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Protein

Pyrimidine pathway regulatory protein 1

Gene

PPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of URA1 and URA3 expression.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Zinc 11
Metal bindingi34Zinc 21
Metal bindingi37Zinc 11
Metal bindingi44Zinc 11
Metal bindingi51Zinc 11
Metal bindingi51Zinc 21
Metal bindingi54Zinc 21
Metal bindingi61Zinc 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi34 – 61Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processPyrimidine biosynthesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32175-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrimidine pathway regulatory protein 1
Gene namesi
Name:PPR1
Ordered Locus Names:YLR014C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR014C
SGDiS000004004 PPR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149651 – 904Pyrimidine pathway regulatory protein 1Add BLAST904

Proteomic databases

MaxQBiP07272
PaxDbiP07272
PRIDEiP07272

PTM databases

iPTMnetiP07272

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi31288, 88 interactors
DIPiDIP-2126N
IntActiP07272, 3 interactors
MINTiP07272
STRINGi4932.YLR014C

Structurei

Secondary structure

1904
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 40Combined sources6
Helixi52 – 56Combined sources5
Beta strandi62 – 64Combined sources3
Turni66 – 68Combined sources3
Beta strandi71 – 73Combined sources3
Helixi74 – 93Combined sources20
Turni114 – 116Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PYIX-ray3.20A/B29-123[»]
ProteinModelPortaliP07272
SMRiP07272
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07272

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000112745
HOGENOMiHOG000094249
InParanoidiP07272
OMAiSWRIDID
OrthoDBiEOG092C0G13

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQKKFNSKK SNRTDLSKRG DSPNIGISKS RTACKRCRLK KIKCDQEFPS
60 70 80 90 100
CKRCAKLEVP CVSLDPATGK DVPRSYVFFL EDRLAVMMRV LKEYGVDPTK
110 120 130 140 150
IRGNIPATSD DEPFDLKKYS SVSSLGEEGI LPHNGLLADY LVQKGNSMAS
160 170 180 190 200
SAITSKSMAS PQTINVQRKE FLVNSKKQDG SALLPETGSP MTSDARAEEL
210 220 230 240 250
RRCNKEISAL GTMRESSFNS FLGDSSGISF AKLVFTATNF RQDSGDDVLD
260 270 280 290 300
EDIKQREQKY NGYAEAENNP HFDPLELPPR HAAEVMISRF FVDTNSQLPL
310 320 330 340 350
LHRELFLKKY FEPIYGPWNP NIALASDQTG INSAFEIPIT SAFSAHTEPK
360 370 380 390 400
RENVTEKIDV CSSVDVPWYD TWETSQKVNM RPIVELPTKF HIPYFFLNII
410 420 430 440 450
FAIGHATQVL KSDITTVATY KRRATKYIAS LFSSSDRLEA LAGTLLMVIY
460 470 480 490 500
SIMRPNVPGV WYTMGSVLRL TVDLGLHSEK INKNYDAFTR EIRRRLFWCV
510 520 530 540 550
YSLDRQICSY FGRPFGIPEE SITTRYPSLL DDSFITLTNR EIDDYSDLPS
560 570 580 590 600
PNPSSKVIAL AMYKIRRIQA SIVRILYAPG AELPRRFMDL ESWRIETYNE
610 620 630 640 650
LERWFQVDVP KNFEMMNCKF NSIWFDLNYH YSKSILYGLS PKFPTLNDTA
660 670 680 690 700
FKIVLDSTKG TIDVFYNLCV NKKIGYTWVA VHNMFMTGMT YLYVNFYSKN
710 720 730 740 750
NINDCQEKVS EYTEKVLIVL KNLIGFCESA KTCYTSYKIL SSVVIKLKFM
760 770 780 790 800
QINDAKGIFS DSNPLTSQAN RMSSYDKKTN VLGFDDGTFD NKVFNRTNFE
810 820 830 840 850
EKAPFDIPLD EFFTELEKHS NVSQFNTLDV SEGNQVINES ASTNTSSALN
860 870 880 890 900
CQSYTNNQDI MDILFQVTSG SVWDEFFVRS GNGNEGESSY DISKGKNSES

GGIF
Length:904
Mass (Da):102,724
Last modified:April 1, 1988 - v1
Checksum:i836B16CEE27B23BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01739 Genomic DNA Translation: CAA25876.1
Z73186 Genomic DNA Translation: CAA97536.1
X90564 Genomic DNA Translation: CAA62160.1
BK006945 Genomic DNA Translation: DAA09332.1
PIRiS05877 RGBYP1
RefSeqiNP_013114.1, NM_001181901.1

Genome annotation databases

EnsemblFungiiYLR014C; YLR014C; YLR014C
GeneIDi850701
KEGGisce:YLR014C

Similar proteinsi

Entry informationi

Entry nameiPPR1_YEAST
AccessioniPrimary (citable) accession number: P07272
Secondary accession number(s): D6VY16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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