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P07255

- COX9_YEAST

UniProt

P07255 - COX9_YEAST

Protein

Cytochrome c oxidase subunit 7A

Gene

COX9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This small integral protein plays a role in holoenzyme assembly or stability.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciMetaCyc:YDL067C-MONOMER.
    YEAST:YDL067C-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7A (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIIA
    Gene namesi
    Name:COX9
    Ordered Locus Names:YDL067C
    ORF Names:D2520
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    SGDiS000002225. COX9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 5655Cytochrome c oxidase subunit 7APRO_0000006076Add
    BLAST
    Propeptidei57 – 593Removed in mature formPRO_0000006077

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    MaxQBiP07255.
    PaxDbiP07255.

    Expressioni

    Gene expression databases

    GenevestigatoriP07255.

    Interactioni

    Subunit structurei

    Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

    Protein-protein interaction databases

    BioGridi31992. 69 interactions.
    DIPiDIP-5231N.
    IntActiP07255. 7 interactions.
    MINTiMINT-563097.
    STRINGi4932.YDL067C.

    Structurei

    3D structure databases

    ProteinModelPortaliP07255.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3419HelicalAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82857.
    HOGENOMiHOG000199609.
    KOiK02269.
    OMAiVMANAYW.
    OrthoDBiEOG7QRR7G.

    Family and domain databases

    InterProiIPR014368. Cyt_c_oxidase_su7a_fun.
    [Graphical view]
    PIRSFiPIRSF000283. COX9. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07255-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIAPITGTI KRRVIMDIVL GFSLGGVMAS YWWWGFHMDK INKREKFYAE   50
    LAERKKQEN 59
    Length:59
    Mass (Da):6,963
    Last modified:January 23, 2007 - v2
    Checksum:iD228F428EA7DAC7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02633 Genomic DNA. Translation: AAB03896.1.
    M35260 Genomic DNA. Translation: AAA34523.1.
    X16120 Genomic DNA. Translation: CAA34250.1.
    Z74115 Genomic DNA. Translation: CAA98632.1.
    AY558525 Genomic DNA. Translation: AAS56851.1.
    BK006938 Genomic DNA. Translation: DAA11790.1.
    PIRiJQ0325. OBBY7A.
    RefSeqiNP_010216.1. NM_001180126.1.

    Genome annotation databases

    EnsemblFungiiYDL067C; YDL067C; YDL067C.
    GeneIDi851492.
    KEGGisce:YDL067C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02633 Genomic DNA. Translation: AAB03896.1 .
    M35260 Genomic DNA. Translation: AAA34523.1 .
    X16120 Genomic DNA. Translation: CAA34250.1 .
    Z74115 Genomic DNA. Translation: CAA98632.1 .
    AY558525 Genomic DNA. Translation: AAS56851.1 .
    BK006938 Genomic DNA. Translation: DAA11790.1 .
    PIRi JQ0325. OBBY7A.
    RefSeqi NP_010216.1. NM_001180126.1.

    3D structure databases

    ProteinModelPortali P07255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31992. 69 interactions.
    DIPi DIP-5231N.
    IntActi P07255. 7 interactions.
    MINTi MINT-563097.
    STRINGi 4932.YDL067C.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    MaxQBi P07255.
    PaxDbi P07255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL067C ; YDL067C ; YDL067C .
    GeneIDi 851492.
    KEGGi sce:YDL067C.

    Organism-specific databases

    SGDi S000002225. COX9.

    Phylogenomic databases

    eggNOGi NOG82857.
    HOGENOMi HOG000199609.
    KOi K02269.
    OMAi VMANAYW.
    OrthoDBi EOG7QRR7G.

    Enzyme and pathway databases

    BioCyci MetaCyc:YDL067C-MONOMER.
    YEAST:YDL067C-MONOMER.

    Miscellaneous databases

    NextBioi 968822.

    Gene expression databases

    Genevestigatori P07255.

    Family and domain databases

    InterProi IPR014368. Cyt_c_oxidase_su7a_fun.
    [Graphical view ]
    PIRSFi PIRSF000283. COX9. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of COX9, the nuclear gene encoding the yeast mitochondrial protein cytochrome c oxidase subunit VIIa. Subunit VIIa lacks a leader peptide and is an essential component of the holoenzyme."
      Wright R.M., Dircks L.K., Poyton R.O.
      J. Biol. Chem. 261:17183-17191(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Mitochondrial import of cytochrome c oxidase subunit VIIa in Saccharomyces cerevisiae. Identification of sequences required for mitochondrial localization in vivo."
      Duhl D.M., Powell T., Poyton R.O.
      J. Biol. Chem. 265:7273-7277(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast."
      Forsbach V., Pillar T., Gottenoef T., Roedel G.
      Mol. Gen. Genet. 218:57-63(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. "The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis."
      Power S.D., Lochrie M.A., Poyton R.O.
      J. Biol. Chem. 261:9206-9209(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-56.
    8. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
      Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
      Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX9_YEAST
    AccessioniPrimary (citable) accession number: P07255
    Secondary accession number(s): D6VRT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 35500 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3