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Protein

Conantokin-G

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin is selective for the NR2B/GRIN2B subunit. Induces sleep-like symptoms in young mice and hyperactivity in older mice.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei85 – 851Important for selectivity
Metal bindingi90 – 901Divalent metal cation; via 4-carboxyglutamate
Metal bindingi94 – 941Divalent metal cation; via 4-carboxyglutamate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-G
Short name:
Con-G
Alternative name(s):
CGX-1007
Conotoxin GV
Sleeper peptide
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1373. Conantokin-G precursor.
1353. Conantokin-G precursor (variant).

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Failed in phase II clinical trial. Was tested under the name CGX-1007 by Cognetix Inc. to treat convulsion and epilepsy.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi85 – 851L → I: No loss of inhibition of NR1a/NR2B receptor; no inhibition of NR1a/NR2A receptor (as for the wild-type). 1 Publication
Mutagenesisi85 – 851L → V: No loss of inhibition of NR1a/NR2B receptor; no inhibition of NR1a/NR2A receptor (as for the wild-type). 1 Publication
Mutagenesisi85 – 851L → Y: Little loss of inhibition of NR1a/NR2B receptor; 70% of inhibition of NR1a/NR2A receptor. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Propeptidei22 – 8059PRO_0000035060Add
BLAST
Peptidei81 – 9717Conantokin-GPRO_0000035061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 8314-carboxyglutamate1 Publication
Modified residuei84 – 8414-carboxyglutamate1 Publication
Modified residuei87 – 8714-carboxyglutamate1 Publication
Modified residuei90 – 9014-carboxyglutamate1 Publication
Modified residuei94 – 9414-carboxyglutamate1 Publication
Modified residuei97 – 971Asparagine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

Secondary structure

1
100
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi82 – 9615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AD7NMR-A81-97[»]
1AWYNMR-A81-97[»]
1ONUNMR-A81-97[»]
2DPQX-ray1.25A81-97[»]
ProteinModelPortaliP07231.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07231.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 8020Gamma-carboxylation recognition sequence that plays a role in the conversion of Glu to carboxy-Glu (Gla)CuratedAdd
BLAST

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR005918. Conantokin_CS.
[Graphical view]
PROSITEiPS60025. CONANTOKIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLYTYLYLL VPLVTFHLIL GTGTLDDGGA LTERRSADAT ALKAEPVLLQ
60 70 80 90 100
KSAARSTDDN GKDRLTQMKR ILKQRGNKAR GEEELQENQE LIREKSNGKR
Length:100
Mass (Da):11,267
Last modified:December 15, 1998 - v2
Checksum:i3B0050FDFF2B9DFB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851L → V.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043141 mRNA. Translation: AAC15669.1.
PIRiA05168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043141 mRNA. Translation: AAC15669.1.
PIRiA05168.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AD7NMR-A81-97[»]
1AWYNMR-A81-97[»]
1ONUNMR-A81-97[»]
2DPQX-ray1.25A81-97[»]
ProteinModelPortaliP07231.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1373. Conantokin-G precursor.
1353. Conantokin-G precursor (variant).

Miscellaneous databases

EvolutionaryTraceiP07231.

Family and domain databases

InterProiIPR005918. Conantokin_CS.
[Graphical view]
PROSITEiPS60025. CONANTOKIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKG_CONGE
AccessioniPrimary (citable) accession number: P07231
Secondary accession number(s): O61475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: July 22, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The mature peptide does not contain cysteine residue.Curated

Keywords - Technical termi

3D-structure, Pharmaceutical

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.