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P07307

- ASGR2_HUMAN

UniProt

P07307 - ASGR2_HUMAN

Protein

Asialoglycoprotein receptor 2

Gene

ASGR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

    GO - Molecular functioni

    1. asialoglycoprotein receptor activity Source: UniProtKB
    2. carbohydrate binding Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. cell surface receptor signaling pathway Source: ProtInc
    3. glycoprotein metabolic process Source: Ensembl
    4. lipid homeostasis Source: Ensembl
    5. receptor-mediated endocytosis Source: GOC
    6. regulation of protein stability Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Calcium, Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Asialoglycoprotein receptor 2
    Short name:
    ASGP-R 2
    Short name:
    ASGPR 2
    Alternative name(s):
    C-type lectin domain family 4 member H2
    Hepatic lectin H2
    Short name:
    HL-2
    Gene namesi
    Name:ASGR2
    Synonyms:CLEC4H2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:743. ASGR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25043.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Asialoglycoprotein receptor 2PRO_0000046654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi54 – 541S-palmitoyl cysteineBy similarity
    Glycosylationi102 – 1021N-linked (GlcNAc...)2 Publications
    Glycosylationi170 – 1701N-linked (GlcNAc...)1 Publication
    Disulfide bondi177 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 300PROSITE-ProRule annotation
    Disulfide bondi278 ↔ 292PROSITE-ProRule annotation
    Glycosylationi305 – 3051N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP07307.
    PaxDbiP07307.
    PRIDEiP07307.

    PTM databases

    PhosphoSiteiP07307.

    Expressioni

    Tissue specificityi

    Expressed exclusively in hepatic parenchymal cells.

    Gene expression databases

    ArrayExpressiP07307.
    BgeeiP07307.
    CleanExiHS_ASGR2.
    GenevestigatoriP07307.

    Organism-specific databases

    HPAiHPA014899.
    HPA015998.

    Interactioni

    Subunit structurei

    The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CERS2Q96G233EBI-1172636,EBI-1057080

    Protein-protein interaction databases

    BioGridi106925. 12 interactions.
    IntActiP07307. 4 interactions.
    STRINGi9606.ENSP00000347140.

    Structurei

    3D structure databases

    ProteinModelPortaliP07307.
    SMRiP07307. Positions 177-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 311232ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 302127C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi5 – 84Endocytosis signalSequence Analysis

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241599.
    HOGENOMiHOG000034093.
    HOVERGENiHBG000270.
    InParanoidiP07307.
    KOiK10064.
    OMAiQDLKADH.
    OrthoDBiEOG7XDBGR.
    PhylomeDBiP07307.
    TreeFamiTF352155.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR005640. Lectin_N.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    PF03954. Lectin_N. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P07307-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA    50
    QRLCSMVCFS LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF 100
    SNFSSSTLTE VQAISTHGGS VGDKITSLGA KLEKQQQDLK ADHDALLFHL 150
    KHFPVDLRFV ACQMELLHSN GSQRTCCPVN WVEHQGSCYW FSHSGKAWAE 200
    AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS DGSWKWVDGT 250
    DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC 300
    EKRRNATGEV A 311
    Length:311
    Mass (Da):35,092
    Last modified:December 16, 2008 - v2
    Checksum:iC86D2247FFF604DC
    GO
    Isoform 2 (identifier: P07307-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-42: Missing.

    Show »
    Length:292
    Mass (Da):32,988
    Checksum:iC762F780E74A6D50
    GO
    Isoform 3 (identifier: P07307-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-42: Missing.
         82-86: Missing.

    Show »
    Length:287
    Mass (Da):32,550
    Checksum:iE9528ACF7CBB1435
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851G → R.3 Publications
    Corresponds to variant rs2304978 [ dbSNP | Ensembl ].
    VAR_068747

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei24 – 4219Missing in isoform 2 and isoform 3. 1 PublicationVSP_003060Add
    BLAST
    Alternative sequencei82 – 865Missing in isoform 3. 1 PublicationVSP_003061

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11025 mRNA. Translation: AAB59519.1.
    U97197 mRNA. Translation: AAB58308.1.
    X55283 mRNA. Translation: CAA38997.1.
    AC120057 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90259.1.
    CH471108 Genomic DNA. Translation: EAW90260.1.
    CH471108 Genomic DNA. Translation: EAW90261.1.
    CH471108 Genomic DNA. Translation: EAW90263.1.
    BC017251 mRNA. Translation: AAH17251.1.
    CCDSiCCDS11088.1. [P07307-3]
    CCDS32544.1. [P07307-1]
    CCDS45598.1. [P07307-2]
    PIRiA25179. LNHU2A.
    RefSeqiNP_001172.1. NM_001181.4.
    NP_001188281.1. NM_001201352.1.
    NP_550434.1. NM_080912.3.
    NP_550435.1. NM_080913.3. [P07307-3]
    NP_550436.1. NM_080914.2.
    XP_005256705.1. XM_005256648.1. [P07307-3]
    XP_006721589.1. XM_006721526.1. [P07307-3]
    UniGeneiHs.654440.

