Reviewed, UniProtKB/Swiss-Prot P07332 (FES_HUMAN)

Names and origin

Protein names

Recommended name:
    Proto-oncogene tyrosine-protein kinase Fes/Fps
      Short name=C-Fes
    EC=2.7.10.2

Gene names

Name:	FES
Synonyms:	FPS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	822 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 FCH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc multicellular organismal development Traceable author statement. Source: ProtInc peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 822

822

Proto-oncogene tyrosine-protein kinase Fes/Fps

PRO_0000088088

Regions

Domain

1 – 69

69

FCH

Domain

460 – 549

90

SH2

Domain

561 – 822

262

Protein kinase

Nucleotide binding

567 – 575

9

ATP By similarity

Sites

Active site

683

1

Proton acceptor By similarity

Binding site

590

1

ATP By similarity

Amino acid modifications

Modified residue

713

1

Phosphotyrosine; by autocatalysis By similarity

Natural variations

Natural variant

85

1

R → C Ref.5

VAR_041697

Natural variant

246

1

R → Q Ref.5

VAR_041698

Natural variant

323

1

M → V Ref.5

VAR_041699

Experimental info

Sequence conflict

719

1

L → S in CAA36438. Ref.1

Secondary structure

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822

Helix Strand Turn

Details...

Helix

450 – 452

3

Helix

455 – 457

3

Helix

467 – 473

7

Beta strand

479 – 485

7

Turn

486 – 489

4

Beta strand

490 – 497

8

Beta strand

500 – 505

6

Beta strand

507 – 509

3

Beta strand

512 – 517

6

Beta strand

520 – 522

3

Helix

523 – 533

11

Turn

539 – 541

3

Helix

558 – 560

3

Beta strand

561 – 569

9

Beta strand

571 – 580

10

Turn

581 – 583

3

Beta strand

586 – 590

5

Helix

598 – 601

4

Helix

602 – 605

4

Helix

606 – 611

6

Beta strand

622 – 626

5

Beta strand

628 – 631

4

Beta strand

633 – 637

5

Helix

644 – 651

8

Helix

652 – 654

3

Helix

657 – 676

20

Helix

686 – 688

3

Beta strand

689 – 691

3

Beta strand

697 – 699

3

Beta strand

711 – 714

4

Helix

724 – 726

3

Helix

729 – 734

6

Beta strand

736 – 738

3

Helix

739 – 754

16

Helix

766 – 774

9

Helix

787 – 796

10

Helix

801 – 803

3

Helix

807 – 819

13

Sequences

	Sequence		Length	Mass (Da)
	P07332-1 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: 4C2A90555857F045	FASTA	822	93,497
	10 20 30 40 50 60 MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 70 80 90 100 110 120 RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW 130 140 150 160 170 180 QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF 190 200 210 220 230 240 AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE 250 260 270 280 290 300 VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE 310 320 330 340 350 360 LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL 370 380 390 400 410 420 QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR 430 440 450 460 470 480 TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF 490 500 510 520 530 540 LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK 550 560 570 580 590 600 SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL 610 620 630 640 650 660 KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL 670 680 690 700 710 720 LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR 730 740 750 760 770 780 QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP 790 800 810 820 CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene." Alcalay M., Antolini F., van de Ven W.J.M., Lanfrancone L., Grignani F., Pelicci P.G. Oncogene 5:267-275(1990) [PubMed: 2179816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The structure of the human c-fes/fps proto-oncogene." Roebroek A.J.M., Schalken J.A., Verbeek J.S., van den Ouweland A.M.W., Onnekink C., Bloemers H.P.J., van de Ven W.J.M. EMBO J. 4:2897-2903(1985) [PubMed: 4065096] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes." Scott A., Pantoja-Uceda D., Koshiba S., Inoue M., Kigawa T., Terada T., Shirouzu M., Tanaka A., Sugano S., Yokoyama S., Guentert P. J. Biomol. NMR 31:357-361(2005) [PubMed: 15929003] [Abstract] Cited for: STRUCTURE BY NMR OF 450-550.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-85; GLN-246 AND VAL-323.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X52192 mRNA. Translation: CAA36438.1.
X06292 Genomic DNA. Translation: CAA29619.1.
BC035357 mRNA. Translation: AAH35357.1.

IPI

IPI00294344.

PIR

TVHUFF. A24673.

RefSeq

NP_001996.1.

UniGene

Hs.7636

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WQU	NMR	-	A	450-550	[»]
2DCR	NMR	-	A	450-550	[»]
3BKB	X-ray	1.78	A	448-822	[»]
3CBL	X-ray	1.75	A	448-822	[»]
3CD3	X-ray	1.98	A	448-822	[»]

ModBase

Search...

PTM databases

PhosphoSite

P07332.

Proteomic databases

PRIDE

P07332.

Genome annotation databases

Ensembl

ENSG00000182511. Homo sapiens. [Contig view]

GeneID

2242.

KEGG

hsa:2242.

Organism-specific databases

GeneCards

GC15P089230.

H-InvDB

HIX0026902.

HGNC

HGNC:3657. FES.

HPA

HPA001376.

MIM

190030. gene.

PharmGKB

PA28098.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P07332.

HOVERGEN

P07332.

OMA

P07332. CWAYEPG.

Enzyme and pathway databases

BRENDA

2.7.10.2. 247.

Pathway_Interaction_DB

angiopoietinreceptor_pathway. Angiopoietin receptor Tie2-mediated signaling.
il4_2pathway. IL4-mediated signaling events.
vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2.

Gene expression databases

ArrayExpress

P07332.

Bgee

P07332.

CleanEx

HS_FES.

GermOnline

ENSG00000182511. Homo sapiens.

Family and domain databases

InterPro

IPR001060. FCH.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016250. TyrPK_fps.
[Graphical view]

Gene3D

G3DSA:3.30.505.10. SH2. 1 hit.

Pfam

PF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]

PIRSF

PIRSF000632. TyrPK_fps. 1 hit.

PRINTS

PR00401. SH2DOMAIN.
PR00109. TYRKINASE.

ProDom

PD000001. Prot_kinase. 1 hit.
PD000093. SH2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]

PROSITE

PS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

9069.

SOURCE

Search...

Entry information

Entry name

FES_HUMAN

Accession

Primary (citable) accession number: P07332
Secondary accession number(s): Q6GTU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)