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Protein

Chymotrypsinogen B

Gene

Ctrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: RGD

GO - Biological processi

  • digestion Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: RGD
  • protein catabolic process Source: RGD
  • response to cytokine Source: RGD
  • response to food Source: RGD
  • response to nutrient Source: RGD
  • response to peptide hormone Source: RGD
  • response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Enzyme and pathway databases

BRENDAi3.4.21.1. 5301.

Protein family/group databases

MEROPSiS01.152.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:Ctrb1
Synonyms:Ctrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2444. Ctrb1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: UniProtKB-SubCell
  • lysosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000002764219 – 263Chymotrypsinogen BAdd BLAST245
ChainiPRO_000002764319 – 31Chymotrypsin B chain AAdd BLAST13
ChainiPRO_000002764434 – 164Chymotrypsin B chain BAdd BLAST131
ChainiPRO_0000027645167 – 263Chymotrypsin B chain CAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76
Modified residuei93PhosphoserineBy similarity1
Disulfide bondi154 ↔ 219
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiP07338.
PRIDEiP07338.

PTM databases

iPTMnetiP07338.
PhosphoSitePlusiP07338.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026017.

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 52Combined sources5
Beta strandi58 – 72Combined sources15
Beta strandi83 – 87Combined sources5
Beta strandi90 – 93Combined sources4
Beta strandi99 – 108Combined sources10
Turni114 – 116Combined sources3
Beta strandi122 – 128Combined sources7
Beta strandi133 – 135Combined sources3
Beta strandi153 – 158Combined sources6
Beta strandi174 – 181Combined sources8
Helixi183 – 189Combined sources7
Beta strandi198 – 201Combined sources4
Beta strandi204 – 207Combined sources4
Helixi208 – 210Combined sources3
Beta strandi216 – 234Combined sources19
Beta strandi239 – 242Combined sources4
Beta strandi244 – 248Combined sources5
Helixi249 – 260Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KDQX-ray2.55A34-164[»]
B165-263[»]
2JETX-ray2.20A19-28[»]
B37-164[»]
C165-263[»]
ProteinModelPortaliP07338.
SMRiP07338.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP07338.
KOiK01310.
PhylomeDBiP07338.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS
60 70 80 90 100
LQDKTGFHFC GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV
110 120 130 140 150
LKIAQVFKNP KFNMFTVRND ITLLKLATPA QFSETVSAVC LPNVDDDFPP
160 170 180 190 200
GTVCATTGWG KTKYNALKTP EKLQQAALPI VSEADCKKSW GSKITDVMTC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST STPAVYSRVT
260
ALMPWVQQIL EAN
Length:263
Mass (Da):27,849
Last modified:April 1, 1988 - v1
Checksum:iACAFDBACF8C4DA6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02298 Genomic DNA. Translation: AAA98732.1.
PIRiA22658. KYRTB.
RefSeqiNP_036668.1. NM_012536.1.
UniGeneiRn.105845.

Genome annotation databases

GeneIDi24291.
KEGGirno:24291.
UCSCiRGD:2444. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02298 Genomic DNA. Translation: AAA98732.1.
PIRiA22658. KYRTB.
RefSeqiNP_036668.1. NM_012536.1.
UniGeneiRn.105845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KDQX-ray2.55A34-164[»]
B165-263[»]
2JETX-ray2.20A19-28[»]
B37-164[»]
C165-263[»]
ProteinModelPortaliP07338.
SMRiP07338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026017.

Protein family/group databases

MEROPSiS01.152.

PTM databases

iPTMnetiP07338.
PhosphoSitePlusiP07338.

Proteomic databases

PaxDbiP07338.
PRIDEiP07338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24291.
KEGGirno:24291.
UCSCiRGD:2444. rat.

Organism-specific databases

CTDi1504.
RGDi2444. Ctrb1.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP07338.
KOiK01310.
PhylomeDBiP07338.

Enzyme and pathway databases

BRENDAi3.4.21.1. 5301.

Miscellaneous databases

EvolutionaryTraceiP07338.
PROiP07338.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB1_RAT
AccessioniPrimary (citable) accession number: P07338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.