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P07309

- TTHY_MOUSE

UniProt

P07309 - TTHY_MOUSE

Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351Thyroid hormoneBy similarity
    Binding sitei74 – 741Thyroid hormoneBy similarity

    GO - Molecular functioni

    1. hormone binding Source: Ensembl

    GO - Biological processi

    1. retinol metabolic process Source: Ensembl
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hormone, Thyroid hormone

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
    REACT_196607. Non-integrin membrane-ECM interactions.
    REACT_196615. Retinoid cycle disease events.
    REACT_198563. Amyloids.
    REACT_198569. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transthyretin
    Alternative name(s):
    Prealbumin
    Gene namesi
    Name:Ttr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:98865. Ttr.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 147127TransthyretinPRO_0000035760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 6214-carboxyglutamateBy similarity
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Gamma-carboxyglutamic acid, Glycoprotein

    Proteomic databases

    MaxQBiP07309.
    PaxDbiP07309.
    PRIDEiP07309.

    2D gel databases

    UCD-2DPAGEP07309.

    PTM databases

    PhosphoSiteiP07309.

    Expressioni

    Tissue specificityi

    Detected in plasma (at protein level). Detected in liver.

    Gene expression databases

    ArrayExpressiP07309.
    BgeeiP07309.
    CleanExiMM_TTR.
    GenevestigatoriP07309.

    Interactioni

    Subunit structurei

    Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-29726N.
    IntActiP07309. 2 interactions.
    MINTiMINT-1855774.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 387
    Turni39 – 424
    Beta strandi49 – 557
    Beta strandi61 – 688
    Beta strandi73 – 753
    Turni81 – 833
    Beta strandi86 – 938
    Helixi95 – 1017
    Beta strandi107 – 1093
    Beta strandi111 – 1188
    Beta strandi124 – 1329
    Beta strandi135 – 1439

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
    ProteinModelPortaliP07309.
    SMRiP07309. Positions 31-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07309.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1395Thyroid hormone bindingBy similarity

    Sequence similaritiesi

    Belongs to the transthyretin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2351.
    HOGENOMiHOG000251776.
    HOVERGENiHBG000285.
    InParanoidiP07309.
    OMAiRRYTIAA.
    OrthoDBiEOG7S4X7V.
    PhylomeDBiP07309.
    TreeFamiTF300210.

    Family and domain databases

    Gene3Di2.60.40.180. 1 hit.
    InterProiIPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view]
    PfamiPF00576. Transthyretin. 1 hit.
    [Graphical view]
    PRINTSiPR00189. TRNSTHYRETIN.
    SMARTiSM00095. TR_THY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49472. SSF49472. 1 hit.
    PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07309-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV    50
    KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK 100
    TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN 147
    Length:147
    Mass (Da):15,776
    Last modified:April 1, 1988 - v1
    Checksum:i9803CCC3024BA911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03351 mRNA. Translation: CAA27057.1.
    D00073 Genomic DNA. Translation: BAA00050.1.
    D89076 mRNA. Translation: BAA13757.1.
    AK018701 mRNA. Translation: BAB31352.1.
    BC024702 mRNA. Translation: AAH24702.1.
    CCDSiCCDS29085.1.
    PIRiA24132. VBMS.
    RefSeqiNP_038725.1. NM_013697.5.
    UniGeneiMm.2108.

    Genome annotation databases

    EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
    GeneIDi22139.
    KEGGimmu:22139.
    UCSCiuc008eet.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03351 mRNA. Translation: CAA27057.1 .
    D00073 Genomic DNA. Translation: BAA00050.1 .
    D89076 mRNA. Translation: BAA13757.1 .
    AK018701 mRNA. Translation: BAB31352.1 .
    BC024702 mRNA. Translation: AAH24702.1 .
    CCDSi CCDS29085.1.
    PIRi A24132. VBMS.
    RefSeqi NP_038725.1. NM_013697.5.
    UniGenei Mm.2108.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QPF X-ray 2.05 A/B/C/D/E/F/G/H 21-147 [» ]
    ProteinModelPortali P07309.
    SMRi P07309. Positions 31-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29726N.
    IntActi P07309. 2 interactions.
    MINTi MINT-1855774.

    PTM databases

    PhosphoSitei P07309.

    2D gel databases

    UCD-2DPAGE P07309.

    Proteomic databases

    MaxQBi P07309.
    PaxDbi P07309.
    PRIDEi P07309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075312 ; ENSMUSP00000074783 ; ENSMUSG00000061808 .
    GeneIDi 22139.
    KEGGi mmu:22139.
    UCSCi uc008eet.2. mouse.

    Organism-specific databases

    CTDi 7276.
    MGIi MGI:98865. Ttr.

    Phylogenomic databases

    eggNOGi COG2351.
    HOGENOMi HOG000251776.
    HOVERGENi HBG000285.
    InParanoidi P07309.
    OMAi RRYTIAA.
    OrthoDBi EOG7S4X7V.
    PhylomeDBi P07309.
    TreeFami TF300210.

    Enzyme and pathway databases

    Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).
    REACT_196607. Non-integrin membrane-ECM interactions.
    REACT_196615. Retinoid cycle disease events.
    REACT_198563. Amyloids.
    REACT_198569. Retinoid metabolism and transport.

    Miscellaneous databases

    ChiTaRSi TTR. mouse.
    EvolutionaryTracei P07309.
    NextBioi 302028.
    PROi P07309.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07309.
    Bgeei P07309.
    CleanExi MM_TTR.
    Genevestigatori P07309.

    Family and domain databases

    Gene3Di 2.60.40.180. 1 hit.
    InterProi IPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view ]
    Pfami PF00576. Transthyretin. 1 hit.
    [Graphical view ]
    PRINTSi PR00189. TRNSTHYRETIN.
    SMARTi SM00095. TR_THY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49472. SSF49472. 1 hit.
    PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural comparisons between mouse and human prealbumin."
      Wakasugi S., Maeda S., Shimada K., Nakashima H., Migita S.
      J. Biochem. 98:1707-1714(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], THYROID HORMONE-BINDING SITES LYS-35 AND GLU-74.
      Tissue: Liver.
    2. "Structure and expression of the mouse prealbumin gene."
      Wakasugi S., Maeda S., Shimada K.
      J. Biochem. 100:49-58(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Kita H., Kawamoto S., Okubo K., Matsubara K.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6.
      Tissue: Choroid plexus.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
      Strain: C57BL/6.
      Tissue: Plasma.
    7. "Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins."
      Reixach N., Foss T.R., Santelli E., Pascual J., Kelly J.W., Buxbaum J.N.
      J. Biol. Chem. 283:2098-2107(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 21-147, INCREASED STABILITY OF THE MOUSE PROTEIN, SUBUNIT.

    Entry informationi

    Entry nameiTTHY_MOUSE
    AccessioniPrimary (citable) accession number: P07309
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The mouse protein shows increased stability and much reduced propensity to form amyloid fibrils, compared to the human protein.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3