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P07321

- EPO_MOUSE

UniProt

P07321 - EPO_MOUSE

Protein

Erythropoietin

Gene

Epo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

    GO - Molecular functioni

    1. erythropoietin receptor binding Source: DFLAT
    2. protein kinase activator activity Source: UniProtKB

    GO - Biological processi

    1. aging Source: Ensembl
    2. angiogenesis Source: DFLAT
    3. apoptotic process Source: MGI
    4. cardiac muscle tissue morphogenesis Source: DFLAT
    5. cellular hyperosmotic response Source: Ensembl
    6. embryo implantation Source: MGI
    7. erythrocyte differentiation Source: MGI
    8. erythrocyte maturation Source: UniProtKB-KW
    9. heart morphogenesis Source: DFLAT
    10. hemoglobin biosynthetic process Source: MGI
    11. negative regulation of apoptotic process Source: UniProtKB
    12. negative regulation of calcium ion transport into cytosol Source: Ensembl
    13. negative regulation of cation channel activity Source: Ensembl
    14. negative regulation of erythrocyte apoptotic process Source: Ensembl
    15. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
    16. negative regulation of myeloid cell apoptotic process Source: MGI
    17. peptidyl-serine phosphorylation Source: UniProtKB
    18. positive regulation of cell proliferation Source: Ensembl
    19. positive regulation of DNA replication Source: Ensembl
    20. positive regulation of neuron differentiation Source: Ensembl
    21. positive regulation of protein kinase activity Source: UniProtKB
    22. positive regulation of Ras protein signal transduction Source: Ensembl
    23. positive regulation of transcription, DNA-templated Source: Ensembl
    24. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    25. regulation of transcription from RNA polymerase II promoter Source: MGI
    26. response to axon injury Source: Ensembl
    27. response to electrical stimulus Source: Ensembl
    28. response to estrogen Source: Ensembl
    29. response to hyperoxia Source: Ensembl
    30. response to hypoxia Source: MGI
    31. response to interleukin-1 Source: Ensembl
    32. response to lipopolysaccharide Source: Ensembl
    33. response to salt stress Source: Ensembl
    34. response to testosterone Source: Ensembl
    35. response to vitamin A Source: Ensembl
    36. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
    37. ventricular cardiac muscle tissue morphogenesis Source: DFLAT
    38. visceral serous pericardium development Source: DFLAT

    Keywords - Molecular functioni

    Hormone

    Keywords - Biological processi

    Erythrocyte maturation

    Enzyme and pathway databases

    ReactomeiREACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
    SABIO-RKP07321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erythropoietin
    Gene namesi
    Name:Epo
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95407. Epo.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Add
    BLAST
    Chaini27 – 192166ErythropoietinPRO_0000008405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 187By similarity
    Glycosylationi50 – 501N-linked (GlcNAc...)By similarity
    Glycosylationi64 – 641N-linked (GlcNAc...)By similarity
    Glycosylationi109 – 1091N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP07321.

    PTM databases

    PhosphoSiteiP07321.

    Expressioni

    Tissue specificityi

    Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

    Gene expression databases

    BgeeiP07321.
    CleanExiMM_EPO.
    GenevestigatoriP07321.

