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P07321 (EPO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Erythropoietin
Gene names
Name:Epo
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Subcellular location

Secreted.

Tissue specificity

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Sequence similarities

Belongs to the EPO/TPO family.

Ontologies

Keywords
   Biological processErythrocyte maturation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

apoptotic process

Inferred from direct assay PubMed 17300687. Source: MGI

cardiac muscle tissue morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

cellular hyperosmotic response

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from direct assay PubMed 17300687. Source: MGI

erythrocyte differentiation

Inferred from direct assay PubMed 15591122. Source: MGI

erythrocyte maturation

Inferred from electronic annotation. Source: UniProtKB-KW

heart morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

hemoglobin biosynthetic process

Inferred from direct assay PubMed 17300687. Source: MGI

negative regulation of apoptotic process

Inferred from direct assay PubMed 21095239. Source: UniProtKB

negative regulation of calcium ion transport into cytosol

Inferred from electronic annotation. Source: Ensembl

negative regulation of cation channel activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of erythrocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Inferred from electronic annotation. Source: Ensembl

negative regulation of myeloid cell apoptotic process

Inferred from direct assay PubMed 17981124. Source: MGI

peptidyl-serine phosphorylation

Inferred from direct assay PubMed 21095239. Source: UniProtKB

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of Ras protein signal transduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase activity

Inferred from direct assay PubMed 21095239. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17300687. Source: MGI

response to axon injury

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to hyperoxia

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from direct assay PubMed 15016652. Source: MGI

response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to salt stress

Inferred from electronic annotation. Source: Ensembl

response to testosterone

Inferred from electronic annotation. Source: Ensembl

response to vitamin A

Inferred from electronic annotation. Source: Ensembl

vasculogenesis involved in coronary vascular morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

ventricular cardiac muscle tissue morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

visceral serous pericardium development

Traceable author statement PubMed 20299672. Source: DFLAT

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 15016652. Source: MGI

   Molecular_functionerythropoietin receptor binding

Traceable author statement PubMed 20299672. Source: DFLAT

protein kinase activator activity

Inferred from direct assay PubMed 21095239. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 192166Erythropoietin
PRO_0000008405

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) By similarity
Glycosylation641N-linked (GlcNAc...) By similarity
Glycosylation1091N-linked (GlcNAc...) By similarity
Disulfide bond33 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P07321 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 65F94E214E0DEF2E

FASTA19221,365
        10         20         30         40         50         60 
MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN VTMGCAEGPR 

        70         80         90        100        110        120 
LSENITVPDT KVNFYAWKRM EVEEQAIEVW QGLSLLSEAI LQAQALLANS SQPPETLQLH 

       130        140        150        160        170        180 
IDKAISGLRS LTSLLRVLGA QKELMSPPDT TPPAPLRTLT VDTFCKLFRV YANFLRGKLK 

       190 
LYTGEVCRRG DR 

« Hide

References

[1]"Murine erythropoietin gene: cloning, expression, and human gene homology."
Shoemaker C.B., Mitsock L.D.
Mol. Cell. Biol. 6:849-858(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene."
McDonald J.D., Lin F.-K., Goldwasser E.
Mol. Cell. Biol. 6:842-848(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[4]"Abnormal erythropoietin (Epo) gene expression in the murine erythroleukemia IW32 cells results from a rearrangement between the G-protein beta2 subunit gene and the Epo gene."
Chretien S., Duprez V., Maouche L., Gisselbrecht S., Mayeux P., Lacombe C.
Oncogene 15:1995-1999(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-52.
Strain: ICFW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12482 Genomic DNA. Translation: AAA37568.1.
M12930 Genomic DNA. Translation: AAA37570.1.
AF312033 Genomic DNA. Translation: AAK28825.1.
Y11971 mRNA. Translation: CAA72707.1.
CCDSCCDS39332.1.
PIRA24902.
RefSeqNP_031968.1. NM_007942.2.
UniGeneMm.349116.

3D structure databases

ProteinModelPortalP07321.
SMRP07321. Positions 27-192.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP07321.

Proteomic databases

PRIDEP07321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031723; ENSMUSP00000031723; ENSMUSG00000029711.
ENSMUST00000111038; ENSMUSP00000106667; ENSMUSG00000029711.
GeneID13856.
KEGGmmu:13856.
UCSCuc009acm.1. mouse.

Organism-specific databases

CTD2056.
MGIMGI:95407. Epo.

Phylogenomic databases

eggNOGNOG43828.
HOGENOMHOG000052505.
HOVERGENHBG003978.
InParanoidP07321.
KOK05437.
OMANVTMGCA.
OrthoDBEOG7DVDCR.
PhylomeDBP07321.
TreeFamTF333413.

Enzyme and pathway databases

SABIO-RKP07321.

Gene expression databases

BgeeP07321.
CleanExMM_EPO.
GenevestigatorP07321.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERPTHR10370. PTHR10370. 1 hit.
PfamPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFPIRSF001951. EPO. 1 hit.
PRINTSPR00272. ERYTHROPTN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEPO. mouse.
NextBio284726.
PROP07321.
SOURCESearch...

Entry information

Entry nameEPO_MOUSE
AccessionPrimary (citable) accession number: P07321
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot