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Protein

Regulatory protein PHO2

Gene

PHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi77 – 13660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: SGD
  • histidine biosynthetic process Source: SGD
  • positive regulation of DNA binding Source: SGD
  • positive regulation of phosphate metabolic process Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription regulatory region DNA binding Source: SGD
  • purine nucleobase biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein PHO2
Alternative name(s):
General regulatory factor 10
Gene namesi
Name:PHO2
Synonyms:BAS2, GRF10
Ordered Locus Names:YDL106C
ORF Names:D2350
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL106C.
SGDiS000002264. PHO2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Regulatory protein PHO2PRO_0000049247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei542 – 5421PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP07269.

PTM databases

iPTMnetiP07269.

Interactioni

Protein-protein interaction databases

BioGridi31956. 82 interactions.
DIPiDIP-13N.
IntActiP07269. 18 interactions.
MINTiMINT-1623005.

Structurei

3D structure databases

ProteinModelPortaliP07269.
SMRiP07269. Positions 77-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 5230Gln-rich (involved in transcriptional activation)Add
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOGENOMiHOG000115531.
InParanoidiP07269.
KOiK02646.
OMAiNTHFATD.
OrthoDBiEOG092C5IKP.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEEFSYDHD FNTHFATDLD YLQHDQQQQQ QQQHDQQHNQ QQQPQPQPIQ
60 70 80 90 100
TQNLEHDHDQ HTNDMSASSN ASDSGPQRPK RTRAKGEALD VLKRKFEINP
110 120 130 140 150
TPSLVERKKI SDLIGMPEKN VRIWFQNRRA KLRKKQHGSN KDTIPSSQSR
160 170 180 190 200
DIANDYDRGS TDNNLVTTTS TSSIFHDEDL TFFDRIPLNS NNNYYFFDIC
210 220 230 240 250
SITVGSWNRM KSGALQRRNF QSIKELRNLS PIKINNIMSN ATDLMVLISK
260 270 280 290 300
KNSEINYFFS AMANNTKILF RIFFPLSSVT NCSLTLETDD DIINSNNTSD
310 320 330 340 350
KNNSNTNNDD DNDDNSNEDN DNSSEDKRNA KDNFGELKLT VTRSPTFAVY
360 370 380 390 400
FLNNAPDEDP NLNNQWSICD DFSEGRQVND AFVGGSNIPH TLKGLQKSLR
410 420 430 440 450
FMNSLILDYK SSNEILPTIN TAIPTAAVPQ QNIAPPFLNT NSSATDSNPN
460 470 480 490 500
TNLEDSLFFD HDLLSSSITN TNNGQGSNNG RQASKDDTLN LLDTTVNSNN
510 520 530 540 550
NHNANNEENH LAQEHLSNDA DIVANPNDHL LSLPTDSELP NTPDFLKNTN

ELTDEHRWI
Length:559
Mass (Da):63,391
Last modified:April 1, 1988 - v1
Checksum:iBE20E396D6AA0281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05062 Genomic DNA. Translation: CAA28729.1.
M22259 Genomic DNA. Translation: AAA34866.1.
X95644 Genomic DNA. Translation: CAA64906.1.
Z74154 Genomic DNA. Translation: CAA98673.1.
BK006938 Genomic DNA. Translation: DAA11754.1.
PIRiA25872.
RefSeqiNP_010177.1. NM_001180165.1.

Genome annotation databases

EnsemblFungiiYDL106C; YDL106C; YDL106C.
GeneIDi851452.
KEGGisce:YDL106C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05062 Genomic DNA. Translation: CAA28729.1.
M22259 Genomic DNA. Translation: AAA34866.1.
X95644 Genomic DNA. Translation: CAA64906.1.
Z74154 Genomic DNA. Translation: CAA98673.1.
BK006938 Genomic DNA. Translation: DAA11754.1.
PIRiA25872.
RefSeqiNP_010177.1. NM_001180165.1.

3D structure databases

ProteinModelPortaliP07269.
SMRiP07269. Positions 77-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31956. 82 interactions.
DIPiDIP-13N.
IntActiP07269. 18 interactions.
MINTiMINT-1623005.

PTM databases

iPTMnetiP07269.

Proteomic databases

MaxQBiP07269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL106C; YDL106C; YDL106C.
GeneIDi851452.
KEGGisce:YDL106C.

Organism-specific databases

EuPathDBiFungiDB:YDL106C.
SGDiS000002264. PHO2.

Phylogenomic databases

HOGENOMiHOG000115531.
InParanoidiP07269.
KOiK02646.
OMAiNTHFATD.
OrthoDBiEOG092C5IKP.

Enzyme and pathway databases

BioCyciYEAST:G3O-29507-MONOMER.

Miscellaneous databases

PROiP07269.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHO2_YEAST
AccessioniPrimary (citable) accession number: P07269
Secondary accession number(s): D6VRP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.