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Protein

Alcohol dehydrogenase 1A

Gene

ADH1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi175Zinc 1; catalytic1
Binding sitei224NAD2 Publications1
Binding sitei229NAD2 Publications1
Binding sitei370NAD2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NAD2 Publications6
Nucleotide bindingi293 – 295NAD2 Publications3

GO - Molecular functioni

GO - Biological processi

  • alcohol metabolic process Source: UniProtKB
  • drug metabolic process Source: Reactome
  • ethanol oxidation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2161541. Abacavir metabolism.
R-HSA-5365859. RA biosynthesis pathway.
R-HSA-71384. Ethanol oxidation.
SABIO-RKP07327.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1A (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase subunit alpha
Gene namesi
Name:ADH1A
Synonyms:ADH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:249. ADH1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi124.
OpenTargetsiENSG00000187758.
PharmGKBiPA24570.

Chemistry databases

ChEMBLiCHEMBL1970.
DrugBankiDB00898. Ethanol.
DB01213. Fomepizole.

Polymorphism and mutation databases

BioMutaiADH1A.
DMDMi113390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606582 – 375Alcohol dehydrogenase 1AAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP07327.
PaxDbiP07327.
PeptideAtlasiP07327.
PRIDEiP07327.

PTM databases

iPTMnetiP07327.
PhosphoSitePlusiP07327.

Expressioni

Gene expression databases

BgeeiENSG00000187758.
CleanExiHS_ADH1A.
GenevisibleiP07327. HS.

Organism-specific databases

HPAiCAB009562.
HPA047814.
HPA060902.

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types; alpha, beta and gamma.2 Publications

Protein-protein interaction databases

BioGridi106636. 2 interactors.
IntActiP07327. 2 interactors.
STRINGi9606.ENSP00000209668.

Chemistry databases

BindingDBiP07327.

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Beta strandi23 – 29Combined sources7
Beta strandi36 – 45Combined sources10
Helixi48 – 54Combined sources7
Beta strandi62 – 65Combined sources4
Beta strandi69 – 77Combined sources9
Beta strandi89 – 92Combined sources4
Beta strandi99 – 101Combined sources3
Helixi102 – 105Combined sources4
Beta strandi116 – 119Combined sources4
Beta strandi131 – 133Combined sources3
Beta strandi136 – 139Combined sources4
Turni142 – 144Combined sources3
Beta strandi147 – 154Combined sources8
Helixi155 – 157Combined sources3
Beta strandi158 – 160Combined sources3
Helixi167 – 170Combined sources4
Helixi171 – 174Combined sources4
Helixi176 – 185Combined sources10
Turni186 – 188Combined sources3
Beta strandi195 – 199Combined sources5
Helixi203 – 214Combined sources12
Beta strandi218 – 223Combined sources6
Helixi227 – 229Combined sources3
Helixi230 – 235Combined sources6
Beta strandi239 – 242Combined sources4
Helixi244 – 246Combined sources3
Helixi251 – 258Combined sources8
Turni259 – 261Combined sources3
Beta strandi263 – 268Combined sources6
Helixi273 – 282Combined sources10
Turni285 – 287Combined sources3
Beta strandi289 – 292Combined sources4
Beta strandi302 – 304Combined sources3
Helixi307 – 310Combined sources4
Beta strandi314 – 317Combined sources4
Helixi320 – 322Combined sources3
Helixi325 – 337Combined sources13
Helixi344 – 346Combined sources3
Beta strandi347 – 352Combined sources6
Helixi353 – 355Combined sources3
Helixi356 – 364Combined sources9
Beta strandi369 – 374Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSOX-ray2.50A/B2-375[»]
1U3TX-ray2.49A/B2-375[»]
ProteinModelPortaliP07327.
SMRiP07327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiP07327.
KOiK13951.
OMAiNPQGTLQ.
OrthoDBiEOG091G08N3.
PhylomeDBiP07327.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD
60 70 80 90 100
DHVVSGTMVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK
110 120 130 140 150
CRICKNPESN YCLKNDVSNP QGTLQDGTSR FTCRRKPIHH FLGISTFSQY
160 170 180 190 200
TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP
260 270 280 290 300
IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
310 320 330 340 350
NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV
360 370
LPFEKINEGF DLLHSGKSIR TILMF
Length:375
Mass (Da):39,859
Last modified:January 23, 2007 - v2
Checksum:iB6DF4D57080D9BC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12963 mRNA. Translation: AAA51590.1.
M12271 mRNA. Translation: AAA68131.1.
BT019812 mRNA. Translation: AAV38615.1.
AY948115 Genomic DNA. Translation: AAX20115.1.
AK290558 mRNA. Translation: BAF83247.1.
CH471057 Genomic DNA. Translation: EAX06094.1.
BC074738 mRNA. Translation: AAH74738.1.
BC117442 mRNA. Translation: AAI17443.1.
BC126306 mRNA. Translation: AAI26307.1.
M37066 Genomic DNA. Translation: AAA51591.1.
CCDSiCCDS3648.1.
PIRiS02265. DEHUAA.
RefSeqiNP_000658.1. NM_000667.3.
UniGeneiHs.654433.

