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P07309

- TTHY_MOUSE

UniProt

P07309 - TTHY_MOUSE

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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Thyroid hormoneBy similarity
Binding sitei74 – 741Thyroid hormoneBy similarity

GO - Molecular functioni

  1. hormone binding Source: Ensembl

GO - Biological processi

  1. retinol metabolic process Source: Ensembl
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196615. Retinoid cycle disease events.
REACT_198563. Amyloids.
REACT_198569. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:Ttr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:98865. Ttr.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 147127TransthyretinPRO_0000035760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 6214-carboxyglutamateBy similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein

Proteomic databases

MaxQBiP07309.
PaxDbiP07309.
PRIDEiP07309.

2D gel databases

UCD-2DPAGEP07309.

PTM databases

PhosphoSiteiP07309.

Expressioni

Tissue specificityi

Detected in plasma (at protein level). Detected in liver.

Gene expression databases

BgeeiP07309.
CleanExiMM_TTR.
ExpressionAtlasiP07309. baseline and differential.
GenevestigatoriP07309.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 By similarity.By similarity

Protein-protein interaction databases

DIPiDIP-29726N.
IntActiP07309. 2 interactions.
MINTiMINT-1855774.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 387
Turni39 – 424
Beta strandi49 – 557
Beta strandi61 – 688
Beta strandi73 – 753
Turni81 – 833
Beta strandi86 – 938
Helixi95 – 1017
Beta strandi107 – 1093
Beta strandi111 – 1188
Beta strandi124 – 1329
Beta strandi135 – 1439

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309.
SMRiP07309. Positions 31-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07309.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Thyroid hormone bindingBy similarity

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2351.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07309.
OMAiRRYTIAA.
OrthoDBiEOG7S4X7V.
PhylomeDBiP07309.
TreeFamiTF300210.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07309-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:April 1, 1988 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03351 mRNA. Translation: CAA27057.1.
D00073 Genomic DNA. Translation: BAA00050.1.
D89076 mRNA. Translation: BAA13757.1.
AK018701 mRNA. Translation: BAB31352.1.
BC024702 mRNA. Translation: AAH24702.1.
CCDSiCCDS29085.1.
PIRiA24132. VBMS.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
GeneIDi22139.
KEGGimmu:22139.
UCSCiuc008eet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03351 mRNA. Translation: CAA27057.1 .
D00073 Genomic DNA. Translation: BAA00050.1 .
D89076 mRNA. Translation: BAA13757.1 .
AK018701 mRNA. Translation: BAB31352.1 .
BC024702 mRNA. Translation: AAH24702.1 .
CCDSi CCDS29085.1.
PIRi A24132. VBMS.
RefSeqi NP_038725.1. NM_013697.5.
UniGenei Mm.2108.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QPF X-ray 2.05 A/B/C/D/E/F/G/H 21-147 [» ]
ProteinModelPortali P07309.
SMRi P07309. Positions 31-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29726N.
IntActi P07309. 2 interactions.
MINTi MINT-1855774.

PTM databases

PhosphoSitei P07309.

2D gel databases

UCD-2DPAGE P07309.

Proteomic databases

MaxQBi P07309.
PaxDbi P07309.
PRIDEi P07309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075312 ; ENSMUSP00000074783 ; ENSMUSG00000061808 .
GeneIDi 22139.
KEGGi mmu:22139.
UCSCi uc008eet.2. mouse.

Organism-specific databases

CTDi 7276.
MGIi MGI:98865. Ttr.

Phylogenomic databases

eggNOGi COG2351.
HOGENOMi HOG000251776.
HOVERGENi HBG000285.
InParanoidi P07309.
OMAi RRYTIAA.
OrthoDBi EOG7S4X7V.
PhylomeDBi P07309.
TreeFami TF300210.

Enzyme and pathway databases

Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196615. Retinoid cycle disease events.
REACT_198563. Amyloids.
REACT_198569. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSi TTR. mouse.
EvolutionaryTracei P07309.
NextBioi 302028.
PROi P07309.
SOURCEi Search...

Gene expression databases

Bgeei P07309.
CleanExi MM_TTR.
ExpressionAtlasi P07309. baseline and differential.
Genevestigatori P07309.

Family and domain databases

Gene3Di 2.60.40.180. 1 hit.
InterProi IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view ]
Pfami PF00576. Transthyretin. 1 hit.
[Graphical view ]
PRINTSi PR00189. TRNSTHYRETIN.
SMARTi SM00095. TR_THY. 1 hit.
[Graphical view ]
SUPFAMi SSF49472. SSF49472. 1 hit.
PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural comparisons between mouse and human prealbumin."
    Wakasugi S., Maeda S., Shimada K., Nakashima H., Migita S.
    J. Biochem. 98:1707-1714(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], THYROID HORMONE-BINDING SITES LYS-35 AND GLU-74.
    Tissue: Liver.
  2. "Structure and expression of the mouse prealbumin gene."
    Wakasugi S., Maeda S., Shimada K.
    J. Biochem. 100:49-58(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Kita H., Kawamoto S., Okubo K., Matsubara K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
    Tissue: Choroid plexus.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. "Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins."
    Reixach N., Foss T.R., Santelli E., Pascual J., Kelly J.W., Buxbaum J.N.
    J. Biol. Chem. 283:2098-2107(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 21-147, INCREASED STABILITY OF THE MOUSE PROTEIN, SUBUNIT.

Entry informationi

Entry nameiTTHY_MOUSE
AccessioniPrimary (citable) accession number: P07309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The mouse protein shows increased stability and much reduced propensity to form amyloid fibrils, compared to the human protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3