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P07256 (QCR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene names
Name:COR1
Synonyms:QCR1
Ordered Locus Names:YBL045C
ORF Names:YBL0403
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. COR1 may mediate formation of the complex between cytochromes c and c1.

Subunit structure

Fungi cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Subcellular location

Mitochondrion inner membrane Ref.6.

Miscellaneous

Present with 19300 molecules/cell in log phase SD medium. Ref.7

Sequence similarities

Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

QCR2P072575EBI-19922,EBI-19929

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion
Chain27 – 457431Cytochrome b-c1 complex subunit 1, mitochondrial
PRO_0000026788

Amino acid modifications

Modified residue1401Phosphothreonine Ref.8

Secondary structure

........................................................................ 457
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07256 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: AE58739EFB695254

FASTA45750,228
        10         20         30         40         50         60 
MLRTVTSKTV SNQFKRSLAT AVATPKAEVT QLSNGIVVAT EHNPSAHTAS VGVVFGSGAA 

        70         80         90        100        110        120 
NENPYNNGVS NLWKNIFLSK ENSAVAAKEG LALSSNISRD FQSYIVSSLP GSTDKSLDFL 

       130        140        150        160        170        180 
NQSFIQQKAN LLSSSNFEAT KKSVLKQVQD FEENDHPNRV LEHLHSTAFQ NTPLSLPTRG 

       190        200        210        220        230        240 
TLESLENLVV ADLESFANNH FLNSNAVVVG TGNIKHEDLV NSIESKNLSL QTGTKPVLKK 

       250        260        270        280        290        300 
KAAFLGSEVR LRDDTLPKAW ISLAVEGEPV NSPNYFVAKL AAQIFGSYNA FEPASRLQGI 

       310        320        330        340        350        360 
KLLDNIQEYQ LCDNFNHFSL SYKDSGLWGF STATRNVTMI DDLIHFTLKQ WNRLTISVTD 

       370        380        390        400        410        420 
TEVERAKSLL KLQLGQLYES GNPVNDANLL GAEVLIKGSK LSLGEAFKKI DAITVKDVKA 

       430        440        450 
WAGKRLWDQD IAIAGTGQIE GLLDYMRIRS DMSMMRW 

« Hide

References

« Hide 'large scale' references
[1]"Assembly of the mitochondrial membrane system. Characterization of COR1, the structural gene for the 44-kilodalton core protein of yeast coenzyme QH2-cytochrome c reductase."
Tzagoloff A., Wu M., Crivellone M.
J. Biol. Chem. 261:17163-17169(1986) [PubMed: 3023384] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein."
de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J., Goffeau A.
Yeast 10:1489-1496(1994) [PubMed: 7871888] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
Biochemistry 40:9758-9769(2001) [PubMed: 11502169] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, MASS SPECTROMETRY.
[9]"Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment."
Hunte C., Koepke J., Lange C., Rossmanith T., Michel H.
Structure 8:669-684(2000) [PubMed: 10873857] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[10]"Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c."
Lange C., Hunte C.
Proc. Natl. Acad. Sci. U.S.A. 99:2800-2805(2002) [PubMed: 11880631] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02636 Genomic DNA. Translation: AAA34508.1.
X78214 Genomic DNA. Translation: CAA55050.1.
Z35806 Genomic DNA. Translation: CAA84865.1.
AY693047 Genomic DNA. Translation: AAT93066.1.
BK006936 Genomic DNA. Translation: DAA07073.1.
PIRA25351.
RefSeqNP_009508.1. NM_001178285.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30A27-457[»]
1KB9X-ray2.30A27-457[»]
1KYOX-ray2.97A/L27-457[»]
1P84X-ray2.50A27-457[»]
2IBZX-ray2.30A27-457[»]
3CX5X-ray1.90A/L27-457[»]
3CXHX-ray2.50A/L27-457[»]
ProteinModelPortalP07256.
SMRP07256. Positions 27-457.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2635N.
IntActP07256. 24 interactions.
MINTMINT-424492.
STRINGP07256.

Protein family/group databases

MEROPSM16.973.

Proteomic databases

PeptideAtlasP07256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBL045C; YBL045C; YBL045C.
GeneID852235.
KEGGsce:YBL045C.
NMPDRfig|4932.3.peg.198.

Organism-specific databases

CYGDYBL045c.
SGDS000000141. COR1.

Phylogenomic databases

eggNOGfuNOG07954.
GeneTreeEFGT00050000004568.
HOGENOMHBG476859.
OMATAFQNTP.
OrthoDBEOG4VMJQ9.

Enzyme and pathway databases

BRENDA2.3.1.9. 6758.

Gene expression databases

ArrayExpressP07256.
GenevestigatorP07256.
GermOnlineYBL045C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011249. Metalloenz_metal-bd.
IPR011237. Pept_M16_core.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
Gene3DG3DSA:3.30.830.10. Pept_M16_core. 2 hits.
KOK00414.
PfamPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMSSF63411. Metalloenz_metal-bd. 2 hits.
PROSITEPS00143. INSULINASE. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio970775.

Entry information

Entry nameQCR1_YEAST
AccessionPrimary (citable) accession number: P07256
Secondary accession number(s): D6VPV3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: December 14, 2011
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families