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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR2 is required for the assembly of the complex.

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YPR191W-MONOMER.

Protein family/group databases

MEROPSiM16.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:QCR2
Synonyms:COR2, UCR2
Ordered Locus Names:YPR191W
ORF Names:P9677.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR191W.
SGDiS000006395. QCR2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: SGD
  • mitochondrial respiratory chain complex III Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616MitochondrionAdd
BLAST
Chaini17 – 368352Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000026801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphoserineCombined sources
Modified residuei168 – 1681PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP07257.

PTM databases

iPTMnetiP07257.

Interactioni

Subunit structurei

Fungi cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
COR1P072565EBI-19929,EBI-19922

Protein-protein interaction databases

BioGridi36363. 180 interactions.
DIPiDIP-3820N.
IntActiP07257. 18 interactions.
MINTiMINT-493086.

Structurei

Secondary structure

1
368
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 225Combined sources
Beta strandi27 – 3610Combined sources
Helixi39 – 413Combined sources
Helixi47 – 548Combined sources
Beta strandi59 – 624Combined sources
Helixi64 – 7411Combined sources
Beta strandi77 – 826Combined sources
Beta strandi87 – 948Combined sources
Helixi95 – 973Combined sources
Helixi98 – 11114Combined sources
Helixi116 – 1216Combined sources
Helixi123 – 13513Combined sources
Helixi138 – 15114Combined sources
Turni152 – 1565Combined sources
Beta strandi163 – 1653Combined sources
Helixi169 – 17911Combined sources
Helixi182 – 1843Combined sources
Beta strandi185 – 1928Combined sources
Helixi194 – 20310Combined sources
Turni205 – 2084Combined sources
Beta strandi228 – 2325Combined sources
Beta strandi234 – 24512Combined sources
Turni247 – 2493Combined sources
Helixi250 – 26112Combined sources
Beta strandi262 – 2654Combined sources
Helixi268 – 2703Combined sources
Beta strandi272 – 2798Combined sources
Beta strandi282 – 29211Combined sources
Helixi294 – 30916Combined sources
Helixi315 – 3173Combined sources
Helixi318 – 32811Combined sources
Helixi329 – 3313Combined sources
Helixi340 – 3423Combined sources
Beta strandi352 – 3587Combined sources
Helixi359 – 3613Combined sources
Helixi365 – 3673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30B17-368[»]
1KB9X-ray2.30B17-368[»]
1KYOX-ray2.97B/M17-368[»]
1P84X-ray2.50B17-368[»]
2IBZX-ray2.30B17-368[»]
3CX5X-ray1.90B/M17-368[»]
3CXHX-ray2.50B/M17-368[»]
4PD4X-ray3.04B17-368[»]
ProteinModelPortaliP07257.
SMRiP07257. Positions 17-368.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07257.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000159494.
InParanoidiP07257.
KOiK00415.
OMAiGSRYATK.
OrthoDBiEOG092C25X9.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL
60 70 80 90 100
LNRFNFQNTN TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY
110 120 130 140 150
YVNALADVLY KTAFKPHELT ESVLPAARYD YAVAEQCPVK SAEDQLYAIT
160 170 180 190 200
FRKGLGNPLL YDGVERVSLQ DIKDFADKVY TKENLEVSGE NVVEADLKRF
210 220 230 240 250
VDESLLSTLP AGKSLVSKSE PKFFLGEENR VRFIGDSVAA IGIPVNKASL
260 270 280 290 300
AQYEVLANYL TSALSELSGL ISSAKLDKFT DGGLFTLFVR DQDSAVVSSN
310 320 330 340 350
IKKIVADLKK GKDLSPAINY TKLKNAVQNE SVSSPIELNF DAVKDFKLGK
360
FNYVAVGDVS NLPYLDEL
Length:368
Mass (Da):40,478
Last modified:April 1, 1988 - v1
Checksum:i51FDE1C5DA4420D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05120 Genomic DNA. Translation: CAA28768.1.
U25841 Genomic DNA. Translation: AAB64620.1.
AY558068 Genomic DNA. Translation: AAS56394.1.
BK006949 Genomic DNA. Translation: DAA11607.1.
PIRiA27535.
RefSeqiNP_015517.1. NM_001184288.1.

Genome annotation databases

EnsemblFungiiYPR191W; YPR191W; YPR191W.
GeneIDi856321.
KEGGisce:YPR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05120 Genomic DNA. Translation: CAA28768.1.
U25841 Genomic DNA. Translation: AAB64620.1.
AY558068 Genomic DNA. Translation: AAS56394.1.
BK006949 Genomic DNA. Translation: DAA11607.1.
PIRiA27535.
RefSeqiNP_015517.1. NM_001184288.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30B17-368[»]
1KB9X-ray2.30B17-368[»]
1KYOX-ray2.97B/M17-368[»]
1P84X-ray2.50B17-368[»]
2IBZX-ray2.30B17-368[»]
3CX5X-ray1.90B/M17-368[»]
3CXHX-ray2.50B/M17-368[»]
4PD4X-ray3.04B17-368[»]
ProteinModelPortaliP07257.
SMRiP07257. Positions 17-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36363. 180 interactions.
DIPiDIP-3820N.
IntActiP07257. 18 interactions.
MINTiMINT-493086.

Protein family/group databases

MEROPSiM16.974.

PTM databases

iPTMnetiP07257.

Proteomic databases

MaxQBiP07257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR191W; YPR191W; YPR191W.
GeneIDi856321.
KEGGisce:YPR191W.

Organism-specific databases

EuPathDBiFungiDB:YPR191W.
SGDiS000006395. QCR2.

Phylogenomic databases

HOGENOMiHOG000159494.
InParanoidiP07257.
KOiK00415.
OMAiGSRYATK.
OrthoDBiEOG092C25X9.

Enzyme and pathway databases

BioCyciYEAST:YPR191W-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP07257.
PROiP07257.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQCR2_YEAST
AccessioniPrimary (citable) accession number: P07257
Secondary accession number(s): D6W4J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 35700 molecules/cell in log phase SD medium.1 Publication

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.