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P07307

- ASGR2_HUMAN

UniProt

P07307 - ASGR2_HUMAN

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Protein

Asialoglycoprotein receptor 2

Gene

ASGR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

GO - Molecular functioni

  1. asialoglycoprotein receptor activity Source: UniProtKB
  2. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell surface receptor signaling pathway Source: ProtInc
  3. glycoprotein metabolic process Source: Ensembl
  4. lipid homeostasis Source: Ensembl
  5. receptor-mediated endocytosis Source: GOC
  6. regulation of protein stability Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 2
Short name:
ASGP-R 2
Short name:
ASGPR 2
Alternative name(s):
C-type lectin domain family 4 member H2
Hepatic lectin H2
Short name:
HL-2
Gene namesi
Name:ASGR2
Synonyms:CLEC4H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:743. ASGR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei59 – 7921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini80 – 311232ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Asialoglycoprotein receptor 2PRO_0000046654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi54 – 541S-palmitoyl cysteineBy similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)2 Publications
Glycosylationi170 – 1701N-linked (GlcNAc...)1 Publication
Disulfide bondi177 ↔ 188PROSITE-ProRule annotation
Disulfide bondi205 ↔ 300PROSITE-ProRule annotation
Disulfide bondi278 ↔ 292PROSITE-ProRule annotation
Glycosylationi305 – 3051N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP07307.
PaxDbiP07307.
PRIDEiP07307.

PTM databases

PhosphoSiteiP07307.

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiP07307.
CleanExiHS_ASGR2.
ExpressionAtlasiP07307. baseline and differential.
GenevestigatoriP07307.

Organism-specific databases

HPAiHPA014899.
HPA015998.

Interactioni

Subunit structurei

The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172636,EBI-1057080

Protein-protein interaction databases

BioGridi106925. 42 interactions.
IntActiP07307. 4 interactions.
STRINGi9606.ENSP00000347140.

Structurei

3D structure databases

ProteinModelPortaliP07307.
SMRiP07307. Positions 177-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 302127C-type lectinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 84Endocytosis signalSequence Analysis

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241599.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP07307.
KOiK10064.
OMAiQDLKADH.
OrthoDBiEOG7XDBGR.
PhylomeDBiP07307.
TreeFamiTF352155.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P07307-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA
60 70 80 90 100
QRLCSMVCFS LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF
110 120 130 140 150
SNFSSSTLTE VQAISTHGGS VGDKITSLGA KLEKQQQDLK ADHDALLFHL
160 170 180 190 200
KHFPVDLRFV ACQMELLHSN GSQRTCCPVN WVEHQGSCYW FSHSGKAWAE
210 220 230 240 250
AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS DGSWKWVDGT
260 270 280 290 300
DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC
310
EKRRNATGEV A
Length:311
Mass (Da):35,092
Last modified:December 16, 2008 - v2
Checksum:iC86D2247FFF604DC
GO
Isoform 2 (identifier: P07307-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.

Show »
Length:292
Mass (Da):32,988
Checksum:iC762F780E74A6D50
GO
Isoform 3 (identifier: P07307-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.
     82-86: Missing.

Show »
Length:287
Mass (Da):32,550
Checksum:iE9528ACF7CBB1435
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851G → R.3 Publications
Corresponds to variant rs2304978 [ dbSNP | Ensembl ].
VAR_068747

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 4219Missing in isoform 2 and isoform 3. 1 PublicationVSP_003060Add
BLAST
Alternative sequencei82 – 865Missing in isoform 3. 1 PublicationVSP_003061

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11025 mRNA. Translation: AAB59519.1.
U97197 mRNA. Translation: AAB58308.1.
X55283 mRNA. Translation: CAA38997.1.
AC120057 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90259.1.
CH471108 Genomic DNA. Translation: EAW90260.1.
CH471108 Genomic DNA. Translation: EAW90261.1.
CH471108 Genomic DNA. Translation: EAW90263.1.
BC017251 mRNA. Translation: AAH17251.1.
CCDSiCCDS11088.1. [P07307-3]
CCDS32544.1. [P07307-1]
CCDS45598.1. [P07307-2]
PIRiA25179. LNHU2A.
RefSeqiNP_001172.1. NM_001181.4.
NP_001188281.1. NM_001201352.1.
NP_550434.1. NM_080912.3.
NP_550435.1. NM_080913.3. [P07307-3]
NP_550436.1. NM_080914.2.
XP_005256705.1. XM_005256648.1. [P07307-3]
XP_006721589.1. XM_006721526.1. [P07307-3]
UniGeneiHs.654440.

