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Protein

Histone H1.0

Gene

H1F0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

GO - Molecular functioni

  1. chromatin DNA binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. apoptotic DNA fragmentation Source: Reactome
  2. apoptotic process Source: Reactome
  3. cellular component disassembly involved in execution phase of apoptosis Source: Reactome
  4. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_13462. Activation of DNA fragmentation factor.
REACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1'
Histone H1(0)
Cleaved into the following chain:
Gene namesi
Name:H1F0
Synonyms:H1FV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4714. H1F0.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation. Chromosome 1 PublicationPROSITE-ProRule annotation
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. Golgi apparatus Source: HPA
  3. nuclear chromatin Source: UniProtKB
  4. nuclear euchromatin Source: UniProtKB
  5. nucleoplasm Source: HPA
  6. nucleosome Source: InterPro
  7. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Histone H1.0PRO_0000423207Add
BLAST
Initiator methioninei1 – 11Removed; alternate1 Publication
Chaini2 – 194193Histone H1.0, N-terminally processedPRO_0000195904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei2 – 21N-acetylthreonine; partial; in Histone H1.0, N-terminally processed2 Publications
Modified residuei4 – 41Deamidated asparagine; partial1 Publication
Modified residuei42 – 421CitrullineBy similarity

Post-translational modificationi

Phosphorylated on Ser-17 in RNA edited version.

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

MaxQBiP07305.
PaxDbiP07305.
PeptideAtlasiP07305.
PRIDEiP07305.

PTM databases

PhosphoSiteiP07305.

Expressioni

Inductioni

Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).1 Publication

Gene expression databases

BgeeiP07305.
CleanExiHS_H1F0.
GenevestigatoriP07305.

Organism-specific databases

HPAiHPA000843.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E1P040142EBI-725224,EBI-7014446From a different organism.

Protein-protein interaction databases

BioGridi109260. 27 interactions.
DIPiDIP-41775N.
IntActiP07305. 8 interactions.
MINTiMINT-276185.
STRINGi9606.ENSP00000344504.

Structurei

3D structure databases

ProteinModelPortaliP07305.
SMRiP07305. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9774H15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG126832.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG069502.
InParanoidiP07305.
KOiK11275.
OMAiDEPKRSV.
OrthoDBiEOG75QR72.
PhylomeDBiP07305.
TreeFamiTF313664.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P07305-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE
110 120 130 140 150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL
160 170 180 190
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Length:194
Mass (Da):20,863
Last modified:January 23, 2007 - v3
Checksum:i03ED6F01919F8BE1
GO
Isoform 2 (identifier: P07305-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-19: Missing.

Show »
Length:177
Mass (Da):19,167
Checksum:i8CD558F288DB593A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651D → H in AAH29046. (PubMed:15489334)Curated

RNA editingi

Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1 – 11M → MLGKGRQRRRRQRQRQSPVP RPSDRPAGLGLAKPARRALP TPEPGRKSSDSSLASPGAAL QTGPVVRGSGADPEAGFAQP PTRAGPLEGAFNSRTRQATM in RNA edited version.
VAR_054789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3 – 1917Missing in isoform 2. 1 PublicationVSP_042163Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03473 Genomic DNA. Translation: CAA27190.1.
CR456502 mRNA. Translation: CAG30388.1.
CR542220 mRNA. Translation: CAG47016.1.
AK299209 mRNA. Translation: BAG61248.1.
AK312583 mRNA. Translation: BAG35477.1.
Z97630 Genomic DNA. Translation: CAB42829.1.
CH471095 Genomic DNA. Translation: EAW60188.1.
BC000145 mRNA. Translation: AAH00145.1.
BC029046 mRNA. Translation: AAH29046.1.
CCDSiCCDS13956.1. [P07305-1]
PIRiA24850. HSHU10.
RefSeqiNP_005309.1. NM_005318.3. [P07305-1]
UniGeneiHs.745024.

Genome annotation databases

EnsembliENST00000340857; ENSP00000344504; ENSG00000189060. [P07305-1]
GeneIDi3005.
KEGGihsa:3005.
UCSCiuc003aty.3. human. [P07305-1]

Polymorphism databases

DMDMi121897.

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Cross-referencesi

Web resourcesi

Wikipedia

Histone H1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03473 Genomic DNA. Translation: CAA27190.1.
CR456502 mRNA. Translation: CAG30388.1.
CR542220 mRNA. Translation: CAG47016.1.
AK299209 mRNA. Translation: BAG61248.1.
AK312583 mRNA. Translation: BAG35477.1.
Z97630 Genomic DNA. Translation: CAB42829.1.
CH471095 Genomic DNA. Translation: EAW60188.1.
BC000145 mRNA. Translation: AAH00145.1.
BC029046 mRNA. Translation: AAH29046.1.
CCDSiCCDS13956.1. [P07305-1]
PIRiA24850. HSHU10.
RefSeqiNP_005309.1. NM_005318.3. [P07305-1]
UniGeneiHs.745024.

3D structure databases

ProteinModelPortaliP07305.
SMRiP07305. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109260. 27 interactions.
DIPiDIP-41775N.
IntActiP07305. 8 interactions.
MINTiMINT-276185.
STRINGi9606.ENSP00000344504.

Chemistry

BindingDBiP07305.

PTM databases

PhosphoSiteiP07305.

Polymorphism databases

DMDMi121897.

Proteomic databases

MaxQBiP07305.
PaxDbiP07305.
PeptideAtlasiP07305.
PRIDEiP07305.

Protocols and materials databases

DNASUi3005.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340857; ENSP00000344504; ENSG00000189060. [P07305-1]
GeneIDi3005.
KEGGihsa:3005.
UCSCiuc003aty.3. human. [P07305-1]

Organism-specific databases

CTDi3005.
GeneCardsiGC22P038201.
H-InvDBHIX0016454.
HGNCiHGNC:4714. H1F0.
HPAiHPA000843.
MIMi142708. gene.
neXtProtiNX_P07305.
PharmGKBiPA29092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG126832.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG069502.
InParanoidiP07305.
KOiK11275.
OMAiDEPKRSV.
OrthoDBiEOG75QR72.
PhylomeDBiP07305.
TreeFamiTF313664.

Enzyme and pathway databases

ReactomeiREACT_13462. Activation of DNA fragmentation factor.
REACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Miscellaneous databases

ChiTaRSiH1F0. human.
GenomeRNAii3005.
NextBioi11916.
PROiP07305.
SOURCEiSearch...

Gene expression databases

BgeeiP07305.
CleanExiHS_H1F0.
GenevestigatoriP07305.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene."
    Doenecke D., Tonjes R.
    J. Mol. Biol. 187:461-464(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Placenta.
  8. Cited for: PARTIAL PROTEIN SEQUENCE (RNA EDITED VERSION), IDENTIFICATION BY MASS SPECTROMETRY, RNA EDITING, SUBCELLULAR LOCATION, INDUCTION.
  9. "The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation."
    Lindner H., Sarg B., Hoertnagl B., Helliger W.
    J. Biol. Chem. 273:13324-13330(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT THR-2, CLEAVAGE OF INITIATOR METHIONINE, DEAMIDATION AT ASN-4.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH10_HUMAN
AccessioniPrimary (citable) accession number: P07305
Secondary accession number(s): B2R6I0
, B4DRD6, Q6FG88, Q8N6R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.