Skip Header

Contribute Send feedback
Read comments (?) or add your own

P07338 (CTRB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsinogen B
EC=3.4.21.1

Cleaved into the following 3 chains:

  1. Chymotrypsin B chain A
  2. Chymotrypsin B chain B
  3. Chymotrypsin B chain C
Gene names
Name:Ctrb1
Synonyms:Ctrb
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secreted › extracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 263245Chymotrypsinogen B
PRO_0000027642
Chain19 – 3113Chymotrypsin B chain A
PRO_0000027643
Chain34 – 164131Chymotrypsin B chain B
PRO_0000027644
Chain167 – 26397Chymotrypsin B chain C
PRO_0000027645

Regions

Domain34 – 261228Peptidase S1

Sites

Active site751Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2131Charge relay system By similarity

Amino acid modifications

Disulfide bond19 ↔ 140 By similarity
Disulfide bond60 ↔ 76
Disulfide bond154 ↔ 219
Disulfide bond186 ↔ 200 By similarity
Disulfide bond209 ↔ 238 By similarity

Secondary structure

1 ............................... 263
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07338 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: ACAFDBACF8C4DA6D

FASTA26327,849
        10         20         30         40         50         60 
MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS LQDKTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV LKIAQVFKNP KFNMFTVRND 

       130        140        150        160        170        180 
ITLLKLATPA QFSETVSAVC LPNVDDDFPP GTVCATTGWG KTKYNALKTP EKLQQAALPI 

       190        200        210        220        230        240 
VSEADCKKSW GSKITDVMTC AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST 

       250        260 
STPAVYSRVT ALMPWVQQIL EAN

« Hide

References

[1]"Isolation and sequence of a rat chymotrypsin B gene."
Bell G.I., Quinto C., Quiroga M., Valenzuela P., Craik C.S., Rutter W.J.
J. Biol. Chem. 259:14265-14270(1984) [PubMed: 6209274] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		K02298 Genomic DNA. Translation: AAA98732.1.
IPIIPI00206309.
PIRKYRTB. A22658.
RefSeqNP_036668.1. NM_012536.1.
UniGeneRn.105845.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KDQX-ray2.55A34-164[»]
B165-263[»]
2JETX-ray2.20A19-28[»]
B37-164[»]
C165-263[»]
ProteinModelPortalP07338.
SMRP07338. Positions 19-263.
ModBaseSearch...

Protein-protein interaction databases

STRINGP07338.

Protein family/group databases

MEROPSS01.152.

PTM databases

PhosphoSiteP07338.

Proteomic databases

PRIDEP07338.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24291.
KEGGrno:24291.

Organism-specific databases

CTD1504.
RGD2444. Ctrb1.

Phylogenomic databases

eggNOGroNOG11118.
GeneTreeENSGT00550000074117.
HOVERGENHBG013304.
InParanoidP07338.
OrthoDBEOG4VMFG1.

Enzyme and pathway databases

BRENDA3.4.21.1. 5301.

Gene expression databases

ArrayExpressP07338.
GenevestigatorP07338.
GermOnlineENSRNOG00000019068. Rattus norvegicus.

Family and domain databases

InterProIPR009003. Pept_cys/ser_Trypsin-like.
IPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]
KOK01310.
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602890.

Entry information

Entry nameCTRB1_RAT
AccessionPrimary (citable) accession number: P07338
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 16, 2011
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents