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P07311

- ACYP1_HUMAN

UniProt

P07311 - ACYP1_HUMAN

Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Its physiological role is not yet clear.

    Catalytic activityi

    An acylphosphate + H2O = a carboxylate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei24 – 241PROSITE-ProRule annotation
    Active sitei42 – 421PROSITE-ProRule annotation

    GO - Molecular functioni

    1. acylphosphatase activity Source: RefGenome

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    SABIO-RKP07311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylphosphatase-1 (EC:3.6.1.7)
    Alternative name(s):
    Acylphosphatase, erythrocyte isozyme
    Acylphosphatase, organ-common type isozyme
    Acylphosphate phosphohydrolase 1
    Gene namesi
    Name:ACYP1
    Synonyms:ACYPE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:179. ACYP1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24499.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 9998Acylphosphatase-1PRO_0000158535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP07311.
    PaxDbiP07311.
    PRIDEiP07311.

    PTM databases

    PhosphoSiteiP07311.

    Expressioni

    Tissue specificityi

    Organ-common type isozyme is found in many different tissues.

    Gene expression databases

    ArrayExpressiP07311.
    BgeeiP07311.
    CleanExiHS_ACYP1.
    GenevestigatoriP07311.

    Organism-specific databases

    HPAiHPA034944.

    Interactioni

    Protein-protein interaction databases

    BioGridi106612. 2 interactions.
    STRINGi9606.ENSP00000238618.

    Structurei

    Secondary structure

    1
    99
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 1711
    Beta strandi19 – 213
    Helixi23 – 3311
    Beta strandi37 – 426
    Beta strandi44 – 463
    Beta strandi48 – 558
    Helixi56 – 6813
    Beta strandi72 – 743
    Beta strandi75 – 8915
    Beta strandi93 – 975

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K7JNMR-A2-99[»]
    2K7KNMR-A2-99[»]
    2VH7X-ray1.45A1-99[»]
    2W4CX-ray1.52A1-99[»]
    2W4PX-ray1.70A1-99[»]
    3TOQX-ray2.00A1-99[»]
    ProteinModelPortaliP07311.
    SMRiP07311. Positions 6-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07311.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 9991Acylphosphatase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acylphosphatase family.Curated
    Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG289322.
    HOGENOMiHOG000292688.
    HOVERGENiHBG050454.
    InParanoidiP07311.
    KOiK01512.
    OrthoDBiEOG7ZGX55.
    PhylomeDBiP07311.
    TreeFamiTF300288.

    Family and domain databases

    InterProiIPR020456. Acylphosphatase.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view]
    PfamiPF00708. Acylphosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00112. ACYLPHPHTASE.
    SUPFAMiSSF54975. SSF54975. 1 hit.
    PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P07311-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG   50
    QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK 99
    Length:99
    Mass (Da):11,261
    Last modified:January 23, 2007 - v2
    Checksum:iF9F787E490BC8296
    GO
    Isoform 2 (identifier: P07311-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-99: AEGKKLGLVG...LDYSDFQIVK → EMTVENRIAETHSKSCVPVSFATSYAG

    Note: No experimental confirmation available.

    Show »
    Length:55
    Mass (Da):6,113
    Checksum:i37822D3FA5EF8F81
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei29 – 9971AEGKK…FQIVK → EMTVENRIAETHSKSCVPVS FATSYAG in isoform 2. 1 PublicationVSP_045688Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84194 mRNA. Translation: CAA58987.1.
    AK312101 mRNA. Translation: BAG35037.1.
    AC007055 Genomic DNA. Translation: AAD31937.1.
    AL049780 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81216.1.
    BC035568 mRNA. Translation: AAH35568.1.
    BG614847 mRNA. No translation available.
    CCDSiCCDS45137.1. [P07311-2]
    CCDS9838.1. [P07311-1]
    PIRiS66187. QPHUE.
    RefSeqiNP_001098.1. NM_001107.3. [P07311-1]
    NP_982355.1. NM_203488.1. [P07311-2]
    UniGeneiHs.18573.

    Genome annotation databases

    GeneIDi97.
    KEGGihsa:97.
    UCSCiuc001xrg.3. human. [P07311-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84194 mRNA. Translation: CAA58987.1 .
    AK312101 mRNA. Translation: BAG35037.1 .
    AC007055 Genomic DNA. Translation: AAD31937.1 .
    AL049780 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81216.1 .
    BC035568 mRNA. Translation: AAH35568.1 .
    BG614847 mRNA. No translation available.
    CCDSi CCDS45137.1. [P07311-2 ]
    CCDS9838.1. [P07311-1 ]
    PIRi S66187. QPHUE.
    RefSeqi NP_001098.1. NM_001107.3. [P07311-1 ]
    NP_982355.1. NM_203488.1. [P07311-2 ]
    UniGenei Hs.18573.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K7J NMR - A 2-99 [» ]
    2K7K NMR - A 2-99 [» ]
    2VH7 X-ray 1.45 A 1-99 [» ]
    2W4C X-ray 1.52 A 1-99 [» ]
    2W4P X-ray 1.70 A 1-99 [» ]
    3TOQ X-ray 2.00 A 1-99 [» ]
    ProteinModelPortali P07311.
    SMRi P07311. Positions 6-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106612. 2 interactions.
    STRINGi 9606.ENSP00000238618.

    PTM databases

    PhosphoSitei P07311.

    Proteomic databases

    MaxQBi P07311.
    PaxDbi P07311.
    PRIDEi P07311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 97.
    KEGGi hsa:97.
    UCSCi uc001xrg.3. human. [P07311-1 ]

    Organism-specific databases

    CTDi 97.
    GeneCardsi GC14M075519.
    HGNCi HGNC:179. ACYP1.
    HPAi HPA034944.
    MIMi 600875. gene.
    neXtProti NX_P07311.
    PharmGKBi PA24499.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289322.
    HOGENOMi HOG000292688.
    HOVERGENi HBG050454.
    InParanoidi P07311.
    KOi K01512.
    OrthoDBi EOG7ZGX55.
    PhylomeDBi P07311.
    TreeFami TF300288.

    Enzyme and pathway databases

    SABIO-RK P07311.

    Miscellaneous databases

    EvolutionaryTracei P07311.
    GeneWikii ACYP1.
    GenomeRNAii 97.
    NextBioi 367.
    PROi P07311.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07311.
    Bgeei P07311.
    CleanExi HS_ACYP1.
    Genevestigatori P07311.

    Family and domain databases

    InterProi IPR020456. Acylphosphatase.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view ]
    Pfami PF00708. Acylphosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00112. ACYLPHPHTASE.
    SUPFAMi SSF54975. SSF54975. 1 hit.
    PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Raugei G.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Embryonic carcinoma and Mammary gland.
    6. "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure."
      Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G.
      Biochemistry 25:8089-8094(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-99, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2.
    7. "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase."
      Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.
      FEBS Lett. 367:145-148(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 10-86.
      Tissue: Placenta.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase."
      Yeung R.C., Lam S.Y., Wong K.B.
      Acta Crystallogr. F 62:80-82(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
    10. "Rational stabilization of enzymes by computational redesign of surface charge-charge interactions."
      Gribenko A.V., Patel M.M., Liu J., McCallum S.A., Wang C., Makhatadze G.I.
      Proc. Natl. Acad. Sci. U.S.A. 106:2601-2606(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 2-99.

    Entry informationi

    Entry nameiACYP1_HUMAN
    AccessioniPrimary (citable) accession number: P07311
    Secondary accession number(s): A6NDV8, B2R590
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3