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P07338

- CTRB1_RAT

UniProt

P07338 - CTRB1_RAT

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Protein
Chymotrypsinogen B
Gene
Ctrb1, Ctrb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay system By similarity
Active sitei120 – 1201Charge relay system By similarity
Active sitei213 – 2131Charge relay system By similarity

GO - Molecular functioni

  1. protein binding Source: RGD
  2. serine-type endopeptidase activity Source: RGD

GO - Biological processi

  1. digestion Source: UniProtKB-KW
  2. positive regulation of apoptotic process Source: RGD
  3. protein catabolic process Source: RGD
  4. response to cytokine Source: RGD
  5. response to food Source: RGD
  6. response to nutrient Source: RGD
  7. response to peptide hormone Source: RGD
  8. response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Enzyme and pathway databases

BRENDAi3.4.21.1. 5301.

Protein family/group databases

MEROPSiS01.152.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:Ctrb1
Synonyms:Ctrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2444. Ctrb1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: UniProtKB-SubCell
  3. lysosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818
Add
BLAST
Chaini19 – 263245Chymotrypsinogen B
PRO_0000027642Add
BLAST
Chaini19 – 3113Chymotrypsin B chain A
PRO_0000027643Add
BLAST
Chaini34 – 164131Chymotrypsin B chain B
PRO_0000027644Add
BLAST
Chaini167 – 26397Chymotrypsin B chain C
PRO_0000027645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 140 By similarity
Disulfide bondi60 ↔ 76
Disulfide bondi154 ↔ 219
Disulfide bondi186 ↔ 200 By similarity
Disulfide bondi209 ↔ 238 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP07338.
PRIDEiP07338.

PTM databases

PhosphoSiteiP07338.

Expressioni

Gene expression databases

GenevestigatoriP07338.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026017.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 525
Beta strandi58 – 7215
Beta strandi83 – 875
Beta strandi90 – 934
Beta strandi99 – 10810
Turni114 – 1163
Beta strandi122 – 1287
Beta strandi133 – 1353
Beta strandi153 – 1586
Beta strandi174 – 1818
Helixi183 – 1897
Beta strandi198 – 2014
Beta strandi204 – 2074
Helixi208 – 2103
Beta strandi216 – 23419
Beta strandi239 – 2424
Beta strandi244 – 2485
Helixi249 – 26012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KDQX-ray2.55A34-164[»]
B165-263[»]
2JETX-ray2.20A19-28[»]
B37-164[»]
C165-263[»]
ProteinModelPortaliP07338.
SMRiP07338. Positions 19-263.

Miscellaneous databases

EvolutionaryTraceiP07338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP07338.
KOiK01310.
PhylomeDBiP07338.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07338-1 [UniParc]FASTAAdd to Basket

« Hide

MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS    50
LQDKTGFHFC GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV 100
LKIAQVFKNP KFNMFTVRND ITLLKLATPA QFSETVSAVC LPNVDDDFPP 150
GTVCATTGWG KTKYNALKTP EKLQQAALPI VSEADCKKSW GSKITDVMTC 200
AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST STPAVYSRVT 250
ALMPWVQQIL EAN 263
Length:263
Mass (Da):27,849
Last modified:April 1, 1988 - v1
Checksum:iACAFDBACF8C4DA6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02298 Genomic DNA. Translation: AAA98732.1.
PIRiA22658. KYRTB.
RefSeqiNP_036668.1. NM_012536.1.
UniGeneiRn.105845.

Genome annotation databases

GeneIDi24291.
KEGGirno:24291.
UCSCiRGD:2444. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02298 Genomic DNA. Translation: AAA98732.1 .
PIRi A22658. KYRTB.
RefSeqi NP_036668.1. NM_012536.1.
UniGenei Rn.105845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KDQ X-ray 2.55 A 34-164 [» ]
B 165-263 [» ]
2JET X-ray 2.20 A 19-28 [» ]
B 37-164 [» ]
C 165-263 [» ]
ProteinModelPortali P07338.
SMRi P07338. Positions 19-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026017.

Protein family/group databases

MEROPSi S01.152.

PTM databases

PhosphoSitei P07338.

Proteomic databases

PaxDbi P07338.
PRIDEi P07338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24291.
KEGGi rno:24291.
UCSCi RGD:2444. rat.

Organism-specific databases

CTDi 1504.
RGDi 2444. Ctrb1.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P07338.
KOi K01310.
PhylomeDBi P07338.

Enzyme and pathway databases

BRENDAi 3.4.21.1. 5301.

Miscellaneous databases

EvolutionaryTracei P07338.
NextBioi 602890.

Gene expression databases

Genevestigatori P07338.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence of a rat chymotrypsin B gene."
    Bell G.I., Quinto C., Quiroga M., Valenzuela P., Craik C.S., Rutter W.J.
    J. Biol. Chem. 259:14265-14270(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCTRB1_RAT
AccessioniPrimary (citable) accession number: P07338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 11, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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