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Protein

Cytochrome c oxidase subunit 7A

Gene

COX9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This small integral protein plays a role in holoenzyme assembly or stability.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YDL067C-MONOMER.
YEAST:YDL067C-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIIA
Gene namesi
Name:COX9
Ordered Locus Names:YDL067C
ORF Names:D2520
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL067C.
SGDiS000002225. COX9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3419HelicalAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 5655Cytochrome c oxidase subunit 7APRO_0000006076Add
BLAST
Propeptidei57 – 593Removed in mature formPRO_0000006077

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiP07255.
TopDownProteomicsiP07255.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi31992. 69 interactions.
DIPiDIP-5231N.
IntActiP07255. 7 interactions.
MINTiMINT-563097.

Structurei

3D structure databases

ProteinModelPortaliP07255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000199609.
InParanoidiP07255.
KOiK02269.
OMAiKREAYYA.
OrthoDBiEOG092C5ZHJ.

Family and domain databases

InterProiIPR014368. Cyt_c_oxidase_su7a_fun.
[Graphical view]
PIRSFiPIRSF000283. COX9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAPITGTI KRRVIMDIVL GFSLGGVMAS YWWWGFHMDK INKREKFYAE

LAERKKQEN
Length:59
Mass (Da):6,963
Last modified:January 23, 2007 - v2
Checksum:iD228F428EA7DAC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02633 Genomic DNA. Translation: AAB03896.1.
M35260 Genomic DNA. Translation: AAA34523.1.
X16120 Genomic DNA. Translation: CAA34250.1.
Z74115 Genomic DNA. Translation: CAA98632.1.
AY558525 Genomic DNA. Translation: AAS56851.1.
BK006938 Genomic DNA. Translation: DAA11790.1.
PIRiJQ0325. OBBY7A.
RefSeqiNP_010216.1. NM_001180126.1.

Genome annotation databases

EnsemblFungiiYDL067C; YDL067C; YDL067C.
GeneIDi851492.
KEGGisce:YDL067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02633 Genomic DNA. Translation: AAB03896.1.
M35260 Genomic DNA. Translation: AAA34523.1.
X16120 Genomic DNA. Translation: CAA34250.1.
Z74115 Genomic DNA. Translation: CAA98632.1.
AY558525 Genomic DNA. Translation: AAS56851.1.
BK006938 Genomic DNA. Translation: DAA11790.1.
PIRiJQ0325. OBBY7A.
RefSeqiNP_010216.1. NM_001180126.1.

3D structure databases

ProteinModelPortaliP07255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31992. 69 interactions.
DIPiDIP-5231N.
IntActiP07255. 7 interactions.
MINTiMINT-563097.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP07255.
TopDownProteomicsiP07255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL067C; YDL067C; YDL067C.
GeneIDi851492.
KEGGisce:YDL067C.

Organism-specific databases

EuPathDBiFungiDB:YDL067C.
SGDiS000002225. COX9.

Phylogenomic databases

HOGENOMiHOG000199609.
InParanoidiP07255.
KOiK02269.
OMAiKREAYYA.
OrthoDBiEOG092C5ZHJ.

Enzyme and pathway databases

BioCyciMetaCyc:YDL067C-MONOMER.
YEAST:YDL067C-MONOMER.

Miscellaneous databases

PROiP07255.

Family and domain databases

InterProiIPR014368. Cyt_c_oxidase_su7a_fun.
[Graphical view]
PIRSFiPIRSF000283. COX9. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX9_YEAST
AccessioniPrimary (citable) accession number: P07255
Secondary accession number(s): D6VRT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 35500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.