Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulatory protein PHO2

Gene

PHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters.1 Publication

Miscellaneous

Present with 6420 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi77 – 136HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: SGD
  • histidine biosynthetic process Source: SGD
  • positive regulation of DNA binding Source: SGD
  • positive regulation of phosphate metabolic process Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription regulatory region DNA binding Source: SGD
  • purine nucleobase biosynthetic process Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29507-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein PHO2
Alternative name(s):
General regulatory factor 10
Gene namesi
Name:PHO2
Synonyms:BAS2, GRF10
Ordered Locus Names:YDL106C
ORF Names:D2350
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL106C
SGDiS000002264 PHO2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492471 – 559Regulatory protein PHO2Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei542PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP07269
PaxDbiP07269
PRIDEiP07269

PTM databases

iPTMnetiP07269

Interactioni

Protein-protein interaction databases

BioGridi31956, 174 interactors
DIPiDIP-13N
IntActiP07269, 18 interactors
STRINGi4932.YDL106C

Structurei

3D structure databases

ProteinModelPortaliP07269
SMRiP07269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 52Gln-rich (involved in transcriptional activation)Add BLAST30

Keywords - Domaini

Homeobox

Phylogenomic databases

HOGENOMiHOG000115531
InParanoidiP07269
KOiK02646
OMAiNTHFATD
OrthoDBiEOG092C5IKP

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEEFSYDHD FNTHFATDLD YLQHDQQQQQ QQQHDQQHNQ QQQPQPQPIQ
60 70 80 90 100
TQNLEHDHDQ HTNDMSASSN ASDSGPQRPK RTRAKGEALD VLKRKFEINP
110 120 130 140 150
TPSLVERKKI SDLIGMPEKN VRIWFQNRRA KLRKKQHGSN KDTIPSSQSR
160 170 180 190 200
DIANDYDRGS TDNNLVTTTS TSSIFHDEDL TFFDRIPLNS NNNYYFFDIC
210 220 230 240 250
SITVGSWNRM KSGALQRRNF QSIKELRNLS PIKINNIMSN ATDLMVLISK
260 270 280 290 300
KNSEINYFFS AMANNTKILF RIFFPLSSVT NCSLTLETDD DIINSNNTSD
310 320 330 340 350
KNNSNTNNDD DNDDNSNEDN DNSSEDKRNA KDNFGELKLT VTRSPTFAVY
360 370 380 390 400
FLNNAPDEDP NLNNQWSICD DFSEGRQVND AFVGGSNIPH TLKGLQKSLR
410 420 430 440 450
FMNSLILDYK SSNEILPTIN TAIPTAAVPQ QNIAPPFLNT NSSATDSNPN
460 470 480 490 500
TNLEDSLFFD HDLLSSSITN TNNGQGSNNG RQASKDDTLN LLDTTVNSNN
510 520 530 540 550
NHNANNEENH LAQEHLSNDA DIVANPNDHL LSLPTDSELP NTPDFLKNTN

ELTDEHRWI
Length:559
Mass (Da):63,391
Last modified:April 1, 1988 - v1
Checksum:iBE20E396D6AA0281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05062 Genomic DNA Translation: CAA28729.1
M22259 Genomic DNA Translation: AAA34866.1
X95644 Genomic DNA Translation: CAA64906.1
Z74154 Genomic DNA Translation: CAA98673.1
BK006938 Genomic DNA Translation: DAA11754.1
PIRiA25872
RefSeqiNP_010177.1, NM_001180165.1

Genome annotation databases

EnsemblFungiiYDL106C; YDL106C; YDL106C
GeneIDi851452
KEGGisce:YDL106C

Similar proteinsi

Entry informationi

Entry nameiPHO2_YEAST
AccessioniPrimary (citable) accession number: P07269
Secondary accession number(s): D6VRP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health