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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

COR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. COR1 may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YBL045C-MONOMER.
BRENDAi2.3.1.9. 6758.

Protein family/group databases

MEROPSiM16.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:COR1
Synonyms:QCR1
Ordered Locus Names:YBL045C
ORF Names:YBL0403
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL045C.
SGDiS000000141. COR1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionAdd BLAST26
ChainiPRO_000002678827 – 457Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST431

Proteomic databases

MaxQBiP07256.
PRIDEiP07256.

PTM databases

iPTMnetiP07256.

Interactioni

Subunit structurei

Fungi cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
QCR2P072575EBI-19922,EBI-19929

Protein-protein interaction databases

BioGridi32652. 134 interactors.
DIPiDIP-2635N.
IntActiP07256. 17 interactors.
MINTiMINT-424492.

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 42Combined sources13
Beta strandi47 – 56Combined sources10
Helixi59 – 61Combined sources3
Turni64 – 68Combined sources5
Helixi69 – 77Combined sources9
Helixi80 – 88Combined sources9
Beta strandi92 – 97Combined sources6
Beta strandi102 – 108Combined sources7
Helixi110 – 112Combined sources3
Helixi113 – 124Combined sources12
Turni129 – 132Combined sources4
Helixi134 – 154Combined sources21
Helixi156 – 168Combined sources13
Turni169 – 171Combined sources3
Helixi173 – 175Combined sources3
Helixi182 – 186Combined sources5
Helixi190 – 200Combined sources11
Helixi203 – 205Combined sources3
Beta strandi206 – 213Combined sources8
Helixi216 – 223Combined sources8
Beta strandi247 – 252Combined sources6
Beta strandi256 – 266Combined sources11
Helixi275 – 285Combined sources11
Beta strandi287 – 289Combined sources3
Helixi295 – 297Combined sources3
Helixi302 – 307Combined sources6
Turni308 – 310Combined sources3
Beta strandi313 – 321Combined sources9
Beta strandi326 – 335Combined sources10
Helixi340 – 356Combined sources17
Helixi360 – 378Combined sources19
Helixi383 – 397Combined sources15
Helixi403 – 412Combined sources10
Helixi415 – 425Combined sources11
Turni426 – 428Combined sources3
Beta strandi432 – 438Combined sources7
Beta strandi440 – 442Combined sources3
Helixi445 – 450Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30A27-457[»]
1KB9X-ray2.30A27-457[»]
1KYOX-ray2.97A/L27-457[»]
1P84X-ray2.50A27-457[»]
2IBZX-ray2.30A27-457[»]
3CX5X-ray1.90A/L27-457[»]
3CXHX-ray2.50A/L27-457[»]
4PD4X-ray3.04A27-457[»]
ProteinModelPortaliP07256.
SMRiP07256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07256.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000242450.
InParanoidiP07256.
KOiK00414.
OMAiYKDSGLW.
OrthoDBiEOG092C25X9.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTVTSKTV SNQFKRSLAT AVATPKAEVT QLSNGIVVAT EHNPSAHTAS
60 70 80 90 100
VGVVFGSGAA NENPYNNGVS NLWKNIFLSK ENSAVAAKEG LALSSNISRD
110 120 130 140 150
FQSYIVSSLP GSTDKSLDFL NQSFIQQKAN LLSSSNFEAT KKSVLKQVQD
160 170 180 190 200
FEENDHPNRV LEHLHSTAFQ NTPLSLPTRG TLESLENLVV ADLESFANNH
210 220 230 240 250
FLNSNAVVVG TGNIKHEDLV NSIESKNLSL QTGTKPVLKK KAAFLGSEVR
260 270 280 290 300
LRDDTLPKAW ISLAVEGEPV NSPNYFVAKL AAQIFGSYNA FEPASRLQGI
310 320 330 340 350
KLLDNIQEYQ LCDNFNHFSL SYKDSGLWGF STATRNVTMI DDLIHFTLKQ
360 370 380 390 400
WNRLTISVTD TEVERAKSLL KLQLGQLYES GNPVNDANLL GAEVLIKGSK
410 420 430 440 450
LSLGEAFKKI DAITVKDVKA WAGKRLWDQD IAIAGTGQIE GLLDYMRIRS

DMSMMRW
Length:457
Mass (Da):50,228
Last modified:April 1, 1988 - v1
Checksum:iAE58739EFB695254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02636 Genomic DNA. Translation: AAA34508.1.
X78214 Genomic DNA. Translation: CAA55050.1.
Z35806 Genomic DNA. Translation: CAA84865.1.
AY693047 Genomic DNA. Translation: AAT93066.1.
BK006936 Genomic DNA. Translation: DAA07073.1.
PIRiA25351.
RefSeqiNP_009508.1. NM_001178285.1.

Genome annotation databases

EnsemblFungiiYBL045C; YBL045C; YBL045C.
GeneIDi852235.
KEGGisce:YBL045C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02636 Genomic DNA. Translation: AAA34508.1.
X78214 Genomic DNA. Translation: CAA55050.1.
Z35806 Genomic DNA. Translation: CAA84865.1.
AY693047 Genomic DNA. Translation: AAT93066.1.
BK006936 Genomic DNA. Translation: DAA07073.1.
PIRiA25351.
RefSeqiNP_009508.1. NM_001178285.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30A27-457[»]
1KB9X-ray2.30A27-457[»]
1KYOX-ray2.97A/L27-457[»]
1P84X-ray2.50A27-457[»]
2IBZX-ray2.30A27-457[»]
3CX5X-ray1.90A/L27-457[»]
3CXHX-ray2.50A/L27-457[»]
4PD4X-ray3.04A27-457[»]
ProteinModelPortaliP07256.
SMRiP07256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32652. 134 interactors.
DIPiDIP-2635N.
IntActiP07256. 17 interactors.
MINTiMINT-424492.

Protein family/group databases

MEROPSiM16.973.

PTM databases

iPTMnetiP07256.

Proteomic databases

MaxQBiP07256.
PRIDEiP07256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL045C; YBL045C; YBL045C.
GeneIDi852235.
KEGGisce:YBL045C.

Organism-specific databases

EuPathDBiFungiDB:YBL045C.
SGDiS000000141. COR1.

Phylogenomic databases

HOGENOMiHOG000242450.
InParanoidiP07256.
KOiK00414.
OMAiYKDSGLW.
OrthoDBiEOG092C25X9.

Enzyme and pathway databases

BioCyciYEAST:YBL045C-MONOMER.
BRENDAi2.3.1.9. 6758.

Miscellaneous databases

EvolutionaryTraceiP07256.
PROiP07256.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR1_YEAST
AccessioniPrimary (citable) accession number: P07256
Secondary accession number(s): D6VPV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 19300 molecules/cell in log phase SD medium.1 Publication

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.