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Protein

Protein URA2

Gene

URA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).

Catalytic activityi

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Protein URA2 (URA2)
  2. Protein URA2 (URA2)
  3. Dihydroorotase (URA4)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 3021For GATase activityBy similarity
Active sitei386 – 3861For GATase activityBy similarity
Active sitei388 – 3881For GATase activityBy similarity

GO - Molecular functioni

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: SGD
  • 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  • arginine biosynthetic process Source: GO_Central
  • glutamine metabolic process Source: SGD
  • negative regulation of pyrimidine nucleobase metabolic process Source: SGD
  • urea cycle Source: GO_Central

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YJL130C-MONOMER.
BRENDAi6.3.5.5. 984.
ReactomeiR-SCE-500753. Pyrimidine biosynthesis.
R-SCE-70635. Urea cycle.
UniPathwayiUPA00070; UER00115.
UPA00070; UER00116.

Protein family/group databases

MEROPSiS08.056.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein URA2
Including the following 2 domains:
Glutamine-dependent carbamoyl-phosphate synthase (EC:6.3.5.5)
Aspartate carbamoyltransferase (EC:2.1.3.2)
Gene namesi
Name:URA2
Ordered Locus Names:YJL130C
ORF Names:J0686
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL130C.
SGDiS000003666. URA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • integral component of membrane Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 22142213Protein URA2PRO_0000199511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Cross-linki1853 – 1853Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei1857 – 18571Phosphoserine; by PKACombined sources1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP07259.
PRIDEiP07259.

PTM databases

iPTMnetiP07259.

Interactioni

Protein-protein interaction databases

BioGridi33626. 128 interactions.
DIPiDIP-7215N.
IntActiP07259. 416 interactions.
MINTiMINT-1323915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 413186Glutamine amidotransferase type-1Add
BLAST
Domaini562 – 754193ATP-grasp 1Add
BLAST
Domaini1099 – 1290192ATP-grasp 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 400399GATase (Glutamine amidotransferase)Add
BLAST
Regioni401 – 44040LinkerAdd
BLAST
Regioni441 – 14821042CPSase (Carbamoyl-phosphate synthase)Add
BLAST
Regioni1483 – 149210Linker
Regioni1493 – 1821329Defective DHOase domainAdd
BLAST
Regioni1822 – 190988LinkerAdd
BLAST
Regioni1910 – 2214305ATCase (Aspartate transcarbamylase)Add
BLAST

Domaini

The DHOase domain is defective.

