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Protein

Asialoglycoprotein receptor 1

Gene

ASGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Calcium 1; via carbonyl oxygen1
Metal bindingi197Calcium 11
Metal bindingi216Calcium 21
Metal bindingi240Calcium 31
Binding sitei240Carbohydrate1
Metal bindingi242Calcium 31
Metal bindingi243Calcium 21
Binding sitei244Carbohydrate1
Metal bindingi253Calcium 2; via carbonyl oxygen1
Metal bindingi253Calcium 31
Binding sitei253Carbohydrate1
Metal bindingi254Calcium 21
Metal bindingi265Calcium 31
Metal bindingi266Calcium 31
Metal bindingi278Calcium 11

GO - Molecular functioni

  • asialoglycoprotein receptor activity Source: ProtInc
  • carbohydrate binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to extracellular stimulus Source: Ensembl
  • receptor-mediated endocytosis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141505-MONOMER.
ReactomeiR-HSA-446203. Asparagine N-linked glycosylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 1
Short name:
ASGP-R 1
Short name:
ASGPR 1
Alternative name(s):
C-type lectin domain family 4 member H1
Hepatic lectin H1
Short name:
HL-1
Gene namesi
Name:ASGR1
Synonyms:CLEC4H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:742. ASGR1.

Subcellular locationi

Isoform H1b :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicCuratedAdd BLAST40
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini62 – 291ExtracellularCuratedAdd BLAST230

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi432.
OpenTargetsiENSG00000141505.
PharmGKBiPA25042.

Chemistry databases

ChEMBLiCHEMBL2084.

Polymorphism and mutation databases

BioMutaiASGR1.
DMDMi126132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466501 – 291Asialoglycoprotein receptor 1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Lipidationi36S-palmitoyl cysteine1 Publication1
Glycosylationi79N-linked (GlcNAc...)1 Publication1
Glycosylationi147N-linked (GlcNAc...)1 Publication1
Disulfide bondi154 ↔ 165
Disulfide bondi182 ↔ 277
Disulfide bondi255 ↔ 269
Modified residuei285PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on a cytoplasmic Ser residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP07306.
PeptideAtlasiP07306.
PRIDEiP07306.

PTM databases

iPTMnetiP07306.
PhosphoSitePlusiP07306.
SwissPalmiP07306.

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiENSG00000141505.
CleanExiHS_ASGR1.
ExpressionAtlasiP07306. baseline and differential.
GenevisibleiP07306. HS.

Organism-specific databases

HPAiHPA011954.
HPA012852.

Interactioni

Subunit structurei

Interacts with LASS2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172335,EBI-1057080

Protein-protein interaction databases

BioGridi106924. 16 interactors.
IntActiP07306. 6 interactors.
STRINGi9606.ENSP00000269299.

Chemistry databases

BindingDBiP07306.

Structurei

Secondary structure

1291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi159 – 161Combined sources3
Beta strandi164 – 168Combined sources5
Helixi175 – 184Combined sources10
Helixi195 – 205Combined sources11
Beta strandi210 – 215Combined sources6
Beta strandi248 – 251Combined sources4
Beta strandi255 – 258Combined sources4
Beta strandi264 – 267Combined sources4
Beta strandi273 – 280Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DV8X-ray2.30A154-281[»]
ProteinModelPortaliP07306.
SMRiP07306.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07306.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 278C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 123Sequence analysisAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP07306.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG091G062T.
PhylomeDBiP07306.
TreeFamiTF352155.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform H1a (identifier: P07306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL
60 70 80 90 100
LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR
110 120 130 140 150
KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE
160 170 180 190 200
RTCCPVNWVE HERSCYWFSR SGKAWADADN YCRLEDAHLV VVTSWEEQKF
210 220 230 240 250
VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ PDDWYGHGLG
260 270 280 290
GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L
Length:291
Mass (Da):33,186
Last modified:January 23, 2007 - v2
Checksum:i9B825527B2FC1FD0
GO
Isoform H1b (identifier: P07306-2) [UniParc]FASTAAdd to basket
Also known as: sASGPR

