Reviewed, UniProtKB/Swiss-Prot P07311 (ACYP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-1
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 1
    Acylphosphatase, organ-common type isozyme
    Acylphosphatase, erythrocyte isozyme

Gene names

Name:	ACYP1
Synonyms:	ACYPE

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Tissue specificity	Organ-common type isozyme is found in many different tissues.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	phosphate metabolic process Ref.4 Traceable author statement. Source: ProtInc
Molecular function	acylphosphatase activity Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 99	98	Acylphosphatase-1		PRO_0000158535
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.4
Experimental info
	Sequence conflict	20	1	G → R Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P07311-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F9F787E490BC8296	FASTA	99	11,261
	10 20 30 40 50 60 MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 70 80 90 HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Raugei G. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[4]	"A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure." Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G. Biochemistry 25:8089-8094(1986) [PubMed: 3026468] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99.
[5]	"Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase." Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G. FEBS Lett. 367:145-148(1995) [PubMed: 7796909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-86. Tissue: Placenta.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X84194 mRNA. Translation: CAA58987.1.
AC007055 Genomic DNA. Translation: AAD31937.1.
BC035568 mRNA. Translation: AAH35568.1.

IPI

IPI00221117.

PIR

QPHUE. S66187.

RefSeq

NP_001098.1.
NP_982355.1.

UniGene

Hs.18573
Hs.436650

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K7J	NMR	-	A	2-99	[»]
2K7K	NMR	-	A	2-99	[»]
2VH7	X-ray	1.45	A	1-99	[»]

SMR

P07311. Positions 2-99.

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000119640. Homo sapiens. [Contig view]

GeneID

97.

KEGG

hsa:97.

UCSC

uc001xrg.1. human.

Organism-specific databases

GeneCards

GC14M074589.

H-InvDB

HIX0026751.
HIX0074267.

HGNC

HGNC:179. ACYP1.

MIM

600875. gene.

PharmGKB

PA24499.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P07311.

HOVERGEN

P07311.

OMA

P07311. HIDRANF.

Enzyme and pathway databases

BRENDA

3.6.1.7. 247.

Gene expression databases

ArrayExpress

P07311.

CleanEx

HS_ACYP1.

GermOnline

ENSG00000119640. Homo sapiens.

Family and domain databases

InterPro

IPR001792. Acylphosphatase.
IPR017968. Acylphosphatase_CS.
[Graphical view]

PANTHER

PTHR10029. Acylphosphatase. 1 hit.

Pfam

PF00708. Acylphosphatase. 1 hit.
[Graphical view]

ProDom

PD001884. Acylphosphatase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

367.

SOURCE

Search...

Entry information

Entry name

ACYP1_HUMAN

Accession

Primary (citable) accession number: P07311

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	July 7, 2009
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)