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Protein

Beta-glucosidase

Gene
N/A
Organism
Kluyveromyces marxianus (Yeast) (Candida kefyr)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway:icellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BRENDAi3.2.1.21. 1120.
UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
OrganismiKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifieri4911 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 845Beta-glucosidasePRO_0000011778
Signal peptidei1 – ?

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi621 – 6211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP07337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFDVEQLL SELNQDEKIS LLSAVDFWHT KKIERLGIPA VRVSDGPNGI
60 70 80 90 100
RGTKFFDGVP SGCFPNGTGL ASTFDRDLLE TAGKLMAKES IAKNAAVILG
110 120 130 140 150
PTTNMQRGPL GGRGFESFSE DPYLAGMATS SVVKGMQGEG IAATVKHFVC
160 170 180 190 200
NDLEDQRFSS NSIVSERALR EIYLEPFRLA VKHANPVCIM TAYNKVNGDH
210 220 230 240 250
CSQSKKLLID ILRDEWKWDG MLMSDWFGTY TTAAAIKNGL DIEFPGPTRW
260 270 280 290 300
RTRALVSHSL NSREQITTED VDDRVRQVLK MIKFVVDNLE KTGIVENGPE
310 320 330 340 350
STSNNTKETS DLLREIAADS IVLLKNKNNY LTSKERRQYH VIGPNAKAKT
360 370 380 390 400
SSGGGSASMN SYYVVSPYEG IVNKLGKEVD YTVGAYSHKS IGGLAESSLI
410 420 430 440 450
DAAKPADAEN AGLIAKFYSN PVEERSEDEE PFHVTKVNRS NVHLFDFKHE
460 470 480 490 500
KVDPKNPYFF VTLTGQYVPQ EDGDYIFSLQ VYGSGLFYLN DELIIDQKHN
510 520 530 540 550
QERGSFCFGA GTKERTKKLT LKKGQVYNVR VEYGSGPTSG LVGEFGAGGF
560 570 580 590 600
QAGVIKAIDD DEEIRNAAEL AAKHDKAVLI IGLNGEWETE GYDRENMDLP
610 620 630 640 650
KRTNELVRAV LKANPNTVIV NQSGTPVEFP WLEEANALVQ AWYGGNELGN
660 670 680 690 700
AIADVLYGDV VPNGKLSLSW PFKLQDNPAF LNFKTEFGRV VYGEDIFVGY
710 720 730 740 750
RYYEKLQRKV AFPFGYGLSY TTFELDISDF KVTDDKIDIS VDVKNTGDKF
760 770 780 790 800
AGSEVVQVYF SALNSKVSRP VKELKGFEKV HLEPGEKKTV NIELELKDAI
810 820 830 840
SYFNEELGKW HVEAGEYLVS VGTSSDDILS VKEFKVEKDL YWKGL
Length:845
Mass (Da):93,917
Last modified:April 1, 1988 - v1
Checksum:i78D4C1550D5992B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05918 Genomic DNA. Translation: CAA29353.1.
PIRiA29148. GLVK.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05918 Genomic DNA. Translation: CAA29353.1.
PIRiA29148. GLVK.

3D structure databases

ProteinModelPortaliP07337.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00696.
BRENDAi3.2.1.21. 1120.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and transcription of the beta-glucosidase gene of Kluyveromyces fragilis cloned in Saccharomyces cerevisiae."
    Raynal A., Gerbaud C., Francingues M.C., Guerineau M.
    Curr. Genet. 12:175-184(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 12424 / NRRL Y-610.

Entry informationi

Entry nameiBGLS_KLUMA
AccessioniPrimary (citable) accession number: P07337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.