Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P07265 (MAL62_YEASX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-glucosidase MAL62

EC=3.2.1.20
Alternative name(s):
Maltase
Gene names
Name:MAL62
Synonyms:MAL6S
OrganismSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
   Biological processMaltose metabolism
   Molecular functionGlycosidase
Hydrolase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processmaltose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncation binding

Inferred from electronic annotation. Source: InterPro

maltose alpha-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Alpha-glucosidase MAL62
PRO_0000054330

Sites

Active site2141Nucleophile By similarity
Active site2761Proton donor By similarity
Site3491Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P07265 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: D091CCCC63E58765

FASTA58468,183
        10         20         30         40         50         60 
MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD LGVDAIWVCP 

        70         80         90        100        110        120 
FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG MKFITDLVIN HCSTEHEWFK 

       130        140        150        160        170        180 
ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP PNNWKSFFGG SAWTFDETTN EFYLRLFASR 

       190        200        210        220        230        240 
QVDLNWENED CRRAIFESAV GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP 

       250        260        270        280        290        300 
NWGSHNGPRI HEYHQELHRF MKNRVKDGRE IMRVGEVAHG SDNALYTSAA RYEVSEVFSF 

       310        320        330        340        350        360 
THVEVGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ ARSITRFADD 

       370        380        390        400        410        420 
SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP IEKYEDVDVK NNYEIIKKSF 

       430        440        450        460        470        480 
GKNSKEMKDF FKGIALLSRD HSRTPMPWTK DKPNAGFTGP DVKPWFFLNE SFEQGINVEQ 

       490        500        510        520        530        540 
ESRDDDSVLN FWKRALQARK KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF 

       550        560        570        580 
SGEEIEFSLP REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK 

« Hide

References

[1]"Primary structure of the maltase gene of the MAL6 locus of Saccharomyces carlsbergensis."
Hong S.H., Marmur J.
Gene 41:75-84(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Carlsbergensis / CB11.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12601 Genomic DNA. Translation: AAA34757.1.
PIRALBY. S05847.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G7PX-ray1.50P438-446[»]
ProteinModelPortalP07265.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP07265.
ChEMBLCHEMBL4357.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.
mycoCLAPAGL13F_YEAST.

Proteomic databases

PaxDbP07265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

SGDS000029690. MAL62.

Phylogenomic databases

eggNOGCOG0366.

Gene expression databases

GenevestigatorP07265.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMAL62_YEASX
AccessionPrimary (citable) accession number: P07265
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries