P07311 (ACYP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylphosphatase-1
EC=3.6.1.7

Alternative name(s):
Acylphosphatase, erythrocyte isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1

Gene names

Name:	ACYP1
Synonyms:	ACYPE

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Tissue specificity	Organ-common type isozyme is found in many different tissues.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	phosphate-containing compound metabolic process Traceable author statement. Source: ProtInc
Molecular function	acylphosphatase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.6

Chain

2 – 99

98

Acylphosphatase-1

PRO_0000158535

Regions

Domain

9 – 99

91

Acylphosphatase-like

Sites

Active site

24

1

Potential

Active site

42

1

Potential

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.6

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

99

Helix Strand Turn

Details...

Beta strand

7 – 15

9

Helix

23 – 29

7

Beta strand

40 – 42

3

Helix

56 – 68

13

Beta strand

77 – 89

13

Sequences

	Sequence		Length	Mass (Da)
	P07311 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F9F787E490BC8296	FASTA	99	11,261
	10 20 30 40 50 60 MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 70 80 90 HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Raugei G. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[6]	"A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure." Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G. Biochemistry 25:8089-8094(1986) [PubMed: 3026468] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99.
[7]	"Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase." Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G. FEBS Lett. 367:145-148(1995) [PubMed: 7796909] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 10-86. Tissue: Placenta.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase." Yeung R.C., Lam S.Y., Wong K.B. Acta Crystallogr. F 62:80-82(2006) [PubMed: 16511269] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
[10]	"Rational stabilization of enzymes by computational redesign of surface charge-charge interactions." Gribenko A.V., Patel M.M., Liu J., McCallum S.A., Wang C., Makhatadze G.I. Proc. Natl. Acad. Sci. U.S.A. 106:2601-2606(2009) [PubMed: 19196981] [Abstract] Cited for: STRUCTURE BY NMR OF 2-99.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X84194 mRNA. Translation: CAA58987.1.
AK312101 mRNA. Translation: BAG35037.1.
AC007055 Genomic DNA. Translation: AAD31937.1.
CH471061 Genomic DNA. Translation: EAW81216.1.
BC035568 mRNA. Translation: AAH35568.1.

IPI

IPI00221117.

PIR

QPHUE. S66187.

RefSeq

NP_001098.1. NM_001107.3.
NP_982355.1. NM_203488.1.

UniGene

Hs.18573.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K7J	NMR	-	A	2-99	[»]
2K7K	NMR	-	A	2-99	[»]
2VH7	X-ray	1.45	A	1-99	[»]
2W4C	X-ray	1.52	A	1-98	[»]
2W4P	X-ray	1.70	A	1-98	[»]

ProteinModelPortal

P07311.

SMR

P07311. Positions 6-99.

ModBase

Search...

Protein-protein interaction databases

STRING

P07311.

Polymorphism databases

DMDM

2507560.

Proteomic databases

PRIDE

P07311.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000238618; ENSP00000238618; ENSG00000119640.

GeneID

97.

KEGG

hsa:97.

UCSC

uc001xrg.1. human.

Organism-specific databases

CTD

97.

GeneCards

GC14M075519.

H-InvDB

HIX0202094.

HGNC

HGNC:179. ACYP1.

HPA

HPA034944.

MIM

600875. gene.

neXtProt

NX_P07311.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20949.

GeneTree

ENSGT00390000011103.

HOGENOM

HBG750266.

HOVERGEN

HBG050454.

InParanoid

P07311.

OMA

ASFNNEK.

OrthoDB

EOG4XD3SN.

PhylomeDB

P07311.

Gene expression databases

CleanEx

HS_ACYP1.

Genevestigator

P07311.

GermOnline

ENSG00000119640. Homo sapiens.

Family and domain databases

InterPro

IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like.
IPR017968. Acylphosphatase_CS.
[Graphical view]

KO

K01512.

Pfam

PF00708. Acylphosphatase. 1 hit.
[Graphical view]

PRINTS

PR00112. ACYLPHPHTASE.

SUPFAM

SSF54975. Acylphosphatase. 1 hit.

PROSITE

PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

367.

SOURCE

Search...

Entry information

Entry name

ACYP1_HUMAN

Accession

Primary (citable) accession number: P07311
Secondary accession number(s): B2R590

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.