Sequence similaritiesi

In the central section; belongs to the DHOase family.Curated
Contains 2 ATP-grasp domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000015604.
HOGENOMiHOG000234584.
InParanoidiP07259.
KOiK11541.
OMAiIEIDRPY.
OrthoDBiEOG092C0957.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
MF_01209. CPSase_S_chain. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR032466. Metal_Hydrolase.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF51556. SSF51556. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIAPTAPI TPPMESTGDR LVTLELKDGT VLQGYSFGAE KSVAGELVFQ
60 70 80 90 100
TGMVGYPESV TDPSYEGQIL VITYPLVGNY GVPDMHLRDE LVEELPRYFE
110 120 130 140 150
SNRIHIAGLV ISHYTDEYSH YLAKSSLGKW LQNEGIPAVY GVDTRSLTKH
160 170 180 190 200
LRDAGSMLGR LSLEKSGSDR TISRSSSWRS AFDVPEWVDP NVQNLVSKVS
210 220 230 240 250
INEPKLYVPP ADNKHIELQT GPDGKVLRIL AIDVGMKYNQ IRCFIKRGVE
260 270 280 290 300
LKVVPWNYDF TKEDYDGLFI SNGPGDPSVL DDLSQRLSNV LEAKKTPVFG
310 320 330 340 350
ICLGHQLIAR AAGASTLKLK FGNRGHNIPC TSTISGRCYI TSQNHGFAVD
360 370 380 390 400
VDTLTSGWKP LFVNANDDSN EGIYHSELPY FSVQFHPEST PGPRDTEFLF
410 420 430 440 450
DVFIQAVKEF KYTQVLKPIA FPGGLLEDNV KAHPRIEAKK VLVLGSGGLS
460 470 480 490 500
IGQAGEFDYS GSQAIKALKE EGIYTILINP NIATIQTSKG LADKVYFVPV
510 520 530 540 550
TAEFVRKVIL HERPDAIYVT FGGQTALSVG IAMKDEFEAL GVKVLGTPID
560 570 580 590 600
TIITTEDREL FSNAIDEINE KCAKSQAANS VDEALAAVKE IGFPVIVRAA
610 620 630 640 650
YALGGLGSGF ANNEKELVDL CNVAFSSSPQ VLVEKSMKGW KEVEYEVVRD
660 670 680 690 700
AFDNCITVCN MENFDPLGIH TGDSIVVAPS QTLSDEDYNM LRTTAVNVIR
710 720 730 740 750
HLGVVGECNI QYALNPVSKD YCIIEVNARL SRSSALASKA TGYPLAYTAA
760 770 780 790 800
KLGLNIPLNE VKNSVTKSTC ACFEPSLDYC VVKMPRWDLK KFTRVSTELS
810 820 830 840 850
SSMKSVGEVM SIGRTFEEAI QKAIRSTEYA NLGFNETDLD IDIDYELNNP
860 870 880 890 900
TDMRVFAIAN AFAKKGYSVD KVWEMTRIDK WFLNKLHDLV QFAEKISSFG
910 920 930 940 950
TKEELPSLVL RQAKQLGFDD RQIARFLDSN EVAIRRLRKE YGITPFVKQI
960 970 980 990 1000
DTVAAEFPAY TNYLYMTYNA DSHDLSFDDH GVMVLGSGVY RIGSSVEFDW
1010 1020 1030 1040 1050
CAVTAVRTLR ANNIKTIMVN YNPETVSTDY DEADRLYFET INLERVLDIY
1060 1070 1080 1090 1100
EIENSSGVVV SMGGQTSNNI AMTLHRENVK ILGTSPDMID SAENRYKFSR
1110 1120 1130 1140 1150
MLDQIGVDQP AWKELTSMDE AESFAEKVGY PVLVRPSYVL SGAAMNTVYS
1160 1170 1180 1190 1200
KNDLESYLNQ AVEVSRDYPV VITKYIENAK EIEMDAVARN GELVMHVVSE
1210 1220 1230 1240 1250
HVENAGVHSG DATLIVPPQD LAPETVDRIV VATAKIGKAL KITGPYNIQF
1260 1270 1280 1290 1300
IAKDNEIKVI ECNVRASRSF PFISKVVGVN LIELATKAIM GLPLTPYPVE
1310 1320 1330 1340 1350
KLPDDYVAVK VPQFSFPRLA GADPVLGVEM ASTGEVATFG HSKYEAYLKS
1360 1370 1380 1390 1400
LLATGFKLPK KNILLSIGSY KEKQELLSSV QKLYNMGYKL FATSGTADFL
1410 1420 1430 1440 1450
SEHGIAVQYL EVLNKDDDDQ KSEYSLTQHL ANNEIDLYIN LPSANRFRRP
1460 1470 1480 1490 1500
ASYVSKGYKT RRLAVDYSVP LVTNVKCAKL LIEAISRNIT LDVSERDAQT
1510 1520 1530 1540 1550
SHRTITLPGL INIATYVPNA SHVIKGPAEL KETTRLFLES GFTYCQLMPR
1560 1570 1580 1590 1600
SISGPVITDV ASLKAANSVS QDSSYTDFSF TIAGTAHNAH SVTQSASKVT
1610 1620 1630 1640 1650
ALFLPLRELK NKITAVAELL NQWPTEKQVI AEAKTADLAS VLLLTSLQNR
1660 1670 1680 1690 1700
SIHITGVSNK EDLALIMTVK AKDPRVTCDV NIYSLFIAQD DYPEAVFLPT
1710 1720 1730 1740 1750
KEDQEFFWNN LDSIDAFSVG ALPVALANVT GNKVDVGMGI KDSLPLLLAA
1760 1770 1780 1790 1800
VEEGKLTIDD IVLRLHDNPA KIFNIPTQDS VVEIDLDYSF RRNKRWSPFN
1810 1820 1830 1840 1850
KDMNGGIERV VYNGETLVLS GELVSPGAKG KCIVNPSPAS ITASAELQST
1860 1870 1880 1890 1900
SAKRRFSITE EAIADNLDAA EDAIPEQPLE QKLMSSRPPR ELVAPGAIQN
1910 1920 1930 1940 1950
LIRSNNPFRG RHILSIKQFK RSDFHVLFAV AQELRAAVAR EGVLDLMKGH
1960 1970 1980 1990 2000
VITTIFFEPS TRTCSSFIAA MERLGGRIVN VNPLVSSVKK GETLQDTIRT
2010 2020 2030 2040 2050
LACYSDAIVM RHSEEMSVHI AAKYSPVPII NGGNGSREHP TQAFLDLFTI
2060 2070 2080 2090 2100
REEIGTVNGI TVTFMGDLKH GRTVHSLCRL LMHYQVRINL VSPPELRLPE
2110 2120 2130 2140 2150
GLREELRKAG LLGVESIELT PHIISKTDVL YCTRVQEERF NSPEEYARLK
2160 2170 2180 2190 2200
DTYIVDNKIL AHAKENMAIM HPLPRVNEIK EEVDYDHRAA YFRQMKYGLF
2210
VRMALLAMVM GVDM
Length:2,214
Mass (Da):245,041
Last modified:September 21, 2011 - v5
Checksum:iD5A47F4E42A9B1A7
GO