Genome annotation databases

EnsembliENST00000209668; ENSP00000209668; ENSG00000187758.
GeneIDi124.
KEGGihsa:124.
UCSCiuc003hur.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12963 mRNA. Translation: AAA51590.1.
M12271 mRNA. Translation: AAA68131.1.
BT019812 mRNA. Translation: AAV38615.1.
AY948115 Genomic DNA. Translation: AAX20115.1.
AK290558 mRNA. Translation: BAF83247.1.
CH471057 Genomic DNA. Translation: EAX06094.1.
BC074738 mRNA. Translation: AAH74738.1.
BC117442 mRNA. Translation: AAI17443.1.
BC126306 mRNA. Translation: AAI26307.1.
M37066 Genomic DNA. Translation: AAA51591.1.
CCDSiCCDS3648.1.
PIRiS02265. DEHUAA.
RefSeqiNP_000658.1. NM_000667.3.
UniGeneiHs.654433.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSOX-ray2.50A/B2-375[»]
1U3TX-ray2.49A/B2-375[»]
ProteinModelPortaliP07327.
SMRiP07327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106636. 2 interactors.
IntActiP07327. 2 interactors.
STRINGi9606.ENSP00000209668.

Chemistry databases

BindingDBiP07327.
ChEMBLiCHEMBL1970.
DrugBankiDB00898. Ethanol.
DB01213. Fomepizole.

PTM databases

iPTMnetiP07327.
PhosphoSitePlusiP07327.

Polymorphism and mutation databases

BioMutaiADH1A.
DMDMi113390.

Proteomic databases

MaxQBiP07327.
PaxDbiP07327.
PeptideAtlasiP07327.
PRIDEiP07327.

Protocols and materials databases

DNASUi124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209668; ENSP00000209668; ENSG00000187758.
GeneIDi124.
KEGGihsa:124.
UCSCiuc003hur.3. human.

Organism-specific databases

CTDi124.
DisGeNETi124.
GeneCardsiADH1A.
HGNCiHGNC:249. ADH1A.
HPAiCAB009562.
HPA047814.
HPA060902.
MIMi103700. gene.
neXtProtiNX_P07327.
OpenTargetsiENSG00000187758.
PharmGKBiPA24570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiP07327.
KOiK13951.
OMAiNPQGTLQ.
OrthoDBiEOG091G08N3.
PhylomeDBiP07327.
TreeFamiTF300429.

Enzyme and pathway databases

ReactomeiR-HSA-2161541. Abacavir metabolism.
R-HSA-5365859. RA biosynthesis pathway.
R-HSA-71384. Ethanol oxidation.
SABIO-RKP07327.

Miscellaneous databases

EvolutionaryTraceiP07327.
GeneWikiiADH1A.
GenomeRNAii124.
PROiP07327.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187758.
CleanExiHS_ADH1A.
GenevisibleiP07327. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH1A_HUMAN
AccessioniPrimary (citable) accession number: P07327
Secondary accession number(s): A8K3E3, Q17R68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.