The sequence of this isoform differs from the canonical sequence as follows:
     24-63: GPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQN → D

Show »
Length:252
Mass (Da):29,144
Checksum:iB0F8C6FA80E1CCF2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04448024 – 63GPPPP…IGSQN → D in isoform H1b. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10058 mRNA. Translation: AAA51785.1.
AB070933 mRNA. Translation: BAB83508.1.
FJ410292 mRNA. Translation: ACQ90237.1.
AC120057 Genomic DNA. No translation available.
BC032130 mRNA. Translation: AAH32130.1.
CCDSiCCDS11089.1. [P07306-1]
CCDS56017.1. [P07306-2]
PIRiA22509. LNHU1.
RefSeqiNP_001184145.1. NM_001197216.2. [P07306-2]
NP_001662.1. NM_001671.4. [P07306-1]
XP_011522163.1. XM_011523861.2. [P07306-1]
UniGeneiHs.12056.
Hs.731669.

Genome annotation databases

EnsembliENST00000269299; ENSP00000269299; ENSG00000141505. [P07306-1]
ENST00000574388; ENSP00000459169; ENSG00000141505. [P07306-2]
ENST00000619926; ENSP00000481182; ENSG00000141505. [P07306-2]
GeneIDi432.
KEGGihsa:432.
UCSCiuc021toy.3. human. [P07306-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10058 mRNA. Translation: AAA51785.1.
AB070933 mRNA. Translation: BAB83508.1.
FJ410292 mRNA. Translation: ACQ90237.1.
AC120057 Genomic DNA. No translation available.
BC032130 mRNA. Translation: AAH32130.1.
CCDSiCCDS11089.1. [P07306-1]
CCDS56017.1. [P07306-2]
PIRiA22509. LNHU1.
RefSeqiNP_001184145.1. NM_001197216.2. [P07306-2]
NP_001662.1. NM_001671.4. [P07306-1]
XP_011522163.1. XM_011523861.2. [P07306-1]
UniGeneiHs.12056.
Hs.731669.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DV8X-ray2.30A154-281[»]
ProteinModelPortaliP07306.
SMRiP07306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106924. 16 interactors.
IntActiP07306. 6 interactors.
STRINGi9606.ENSP00000269299.

Chemistry databases

BindingDBiP07306.
ChEMBLiCHEMBL2084.

PTM databases

iPTMnetiP07306.
PhosphoSitePlusiP07306.
SwissPalmiP07306.

Polymorphism and mutation databases

BioMutaiASGR1.
DMDMi126132.

Proteomic databases

PaxDbiP07306.
PeptideAtlasiP07306.
PRIDEiP07306.

Protocols and materials databases

DNASUi432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269299; ENSP00000269299; ENSG00000141505. [P07306-1]
ENST00000574388; ENSP00000459169; ENSG00000141505. [P07306-2]
ENST00000619926; ENSP00000481182; ENSG00000141505. [P07306-2]
GeneIDi432.
KEGGihsa:432.
UCSCiuc021toy.3. human. [P07306-1]

Organism-specific databases

CTDi432.
DisGeNETi432.
GeneCardsiASGR1.
HGNCiHGNC:742. ASGR1.
HPAiHPA011954.
HPA012852.
MIMi108360. gene.
neXtProtiNX_P07306.
OpenTargetsiENSG00000141505.
PharmGKBiPA25042.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP07306.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG091G062T.
PhylomeDBiP07306.
TreeFamiTF352155.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141505-MONOMER.
ReactomeiR-HSA-446203. Asparagine N-linked glycosylation.

Miscellaneous databases

ChiTaRSiASGR1. human.
EvolutionaryTraceiP07306.
GenomeRNAii432.
PROiP07306.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141505.
CleanExiHS_ASGR1.
ExpressionAtlasiP07306. baseline and differential.
GenevisibleiP07306. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASGR1_HUMAN
AccessioniPrimary (citable) accession number: P07306
Secondary accession number(s): I3L1X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Calcium is required for ligand binding.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.