    Structurei

    3D structure databases

    ProteinModelPortaliP07321.
    SMRiP07321. Positions 27-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPO/TPO family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43828.
    HOGENOMiHOG000052505.
    HOVERGENiHBG003978.
    InParanoidiP07321.
    KOiK05437.
    OMAiNVTMGCA.
    OrthoDBiEOG7DVDCR.
    PhylomeDBiP07321.
    TreeFamiTF333413.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view]
    PANTHERiPTHR10370. PTHR10370. 1 hit.
    PfamiPF00758. EPO_TPO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001951. EPO. 1 hit.
    PRINTSiPR00272. ERYTHROPTN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00817. EPO_TPO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN    50
    VTMGCAEGPR LSENITVPDT KVNFYAWKRM EVEEQAIEVW QGLSLLSEAI 100
    LQAQALLANS SQPPETLQLH IDKAISGLRS LTSLLRVLGA QKELMSPPDT 150
    TPPAPLRTLT VDTFCKLFRV YANFLRGKLK LYTGEVCRRG DR 192
    Length:192
    Mass (Da):21,365
    Last modified:April 1, 1988 - v1
    Checksum:i65F94E214E0DEF2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12482 Genomic DNA. Translation: AAA37568.1.
    M12930 Genomic DNA. Translation: AAA37570.1.
    AF312033 Genomic DNA. Translation: AAK28825.1.
    Y11971 mRNA. Translation: CAA72707.1.
    CCDSiCCDS39332.1.
    PIRiA24902.
    RefSeqiNP_031968.1. NM_007942.2.
    UniGeneiMm.349116.

    Genome annotation databases

    EnsembliENSMUST00000031723; ENSMUSP00000031723; ENSMUSG00000029711.
    ENSMUST00000111038; ENSMUSP00000106667; ENSMUSG00000029711.
    GeneIDi13856.
    KEGGimmu:13856.
    UCSCiuc009acm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12482 Genomic DNA. Translation: AAA37568.1 .
    M12930 Genomic DNA. Translation: AAA37570.1 .
    AF312033 Genomic DNA. Translation: AAK28825.1 .
    Y11971 mRNA. Translation: CAA72707.1 .
    CCDSi CCDS39332.1.
    PIRi A24902.
    RefSeqi NP_031968.1. NM_007942.2.
    UniGenei Mm.349116.

    3D structure databases

    ProteinModelPortali P07321.
    SMRi P07321. Positions 27-192.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P07321.

    Proteomic databases

    PRIDEi P07321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031723 ; ENSMUSP00000031723 ; ENSMUSG00000029711 .
    ENSMUST00000111038 ; ENSMUSP00000106667 ; ENSMUSG00000029711 .
    GeneIDi 13856.
    KEGGi mmu:13856.
    UCSCi uc009acm.1. mouse.

    Organism-specific databases

    CTDi 2056.
    MGIi MGI:95407. Epo.

    Phylogenomic databases

    eggNOGi NOG43828.
    HOGENOMi HOG000052505.
    HOVERGENi HBG003978.
    InParanoidi P07321.
    KOi K05437.
    OMAi NVTMGCA.
    OrthoDBi EOG7DVDCR.
    PhylomeDBi P07321.
    TreeFami TF333413.

    Enzyme and pathway databases

    Reactomei REACT_199107. Regulation of gene expression by Hypoxia-inducible Factor.
    SABIO-RK P07321.

    Miscellaneous databases

    ChiTaRSi EPO. mouse.
    NextBioi 284726.
    PROi P07321.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07321.
    CleanExi MM_EPO.
    Genevestigatori P07321.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view ]
    PANTHERi PTHR10370. PTHR10370. 1 hit.
    Pfami PF00758. EPO_TPO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001951. EPO. 1 hit.
    PRINTSi PR00272. ERYTHROPTN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00817. EPO_TPO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine erythropoietin gene: cloning, expression, and human gene homology."
      Shoemaker C.B., Mitsock L.D.
      Mol. Cell. Biol. 6:849-858(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene."
      McDonald J.D., Lin F.-K., Goldwasser E.
      Mol. Cell. Biol. 6:842-848(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
      Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    4. "Abnormal erythropoietin (Epo) gene expression in the murine erythroleukemia IW32 cells results from a rearrangement between the G-protein beta2 subunit gene and the Epo gene."
      Chretien S., Duprez V., Maouche L., Gisselbrecht S., Mayeux P., Lacombe C.
      Oncogene 15:1995-1999(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-52.
      Strain: ICFW.

    Entry informationi

    Entry nameiEPO_MOUSE
    AccessioniPrimary (citable) accession number: P07321
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3