Sequence cautioni

The sequence ABI95879 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861H → D in CAA29068 (PubMed:3039294).Curated
Sequence conflicti123 – 1231A → R in CAA89425 (PubMed:8641269).Curated
Sequence conflicti250 – 2578ELKVVPWN → RIESCSMD in CAA29068 (PubMed:3039294).Curated
Sequence conflicti270 – 2701I → Y in CAA29068 (PubMed:3039294).Curated
Sequence conflicti313 – 3142GA → VQ in CAA29068 (PubMed:3039294).Curated
Sequence conflicti372 – 3732GI → RF in CAA29068 (PubMed:3039294).Curated
Sequence conflicti394 – 4029RDTEFLFDV → EIQNSCLT in CAA29068 (PubMed:3039294).Curated
Sequence conflicti431 – 4333KAH → QGT in CAA29068 (PubMed:3039294).Curated
Sequence conflicti482 – 4821I → T in CAA29068 (PubMed:3039294).Curated
Sequence conflicti485 – 4851I → N in CAA29068 (PubMed:3039294).Curated
Sequence conflicti492 – 4921A → G in CAA29068 (PubMed:3039294).Curated
Sequence conflicti501 – 51010TAEFVRKVIL → NAAKQRDVDR in CAA29068 (PubMed:3039294).Curated
Sequence conflicti1411 – 14122EV → S in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1582 – 15821I → M in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1588 – 15881N → K in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1592 – 15921V → G in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1595 – 15951S → A in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1872 – 18721Missing AA sequence (PubMed:1977585).Curated
Sequence conflicti1937 – 19371A → R in AAA68280 (PubMed:2570735).Curated
Sequence conflicti1937 – 19371A → R in AAA35198 (PubMed:2498313).Curated
Sequence conflicti1997 – 19971T → I in AAA35198 (PubMed:2498313).Curated
Sequence conflicti2039 – 20391H → L in AAA35198 (PubMed:2498313).Curated
Sequence conflicti2158 – 21658KILAHAKE → VRSWHTQQK in AAA35198 (PubMed:2498313).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27174 Genomic DNA. Translation: AAA68280.1.
Z49405 Genomic DNA. Translation: CAA89425.1.
X05553 Genomic DNA. Translation: CAA29068.1.
DQ881452 mRNA. Translation: ABI95879.1. Different initiation.
EF123133 mRNA. Translation: ABM97477.1.
X87371 Genomic DNA. Translation: CAA60825.1.
D28139 Genomic DNA. Translation: BAA05680.1.
J04711 Genomic DNA. Translation: AAA35198.1.
BK006943 Genomic DNA. Translation: DAA08671.2.
PIRiS56911. QZBYU2.
RefSeqiNP_012405.2. NM_001181563.2.

Genome annotation databases

EnsemblFungiiYJL130C; YJL130C; YJL130C.
GeneIDi853311.
KEGGisce:YJL130C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27174 Genomic DNA. Translation: AAA68280.1.
Z49405 Genomic DNA. Translation: CAA89425.1.
X05553 Genomic DNA. Translation: CAA29068.1.
DQ881452 mRNA. Translation: ABI95879.1. Different initiation.
EF123133 mRNA. Translation: ABM97477.1.
X87371 Genomic DNA. Translation: CAA60825.1.
D28139 Genomic DNA. Translation: BAA05680.1.
J04711 Genomic DNA. Translation: AAA35198.1.
BK006943 Genomic DNA. Translation: DAA08671.2.
PIRiS56911. QZBYU2.
RefSeqiNP_012405.2. NM_001181563.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33626. 128 interactions.
DIPiDIP-7215N.
IntActiP07259. 416 interactions.
MINTiMINT-1323915.

Protein family/group databases

MEROPSiS08.056.

PTM databases

iPTMnetiP07259.

Proteomic databases

MaxQBiP07259.
PRIDEiP07259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL130C; YJL130C; YJL130C.
GeneIDi853311.
KEGGisce:YJL130C.

Organism-specific databases

EuPathDBiFungiDB:YJL130C.
SGDiS000003666. URA2.

Phylogenomic databases

GeneTreeiENSGT00390000015604.
HOGENOMiHOG000234584.
InParanoidiP07259.
KOiK11541.
OMAiIEIDRPY.
OrthoDBiEOG092C0957.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00115.
UPA00070; UER00116.
BioCyciYEAST:YJL130C-MONOMER.
BRENDAi6.3.5.5. 984.
ReactomeiR-SCE-500753. Pyrimidine biosynthesis.
R-SCE-70635. Urea cycle.

Miscellaneous databases

PROiP07259.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
MF_01209. CPSase_S_chain. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR032466. Metal_Hydrolase.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF51556. SSF51556. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYR1_YEAST
AccessioniPrimary (citable) accession number: P07259
Secondary accession number(s): A2TBN0, D6VW55, Q06HN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 194 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5).
In eukaryotes EC 6.3.5.5 is synthesized by two pathway-specific (arginine and pyrimidine) genes under separate control.
Present with 11000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.