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P07307 (ASGR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Asialoglycoprotein receptor 2

Short name=ASGP-R 2
Short name=ASGPR 2
Alternative name(s):
C-type lectin domain family 4 member H2
Hepatic lectin H2
Short name=HL-2
Gene names
Name:ASGR2
Synonyms:CLEC4H2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Subunit structure

The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2. Ref.6

Subcellular location

Membrane; Single-pass type II membrane protein.

Tissue specificity

Expressed exclusively in hepatic parenchymal cells.

Miscellaneous

Calcium is required for ligand binding.

Sequence similarities

Contains 1 C-type lectin domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CERS2Q96G233EBI-1172636,EBI-1057080

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P07307-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P07307-2)

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.
Isoform 3 (identifier: P07307-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.
     82-86: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Asialoglycoprotein receptor 2
PRO_0000046654

Regions

Topological domain1 – 5858Cytoplasmic Potential
Transmembrane59 – 7921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain80 – 311232Extracellular Potential
Domain176 – 302127C-type lectin
Motif5 – 84Endocytosis signal Potential

Amino acid modifications

Lipidation541S-palmitoyl cysteine By similarity
Glycosylation1021N-linked (GlcNAc...) Ref.7 Ref.8
Glycosylation1701N-linked (GlcNAc...) Ref.8
Glycosylation3051N-linked (GlcNAc...)
Disulfide bond177 ↔ 188 By similarity
Disulfide bond205 ↔ 300 By similarity
Disulfide bond278 ↔ 292 By similarity

Natural variations

Alternative sequence24 – 4219Missing in isoform 2 and isoform 3.
VSP_003060
Alternative sequence82 – 865Missing in isoform 3.
VSP_003061
Natural variant851G → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs2304978 [ dbSNP | Ensembl ].
VAR_068747

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: C86D2247FFF604DC

FASTA31135,092
        10         20         30         40         50         60 
MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS 

        70         80         90        100        110        120 
LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF SNFSSSTLTE VQAISTHGGS 

       130        140        150        160        170        180 
VGDKITSLGA KLEKQQQDLK ADHDALLFHL KHFPVDLRFV ACQMELLHSN GSQRTCCPVN 

       190        200        210        220        230        240 
WVEHQGSCYW FSHSGKAWAE AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS 

       250        260        270        280        290        300 
DGSWKWVDGT DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC 

       310 
EKRRNATGEV A 

« Hide

Isoform 2 [UniParc].

Checksum: C762F780E74A6D50
Show »

FASTA29232,988
Isoform 3 [UniParc].

Checksum: E9528ACF7CBB1435
Show »

FASTA28732,550

References

« Hide 'large scale' references
[1]"Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution."
Spiess M., Lodish H.F.
Proc. Natl. Acad. Sci. U.S.A. 82:6465-6469(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
[2]"Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver."
Paietta E., Stockert R.J., Racevskis J.
Hepatology 15:395-402(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
Tissue: Liver.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-85.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Liver.
[6]"Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.
Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LASS2.
[7]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102.
Tissue: Plasma.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102 AND ASN-170.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 2

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11025 mRNA. Translation: AAB59519.1.
U97197 mRNA. Translation: AAB58308.1.
X55283 mRNA. Translation: CAA38997.1.
AC120057 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90259.1.
CH471108 Genomic DNA. Translation: EAW90260.1.
CH471108 Genomic DNA. Translation: EAW90261.1.
CH471108 Genomic DNA. Translation: EAW90263.1.
BC017251 mRNA. Translation: AAH17251.1.
PIRLNHU2A. A25179.
RefSeqNP_001172.1. NM_001181.4.
NP_001188281.1. NM_001201352.1.
NP_550434.1. NM_080912.3.
NP_550435.1. NM_080913.3.
NP_550436.1. NM_080914.2.
XP_005256705.1. XM_005256648.1.
UniGeneHs.654440.

3D structure databases

ProteinModelPortalP07307.
SMRP07307. Positions 177-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106925. 12 interactions.
IntActP07307. 4 interactions.
STRING9606.ENSP00000347140.

Chemistry

BindingDBP07307.
DrugBankDB00025. Antihemophilic Factor.

PTM databases

PhosphoSiteP07307.

Polymorphism databases

DMDM218511923.

Proteomic databases

PaxDbP07307.
PRIDEP07307.

Protocols and materials databases

DNASU433.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254850; ENSP00000254850; ENSG00000161944. [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944. [P07307-1]
ENST00000380952; ENSP00000370339; ENSG00000161944. [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944. [P07307-2]
GeneID433.
KEGGhsa:433.
UCSCuc002gen.1. human. [P07307-2]
uc002gep.3. human. [P07307-1]
uc002geq.3. human. [P07307-3]

Organism-specific databases

CTD433.
GeneCardsGC17M007004.
HGNCHGNC:743. ASGR2.
HPAHPA014899.
HPA015998.
MIM108361. gene.
neXtProtNX_P07307.
PharmGKBPA25043.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241599.
HOGENOMHOG000034093.
HOVERGENHBG000270.
InParanoidP07307.
KOK10064.
OMAQDLKADH.
OrthoDBEOG7XDBGR.
PhylomeDBP07307.
TreeFamTF352155.

Gene expression databases

ArrayExpressP07307.
BgeeP07307.
CleanExHS_ASGR2.
GenevestigatorP07307.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSASGR2. human.
GenomeRNAi433.
NextBio1807.
PROP07307.
SOURCESearch...

Entry information

Entry nameASGR2_HUMAN
AccessionPrimary (citable) accession number: P07307
Secondary accession number(s): A6NLV8 expand/collapse secondary AC list , A8MT12, D3DTM9, D3DTN0, O00448, Q03969
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM