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Protein

Anthranilate phosphoribosyltransferase

Gene

TRP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (TRP3), Anthranilate synthase component 1 (TRP2)
  2. Anthranilate phosphoribosyltransferase (TRP4)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. Multifunctional tryptophan biosynthesis protein (TRP3)
  5. Tryptophan synthase (TRP5)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • anthranilate phosphoribosyltransferase activity Source: SGD

GO - Biological processi

  • tryptophan biosynthetic process Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YDR354W-MONOMER
UniPathwayiUPA00035; UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase (EC:2.4.2.18)
Gene namesi
Name:TRP4
Ordered Locus Names:YDR354W
ORF Names:D9476.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR354W
SGDiS000002762 TRP4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545281 – 380Anthranilate phosphoribosyltransferaseAdd BLAST380

Proteomic databases

MaxQBiP07285
PaxDbiP07285
PRIDEiP07285

Interactioni

Protein-protein interaction databases

BioGridi32411, 167 interactors
IntActiP07285, 2 interactors
MINTiP07285
STRINGi4932.YDR354W

Structurei

3D structure databases

ProteinModelPortaliP07285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000230451
InParanoidiP07285
KOiK00766
OMAiLCALKIK
OrthoDBiEOG092C2OPT

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

P07285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATLLSYT KKLLASPPQL SSTDLHDALL VILSLLQKCD TNSDESLSIY
60 70 80 90 100
TKVSSFLTAL RVTKLDHKAE YIAEAAKAVL RHSDLVDLPL PKKDELHPED
110 120 130 140 150
GPVILDIVGT GGDGQNTFNV STSAAIVASG IQGLKICKHG GKASTSNSGA
160 170 180 190 200
GDLIGTLGCD MFKVNSSTVP KLWPDNTFMF LLAPFFHHGM GHVSKIRKFL
210 220 230 240 250
GIPTVFNVLG PLLHPVSHVN KRILGVYSKE LAPEYAKAAA LVYPGSETFI
260 270 280 290 300
VWGHVGLDEV SPIGKTTVWH IDPTSSELKL KTFQLEPSMF GLEEHELSKC
310 320 330 340 350
ASYGPKENAR ILKEEVLSGK YHLGDNNPIY DYILMNTAVL YCLSQGHQNW
360 370 380
KEGIIKAEES IHSGNALRSL EHFIDSVSSL
Length:380
Mass (Da):41,374
Last modified:April 1, 1988 - v1
Checksum:i9E231587F085F32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04273 Genomic DNA Translation: CAA27822.1
U28372 Genomic DNA Translation: AAB64790.1
X73297 Genomic DNA Translation: CAA51732.1
BK006938 Genomic DNA Translation: DAA12194.1
PIRiS05865 NPBY
RefSeqiNP_010641.3, NM_001180662.3

Genome annotation databases

EnsemblFungiiYDR354W; YDR354W; YDR354W
GeneIDi851956
KEGGisce:YDR354W

Similar proteinsi

Entry informationi

Entry nameiTRPD_YEAST
AccessioniPrimary (citable) accession number: P07285
Secondary accession number(s): D6VSY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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