P07298 (VNCS_PAVHU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
NCVP1
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Human parvovirus B19 (isolate AU) (HPV B19) [Complete proteome]

Taxonomic identifier

648238 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Erythrovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 671	671	Non-capsid protein NS-1		PRO_0000222467
Regions
	Domain	302 – 457	156	SF3 helicase
	Nucleotide binding	328 – 335	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P07298 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: E8845201FDB3F208	FASTA	671	74,097
	10 20 30 40 50 60 MELFRGVLQV SSNVLDCAND NWWCSLLDLD TSDWEPLTHT NRLMAIYLSS VASKLDFTGG 70 80 90 100 110 120 PLAGCLYFFQ VECNKFEEGY HIHVVTGGPG LNPRNLTVCV EGLFNNVLYH LVTENVKLKF 130 140 150 160 170 180 LPGMTTKGKY FRDGEQFIEN YLMKKIPLNV VWCVTNIDGY IDTCISATFR RGACHAKKPR 190 200 210 220 230 240 ITTAINDTSS DAGESSGTGA EVVPFNGKGT KASIKFQTMV NWLCENRVFT EDKWKLVDFN 250 260 270 280 290 300 QYTLLSSSHS GSFQIQSALK LAIYKATNLV PTSTFLLHTD FEQVMCIKDN KIVKLLLCQN 310 320 330 340 350 360 YDPLLVGQHV LKWIDKKCGK KNTLWFYGPP STGKTNLAMA IAKSVPVYGM VNWNNENFPF 370 380 390 400 410 420 NDVAGKSLVV WDEGIIKSTI VEAAKAILGG QPTRVDQKMR GSVAVPGVPV VITSNGDITF 430 440 450 460 470 480 VVSGNTTTTV HAKALKERMV KLNFTVRCSP DMGLLTEADV QQWLTWCNAQ SWDHYENWAI 490 500 510 520 530 540 NYTFDFPGIN ADALHPDLQT TPIVTDTSIS SSGGESSEEL SESSFFNLIT PGAWNTETPR 550 560 570 580 590 600 SSTPIPGTSS GESFVGSPVS SEVVAASWEE AFYTPLADQF RELLVGVDYV WDGVRGLPVC 610 620 630 640 650 660 CVQHINNSGG GLGLCPHCIN VGAWYNGWKF REFTPDLVRC SCHVGASNPF SVLTCKKCAY 670 LSGLQSFVDY E

References

[1]	"Nucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis." Shade R.O., Blundell M.C., Cotmore S.F., Tattersall P., Astell C.R. J. Virol. 58:921-936(1986) [PubMed: 3701931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13178 Genomic DNA. Translation: AAA66866.1.
PIR	UYPV19. B24299.
3D structure databases
ProteinModelPortal	P07298.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR001257. Parvovirus_NS1_helicase. IPR014835. Rep_N. [Graphical view]
Pfam	PF01057. Parvo_NS1. 1 hit. PF08724. Rep_N. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_PAVHU

Accession

Primary (citable) accession number: P07298

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program