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P07311

- ACYP1_HUMAN

UniProt

P07311 - ACYP1_HUMAN

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Protein

Acylphosphatase-1

Gene
ACYP1, ACYPE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241 Reviewed prediction
Active sitei42 – 421 Reviewed prediction

GO - Molecular functioni

  1. acylphosphatase activity Source: RefGenome

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKP07311.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, erythrocyte isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:ACYP1
Synonyms:ACYPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:179. ACYP1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 9998Acylphosphatase-1PRO_0000158535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP07311.
PaxDbiP07311.
PRIDEiP07311.

PTM databases

PhosphoSiteiP07311.

Expressioni

Tissue specificityi

Organ-common type isozyme is found in many different tissues.

Gene expression databases

ArrayExpressiP07311.
BgeeiP07311.
CleanExiHS_ACYP1.
GenevestigatoriP07311.

Organism-specific databases

HPAiHPA034944.

Interactioni

Protein-protein interaction databases

BioGridi106612. 2 interactions.
STRINGi9606.ENSP00000238618.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 1711
Beta strandi19 – 213
Helixi23 – 3311
Beta strandi37 – 426
Beta strandi44 – 463
Beta strandi48 – 558
Helixi56 – 6813
Beta strandi72 – 743
Beta strandi75 – 8915
Beta strandi93 – 975

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K7JNMR-A2-99[»]
2K7KNMR-A2-99[»]
2VH7X-ray1.45A1-99[»]
2W4CX-ray1.52A1-99[»]
2W4PX-ray1.70A1-99[»]
3TOQX-ray2.00A1-99[»]
ProteinModelPortaliP07311.
SMRiP07311. Positions 6-99.

Miscellaneous databases

EvolutionaryTraceiP07311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9991Acylphosphatase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.

Phylogenomic databases

eggNOGiNOG289322.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP07311.
KOiK01512.
OrthoDBiEOG7ZGX55.
PhylomeDBiP07311.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P07311-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG   50
QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK 99
Length:99
Mass (Da):11,261
Last modified:January 23, 2007 - v2
Checksum:iF9F787E490BC8296
GO
Isoform 2 (identifier: P07311-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-99: AEGKKLGLVG...LDYSDFQIVK → EMTVENRIAETHSKSCVPVSFATSYAG

Note: No experimental confirmation available.

Show »
Length:55
Mass (Da):6,113
Checksum:i37822D3FA5EF8F81
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 9971AEGKK…FQIVK → EMTVENRIAETHSKSCVPVS FATSYAG in isoform 2. VSP_045688Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84194 mRNA. Translation: CAA58987.1.
AK312101 mRNA. Translation: BAG35037.1.
AC007055 Genomic DNA. Translation: AAD31937.1.
AL049780 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81216.1.
BC035568 mRNA. Translation: AAH35568.1.
BG614847 mRNA. No translation available.
CCDSiCCDS45137.1. [P07311-2]
CCDS9838.1. [P07311-1]
PIRiS66187. QPHUE.
RefSeqiNP_001098.1. NM_001107.3. [P07311-1]
NP_982355.1. NM_203488.1. [P07311-2]
UniGeneiHs.18573.

Genome annotation databases

EnsembliENST00000238618; ENSP00000238618; ENSG00000119640. [P07311-1]
ENST00000357971; ENSP00000350655; ENSG00000119640. [P07311-2]
ENST00000555694; ENSP00000451581; ENSG00000119640. [P07311-1]
GeneIDi97.
KEGGihsa:97.
UCSCiuc001xrg.3. human. [P07311-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84194 mRNA. Translation: CAA58987.1 .
AK312101 mRNA. Translation: BAG35037.1 .
AC007055 Genomic DNA. Translation: AAD31937.1 .
AL049780 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81216.1 .
BC035568 mRNA. Translation: AAH35568.1 .
BG614847 mRNA. No translation available.
CCDSi CCDS45137.1. [P07311-2 ]
CCDS9838.1. [P07311-1 ]
PIRi S66187. QPHUE.
RefSeqi NP_001098.1. NM_001107.3. [P07311-1 ]
NP_982355.1. NM_203488.1. [P07311-2 ]
UniGenei Hs.18573.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2K7J NMR - A 2-99 [» ]
2K7K NMR - A 2-99 [» ]
2VH7 X-ray 1.45 A 1-99 [» ]
2W4C X-ray 1.52 A 1-99 [» ]
2W4P X-ray 1.70 A 1-99 [» ]
3TOQ X-ray 2.00 A 1-99 [» ]
ProteinModelPortali P07311.
SMRi P07311. Positions 6-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106612. 2 interactions.
STRINGi 9606.ENSP00000238618.

PTM databases

PhosphoSitei P07311.

Proteomic databases

MaxQBi P07311.
PaxDbi P07311.
PRIDEi P07311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238618 ; ENSP00000238618 ; ENSG00000119640 . [P07311-1 ]
ENST00000357971 ; ENSP00000350655 ; ENSG00000119640 . [P07311-2 ]
ENST00000555694 ; ENSP00000451581 ; ENSG00000119640 . [P07311-1 ]
GeneIDi 97.
KEGGi hsa:97.
UCSCi uc001xrg.3. human. [P07311-1 ]

Organism-specific databases

CTDi 97.
GeneCardsi GC14M075519.
HGNCi HGNC:179. ACYP1.
HPAi HPA034944.
MIMi 600875. gene.
neXtProti NX_P07311.
PharmGKBi PA24499.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289322.
HOGENOMi HOG000292688.
HOVERGENi HBG050454.
InParanoidi P07311.
KOi K01512.
OrthoDBi EOG7ZGX55.
PhylomeDBi P07311.
TreeFami TF300288.

Enzyme and pathway databases

SABIO-RK P07311.

Miscellaneous databases

EvolutionaryTracei P07311.
GeneWikii ACYP1.
GenomeRNAii 97.
NextBioi 367.
PROi P07311.
SOURCEi Search...

Gene expression databases

ArrayExpressi P07311.
Bgeei P07311.
CleanExi HS_ACYP1.
Genevestigatori P07311.

Family and domain databases

InterProi IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view ]
Pfami PF00708. Acylphosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00112. ACYLPHPHTASE.
SUPFAMi SSF54975. SSF54975. 1 hit.
PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Raugei G.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryonic carcinoma and Mammary gland.
  6. "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure."
    Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G.
    Biochemistry 25:8089-8094(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-99, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2.
  7. "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase."
    Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.
    FEBS Lett. 367:145-148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 10-86.
    Tissue: Placenta.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase."
    Yeung R.C., Lam S.Y., Wong K.B.
    Acta Crystallogr. F 62:80-82(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
  10. "Rational stabilization of enzymes by computational redesign of surface charge-charge interactions."
    Gribenko A.V., Patel M.M., Liu J., McCallum S.A., Wang C., Makhatadze G.I.
    Proc. Natl. Acad. Sci. U.S.A. 106:2601-2606(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-99.

Entry informationi

Entry nameiACYP1_HUMAN
AccessioniPrimary (citable) accession number: P07311
Secondary accession number(s): A6NDV8, B2R590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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