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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Miscellaneous

The mouse protein shows increased stability and much reduced propensity to form amyloid fibrils, compared to the human protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Thyroid hormoneBy similarity1
Binding sitei74Thyroid hormoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-3000171. Non-integrin membrane-ECM interactions.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:Ttr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:98865. Ttr.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003576021 – 147TransthyretinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei624-carboxyglutamateBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi118N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07309.
PeptideAtlasiP07309.
PRIDEiP07309.

2D gel databases

UCD-2DPAGEiP07309.

PTM databases

iPTMnetiP07309.
PhosphoSitePlusiP07309.

Expressioni

Tissue specificityi

Detected in plasma (at protein level). Detected in liver.

Gene expression databases

BgeeiENSMUSG00000061808.
CleanExiMM_TTR.
ExpressionAtlasiP07309. baseline and differential.
GenevisibleiP07309. MM.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29726N.
IntActiP07309. 2 interactors.
MINTiMINT-1855774.
STRINGi10090.ENSMUSP00000074783.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 38Combined sources7
Turni39 – 42Combined sources4
Beta strandi49 – 55Combined sources7
Beta strandi61 – 68Combined sources8
Beta strandi73 – 75Combined sources3
Turni81 – 83Combined sources3
Beta strandi86 – 93Combined sources8
Helixi95 – 101Combined sources7
Beta strandi107 – 109Combined sources3
Beta strandi111 – 118Combined sources8
Beta strandi124 – 132Combined sources9
Beta strandi135 – 143Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309.
SMRiP07309.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07309.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Thyroid hormone bindingBy similarity5

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07309.
KOiK20731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.
PhylomeDBiP07309.
TreeFamiTF300210.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:April 1, 1988 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA. Translation: CAA27057.1.
D00073 Genomic DNA. Translation: BAA00050.1.
D89076 mRNA. Translation: BAA13757.1.
AK018701 mRNA. Translation: BAB31352.1.
BC024702 mRNA. Translation: AAH24702.1.
CCDSiCCDS29085.1.
PIRiA24132. VBMS.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
GeneIDi22139.
KEGGimmu:22139.
UCSCiuc008eet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA. Translation: CAA27057.1.
D00073 Genomic DNA. Translation: BAA00050.1.
D89076 mRNA. Translation: BAA13757.1.
AK018701 mRNA. Translation: BAB31352.1.
BC024702 mRNA. Translation: AAH24702.1.
CCDSiCCDS29085.1.
PIRiA24132. VBMS.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309.
SMRiP07309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29726N.
IntActiP07309. 2 interactors.
MINTiMINT-1855774.
STRINGi10090.ENSMUSP00000074783.

PTM databases

iPTMnetiP07309.
PhosphoSitePlusiP07309.

2D gel databases

UCD-2DPAGEiP07309.

Proteomic databases

PaxDbiP07309.
PeptideAtlasiP07309.
PRIDEiP07309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
GeneIDi22139.
KEGGimmu:22139.
UCSCiuc008eet.2. mouse.

Organism-specific databases

CTDi7276.
MGIiMGI:98865. Ttr.

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07309.
KOiK20731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.
PhylomeDBiP07309.
TreeFamiTF300210.

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-3000171. Non-integrin membrane-ECM interactions.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiTtr. mouse.
EvolutionaryTraceiP07309.
PROiPR:P07309.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061808.
CleanExiMM_TTR.
ExpressionAtlasiP07309. baseline and differential.
GenevisibleiP07309. MM.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiView protein in InterPro
IPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
PANTHERiPTHR10395. PTHR10395. 1 hit.
PTHR10395:SF19. PTHR10395:SF19. 1 hit.
PfamiView protein in Pfam
PF00576. Transthyretin. 1 hit.
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiView protein in SMART
SM00095. TR_THY. 1 hit.
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiView protein in PROSITE
PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTTHY_MOUSE
AccessioniPrimary (citable) accession number: P07309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 15, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.