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Protein

Erythropoietin

Gene

Epo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processErythrocyte maturation

Enzyme and pathway databases

SABIO-RKiP07321.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:Epo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95407. Epo.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000000840527 – 192ErythropoietinAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 187By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi64N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi109N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07321.
PRIDEiP07321.

PTM databases

PhosphoSitePlusiP07321.

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

BgeeiENSMUSG00000029711.
CleanExiMM_EPO.
ExpressionAtlasiP07321. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031723.

Structurei

3D structure databases

ProteinModelPortaliP07321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP07321.
KOiK05437.
OMAiEAENVTM.
OrthoDBiEOG091G0PMA.
PhylomeDBiP07321.
TreeFamiTF333413.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiView protein in Pfam
PF00758. EPO_TPO. 1 hit.
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00817. EPO_TPO. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN
60 70 80 90 100
VTMGCAEGPR LSENITVPDT KVNFYAWKRM EVEEQAIEVW QGLSLLSEAI
110 120 130 140 150
LQAQALLANS SQPPETLQLH IDKAISGLRS LTSLLRVLGA QKELMSPPDT
160 170 180 190
TPPAPLRTLT VDTFCKLFRV YANFLRGKLK LYTGEVCRRG DR
Length:192
Mass (Da):21,365
Last modified:April 1, 1988 - v1
Checksum:i65F94E214E0DEF2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12482 Genomic DNA. Translation: AAA37568.1.
M12930 Genomic DNA. Translation: AAA37570.1.
AF312033 Genomic DNA. Translation: AAK28825.1.
Y11971 mRNA. Translation: CAA72707.1.
CCDSiCCDS39332.1.
PIRiA24902.
RefSeqiNP_031968.1. NM_007942.2.
UniGeneiMm.349116.

Genome annotation databases

EnsembliENSMUST00000031723; ENSMUSP00000031723; ENSMUSG00000029711.
ENSMUST00000111038; ENSMUSP00000106667; ENSMUSG00000029711.
GeneIDi13856.
KEGGimmu:13856.
UCSCiuc009acm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiEPO_MOUSE
AccessioniPrimary (citable) accession number: P07321
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families