##gff-version 3
P07245	UniProtKB	Initiator methionine	1	1	.	.	.	Note=Removed;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:329838,ECO:0000269|PubMed:3514599;Dbxref=PMID:329838,PMID:3514599	
P07245	UniProtKB	Chain	2	946	.	.	.	ID=PRO_0000199326;Note=C-1-tetrahydrofolate synthase%2C cytoplasmic	
P07245	UniProtKB	Region	2	319	.	.	.	Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3514599;Dbxref=PMID:3514599	
P07245	UniProtKB	Region	320	946	.	.	.	Note=Formyltetrahydrofolate synthetase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3514599;Dbxref=PMID:3514599	
P07245	UniProtKB	Binding site	51	55	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Binding site	98	100	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Binding site	169	171	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Binding site	194	194	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Binding site	277	281	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Binding site	384	391	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07245	UniProtKB	Modified residue	176	176	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18407956,ECO:0007744|PubMed:19779198;Dbxref=PMID:18407956,PMID:19779198	
P07245	UniProtKB	Modified residue	318	318	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19779198;Dbxref=PMID:19779198	
P07245	UniProtKB	Modified residue	322	322	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19779198;Dbxref=PMID:19779198	
P07245	UniProtKB	Mutagenesis	11	11	.	.	.	Note=Almost no effect on activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2541774;Dbxref=PMID:2541774	
P07245	UniProtKB	Mutagenesis	144	144	.	.	.	Note=Cyclohydrolase activity is reduced 20-fold. Dehydrogenase Km is increased 7-fold. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2541774;Dbxref=PMID:2541774	
P07245	UniProtKB	Mutagenesis	257	257	.	.	.	Note=Cyclohydrolase activity is increased 2-fold. Dehydrogenase Km is increased 2-fold. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2541774;Dbxref=PMID:2541774	
P07245	UniProtKB	Sequence conflict	4	4	.	.	.	Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305