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P07308 (ACOD1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-CoA desaturase 1
EC=1.14.19.1
Alternative name(s):
Delta(9)-desaturase 1
Short name=Delta-9 desaturase 1
Fatty acid desaturase 1
Stearoyl-CoA desaturase 1
Gene names
Name:Scd1
Synonyms:Scd
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Induction

This protein is the only inducible component of this fatty acyl-CoA desaturase system.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Miscellaneous

Desaturase has a half-life of only 4 hours.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 358357Acyl-CoA desaturase 1
PRO_0000185400

Regions

Topological domain2 – 7069Cytoplasmic Potential
Transmembrane71 – 9222Helical; Potential
Topological domain93 – 1019Lumenal Potential
Transmembrane102 – 11817Helical; Potential
Topological domain119 – 21597Cytoplasmic Potential
Transmembrane216 – 23419Helical; Potential
Topological domain235 – 24915Lumenal Potential
Transmembrane250 – 27223Helical; Potential
Topological domain273 – 35886Cytoplasmic Potential
Motif119 – 1246Histidine box-1
Motif156 – 1605Histidine box-2
Motif297 – 3015Histidine box-3

Experimental info

Sequence conflict2911A → S in AAA42116. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P07308 [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: B4C960A969B63774

FASTA35841,467
        10         20         30         40         50         60 
MPAHMLQEIS SSYTTTTTIT EPPSGNLQNG REKMKKVPLY LEEDIRPEMR EDIHDPSYQD 

        70         80         90        100        110        120 
EEGPPPKLEY VWRNIILMAL LHVGALYGIT LIPSSKVYTL LWGIFYYLIS ALGITAGAHR 

       130        140        150        160        170        180 
LWSHRTYKAR LPLRIFLIIA NTMAFQNDVY EWARDHRAHH KFSETHADPH NSRRGFFFSH 

       190        200        210        220        230        240 
VGWLLVRKHP AVKEKGGKLD MSDLKAEKLV MFQRRYYKPG LLLMCFILPT LVPWYCWGET 

       250        260        270        280        290        300 
FLHSLFVSTF LRYTLVLNAT WLVNSAAHLY GYRPYDKNIQ SRENILVSLG AVGEGFHNYH 

       310        320        330        340        350 
HAFPYDYSAS EYRWHINFTT FFIDCMAALG LAYDRKKVSK AAVLARIKRT GDGSHKSS

« Hide

References

[1]"Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase."
Thiede M.A., Ozols J., Strittmatter P.
J. Biol. Chem. 261:13230-13235(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene."
Mihara K.
J. Biochem. 108:1022-1029(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats."
Falvella F.S., Pascale R.M., Gariboldi M., Manenti G., De Miglio M.R., Simile M.M., Dragani T.A., Feo F.
Carcinogenesis 23:1933-1936(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown Norway and Fischer 344.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J02585 mRNA. Translation: AAA42116.1.
AF509568 mRNA. Translation: AAM34745.1.
AF509569 mRNA. Translation: AAM34746.1.
IPIIPI00206235.
PIRA24699.
RefSeqNP_631931.2. NM_139192.2.
UniGeneRn.1023.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018447.

PTM databases

PhosphoSiteP07308.

Proteomic databases

PaxDbP07308.
PRIDEP07308.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018447; ENSRNOP00000018447; ENSRNOG00000013552.
GeneID246074.
KEGGrno:246074.

Organism-specific databases

CTD20249.
RGD621176. Scd1.

Phylogenomic databases

eggNOGCOG1398.
GeneTreeENSGT00530000063158.
HOGENOMHOG000270352.
HOVERGENHBG003367.
InParanoidP07308.
KOK00507.
OMATWLWGVF.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14123.
BRENDA1.14.19.1. 5301.

Gene expression databases

ArrayExpressP07308.
GenevestigatorP07308.
GermOnlineENSRNOG00000013552. Rattus norvegicus.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP07308.
ChEMBLCHEMBL5424.
NextBio623356.

Entry information

Entry nameACOD1_RAT
AccessionPrimary (citable) accession number: P07308
Secondary accession number(s): Q8JZL5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 23, 2004
Last modified: April 3, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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