Genome annotation databases

EnsembliENST00000254850; ENSP00000254850; ENSG00000161944. [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944. [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944. [P07307-2]
GeneIDi433.
KEGGihsa:433.
UCSCiuc002gen.1. human. [P07307-2]
uc002gep.3. human. [P07307-1]
uc002geq.3. human. [P07307-3]

Polymorphism databases

DMDMi218511923.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11025 mRNA. Translation: AAB59519.1 .
U97197 mRNA. Translation: AAB58308.1 .
X55283 mRNA. Translation: CAA38997.1 .
AC120057 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90259.1 .
CH471108 Genomic DNA. Translation: EAW90260.1 .
CH471108 Genomic DNA. Translation: EAW90261.1 .
CH471108 Genomic DNA. Translation: EAW90263.1 .
BC017251 mRNA. Translation: AAH17251.1 .
CCDSi CCDS11088.1. [P07307-3 ]
CCDS32544.1. [P07307-1 ]
CCDS45598.1. [P07307-2 ]
PIRi A25179. LNHU2A.
RefSeqi NP_001172.1. NM_001181.4.
NP_001188281.1. NM_001201352.1.
NP_550434.1. NM_080912.3.
NP_550435.1. NM_080913.3. [P07307-3 ]
NP_550436.1. NM_080914.2.
XP_005256705.1. XM_005256648.1. [P07307-3 ]
XP_006721589.1. XM_006721526.1. [P07307-3 ]
UniGenei Hs.654440.

3D structure databases

ProteinModelPortali P07307.
SMRi P07307. Positions 177-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106925. 42 interactions.
IntActi P07307. 4 interactions.
STRINGi 9606.ENSP00000347140.

Chemistry

DrugBanki DB00025. Antihemophilic Factor.

PTM databases

PhosphoSitei P07307.

Polymorphism databases

DMDMi 218511923.

Proteomic databases

MaxQBi P07307.
PaxDbi P07307.
PRIDEi P07307.

Protocols and materials databases

DNASUi 433.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254850 ; ENSP00000254850 ; ENSG00000161944 . [P07307-3 ]
ENST00000355035 ; ENSP00000347140 ; ENSG00000161944 . [P07307-1 ]
ENST00000446679 ; ENSP00000405844 ; ENSG00000161944 . [P07307-2 ]
GeneIDi 433.
KEGGi hsa:433.
UCSCi uc002gen.1. human. [P07307-2 ]
uc002gep.3. human. [P07307-1 ]
uc002geq.3. human. [P07307-3 ]

Organism-specific databases

CTDi 433.
GeneCardsi GC17M007004.
HGNCi HGNC:743. ASGR2.
HPAi HPA014899.
HPA015998.
MIMi 108361. gene.
neXtProti NX_P07307.
PharmGKBi PA25043.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241599.
GeneTreei ENSGT00760000118924.
HOGENOMi HOG000034093.
HOVERGENi HBG000270.
InParanoidi P07307.
KOi K10064.
OMAi QDLKADH.
OrthoDBi EOG7XDBGR.
PhylomeDBi P07307.
TreeFami TF352155.

Miscellaneous databases

ChiTaRSi ASGR2. human.
GenomeRNAii 433.
NextBioi 1807.
PROi P07307.
SOURCEi Search...

Gene expression databases

Bgeei P07307.
CleanExi HS_ASGR2.
ExpressionAtlasi P07307. baseline and differential.
Genevestigatori P07307.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution."
    Spiess M., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 82:6465-6469(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
  2. "Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver."
    Paietta E., Stockert R.J., Racevskis J.
    Hepatology 15:395-402(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-85.
    Tissue: Liver.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-85.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Liver.
  6. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
    Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.
    Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LASS2.
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102.
    Tissue: Plasma.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102 AND ASN-170.
    Tissue: Liver.

Entry informationi

Entry nameiASGR2_HUMAN
AccessioniPrimary (citable) accession number: P07307
Secondary accession number(s): A6NLV8
, A8MT12, D3DTM9, D3DTN0, O00448, Q03969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 16, 2008
Last modified: November 26, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Calcium is required for ligand binding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3