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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR2 is required for the assembly of the complex.

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YPR191W-MONOMER.

Protein family/group databases

MEROPSiM16.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:QCR2
Synonyms:COR2, UCR2
Ordered Locus Names:YPR191W
ORF Names:P9677.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR191W.
SGDiS000006395. QCR2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: SGD
  • mitochondrial respiratory chain complex III Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionAdd BLAST16
ChainiPRO_000002680117 – 368Cytochrome b-c1 complex subunit 2, mitochondrialAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP07257.
PRIDEiP07257.

PTM databases

iPTMnetiP07257.

Interactioni

Subunit structurei

Fungi cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
COR1P072565EBI-19929,EBI-19922

Protein-protein interaction databases

BioGridi36363. 180 interactors.
DIPiDIP-3820N.
IntActiP07257. 18 interactors.
MINTiMINT-493086.

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 22Combined sources5
Beta strandi27 – 36Combined sources10
Helixi39 – 41Combined sources3
Helixi47 – 54Combined sources8
Beta strandi59 – 62Combined sources4
Helixi64 – 74Combined sources11
Beta strandi77 – 82Combined sources6
Beta strandi87 – 94Combined sources8
Helixi95 – 97Combined sources3
Helixi98 – 111Combined sources14
Helixi116 – 121Combined sources6
Helixi123 – 135Combined sources13
Helixi138 – 151Combined sources14
Turni152 – 156Combined sources5
Beta strandi163 – 165Combined sources3
Helixi169 – 179Combined sources11
Helixi182 – 184Combined sources3
Beta strandi185 – 192Combined sources8
Helixi194 – 203Combined sources10
Turni205 – 208Combined sources4
Beta strandi228 – 232Combined sources5
Beta strandi234 – 245Combined sources12
Turni247 – 249Combined sources3
Helixi250 – 261Combined sources12
Beta strandi262 – 265Combined sources4
Helixi268 – 270Combined sources3
Beta strandi272 – 279Combined sources8
Beta strandi282 – 292Combined sources11
Helixi294 – 309Combined sources16
Helixi315 – 317Combined sources3
Helixi318 – 328Combined sources11
Helixi329 – 331Combined sources3
Helixi340 – 342Combined sources3
Beta strandi352 – 358Combined sources7
Helixi359 – 361Combined sources3
Helixi365 – 367Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30B17-368[»]
1KB9X-ray2.30B17-368[»]
1KYOX-ray2.97B/M17-368[»]
1P84X-ray2.50B17-368[»]
2IBZX-ray2.30B17-368[»]
3CX5X-ray1.90B/M17-368[»]
3CXHX-ray2.50B/M17-368[»]
4PD4X-ray3.04B17-368[»]
ProteinModelPortaliP07257.
SMRiP07257.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07257.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000159494.
InParanoidiP07257.
KOiK00415.
OMAiGSRYATK.
OrthoDBiEOG092C25X9.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL
60 70 80 90 100
LNRFNFQNTN TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY
110 120 130 140 150
YVNALADVLY KTAFKPHELT ESVLPAARYD YAVAEQCPVK SAEDQLYAIT
160 170 180 190 200
FRKGLGNPLL YDGVERVSLQ DIKDFADKVY TKENLEVSGE NVVEADLKRF
210 220 230 240 250
VDESLLSTLP AGKSLVSKSE PKFFLGEENR VRFIGDSVAA IGIPVNKASL
260 270 280 290 300
AQYEVLANYL TSALSELSGL ISSAKLDKFT DGGLFTLFVR DQDSAVVSSN
310 320 330 340 350
IKKIVADLKK GKDLSPAINY TKLKNAVQNE SVSSPIELNF DAVKDFKLGK
360
FNYVAVGDVS NLPYLDEL
Length:368
Mass (Da):40,478
Last modified:April 1, 1988 - v1
Checksum:i51FDE1C5DA4420D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05120 Genomic DNA. Translation: CAA28768.1.
U25841 Genomic DNA. Translation: AAB64620.1.
AY558068 Genomic DNA. Translation: AAS56394.1.
BK006949 Genomic DNA. Translation: DAA11607.1.
PIRiA27535.
RefSeqiNP_015517.1. NM_001184288.1.

Genome annotation databases

EnsemblFungiiYPR191W; YPR191W; YPR191W.
GeneIDi856321.
KEGGisce:YPR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05120 Genomic DNA. Translation: CAA28768.1.
U25841 Genomic DNA. Translation: AAB64620.1.
AY558068 Genomic DNA. Translation: AAS56394.1.
BK006949 Genomic DNA. Translation: DAA11607.1.
PIRiA27535.
RefSeqiNP_015517.1. NM_001184288.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30B17-368[»]
1KB9X-ray2.30B17-368[»]
1KYOX-ray2.97B/M17-368[»]
1P84X-ray2.50B17-368[»]
2IBZX-ray2.30B17-368[»]
3CX5X-ray1.90B/M17-368[»]
3CXHX-ray2.50B/M17-368[»]
4PD4X-ray3.04B17-368[»]
ProteinModelPortaliP07257.
SMRiP07257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36363. 180 interactors.
DIPiDIP-3820N.
IntActiP07257. 18 interactors.
MINTiMINT-493086.

Protein family/group databases

MEROPSiM16.974.

PTM databases

iPTMnetiP07257.

Proteomic databases

MaxQBiP07257.
PRIDEiP07257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR191W; YPR191W; YPR191W.
GeneIDi856321.
KEGGisce:YPR191W.

Organism-specific databases

EuPathDBiFungiDB:YPR191W.
SGDiS000006395. QCR2.

Phylogenomic databases

HOGENOMiHOG000159494.
InParanoidiP07257.
KOiK00415.
OMAiGSRYATK.
OrthoDBiEOG092C25X9.

Enzyme and pathway databases

BioCyciYEAST:YPR191W-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP07257.
PROiP07257.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQCR2_YEAST
AccessioniPrimary (citable) accession number: P07257
Secondary accession number(s): D6W4J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 177 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 35700 molecules/cell in log phase SD medium.1 Publication

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.