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Protein

Cytochrome c oxidase subunit 7A

Gene

COX9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This small integral protein plays a role in holoenzyme assembly or stability.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YDL067C-MONOMER.
YEAST:YDL067C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIIA
Gene namesi
Name:COX9
Ordered Locus Names:YDL067C
ORF Names:D2520
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL067C.
SGDiS000002225. COX9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3419HelicalAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 5655Cytochrome c oxidase subunit 7APRO_0000006076Add
BLAST
Propeptidei57 – 593Removed in mature formPRO_0000006077

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiP07255.
PaxDbiP07255.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31992. 69 interactions.
DIPiDIP-5231N.
IntActiP07255. 7 interactions.
MINTiMINT-563097.
STRINGi4932.YDL067C.

Structurei

3D structure databases

ProteinModelPortaliP07255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82857.
HOGENOMiHOG000199609.
InParanoidiP07255.
KOiK02269.
OMAiKREAYYA.
OrthoDBiEOG7QRR7G.

Family and domain databases

InterProiIPR014368. Cyt_c_oxidase_su7a_fun.
[Graphical view]
PIRSFiPIRSF000283. COX9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAPITGTI KRRVIMDIVL GFSLGGVMAS YWWWGFHMDK INKREKFYAE

LAERKKQEN
Length:59
Mass (Da):6,963
Last modified:January 23, 2007 - v2
Checksum:iD228F428EA7DAC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02633 Genomic DNA. Translation: AAB03896.1.
M35260 Genomic DNA. Translation: AAA34523.1.
X16120 Genomic DNA. Translation: CAA34250.1.
Z74115 Genomic DNA. Translation: CAA98632.1.
AY558525 Genomic DNA. Translation: AAS56851.1.
BK006938 Genomic DNA. Translation: DAA11790.1.
PIRiJQ0325. OBBY7A.
RefSeqiNP_010216.1. NM_001180126.1.

Genome annotation databases

EnsemblFungiiYDL067C; YDL067C; YDL067C.
GeneIDi851492.
KEGGisce:YDL067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02633 Genomic DNA. Translation: AAB03896.1.
M35260 Genomic DNA. Translation: AAA34523.1.
X16120 Genomic DNA. Translation: CAA34250.1.
Z74115 Genomic DNA. Translation: CAA98632.1.
AY558525 Genomic DNA. Translation: AAS56851.1.
BK006938 Genomic DNA. Translation: DAA11790.1.
PIRiJQ0325. OBBY7A.
RefSeqiNP_010216.1. NM_001180126.1.

3D structure databases

ProteinModelPortaliP07255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31992. 69 interactions.
DIPiDIP-5231N.
IntActiP07255. 7 interactions.
MINTiMINT-563097.
STRINGi4932.YDL067C.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP07255.
PaxDbiP07255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL067C; YDL067C; YDL067C.
GeneIDi851492.
KEGGisce:YDL067C.

Organism-specific databases

EuPathDBiFungiDB:YDL067C.
SGDiS000002225. COX9.

Phylogenomic databases

eggNOGiNOG82857.
HOGENOMiHOG000199609.
InParanoidiP07255.
KOiK02269.
OMAiKREAYYA.
OrthoDBiEOG7QRR7G.

Enzyme and pathway databases

BioCyciMetaCyc:YDL067C-MONOMER.
YEAST:YDL067C-MONOMER.

Miscellaneous databases

NextBioi968822.
PROiP07255.

Family and domain databases

InterProiIPR014368. Cyt_c_oxidase_su7a_fun.
[Graphical view]
PIRSFiPIRSF000283. COX9. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of COX9, the nuclear gene encoding the yeast mitochondrial protein cytochrome c oxidase subunit VIIa. Subunit VIIa lacks a leader peptide and is an essential component of the holoenzyme."
    Wright R.M., Dircks L.K., Poyton R.O.
    J. Biol. Chem. 261:17183-17191(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Mitochondrial import of cytochrome c oxidase subunit VIIa in Saccharomyces cerevisiae. Identification of sequences required for mitochondrial localization in vivo."
    Duhl D.M., Powell T., Poyton R.O.
    J. Biol. Chem. 265:7273-7277(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast."
    Forsbach V., Pillar T., Gottenoef T., Roedel G.
    Mol. Gen. Genet. 218:57-63(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. "The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis."
    Power S.D., Lochrie M.A., Poyton R.O.
    J. Biol. Chem. 261:9206-9209(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-56.
  8. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX9_YEAST
AccessioniPrimary (citable) accession number: P07255
Secondary accession number(s): D6VRT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 35500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.