    Genome annotation databases

    EnsembliENST00000254850; ENSP00000254850; ENSG00000161944. [P07307-3]
    ENST00000355035; ENSP00000347140; ENSG00000161944. [P07307-1]
    ENST00000446679; ENSP00000405844; ENSG00000161944. [P07307-2]
    GeneIDi433.
    KEGGihsa:433.
    UCSCiuc002gen.1. human. [P07307-2]
    uc002gep.3. human. [P07307-1]
    uc002geq.3. human. [P07307-3]

    Polymorphism databases

    DMDMi218511923.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Hepatic asialoglycoprotein receptor subunit 2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11025 mRNA. Translation: AAB59519.1 .
    U97197 mRNA. Translation: AAB58308.1 .
    X55283 mRNA. Translation: CAA38997.1 .
    AC120057 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90259.1 .
    CH471108 Genomic DNA. Translation: EAW90260.1 .
    CH471108 Genomic DNA. Translation: EAW90261.1 .
    CH471108 Genomic DNA. Translation: EAW90263.1 .
    BC017251 mRNA. Translation: AAH17251.1 .
    CCDSi CCDS11088.1. [P07307-3 ]
    CCDS32544.1. [P07307-1 ]
    CCDS45598.1. [P07307-2 ]
    PIRi A25179. LNHU2A.
    RefSeqi NP_001172.1. NM_001181.4.
    NP_001188281.1. NM_001201352.1.
    NP_550434.1. NM_080912.3.
    NP_550435.1. NM_080913.3. [P07307-3 ]
    NP_550436.1. NM_080914.2.
    XP_005256705.1. XM_005256648.1. [P07307-3 ]
    XP_006721589.1. XM_006721526.1. [P07307-3 ]
    UniGenei Hs.654440.

    3D structure databases

    ProteinModelPortali P07307.
    SMRi P07307. Positions 177-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106925. 12 interactions.
    IntActi P07307. 4 interactions.
    STRINGi 9606.ENSP00000347140.

    Chemistry

    BindingDBi P07307.
    DrugBanki DB00025. Antihemophilic Factor.

    PTM databases

    PhosphoSitei P07307.

    Polymorphism databases

    DMDMi 218511923.

    Proteomic databases

    MaxQBi P07307.
    PaxDbi P07307.
    PRIDEi P07307.

    Protocols and materials databases

    DNASUi 433.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254850 ; ENSP00000254850 ; ENSG00000161944 . [P07307-3 ]
    ENST00000355035 ; ENSP00000347140 ; ENSG00000161944 . [P07307-1 ]
    ENST00000446679 ; ENSP00000405844 ; ENSG00000161944 . [P07307-2 ]
    GeneIDi 433.
    KEGGi hsa:433.
    UCSCi uc002gen.1. human. [P07307-2 ]
    uc002gep.3. human. [P07307-1 ]
    uc002geq.3. human. [P07307-3 ]

    Organism-specific databases

    CTDi 433.
    GeneCardsi GC17M007004.
    HGNCi HGNC:743. ASGR2.
    HPAi HPA014899.
    HPA015998.
    MIMi 108361. gene.
    neXtProti NX_P07307.
    PharmGKBi PA25043.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241599.
    HOGENOMi HOG000034093.
    HOVERGENi HBG000270.
    InParanoidi P07307.
    KOi K10064.
    OMAi QDLKADH.
    OrthoDBi EOG7XDBGR.
    PhylomeDBi P07307.
    TreeFami TF352155.

    Miscellaneous databases

    ChiTaRSi ASGR2. human.
    GenomeRNAii 433.
    NextBioi 1807.
    PROi P07307.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07307.
    Bgeei P07307.
    CleanExi HS_ASGR2.
    Genevestigatori P07307.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR005640. Lectin_N.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    PF03954. Lectin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution."
      Spiess M., Lodish H.F.
      Proc. Natl. Acad. Sci. U.S.A. 82:6465-6469(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
    2. "Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver."
      Paietta E., Stockert R.J., Racevskis J.
      Hepatology 15:395-402(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
      Tissue: Liver.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-85.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Liver.
    6. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
      Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.
      Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LASS2.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102.
      Tissue: Plasma.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102 AND ASN-170.
      Tissue: Liver.

    Entry informationi

    Entry nameiASGR2_HUMAN
    AccessioniPrimary (citable) accession number: P07307
    Secondary accession number(s): A6NLV8
    , A8MT12, D3DTM9, D3DTN0, O00448, Q03969
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Calcium is required for ligand binding.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3