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Protein

Cytochrome c oxidase subunit 7A

Gene

COX9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This small integral protein plays a role in holoenzyme assembly or stability.

Miscellaneous

Present with 35500 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YDL067C-MONOMER
YEAST:YDL067C-MONOMER

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIIA
Gene namesi
Name:COX9
Ordered Locus Names:YDL067C
ORF Names:D2520
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL067C
SGDiS000002225 COX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 34HelicalAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000060762 – 56Cytochrome c oxidase subunit 7AAdd BLAST55
PropeptideiPRO_000000607757 – 59Removed in mature form3

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiP07255
PaxDbiP07255
PRIDEiP07255
TopDownProteomicsiP07255

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31992, 127 interactors
DIPiDIP-5231N
IntActiP07255, 8 interactors
STRINGi4932.YDL067C

Structurei

3D structure databases

ProteinModelPortaliP07255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000199609
InParanoidiP07255
KOiK02269
OMAiIKPITGM
OrthoDBiEOG092C5ZHJ

Family and domain databases

InterProiView protein in InterPro
IPR014368 Cyt_c_oxidase_su7a_fun
PIRSFiPIRSF000283 COX9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAPITGTI KRRVIMDIVL GFSLGGVMAS YWWWGFHMDK INKREKFYAE

LAERKKQEN
Length:59
Mass (Da):6,963
Last modified:January 23, 2007 - v2
Checksum:iD228F428EA7DAC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02633 Genomic DNA Translation: AAB03896.1
M35260 Genomic DNA Translation: AAA34523.1
X16120 Genomic DNA Translation: CAA34250.1
Z74115 Genomic DNA Translation: CAA98632.1
AY558525 Genomic DNA Translation: AAS56851.1
BK006938 Genomic DNA Translation: DAA11790.1
PIRiJQ0325 OBBY7A
RefSeqiNP_010216.1, NM_001180126.1

Genome annotation databases

EnsemblFungiiYDL067C; YDL067C; YDL067C
GeneIDi851492
KEGGisce:YDL067C

Similar proteinsi

Entry informationi

Entry nameiCOX9_YEAST
AccessioniPrimary (citable) accession number: P07255
Secondary accession number(s): D6VRT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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