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Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24PROSITE-ProRule annotation1
Active sitei42PROSITE-ProRule annotation1

GO - Molecular functioni

  • acylphosphatase activity Source: ProtInc

GO - Biological processi

  • phosphate-containing compound metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS04315-MONOMER.
SABIO-RKP07311.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, erythrocyte isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:ACYP1
Synonyms:ACYPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:179. ACYP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119640.
PharmGKBiPA24499.

Polymorphism and mutation databases

BioMutaiACYP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001585352 – 99Acylphosphatase-1Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP07311.
MaxQBiP07311.
PaxDbiP07311.
PeptideAtlasiP07311.
PRIDEiP07311.
TopDownProteomicsiP07311-1. [P07311-1]

PTM databases

iPTMnetiP07311.
PhosphoSitePlusiP07311.

Expressioni

Tissue specificityi

Organ-common type isozyme is found in many different tissues.

Gene expression databases

BgeeiENSG00000119640.
CleanExiHS_ACYP1.
ExpressionAtlasiP07311. baseline and differential.
GenevisibleiP07311. HS.

Organism-specific databases

HPAiHPA034944.

Interactioni

Protein-protein interaction databases

BioGridi106612. 1 interactor.
STRINGi9606.ENSP00000238618.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 17Combined sources11
Beta strandi19 – 21Combined sources3
Helixi23 – 33Combined sources11
Beta strandi37 – 42Combined sources6
Beta strandi44 – 46Combined sources3
Beta strandi48 – 55Combined sources8
Helixi56 – 68Combined sources13
Beta strandi72 – 74Combined sources3
Beta strandi75 – 89Combined sources15
Beta strandi93 – 97Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K7JNMR-A2-99[»]
2K7KNMR-A2-99[»]
2VH7X-ray1.45A1-99[»]
2W4CX-ray1.52A1-99[»]
2W4PX-ray1.70A1-99[»]
3TOQX-ray2.00A1-99[»]
ProteinModelPortaliP07311.
SMRiP07311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 99Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP07311.
KOiK01512.
PhylomeDBiP07311.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG
60 70 80 90
QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK
Length:99
Mass (Da):11,261
Last modified:January 23, 2007 - v2
Checksum:iF9F787E490BC8296
GO
Isoform 2 (identifier: P07311-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-99: AEGKKLGLVG...LDYSDFQIVK → EMTVENRIAETHSKSCVPVSFATSYAG

Note: No experimental confirmation available.
Show »
Length:55
Mass (Da):6,113
Checksum:i37822D3FA5EF8F81
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04568829 – 99AEGKK…FQIVK → EMTVENRIAETHSKSCVPVS FATSYAG in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84194 mRNA. Translation: CAA58987.1.
AK312101 mRNA. Translation: BAG35037.1.
AC007055 Genomic DNA. Translation: AAD31937.1.
AL049780 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81216.1.
BC035568 mRNA. Translation: AAH35568.1.
BG614847 mRNA. No translation available.
CCDSiCCDS9838.1. [P07311-1]
PIRiS66187. QPHUE.
RefSeqiNP_001098.1. NM_001107.4. [P07311-1]
NP_001289545.1. NM_001302616.1. [P07311-1]
UniGeneiHs.18573.

Genome annotation databases

EnsembliENST00000238618; ENSP00000238618; ENSG00000119640. [P07311-1]
ENST00000357971; ENSP00000350655; ENSG00000119640. [P07311-2]
ENST00000555694; ENSP00000451581; ENSG00000119640. [P07311-1]
GeneIDi97.
KEGGihsa:97.
UCSCiuc001xrf.4. human. [P07311-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84194 mRNA. Translation: CAA58987.1.
AK312101 mRNA. Translation: BAG35037.1.
AC007055 Genomic DNA. Translation: AAD31937.1.
AL049780 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81216.1.
BC035568 mRNA. Translation: AAH35568.1.
BG614847 mRNA. No translation available.
CCDSiCCDS9838.1. [P07311-1]
PIRiS66187. QPHUE.
RefSeqiNP_001098.1. NM_001107.4. [P07311-1]
NP_001289545.1. NM_001302616.1. [P07311-1]
UniGeneiHs.18573.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K7JNMR-A2-99[»]
2K7KNMR-A2-99[»]
2VH7X-ray1.45A1-99[»]
2W4CX-ray1.52A1-99[»]
2W4PX-ray1.70A1-99[»]
3TOQX-ray2.00A1-99[»]
ProteinModelPortaliP07311.
SMRiP07311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106612. 1 interactor.
STRINGi9606.ENSP00000238618.

PTM databases

iPTMnetiP07311.
PhosphoSitePlusiP07311.

Polymorphism and mutation databases

BioMutaiACYP1.

Proteomic databases

EPDiP07311.
MaxQBiP07311.
PaxDbiP07311.
PeptideAtlasiP07311.
PRIDEiP07311.
TopDownProteomicsiP07311-1. [P07311-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238618; ENSP00000238618; ENSG00000119640. [P07311-1]
ENST00000357971; ENSP00000350655; ENSG00000119640. [P07311-2]
ENST00000555694; ENSP00000451581; ENSG00000119640. [P07311-1]
GeneIDi97.
KEGGihsa:97.
UCSCiuc001xrf.4. human. [P07311-1]

Organism-specific databases

CTDi97.
GeneCardsiACYP1.
HGNCiHGNC:179. ACYP1.
HPAiHPA034944.
MIMi600875. gene.
neXtProtiNX_P07311.
OpenTargetsiENSG00000119640.
PharmGKBiPA24499.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP07311.
KOiK01512.
PhylomeDBiP07311.
TreeFamiTF300288.

Enzyme and pathway databases

BioCyciZFISH:HS04315-MONOMER.
SABIO-RKP07311.

Miscellaneous databases

EvolutionaryTraceiP07311.
GeneWikiiACYP1.
GenomeRNAii97.
PROiP07311.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119640.
CleanExiHS_ACYP1.
ExpressionAtlasiP07311. baseline and differential.
GenevisibleiP07311. HS.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACYP1_HUMAN
AccessioniPrimary (citable) accession number: P07311
Secondary accession number(s): A6NDV8, B2R590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.