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Protein

Anthranilate phosphoribosyltransferase

Gene

TRP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (TRP3), Anthranilate synthase component 1 (TRP2)
  2. Anthranilate phosphoribosyltransferase (TRP4)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. Multifunctional tryptophan biosynthesis protein (TRP3)
  5. Tryptophan synthase (TRP5)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • anthranilate phosphoribosyltransferase activity Source: SGD
  • catalytic activity Source: GO_Central

GO - Biological processi

  • tryptophan biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YDR354W-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase (EC:2.4.2.18)
Gene namesi
Name:TRP4
Ordered Locus Names:YDR354W
ORF Names:D9476.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR354W.
SGDiS000002762. TRP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Anthranilate phosphoribosyltransferasePRO_0000154528Add
BLAST

Proteomic databases

MaxQBiP07285.

Interactioni

Protein-protein interaction databases

BioGridi32411. 47 interactions.
IntActiP07285. 2 interactions.
MINTiMINT-2784749.

Structurei

3D structure databases

ProteinModelPortaliP07285.
SMRiP07285. Positions 53-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000230451.
InParanoidiP07285.
KOiK00766.
OMAiWRTIFNL.
OrthoDBiEOG092C2OPT.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

P07285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATLLSYT KKLLASPPQL SSTDLHDALL VILSLLQKCD TNSDESLSIY
60 70 80 90 100
TKVSSFLTAL RVTKLDHKAE YIAEAAKAVL RHSDLVDLPL PKKDELHPED
110 120 130 140 150
GPVILDIVGT GGDGQNTFNV STSAAIVASG IQGLKICKHG GKASTSNSGA
160 170 180 190 200
GDLIGTLGCD MFKVNSSTVP KLWPDNTFMF LLAPFFHHGM GHVSKIRKFL
210 220 230 240 250
GIPTVFNVLG PLLHPVSHVN KRILGVYSKE LAPEYAKAAA LVYPGSETFI
260 270 280 290 300
VWGHVGLDEV SPIGKTTVWH IDPTSSELKL KTFQLEPSMF GLEEHELSKC
310 320 330 340 350
ASYGPKENAR ILKEEVLSGK YHLGDNNPIY DYILMNTAVL YCLSQGHQNW
360 370 380
KEGIIKAEES IHSGNALRSL EHFIDSVSSL
Length:380
Mass (Da):41,374
Last modified:April 1, 1988 - v1
Checksum:i9E231587F085F32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04273 Genomic DNA. Translation: CAA27822.1.
U28372 Genomic DNA. Translation: AAB64790.1.
X73297 Genomic DNA. Translation: CAA51732.1.
BK006938 Genomic DNA. Translation: DAA12194.1.
PIRiS05865. NPBY.
RefSeqiNP_010641.3. NM_001180662.3.

Genome annotation databases

EnsemblFungiiYDR354W; YDR354W; YDR354W.
GeneIDi851956.
KEGGisce:YDR354W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04273 Genomic DNA. Translation: CAA27822.1.
U28372 Genomic DNA. Translation: AAB64790.1.
X73297 Genomic DNA. Translation: CAA51732.1.
BK006938 Genomic DNA. Translation: DAA12194.1.
PIRiS05865. NPBY.
RefSeqiNP_010641.3. NM_001180662.3.

3D structure databases

ProteinModelPortaliP07285.
SMRiP07285. Positions 53-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32411. 47 interactions.
IntActiP07285. 2 interactions.
MINTiMINT-2784749.

Proteomic databases

MaxQBiP07285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR354W; YDR354W; YDR354W.
GeneIDi851956.
KEGGisce:YDR354W.

Organism-specific databases

EuPathDBiFungiDB:YDR354W.
SGDiS000002762. TRP4.

Phylogenomic databases

HOGENOMiHOG000230451.
InParanoidiP07285.
KOiK00766.
OMAiWRTIFNL.
OrthoDBiEOG092C2OPT.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciYEAST:YDR354W-MONOMER.

Miscellaneous databases

PROiP07285.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_YEAST
AccessioniPrimary (citable) accession number: P07285
Secondary accession number(s): D6VSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.