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P07265

- MAL62_YEASX

UniProt

P07265 - MAL62_YEASX

Protein

Alpha-glucosidase MAL62

Gene

MAL62

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei214 – 2141NucleophileBy similarity
    Active sitei276 – 2761Proton donorBy similarity
    Sitei349 – 3491Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. maltose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Maltose metabolism

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.
    mycoCLAPiAGL13F_YEAST.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-glucosidase MAL62 (EC:3.2.1.20)
    Alternative name(s):
    Maltase
    Gene namesi
    Name:MAL62
    Synonyms:MAL6S
    OrganismiSaccharomyces cerevisiae (Baker's yeast)
    Taxonomic identifieri4932 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

    Organism-specific databases

    SGDiS000029690. MAL62.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Alpha-glucosidase MAL62PRO_0000054330Add
    BLAST

    Proteomic databases

    PaxDbiP07265.

    Expressioni

    Gene expression databases

    GenevestigatoriP07265.

    Interactioni

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G7PX-ray1.50P438-446[»]
    ProteinModelPortaliP07265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Phylogenomic databases

    eggNOGiCOG0366.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD    50
    LGVDAIWVCP FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG 100
    MKFITDLVIN HCSTEHEWFK ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP 150
    PNNWKSFFGG SAWTFDETTN EFYLRLFASR QVDLNWENED CRRAIFESAV 200
    GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP NWGSHNGPRI 250
    HEYHQELHRF MKNRVKDGRE IMRVGEVAHG SDNALYTSAA RYEVSEVFSF 300
    THVEVGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ 350
    ARSITRFADD SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP 400
    IEKYEDVDVK NNYEIIKKSF GKNSKEMKDF FKGIALLSRD HSRTPMPWTK 450
    DKPNAGFTGP DVKPWFFLNE SFEQGINVEQ ESRDDDSVLN FWKRALQARK 500
    KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF SGEEIEFSLP 550
    REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK 584
    Length:584
    Mass (Da):68,183
    Last modified:April 1, 1988 - v1
    Checksum:iD091CCCC63E58765
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12601 Genomic DNA. Translation: AAA34757.1.
    PIRiS05847. ALBY.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12601 Genomic DNA. Translation: AAA34757.1 .
    PIRi S05847. ALBY.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G7P X-ray 1.50 P 438-446 [» ]
    ProteinModelPortali P07265.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P07265.
    ChEMBLi CHEMBL4357.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.
    mycoCLAPi AGL13F_YEAST.

    Proteomic databases

    PaxDbi P07265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    SGDi S000029690. MAL62.

    Phylogenomic databases

    eggNOGi COG0366.

    Gene expression databases

    Genevestigatori P07265.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the maltase gene of the MAL6 locus of Saccharomyces carlsbergensis."
      Hong S.H., Marmur J.
      Gene 41:75-84(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Carlsbergensis / CB11.

    Entry informationi

    Entry nameiMAL62_YEASX
    AccessioniPrimary (citable) accession number: P07265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3