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Protein

Alcohol dehydrogenase 3, mitochondrial

Gene

ADH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Zinc 1; catalytic1
Metal bindingi94Zinc 1; catalytic1
Metal bindingi125Zinc 21
Metal bindingi128Zinc 21
Metal bindingi131Zinc 21
Metal bindingi139Zinc 21
Metal bindingi181Zinc 1; catalytic1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei368NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 211NADBy similarity7
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • amino acid catabolic process to alcohol via Ehrlich pathway Source: SGD
  • ethanol metabolic process Source: GO_Central
  • fermentation Source: SGD
  • NADH oxidation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YMR083W-MONOMER.
YEAST:YMR083W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3, mitochondrial (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
YADH-3
Gene namesi
Name:ADH3
Ordered Locus Names:YMR083W
ORF Names:YM9582.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR083W.
SGDiS000004688. ADH3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000000087928 – 375Alcohol dehydrogenase 3, mitochondrialAdd BLAST348

Proteomic databases

MaxQBiP07246.
PRIDEiP07246.

PTM databases

iPTMnetiP07246.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi35258. 147 interactors.
DIPiDIP-4445N.
IntActiP07246. 23 interactors.
MINTiMINT-482092.

Structurei

3D structure databases

ProteinModelPortaliP07246.
SMRiP07246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00550000075207.
HOGENOMiHOG000294685.
InParanoidiP07246.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTSTLFTR RVQPSLFSRN ILRLQSTAAI PKTQKGVIFY ENKGKLHYKD
60 70 80 90 100
IPVPEPKPNE ILINVKYSGV CHTDLHAWHG DWPLPVKLPL VGGHEGAGVV
110 120 130 140 150
VKLGSNVKGW KVGDLAGIKW LNGSCMTCEF CESGHESNCP DADLSGYTHD
160 170 180 190 200
GSFQQFATAD AIQAAKIQQG TDLAEVAPIL CAGVTVYKAL KEADLKAGDW
210 220 230 240 250
VAISGAAGGL GSLAVQYATA MGYRVLGIDA GEEKEKLFKK LGGEVFIDFT
260 270 280 290 300
KTKNMVSDIQ EATKGGPHGV INVSVSEAAI SLSTEYVRPC GTVVLVGLPA
310 320 330 340 350
NAYVKSEVFS HVVKSINIKG SYVGNRADTR EALDFFSRGL IKSPIKIVGL
360 370
SELPKVYDLM EKGKILGRYV VDTSK
Length:375
Mass (Da):40,370
Last modified:February 1, 1996 - v2
Checksum:iAB849BC4E9D4EB8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → K in AAA34409 (Ref. 1) Curated1
Sequence conflicti45K → N in AAA34409 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03292 Genomic DNA. Translation: AAA34409.1.
Z49259 Genomic DNA. Translation: CAA89229.1.
AY692988 Genomic DNA. Translation: AAT93007.1.
BK006946 Genomic DNA. Translation: DAA09980.1.
PIRiS54458.
RefSeqiNP_013800.1. NM_001182582.1.

Genome annotation databases

EnsemblFungiiYMR083W; YMR083W; YMR083W.
GeneIDi855107.
KEGGisce:YMR083W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03292 Genomic DNA. Translation: AAA34409.1.
Z49259 Genomic DNA. Translation: CAA89229.1.
AY692988 Genomic DNA. Translation: AAT93007.1.
BK006946 Genomic DNA. Translation: DAA09980.1.
PIRiS54458.
RefSeqiNP_013800.1. NM_001182582.1.

3D structure databases

ProteinModelPortaliP07246.
SMRiP07246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35258. 147 interactors.
DIPiDIP-4445N.
IntActiP07246. 23 interactors.
MINTiMINT-482092.

PTM databases

iPTMnetiP07246.

Proteomic databases

MaxQBiP07246.
PRIDEiP07246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR083W; YMR083W; YMR083W.
GeneIDi855107.
KEGGisce:YMR083W.

Organism-specific databases

EuPathDBiFungiDB:YMR083W.
SGDiS000004688. ADH3.

Phylogenomic databases

GeneTreeiENSGT00550000075207.
HOGENOMiHOG000294685.
InParanoidiP07246.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Enzyme and pathway databases

BioCyciMetaCyc:YMR083W-MONOMER.
YEAST:YMR083W-MONOMER.

Miscellaneous databases

PROiP07246.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_YEAST
AccessioniPrimary (citable) accession number: P07246
Secondary accession number(s): D6VZQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.