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Protein

Protein krueppel

Gene

Kr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 354C2H2-type 5PROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

  • DNA binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • chromatin silencing Source: FlyBase
  • compound eye development Source: FlyBase
  • ganglion mother cell fate determination Source: FlyBase
  • Malpighian tubule bud morphogenesis Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • regulation of development, heterochronic Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • trunk segmentation Source: FlyBase
  • ventral cord development Source: FlyBase
  • zygotic determination of anterior/posterior axis, embryo Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Gap protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP07247

Names & Taxonomyi

Protein namesi
Recommended name:
Protein krueppel
Gene namesi
Name:Kr
ORF Names:CG3340
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001325 Kr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469921 – 502Protein krueppelAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei468Phosphoserine1 Publication1
Modified residuei471Phosphoserine1 Publication1
Modified residuei477Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07247
PRIDEiP07247

PTM databases

iPTMnetiP07247

Expressioni

Gene expression databases

BgeeiFBgn0001325
ExpressionAtlasiP07247 differential
GenevisibleiP07247 DM

Interactioni

Protein-protein interaction databases

BioGridi63578, 39 interactors
IntActiP07247, 5 interactors
STRINGi7227.FBpp0305365

Structurei

3D structure databases

ProteinModelPortaliP07247
SMRiP07247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 354C2H2-type 5PROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144394
HOGENOMiHOG000217450
InParanoidiP07247
KOiK09231
OMAiQTEISMS
OrthoDBiEOG091G0KT0
PhylomeDBiP07247

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

P07247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISMLQDAQ TRTLAAALAG IKQEDVHLDR SMSLSPPMSA NTSATSAAAI
60 70 80 90 100
YPAMGLQQAA AASAFGMLSP TQLLAANRQA AAFMAQLPMS TLANTLFPHN
110 120 130 140 150
PAALFGAWAA QQSLPPQGTH LHSPPASPHS PLSTPLGSGK HPLNSPNSTP
160 170 180 190 200
QHHEPAKKAR KLSVKKEFQT EISMSVNDMY HTSGGPISPP SSGSSPNSTH
210 220 230 240 250
DGAGGNAGCV GVSKDPSRDK SFTCKICSRS FGYKHVLQNH ERTHTGEKPF
260 270 280 290 300
ECPECHKRFT RDHHLKTHMR LHTGEKPYHC SHCDRQFVQV ANLRRHLRVH
310 320 330 340 350
TGERPYTCEI CDGKFSDSNQ LKSHMLVHNG EKPFECERCH MKFRRRHHLM
360 370 380 390 400
NHKCGIQSPP TPALSPAMSG DYPVAISAIA IEASTNRFAA MCATYGGSNE
410 420 430 440 450
SVDMEKATPE DDGPLDLSED GASSVDGHCS NIARRKAQDI RRVFRLPPPQ
460 470 480 490 500
IPHVPSDMPE QTEPEDLSMH SPRSIGSHEQ TDDIDLYDLD DAPASYMGHQ

QH
Length:502
Mass (Da):54,715
Last modified:August 30, 2005 - v2
Checksum:i67A94177A701D976
GO

Sequence cautioni

The sequence CAA27148 differs from that shown. Reason: Frameshift at position 411.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 154HE → Q in AAL48902 (PubMed:12537569).Curated2
Sequence conflicti181 – 182HT → LS in CAA27148 (Ref. 1) Curated2
Sequence conflicti256H → D in CAA27148 (Ref. 1) Curated1
Sequence conflicti329N → T in CAA27148 (Ref. 1) Curated1
Sequence conflicti397G → S in CAA27148 (Ref. 1) Curated1
Sequence conflicti429C → Y (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03414 Genomic DNA Translation: CAA27148.1 Frameshift.
AE013599 Genomic DNA Translation: AAF47321.1
AY071280 mRNA Translation: AAL48902.1
PIRiA24566 TWFF
RefSeqiNP_001261181.1, NM_001274252.1
NP_523867.1, NM_079143.3
UniGeneiDm.2786

Genome annotation databases

EnsemblMetazoaiFBtr0072449; FBpp0072351; FBgn0001325
FBtr0333162; FBpp0305365; FBgn0001325
GeneIDi38012
KEGGidme:Dmel_CG3340

Similar proteinsi

Entry informationi

Entry nameiKRUP_DROME
AccessioniPrimary (citable) accession number: P07247
Secondary accession number(s): Q8SYW3, Q9W0V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: August 30, 2005
Last modified: March 28, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health