsinogen B
    EC=3.4.21.1
Cleaved into the following 3 chains:
    1- Recommended name:
            Chymotrypsin B chain A
    2- Recommended name:
            Chymotrypsin B chain B
    3- Recommended name:
            Chymotrypsin B chain C
Gene names
Name: Ctrb1
Synonyms: Ctrb
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Hide | Top

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secreted › extracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 263245Chymotrypsinogen B
PRO_0000027642
Chain19 – 3113Chymotrypsin B chain A
PRO_0000027643
Chain34 – 164131Chymotrypsin B chain B
PRO_0000027644
Chain167 – 26397Chymotrypsin B chain C
PRO_0000027645

Regions

Domain34 – 261228Peptidase S1

Sites

Active site751Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2131Charge relay system By similarity

Amino acid modifications

Disulfide bond19 ↔ 140 By similarity
Disulfide bond60 ↔ 76
Disulfide bond154 ↔ 219
Disulfide bond186 ↔ 200 By similarity
Disulfide bond209 ↔ 238 By similarity

Secondary structure

1 ............................... 263
Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P07338-1 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: ACAFDBACF8C4DA6D

FASTA26327,849
        10         20         30         40         50         60 
MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS LQDKTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV LKIAQVFKNP KFNMFTVRND 

       130        140        150        160        170        180 
ITLLKLATPA QFSETVSAVC LPNVDDDFPP GTVCATTGWG KTKYNALKTP EKLQQAALPI 

       190        200        210        220        230        240 
VSEADCKKSW GSKITDVMTC AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST 

       250        260 
STPAVYSRVT ALMPWVQQIL EAN

« Hide

Hide | Top

References

[1]"Isolation and sequence of a rat chymotrypsin B gene."
Bell G.I., Quinto C., Quiroga M., Valenzuela P., Craik C.S., Rutter W.J.
J. Biol. Chem. 259:14265-14270(1984) [PubMed: 6209274] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

K02298 Genomic DNA. Translation: AAA98732.1.
IPIIPI00206309.
PIRKYRTB. A22658.
RefSeqNP_036668.1.
UniGeneRn.105845

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1KDQX-ray2.55A34-164[»]
B165-263[»]
2JETX-ray2.20A19-28[»]
B37-164[»]
C165-263[»]
SMRP07338. Positions 19-263.
ModBaseSearch...

Protein family/group databases

MEROPSS01.152.

Genome annotation databases

EnsemblENSRNOG00000019068. Rattus norvegicus. [Contig view]
GeneID24291.
KEGGrno:24291.

Organism-specific databases

RGD2444. Ctrb1.

Phylogenomic databases

HOVERGENP07338.

Enzyme and pathway databases

BRENDA3.4.21.1. 248.

Gene expression databases

ArrayExpressP07338.
GermOnlineENSRNOG00000019068. Rattus norvegicus.

Family and domain databases

InterProIPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio602890.

Hide | Top

Entry information

Entry nameCTRB1_RAT
AccessionPrimary (citable) accession number: P07338
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 16, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents