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P07337 (BGLS_KLUMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
OrganismKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifier4911 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length845 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ?
Chain? – 845Beta-glucosidasePRO_0000011778

Sites

Active site2251 By similarity

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation6211N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P07337 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 78D4C1550D5992B5

FASTA84593,917
        10         20         30         40         50         60 
MSKFDVEQLL SELNQDEKIS LLSAVDFWHT KKIERLGIPA VRVSDGPNGI RGTKFFDGVP 

        70         80         90        100        110        120 
SGCFPNGTGL ASTFDRDLLE TAGKLMAKES IAKNAAVILG PTTNMQRGPL GGRGFESFSE 

       130        140        150        160        170        180 
DPYLAGMATS SVVKGMQGEG IAATVKHFVC NDLEDQRFSS NSIVSERALR EIYLEPFRLA 

       190        200        210        220        230        240 
VKHANPVCIM TAYNKVNGDH CSQSKKLLID ILRDEWKWDG MLMSDWFGTY TTAAAIKNGL 

       250        260        270        280        290        300 
DIEFPGPTRW RTRALVSHSL NSREQITTED VDDRVRQVLK MIKFVVDNLE KTGIVENGPE 

       310        320        330        340        350        360 
STSNNTKETS DLLREIAADS IVLLKNKNNY LTSKERRQYH VIGPNAKAKT SSGGGSASMN 

       370        380        390        400        410        420 
SYYVVSPYEG IVNKLGKEVD YTVGAYSHKS IGGLAESSLI DAAKPADAEN AGLIAKFYSN 

       430        440        450        460        470        480 
PVEERSEDEE PFHVTKVNRS NVHLFDFKHE KVDPKNPYFF VTLTGQYVPQ EDGDYIFSLQ 

       490        500        510        520        530        540 
VYGSGLFYLN DELIIDQKHN QERGSFCFGA GTKERTKKLT LKKGQVYNVR VEYGSGPTSG 

       550        560        570        580        590        600 
LVGEFGAGGF QAGVIKAIDD DEEIRNAAEL AAKHDKAVLI IGLNGEWETE GYDRENMDLP 

       610        620        630        640        650        660 
KRTNELVRAV LKANPNTVIV NQSGTPVEFP WLEEANALVQ AWYGGNELGN AIADVLYGDV 

       670        680        690        700        710        720 
VPNGKLSLSW PFKLQDNPAF LNFKTEFGRV VYGEDIFVGY RYYEKLQRKV AFPFGYGLSY 

       730        740        750        760        770        780 
TTFELDISDF KVTDDKIDIS VDVKNTGDKF AGSEVVQVYF SALNSKVSRP VKELKGFEKV 

       790        800        810        820        830        840 
HLEPGEKKTV NIELELKDAI SYFNEELGKW HVEAGEYLVS VGTSSDDILS VKEFKVEKDL 


YWKGL 

« Hide

References

[1]"Sequence and transcription of the beta-glucosidase gene of Kluyveromyces fragilis cloned in Saccharomyces cerevisiae."
Raynal A., Gerbaud C., Francingues M.C., Guerineau M.
Curr. Genet. 12:175-184(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 12424 / NRRL Y-610.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05918 Genomic DNA. Translation: CAA29353.1.
PIRGLVK. A29148.

3D structure databases

ProteinModelPortalP07337.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SMARTSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLS_KLUMA
AccessionPrimary (citable) accession number: P07337
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 16, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries