P07311 (ACYP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 117.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acylphosphatase-1 EC=3.6.1.7 Alternative name(s): Acylphosphatase, erythrocyte isozyme Acylphosphatase, organ-common type isozyme Acylphosphate phosphohydrolase 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 99 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Its physiological role is not yet clear. |
| Catalytic activity | An acylphosphate + H2O = a carboxylate + phosphate. |
| Tissue specificity | Organ-common type isozyme is found in many different tissues. |
| Sequence similarities | Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase |
| PTM | Acetylation |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | phosphate-containing compound metabolic process Traceable author statement. Source: ProtInc |
| Molecular function | acylphosphatase activity Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.6 | ||||||||||||||||
| Chain | 2 – 99 | 98 | Acylphosphatase-1 | PRO_0000158535 | |||||||||||||||
Regions | |||||||||||||||||||
| Domain | 9 – 99 | 91 | Acylphosphatase-like | ||||||||||||||||
Sites | |||||||||||||||||||
| Active site | 24 | 1 | Potential | ||||||||||||||||
| Active site | 42 | 1 | Potential | ||||||||||||||||
Amino acid modifications | |||||||||||||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.6 | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Beta strand | 7 – 15 | 9 | |||||||||||||||||
| Helix | 23 – 29 | 7 | |||||||||||||||||
| Beta strand | 40 – 42 | 3 | |||||||||||||||||
| Helix | 56 – 68 | 13 | |||||||||||||||||
| Beta strand | 77 – 89 | 13 | |||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | Raugei G. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [3] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland. |
| [6] | "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure." Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G. Biochemistry 25:8089-8094(1986) [PubMed: 3026468] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. |
| [7] | "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase." Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G. FEBS Lett. 367:145-148(1995) [PubMed: 7796909] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 10-86. Tissue: Placenta. |
| [8] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [9] | "Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase." Yeung R.C., Lam S.Y., Wong K.B. Acta Crystallogr. F 62:80-82(2006) [PubMed: 16511269] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS). |
| [10] | "Rational stabilization of enzymes by computational redesign of surface charge-charge interactions." Gribenko A.V., Patel M.M., Liu J., McCallum S.A., Wang C., Makhatadze G.I. Proc. Natl. Acad. Sci. U.S.A. 106:2601-2606(2009) [PubMed: 19196981] [Abstract] Cited for: STRUCTURE BY NMR OF 2-99. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X84194 mRNA. Translation: CAA58987.1. AK312101 mRNA. Translation: BAG35037.1. AC007055 Genomic DNA. Translation: AAD31937.1. CH471061 Genomic DNA. Translation: EAW81216.1. BC035568 mRNA. Translation: AAH35568.1. | ||||||||||||||||||||||||||||||||||||
| IPI | IPI00221117. | ||||||||||||||||||||||||||||||||||||
| PIR | QPHUE. S66187. | ||||||||||||||||||||||||||||||||||||
| RefSeq | NP_001098.1. NM_001107.3. NP_982355.1. NM_203488.1. | ||||||||||||||||||||||||||||||||||||
| UniGene | Hs.18573. | ||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | P07311. | ||||||||||||||||||||||||||||||||||||
| SMR | P07311. Positions 6-99. | ||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||
| STRING | P07311. | ||||||||||||||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||||||||||||||
| DMDM | 2507560. | ||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||
| PRIDE | P07311. | ||||||||||||||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||
| Ensembl | ENST00000238618; ENSP00000238618; ENSG00000119640. | ||||||||||||||||||||||||||||||||||||
| GeneID | 97. | ||||||||||||||||||||||||||||||||||||
| KEGG | hsa:97. | ||||||||||||||||||||||||||||||||||||
| UCSC | uc001xrg.1. human. | ||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||
| CTD | 97. | ||||||||||||||||||||||||||||||||||||
| GeneCards | GC14M075519. | ||||||||||||||||||||||||||||||||||||
| H-InvDB | HIX0202094. | ||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:179. ACYP1. | ||||||||||||||||||||||||||||||||||||
| HPA | HPA034944. | ||||||||||||||||||||||||||||||||||||
| MIM | 600875. gene. | ||||||||||||||||||||||||||||||||||||
| neXtProt | NX_P07311. | ||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||
| eggNOG | prNOG20949. | ||||||||||||||||||||||||||||||||||||
| GeneTree | ENSGT00390000011103. | ||||||||||||||||||||||||||||||||||||
| HOGENOM | HBG750266. | ||||||||||||||||||||||||||||||||||||
| HOVERGEN | HBG050454. | ||||||||||||||||||||||||||||||||||||
| InParanoid | P07311. | ||||||||||||||||||||||||||||||||||||
| OMA | ASFNNEK. | ||||||||||||||||||||||||||||||||||||
| OrthoDB | EOG4XD3SN. | ||||||||||||||||||||||||||||||||||||
| PhylomeDB | P07311. | ||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||
| CleanEx | HS_ACYP1. | ||||||||||||||||||||||||||||||||||||
| Genevestigator | P07311. | ||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000119640. Homo sapiens. | ||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||
| InterPro | IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| KO | K01512. | ||||||||||||||||||||||||||||||||||||
| Pfam | PF00708. Acylphosphatase. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| PRINTS | PR00112. ACYLPHPHTASE. | ||||||||||||||||||||||||||||||||||||
| SUPFAM | SSF54975. Acylphosphatase. 1 hit. | ||||||||||||||||||||||||||||||||||||
| PROSITE | PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||
Other | |||||||||||||||||||||||||||||||||||||
| NextBio | 367. | ||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | ACYP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P07311 Secondary accession number(s): B2R590 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with