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Protein

Pyrimidine pathway regulatory protein 1

Gene

PPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of URA1 and URA3 expression.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Zinc 1
Metal bindingi34 – 341Zinc 2
Metal bindingi37 – 371Zinc 1
Metal bindingi44 – 441Zinc 1
Metal bindingi51 – 511Zinc 1
Metal bindingi51 – 511Zinc 2
Metal bindingi54 – 541Zinc 2
Metal bindingi61 – 611Zinc 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 6128Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: SGD
  • sequence-specific DNA binding Source: SGD
  • zinc ion binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Pyrimidine biosynthesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrimidine pathway regulatory protein 1
Gene namesi
Name:PPR1
Ordered Locus Names:YLR014C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR014C.
SGDiS000004004. PPR1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Pyrimidine pathway regulatory protein 1PRO_0000114965Add
BLAST

Proteomic databases

MaxQBiP07272.

PTM databases

iPTMnetiP07272.

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi31288. 37 interactions.
DIPiDIP-2126N.
IntActiP07272. 3 interactions.
MINTiMINT-473884.

Structurei

Secondary structure

1
904
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 406Combined sources
Helixi52 – 565Combined sources
Beta strandi62 – 643Combined sources
Turni66 – 683Combined sources
Beta strandi71 – 733Combined sources
Helixi74 – 9320Combined sources
Turni114 – 1163Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PYIX-ray3.20A/B29-123[»]
ProteinModelPortaliP07272.
SMRiP07272. Positions 30-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07272.

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000112745.
HOGENOMiHOG000094249.
InParanoidiP07272.
OMAiFWCVYSL.
OrthoDBiEOG092C0G13.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQKKFNSKK SNRTDLSKRG DSPNIGISKS RTACKRCRLK KIKCDQEFPS
60 70 80 90 100
CKRCAKLEVP CVSLDPATGK DVPRSYVFFL EDRLAVMMRV LKEYGVDPTK
110 120 130 140 150
IRGNIPATSD DEPFDLKKYS SVSSLGEEGI LPHNGLLADY LVQKGNSMAS
160 170 180 190 200
SAITSKSMAS PQTINVQRKE FLVNSKKQDG SALLPETGSP MTSDARAEEL
210 220 230 240 250
RRCNKEISAL GTMRESSFNS FLGDSSGISF AKLVFTATNF RQDSGDDVLD
260 270 280 290 300
EDIKQREQKY NGYAEAENNP HFDPLELPPR HAAEVMISRF FVDTNSQLPL
310 320 330 340 350
LHRELFLKKY FEPIYGPWNP NIALASDQTG INSAFEIPIT SAFSAHTEPK
360 370 380 390 400
RENVTEKIDV CSSVDVPWYD TWETSQKVNM RPIVELPTKF HIPYFFLNII
410 420 430 440 450
FAIGHATQVL KSDITTVATY KRRATKYIAS LFSSSDRLEA LAGTLLMVIY
460 470 480 490 500
SIMRPNVPGV WYTMGSVLRL TVDLGLHSEK INKNYDAFTR EIRRRLFWCV
510 520 530 540 550
YSLDRQICSY FGRPFGIPEE SITTRYPSLL DDSFITLTNR EIDDYSDLPS
560 570 580 590 600
PNPSSKVIAL AMYKIRRIQA SIVRILYAPG AELPRRFMDL ESWRIETYNE
610 620 630 640 650
LERWFQVDVP KNFEMMNCKF NSIWFDLNYH YSKSILYGLS PKFPTLNDTA
660 670 680 690 700
FKIVLDSTKG TIDVFYNLCV NKKIGYTWVA VHNMFMTGMT YLYVNFYSKN
710 720 730 740 750
NINDCQEKVS EYTEKVLIVL KNLIGFCESA KTCYTSYKIL SSVVIKLKFM
760 770 780 790 800
QINDAKGIFS DSNPLTSQAN RMSSYDKKTN VLGFDDGTFD NKVFNRTNFE
810 820 830 840 850
EKAPFDIPLD EFFTELEKHS NVSQFNTLDV SEGNQVINES ASTNTSSALN
860 870 880 890 900
CQSYTNNQDI MDILFQVTSG SVWDEFFVRS GNGNEGESSY DISKGKNSES

GGIF
Length:904
Mass (Da):102,724
Last modified:April 1, 1988 - v1
Checksum:i836B16CEE27B23BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01739 Genomic DNA. Translation: CAA25876.1.
Z73186 Genomic DNA. Translation: CAA97536.1.
X90564 Genomic DNA. Translation: CAA62160.1.
BK006945 Genomic DNA. Translation: DAA09332.1.
PIRiS05877. RGBYP1.
RefSeqiNP_013114.1. NM_001181901.1.

Genome annotation databases

EnsemblFungiiYLR014C; YLR014C; YLR014C.
GeneIDi850701.
KEGGisce:YLR014C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01739 Genomic DNA. Translation: CAA25876.1.
Z73186 Genomic DNA. Translation: CAA97536.1.
X90564 Genomic DNA. Translation: CAA62160.1.
BK006945 Genomic DNA. Translation: DAA09332.1.
PIRiS05877. RGBYP1.
RefSeqiNP_013114.1. NM_001181901.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PYIX-ray3.20A/B29-123[»]
ProteinModelPortaliP07272.
SMRiP07272. Positions 30-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31288. 37 interactions.
DIPiDIP-2126N.
IntActiP07272. 3 interactions.
MINTiMINT-473884.

PTM databases

iPTMnetiP07272.

Proteomic databases

MaxQBiP07272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR014C; YLR014C; YLR014C.
GeneIDi850701.
KEGGisce:YLR014C.

Organism-specific databases

EuPathDBiFungiDB:YLR014C.
SGDiS000004004. PPR1.

Phylogenomic databases

GeneTreeiENSGT00730000112745.
HOGENOMiHOG000094249.
InParanoidiP07272.
OMAiFWCVYSL.
OrthoDBiEOG092C0G13.

Enzyme and pathway databases

BioCyciYEAST:G3O-32175-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP07272.
PROiP07272.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1_YEAST
AccessioniPrimary (citable) accession number: P07272
Secondary accession number(s): D6VY16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.