Reviewed,
UniProtKB/Swiss-Prot P07279 (RL18_YEAST)
Last modified
December 15, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60S ribosomal protein L18 Alternative name(s): RP28 | |||||||||||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | |||||||||||||||
| Taxonomic identifier | 4932 [NCBI] | |||||||||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 186 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with NAP1. Ref.6 Ref.11 |
| Subcellular location | |
| Miscellaneous | Present with 63700 molecules/cell in log phase SD medium. Ref.8 There are 2 genes for L18 in yeast. |
| Sequence similarities | Belongs to the ribosomal protein L18e family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | translation Ref.6 Traceable author statement. Source: SGD |
| Cellular component | cytosolic large ribosomal subunit Ref.6 Traceable author statement. Source: SGD |
| Molecular function | structural constituent of ribosome Ref.6 Traceable author statement. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure and organization of two linked ribosomal protein genes in yeast." Molenaar C.M.T., Woudt L.P., Jansen A.E.M., Mager W.H., Planta R.J., Donovan D.M., Pearson N.J. Nucleic Acids Res. 12:7345-7358(1984) [PubMed: 6387623] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL18A AND RPL18B). |
| [2] | "Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene." Maurer K.C.T., Urbanus J.H.M., Planta R.J. Yeast 11:1303-1310(1995) [PubMed: 8553702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL18B). Strain: ATCC 96604 / S288c / FY1679. |
| [3] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. Hani J.Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (RPL18B). Strain: ATCC 96604 / S288c / FY1679. |
| [4] | "DNA sequence analysis of a 10 624 bp fragment of the left arm of chromosome XV from Saccharomyces cerevisiae reveals a RNA binding protein, a mitochondrial protein, two ribosomal proteins and two new open reading frames." Lafuente M.J., Gamo F.-J., Gancedo C. Yeast 12:1041-1045(1996) [PubMed: 8896268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL18A). Strain: ATCC 96604 / S288c / FY1679. |
| [5] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. Kleine K.Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (RPL18A). Strain: ATCC 96604 / S288c / FY1679. |
| [6] | "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed: 9559554] [Abstract] Cited for: NOMENCLATURE, SUBUNIT. |
| [7] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [8] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [9] | "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, MASS SPECTROMETRY. |
| [10] | "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86 AND SER-167, MASS SPECTROMETRY. |
| [11] | "Phosphorylation by casein kinase 2 regulates Nap1 localization and function." Calvert M.E.K., Keck K.M., Ptak C., Shabanowitz J., Hunt D.F., Pemberton L.F. Mol. Cell. Biol. 28:1313-1325(2008) [PubMed: 18086883] [Abstract] Cited for: INTERACTION WITH NAP1, MASS SPECTROMETRY. |
| [12] | "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions." Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J. Cell 107:373-386(2001) [PubMed: 11701127] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 22-141, ELECTRON MICROSCOPY. |
| [13] | "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation." Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J. EMBO J. 23:1008-1019(2004) [PubMed: 14976550] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 22-141, ELECTRON MICROSCOPY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X01099 Genomic DNA. Translation: CAA25573.1. X02635 Genomic DNA. Translation: CAA26481.1. X01100 Genomic DNA. Translation: CAA25574.1. U23084 Genomic DNA. Translation: AAC49097.1. Z71577 Genomic DNA. Translation: CAA96219.1. X95258 Genomic DNA. Translation: CAA64550.1. Z74862 Genomic DNA. Translation: CAA99139.1. | |||||||||||||||||||
| PIR | R5BY8E. S05867. | ||||||||||||||||||
| RefSeq | NP_014098.1. NP_014521.1. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-4554N. | ||||||||||||||||||
| IntAct | P07279. 73 interactions. | ||||||||||||||||||
| STRING | P07279. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P07279. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | YNL301C; YNL301C; YNL301C; Saccharomyces cerevisiae. [Genome view] YOL120C; YOL120C; YOL120C; Saccharomyces cerevisiae. [Genome view] | ||||||||||||||||||
| GeneID | 854029. 855415. | ||||||||||||||||||
| KEGG | sce:YNL301C. sce:YOL120C. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CYGD | YNL301c. YOL120c. | ||||||||||||||||||
| SGD | S000005480. RPL18A. S000005245. RPL18B. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | HBG499813. | ||||||||||||||||||
| OMA | DAPFNKV. | ||||||||||||||||||
| OrthoDB | EOG98SJ98. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P07279. | ||||||||||||||||||
| Genevestigator | P07279. | ||||||||||||||||||
| GermOnline | YNL301C. Saccharomyces cerevisiae. YOL120C. Saccharomyces cerevisiae. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR000039. Ribosomal_L18e. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR10934. Ribosomal_L18e. 1 hit. | ||||||||||||||||||
| Pfam | PF00828. Ribosomal_L18e. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS01106. RIBOSOMAL_L18E. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 975577. | ||||||||||||||||||
Entry information
| Entry name | RL18_YEAST | ||||||||
| Accession | Primary (citable) accession number: P07279 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIV Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names |

Clusters with


