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P07338

- CTRB1_RAT

UniProt

P07338 - CTRB1_RAT

Protein

Chymotrypsinogen B

Gene

Ctrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei213 – 2131Charge relay systemBy similarity

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. serine-type endopeptidase activity Source: RGD

    GO - Biological processi

    1. digestion Source: UniProtKB-KW
    2. positive regulation of apoptotic process Source: RGD
    3. protein catabolic process Source: RGD
    4. response to cytokine Source: RGD
    5. response to food Source: RGD
    6. response to nutrient Source: RGD
    7. response to peptide hormone Source: RGD
    8. response to toxic substance Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Enzyme and pathway databases

    BRENDAi3.4.21.1. 5301.

    Protein family/group databases

    MEROPSiS01.152.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsinogen B (EC:3.4.21.1)
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Ctrb1
    Synonyms:Ctrb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2444. Ctrb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: UniProtKB-SubCell
    3. lysosome Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 263245Chymotrypsinogen BPRO_0000027642Add
    BLAST
    Chaini19 – 3113Chymotrypsin B chain APRO_0000027643Add
    BLAST
    Chaini34 – 164131Chymotrypsin B chain BPRO_0000027644Add
    BLAST
    Chaini167 – 26397Chymotrypsin B chain CPRO_0000027645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 76
    Disulfide bondi154 ↔ 219
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP07338.
    PRIDEiP07338.

    PTM databases

    PhosphoSiteiP07338.

    Expressioni

    Gene expression databases

    GenevestigatoriP07338.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026017.

    Structurei

    Secondary structure

    1
    263
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi48 – 525
    Beta strandi58 – 7215
    Beta strandi83 – 875
    Beta strandi90 – 934
    Beta strandi99 – 10810
    Turni114 – 1163
    Beta strandi122 – 1287
    Beta strandi133 – 1353
    Beta strandi153 – 1586
    Beta strandi174 – 1818
    Helixi183 – 1897
    Beta strandi198 – 2014
    Beta strandi204 – 2074
    Helixi208 – 2103
    Beta strandi216 – 23419
    Beta strandi239 – 2424
    Beta strandi244 – 2485
    Helixi249 – 26012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KDQX-ray2.55A34-164[»]
    B165-263[»]
    2JETX-ray2.20A19-28[»]
    B37-164[»]
    C165-263[»]
    ProteinModelPortaliP07338.
    SMRiP07338. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07338.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP07338.
    KOiK01310.
    PhylomeDBiP07338.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07338-1 [UniParc]FASTAAdd to Basket

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    MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS    50
    LQDKTGFHFC GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV 100
    LKIAQVFKNP KFNMFTVRND ITLLKLATPA QFSETVSAVC LPNVDDDFPP 150
    GTVCATTGWG KTKYNALKTP EKLQQAALPI VSEADCKKSW GSKITDVMTC 200
    AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST STPAVYSRVT 250
    ALMPWVQQIL EAN 263
    Length:263
    Mass (Da):27,849
    Last modified:April 1, 1988 - v1
    Checksum:iACAFDBACF8C4DA6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02298 Genomic DNA. Translation: AAA98732.1.
    PIRiA22658. KYRTB.
    RefSeqiNP_036668.1. NM_012536.1.
    UniGeneiRn.105845.

    Genome annotation databases

    GeneIDi24291.
    KEGGirno:24291.
    UCSCiRGD:2444. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02298 Genomic DNA. Translation: AAA98732.1 .
    PIRi A22658. KYRTB.
    RefSeqi NP_036668.1. NM_012536.1.
    UniGenei Rn.105845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KDQ X-ray 2.55 A 34-164 [» ]
    B 165-263 [» ]
    2JET X-ray 2.20 A 19-28 [» ]
    B 37-164 [» ]
    C 165-263 [» ]
    ProteinModelPortali P07338.
    SMRi P07338. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026017.

    Protein family/group databases

    MEROPSi S01.152.

    PTM databases

    PhosphoSitei P07338.

    Proteomic databases

    PaxDbi P07338.
    PRIDEi P07338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24291.
    KEGGi rno:24291.
    UCSCi RGD:2444. rat.

    Organism-specific databases

    CTDi 1504.
    RGDi 2444. Ctrb1.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P07338.
    KOi K01310.
    PhylomeDBi P07338.

    Enzyme and pathway databases

    BRENDAi 3.4.21.1. 5301.

    Miscellaneous databases

    EvolutionaryTracei P07338.
    NextBioi 602890.

    Gene expression databases

    Genevestigatori P07338.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of a rat chymotrypsin B gene."
      Bell G.I., Quinto C., Quiroga M., Valenzuela P., Craik C.S., Rutter W.J.
      J. Biol. Chem. 259:14265-14270(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCTRB1_RAT
    AccessioniPrimary (citable) accession number: P07338
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3