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P07228

- ITB1_CHICK

UniProt

P07228 - ITB1_CHICK

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Protein

Integrin beta-1

Gene

ITGB1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi156 – 1561MagnesiumBy similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi160 – 1601Calcium 1By similarity
Metal bindingi161 – 1611Calcium 1By similarity
Metal bindingi193 – 1931Calcium 2By similarity
Metal bindingi248 – 2481Calcium 2By similarity
Metal bindingi250 – 2501Calcium 2By similarity
Metal bindingi252 – 2521Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi253 – 2531Calcium 2By similarity
Metal bindingi253 – 2531MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. receptor activity Source: InterPro

GO - Biological processi

  1. cell-matrix adhesion Source: InterPro
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
  3. multicellular organismal development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-1
Alternative name(s):
CSAT antigen
JG22 antigen
RGD-receptor
Gene namesi
Name:ITGB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Cell projectioninvadopodium membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Cell projectionruffle membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Melanosome By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity

GO - Cellular componenti

  1. integrin complex Source: InterPro
  2. invadopodium membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 803779Integrin beta-1PRO_0000016337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Blocked amino end (Gln)
Disulfide bondi31 ↔ 49By similarity
Disulfide bondi39 ↔ 469By similarity
Disulfide bondi42 ↔ 79By similarity
Disulfide bondi52 ↔ 68By similarity
Disulfide bondi211 ↔ 217By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi265 ↔ 305By similarity
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi405 ↔ 419By similarity
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi439 ↔ 467By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi471 ↔ 696By similarity
Disulfide bondi482 ↔ 494By similarity
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi491 ↔ 530By similarity
Disulfide bondi496 ↔ 505By similarity
Disulfide bondi507 ↔ 521By similarity
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi536 ↔ 541By similarity
Disulfide bondi538 ↔ 573By similarity
Disulfide bondi543 ↔ 558By similarity
Disulfide bondi560 ↔ 565By similarity
Disulfide bondi579 ↔ 584By similarity
Disulfide bondi581 ↔ 612By similarity
Disulfide bondi586 ↔ 595By similarity
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi597 ↔ 604By similarity
Disulfide bondi618 ↔ 623By similarity
Disulfide bondi620 ↔ 666By similarity
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi625 ↔ 635By similarity
Disulfide bondi638 ↔ 641By similarity
Disulfide bondi645 ↔ 654By similarity
Disulfide bondi651 ↔ 728By similarity
Disulfide bondi670 ↔ 704By similarity
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
Modified residuei788 – 7881Phosphotyrosine; by Tyr-kinasesSequence Analysis

Post-translational modificationi

The cysteine residues are involved in intrachain disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07228.
PRIDEiP07228.

Expressioni

Tissue specificityi

Expressed on surface of embryonic fibroblasts (at protein level).1 Publication

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P050944EBI-5606437,EBI-5847257
FLNAP213332EBI-5606437,EBI-350432From a different organism.

Protein-protein interaction databases

IntActiP07228. 3 interactions.
MINTiMINT-197077.
STRINGi9031.ENSGALP00000011559.

Structurei

3D structure databases

ProteinModelPortaliP07228.
SMRiP07228. Positions 726-802.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 733709ExtracellularSequence AnalysisAdd
BLAST
Topological domaini757 – 80347CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei734 – 75623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 382239VWFAAdd
BLAST
Repeati471 – 52050IAdd
BLAST
Repeati521 – 56444IIAdd
BLAST
Repeati565 – 60339IIIAdd
BLAST
Repeati604 – 64037IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 640170Cysteine-rich tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP07228.
PhylomeDBiP07228.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07228-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAETNLTLLT WAGILCCLIW SGSAQQGGSD CIKANAKSCG ECIQAGPNCG
60 70 80 90 100
WCKKTDFLQE GEPTSARCDD LAALKSKGCP EQDIENPRGS KRVLEDREVT
110 120 130 140 150
NRKIGAAEKL KPEAITQIQP QKLVLQLRVG EPQTFSLKFK RAEDYPIDLY
160 170 180 190 200
YLMDLSYSMK DDLENVKSLG TALMREMEKI TSDFRIGFGS FVEKTVMPYI
210 220 230 240 250
STTPAKLRNP CTGDQNCTSP FSYKNVLSLT SEGNKFNELV GKQHISGNLD
260 270 280 290 300
SPEGGFDAIM QVAVCGDQIG WRNVTRLLVF STDAGFHFAG DGKLGGIVLP
310 320 330 340 350
NDGKCHLENN MYTMSHYYDY PSIAHLVQKL SENNIQTIFA VTEEFQAVYK
360 370 380 390 400
ELKNLIPKSA VGTLSSNSSN VIQLIIDAYN SLSSEVILEN SKLPKEVTIS
410 420 430 440 450
YKSYCKNGVN DTQEDGRKCS NISIGDEVRF EINVTANECP KKGQNETIKI
460 470 480 490 500
KPLGFTEEVE IHLQFICDCL CQSEGEPNSP ACHDGNGTFE CGACRCNEGR
510 520 530 540 550
IGRLCECSTD EVNSEDMDAY CRRENSTEIC SNNGECICGQ CVCKKRENTN
560 570 580 590 600
EVYSGKYCEC DNFNCDRSNG LICGGNGICK CRVCECFPNF TGSACDCSLD
610 620 630 640 650
TTPCMAGNGQ ICNGRGTCEC GTCNCTDPKF QGPTCEMCQT CLGVCAEHKD
660 670 680 690 700
CVQCRAFEKG EKKETCSQEC MHFNMTRVES RGKLPQPVHP DPLSHCKEKD
710 720 730 740 750
VGDCWFYFTY SVNSNGEASV HVVETPECPS GPDIIPIVAG VVAGIVLIGL
760 770 780 790 800
ALLLIWKLLM IIHDRREFAK FEKEKMNAKW DTGENPIYKS AVTTVVNPKY

EGK
Length:803
Mass (Da):88,554
Last modified:April 1, 1988 - v1
Checksum:i2F6FEFCDF2C80457
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14049 mRNA. Translation: AAA48926.1.
PIRiA23947. IJCH3.
UniGeneiGga.111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14049 mRNA. Translation: AAA48926.1 .
PIRi A23947. IJCH3.
UniGenei Gga.111.

3D structure databases

ProteinModelPortali P07228.
SMRi P07228. Positions 726-802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07228. 3 interactions.
MINTi MINT-197077.
STRINGi 9031.ENSGALP00000011559.

Proteomic databases

PaxDbi P07228.
PRIDEi P07228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG287997.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P07228.
PhylomeDBi P07228.

Miscellaneous databases

NextBioi 20813580.
PROi P07228.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin."
    Tamkun J.W., Desimone D.W., Fonda D., Patel R.S., Buck C., Horwitz A.F., Hynes R.O.
    Cell 46:271-282(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiITB1_CHICK
AccessioniPrimary (citable) accession number: P07228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3