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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Thyroid hormoneBy similarity
Binding sitei74 – 741Thyroid hormoneBy similarity

GO - Molecular functioni

  1. hormone binding Source: Ensembl
  2. identical protein binding Source: MGI

GO - Biological processi

  1. retinol metabolic process Source: Ensembl
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196615. Retinoid cycle disease events.
REACT_198563. Amyloids.
REACT_198569. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:Ttr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:98865. Ttr.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 147127TransthyretinPRO_0000035760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 6214-carboxyglutamateBy similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein

Proteomic databases

MaxQBiP07309.
PaxDbiP07309.
PRIDEiP07309.

2D gel databases

UCD-2DPAGEP07309.

PTM databases

PhosphoSiteiP07309.

Expressioni

Tissue specificityi

Detected in plasma (at protein level). Detected in liver.

Gene expression databases

BgeeiP07309.
CleanExiMM_TTR.
ExpressionAtlasiP07309. baseline and differential.
GenevestigatoriP07309.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-29726N.
IntActiP07309. 2 interactions.
MINTiMINT-1855774.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 387Combined sources
Turni39 – 424Combined sources
Beta strandi49 – 557Combined sources
Beta strandi61 – 688Combined sources
Beta strandi73 – 753Combined sources
Turni81 – 833Combined sources
Beta strandi86 – 938Combined sources
Helixi95 – 1017Combined sources
Beta strandi107 – 1093Combined sources
Beta strandi111 – 1188Combined sources
Beta strandi124 – 1329Combined sources
Beta strandi135 – 1439Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309.
SMRiP07309. Positions 31-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07309.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Thyroid hormone bindingBy similarity

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2351.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07309.
OMAiKAADETW.
OrthoDBiEOG7S4X7V.
PhylomeDBiP07309.
TreeFamiTF300210.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07309-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:April 1, 1988 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA. Translation: CAA27057.1.
D00073 Genomic DNA. Translation: BAA00050.1.
D89076 mRNA. Translation: BAA13757.1.
AK018701 mRNA. Translation: BAB31352.1.
BC024702 mRNA. Translation: AAH24702.1.
CCDSiCCDS29085.1.
PIRiA24132. VBMS.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
GeneIDi22139.
KEGGimmu:22139.
UCSCiuc008eet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA. Translation: CAA27057.1.
D00073 Genomic DNA. Translation: BAA00050.1.
D89076 mRNA. Translation: BAA13757.1.
AK018701 mRNA. Translation: BAB31352.1.
BC024702 mRNA. Translation: AAH24702.1.
CCDSiCCDS29085.1.
PIRiA24132. VBMS.
RefSeqiNP_038725.1. NM_013697.5.
UniGeneiMm.2108.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309.
SMRiP07309. Positions 31-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29726N.
IntActiP07309. 2 interactions.
MINTiMINT-1855774.

PTM databases

PhosphoSiteiP07309.

2D gel databases

UCD-2DPAGEP07309.

Proteomic databases

MaxQBiP07309.
PaxDbiP07309.
PRIDEiP07309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808.
GeneIDi22139.
KEGGimmu:22139.
UCSCiuc008eet.2. mouse.

Organism-specific databases

CTDi7276.
MGIiMGI:98865. Ttr.

Phylogenomic databases

eggNOGiCOG2351.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP07309.
OMAiKAADETW.
OrthoDBiEOG7S4X7V.
PhylomeDBiP07309.
TreeFamiTF300210.

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196615. Retinoid cycle disease events.
REACT_198563. Amyloids.
REACT_198569. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiTtr. mouse.
EvolutionaryTraceiP07309.
NextBioi302028.
PROiP07309.
SOURCEiSearch...

Gene expression databases

BgeeiP07309.
CleanExiMM_TTR.
ExpressionAtlasiP07309. baseline and differential.
GenevestigatoriP07309.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural comparisons between mouse and human prealbumin."
    Wakasugi S., Maeda S., Shimada K., Nakashima H., Migita S.
    J. Biochem. 98:1707-1714(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], THYROID HORMONE-BINDING SITES LYS-35 AND GLU-74.
    Tissue: Liver.
  2. "Structure and expression of the mouse prealbumin gene."
    Wakasugi S., Maeda S., Shimada K.
    J. Biochem. 100:49-58(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Kita H., Kawamoto S., Okubo K., Matsubara K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6.
    Tissue: Choroid plexus.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. "Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins."
    Reixach N., Foss T.R., Santelli E., Pascual J., Kelly J.W., Buxbaum J.N.
    J. Biol. Chem. 283:2098-2107(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 21-147, INCREASED STABILITY OF THE MOUSE PROTEIN, SUBUNIT.

Entry informationi

Entry nameiTTHY_MOUSE
AccessioniPrimary (citable) accession number: P07309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 4, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The mouse protein shows increased stability and much reduced propensity to form amyloid fibrils, compared to the human protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.