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P07308

- ACOD1_RAT

UniProt

P07308 - ACOD1_RAT

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Protein
Acyl-CoA desaturase 1
Gene
Scd1, Scd
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactori

Iron.

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. stearoyl-CoA 9-desaturase activity Source: RGD

GO - Biological processi

  1. brown fat cell differentiation Source: Ensembl
  2. cholesterol esterification Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. fatty acid biosynthetic process Source: RGD
  5. lipid biosynthetic process Source: RGD
  6. negative regulation of growth of symbiont in host Source: Ensembl
  7. white fat cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14123.
BRENDAi1.14.19.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturase 1 (EC:1.14.19.1)
Alternative name(s):
Delta(9)-desaturase 1
Short name:
Delta-9 desaturase 1
Fatty acid desaturase 1
Stearoyl-CoA desaturase 1
Gene namesi
Name:Scd1
Synonyms:Scd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621176. Scd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei71 – 9222Helical; Reviewed prediction
Add
BLAST
Topological domaini93 – 1019Lumenal Reviewed prediction
Transmembranei102 – 11817Helical; Reviewed prediction
Add
BLAST
Topological domaini119 – 21597Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei216 – 23419Helical; Reviewed prediction
Add
BLAST
Topological domaini235 – 24915Lumenal Reviewed prediction
Add
BLAST
Transmembranei250 – 27223Helical; Reviewed prediction
Add
BLAST
Topological domaini273 – 35886Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: RGD
  2. intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Acyl-CoA desaturase 1
PRO_0000185400Add
BLAST

Proteomic databases

PaxDbiP07308.
PRIDEiP07308.

PTM databases

PhosphoSiteiP07308.

Expressioni

Inductioni

This protein is the only inducible component of this fatty acyl-CoA desaturase system.

Gene expression databases

ArrayExpressiP07308.
GenevestigatoriP07308.

Interactioni

Protein-protein interaction databases

BioGridi251497. 1 interaction.
STRINGi10116.ENSRNOP00000018447.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1246Histidine box-1
Motifi156 – 1605Histidine box-2
Motifi297 – 3015Histidine box-3

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1398.
GeneTreeiENSGT00530000063158.
HOGENOMiHOG000270352.
HOVERGENiHBG003367.
InParanoidiP07308.
KOiK00507.
OMAiLARCSRT.
OrthoDBiEOG7ZPNKS.

Family and domain databases

InterProiIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07308-1 [UniParc]FASTAAdd to Basket

« Hide

MPAHMLQEIS SSYTTTTTIT EPPSGNLQNG REKMKKVPLY LEEDIRPEMR    50
EDIHDPSYQD EEGPPPKLEY VWRNIILMAL LHVGALYGIT LIPSSKVYTL 100
LWGIFYYLIS ALGITAGAHR LWSHRTYKAR LPLRIFLIIA NTMAFQNDVY 150
EWARDHRAHH KFSETHADPH NSRRGFFFSH VGWLLVRKHP AVKEKGGKLD 200
MSDLKAEKLV MFQRRYYKPG LLLMCFILPT LVPWYCWGET FLHSLFVSTF 250
LRYTLVLNAT WLVNSAAHLY GYRPYDKNIQ SRENILVSLG AVGEGFHNYH 300
HAFPYDYSAS EYRWHINFTT FFIDCMAALG LAYDRKKVSK AAVLARIKRT 350
GDGSHKSS 358
Length:358
Mass (Da):41,467
Last modified:November 23, 2004 - v2
Checksum:iB4C960A969B63774
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911A → S in AAA42116. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02585 mRNA. Translation: AAA42116.1.
AF509568 mRNA. Translation: AAM34745.1.
AF509569 mRNA. Translation: AAM34746.1.
PIRiA24699.
RefSeqiNP_631931.2. NM_139192.2.
XP_006231495.1. XM_006231433.1.
UniGeneiRn.1023.

Genome annotation databases

EnsembliENSRNOT00000018447; ENSRNOP00000018447; ENSRNOG00000013552.
GeneIDi246074.
KEGGirno:246074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02585 mRNA. Translation: AAA42116.1 .
AF509568 mRNA. Translation: AAM34745.1 .
AF509569 mRNA. Translation: AAM34746.1 .
PIRi A24699.
RefSeqi NP_631931.2. NM_139192.2.
XP_006231495.1. XM_006231433.1.
UniGenei Rn.1023.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251497. 1 interaction.
STRINGi 10116.ENSRNOP00000018447.

Chemistry

BindingDBi P07308.
ChEMBLi CHEMBL5424.

PTM databases

PhosphoSitei P07308.

Proteomic databases

PaxDbi P07308.
PRIDEi P07308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018447 ; ENSRNOP00000018447 ; ENSRNOG00000013552 .
GeneIDi 246074.
KEGGi rno:246074.

Organism-specific databases

CTDi 20249.
RGDi 621176. Scd1.

Phylogenomic databases

eggNOGi COG1398.
GeneTreei ENSGT00530000063158.
HOGENOMi HOG000270352.
HOVERGENi HBG003367.
InParanoidi P07308.
KOi K00507.
OMAi LARCSRT.
OrthoDBi EOG7ZPNKS.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14123.
BRENDAi 1.14.19.1. 5301.

Miscellaneous databases

NextBioi 623356.
PROi P07308.

Gene expression databases

ArrayExpressi P07308.
Genevestigatori P07308.

Family and domain databases

InterProi IPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view ]
Pfami PF00487. FA_desaturase. 1 hit.
[Graphical view ]
PRINTSi PR00075. FACDDSATRASE.
PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase."
    Thiede M.A., Ozols J., Strittmatter P.
    J. Biol. Chem. 261:13230-13235(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene."
    Mihara K.
    J. Biochem. 108:1022-1029(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats."
    Falvella F.S., Pascale R.M., Gariboldi M., Manenti G., De Miglio M.R., Simile M.M., Dragani T.A., Feo F.
    Carcinogenesis 23:1933-1936(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway and Fischer 344.

Entry informationi

Entry nameiACOD1_RAT
AccessioniPrimary (citable) accession number: P07308
Secondary accession number(s): Q8JZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Desaturase has a half-life of only 4 hours.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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