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P07228

- ITB1_CHICK

UniProt

P07228 - ITB1_CHICK

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Protein
Integrin beta-1
Gene
ITGB1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi156 – 1561Magnesium By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygen By similarity
Metal bindingi160 – 1601Calcium 1 By similarity
Metal bindingi161 – 1611Calcium 1 By similarity
Metal bindingi193 – 1931Calcium 2 By similarity
Metal bindingi248 – 2481Calcium 2 By similarity
Metal bindingi250 – 2501Calcium 2 By similarity
Metal bindingi252 – 2521Calcium 2; via carbonyl oxygen By similarity
Metal bindingi253 – 2531Calcium 2 By similarity
Metal bindingi253 – 2531Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. receptor activity Source: InterPro

GO - Biological processi

  1. cell-matrix adhesion Source: InterPro
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
  3. multicellular organismal development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-1
Alternative name(s):
CSAT antigen
JG22 antigen
RGD-receptor
Gene namesi
Name:ITGB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Melanosome By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 733709Extracellular Reviewed prediction
Add
BLAST
Transmembranei734 – 75623Helical; Reviewed prediction
Add
BLAST
Topological domaini757 – 80347Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integrin complex Source: InterPro
  2. lamellipodium Source: UniProtKB-SubCell
  3. melanosome Source: UniProtKB-SubCell
  4. plasma membrane Source: Reactome
  5. ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 803779Integrin beta-1
PRO_0000016337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Blocked amino end (Gln)
Disulfide bondi31 ↔ 49 By similarity
Disulfide bondi39 ↔ 469 By similarity
Disulfide bondi42 ↔ 79 By similarity
Disulfide bondi52 ↔ 68 By similarity
Disulfide bondi211 ↔ 217 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi265 ↔ 305 By similarity
Glycosylationi273 – 2731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi367 – 3671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi405 ↔ 419 By similarity
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi439 ↔ 467 By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi471 ↔ 696 By similarity
Disulfide bondi482 ↔ 494 By similarity
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi491 ↔ 530 By similarity
Disulfide bondi496 ↔ 505 By similarity
Disulfide bondi507 ↔ 521 By similarity
Glycosylationi525 – 5251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi536 ↔ 541 By similarity
Disulfide bondi538 ↔ 573 By similarity
Disulfide bondi543 ↔ 558 By similarity
Disulfide bondi560 ↔ 565 By similarity
Disulfide bondi579 ↔ 584 By similarity
Disulfide bondi581 ↔ 612 By similarity
Disulfide bondi586 ↔ 595 By similarity
Glycosylationi589 – 5891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi597 ↔ 604 By similarity
Disulfide bondi618 ↔ 623 By similarity
Disulfide bondi620 ↔ 666 By similarity
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi625 ↔ 635 By similarity
Disulfide bondi638 ↔ 641 By similarity
Disulfide bondi645 ↔ 654 By similarity
Disulfide bondi651 ↔ 728 By similarity
Disulfide bondi670 ↔ 704 By similarity
Glycosylationi674 – 6741N-linked (GlcNAc...) Reviewed prediction
Modified residuei788 – 7881Phosphotyrosine; by Tyr-kinases Reviewed prediction

Post-translational modificationi

The cysteine residues are involved in intrachain disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07228.
PRIDEiP07228.

Expressioni

Tissue specificityi

Expressed on surface of embryonic fibroblasts (at protein level).1 Publication

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P050944EBI-5606437,EBI-5847257
FLNAP213332EBI-5606437,EBI-350432From a different organism.

Protein-protein interaction databases

IntActiP07228. 3 interactions.
MINTiMINT-197077.
STRINGi9031.ENSGALP00000011559.

Structurei

3D structure databases

ProteinModelPortaliP07228.
SMRiP07228. Positions 726-802.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 382239VWFA
Add
BLAST
Repeati471 – 52050I
Add
BLAST
Repeati521 – 56444II
Add
BLAST
Repeati565 – 60339III
Add
BLAST
Repeati604 – 64037IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 640170Cysteine-rich tandem repeats
Add
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP07228.
PhylomeDBiP07228.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07228-1 [UniParc]FASTAAdd to Basket

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MAETNLTLLT WAGILCCLIW SGSAQQGGSD CIKANAKSCG ECIQAGPNCG    50
WCKKTDFLQE GEPTSARCDD LAALKSKGCP EQDIENPRGS KRVLEDREVT 100
NRKIGAAEKL KPEAITQIQP QKLVLQLRVG EPQTFSLKFK RAEDYPIDLY 150
YLMDLSYSMK DDLENVKSLG TALMREMEKI TSDFRIGFGS FVEKTVMPYI 200
STTPAKLRNP CTGDQNCTSP FSYKNVLSLT SEGNKFNELV GKQHISGNLD 250
SPEGGFDAIM QVAVCGDQIG WRNVTRLLVF STDAGFHFAG DGKLGGIVLP 300
NDGKCHLENN MYTMSHYYDY PSIAHLVQKL SENNIQTIFA VTEEFQAVYK 350
ELKNLIPKSA VGTLSSNSSN VIQLIIDAYN SLSSEVILEN SKLPKEVTIS 400
YKSYCKNGVN DTQEDGRKCS NISIGDEVRF EINVTANECP KKGQNETIKI 450
KPLGFTEEVE IHLQFICDCL CQSEGEPNSP ACHDGNGTFE CGACRCNEGR 500
IGRLCECSTD EVNSEDMDAY CRRENSTEIC SNNGECICGQ CVCKKRENTN 550
EVYSGKYCEC DNFNCDRSNG LICGGNGICK CRVCECFPNF TGSACDCSLD 600
TTPCMAGNGQ ICNGRGTCEC GTCNCTDPKF QGPTCEMCQT CLGVCAEHKD 650
CVQCRAFEKG EKKETCSQEC MHFNMTRVES RGKLPQPVHP DPLSHCKEKD 700
VGDCWFYFTY SVNSNGEASV HVVETPECPS GPDIIPIVAG VVAGIVLIGL 750
ALLLIWKLLM IIHDRREFAK FEKEKMNAKW DTGENPIYKS AVTTVVNPKY 800
EGK 803
Length:803
Mass (Da):88,554
Last modified:April 1, 1988 - v1
Checksum:i2F6FEFCDF2C80457
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14049 mRNA. Translation: AAA48926.1.
PIRiA23947. IJCH3.
UniGeneiGga.111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14049 mRNA. Translation: AAA48926.1 .
PIRi A23947. IJCH3.
UniGenei Gga.111.

3D structure databases

ProteinModelPortali P07228.
SMRi P07228. Positions 726-802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07228. 3 interactions.
MINTi MINT-197077.
STRINGi 9031.ENSGALP00000011559.

Proteomic databases

PaxDbi P07228.
PRIDEi P07228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG287997.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P07228.
PhylomeDBi P07228.

Miscellaneous databases

NextBioi 20813580.
PROi P07228.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin."
    Tamkun J.W., Desimone D.W., Fonda D., Patel R.S., Buck C., Horwitz A.F., Hynes R.O.
    Cell 46:271-282(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiITB1_CHICK
AccessioniPrimary (citable) accession number: P07228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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