Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07228

- ITB1_CHICK

UniProt

P07228 - ITB1_CHICK

Protein

Integrin beta-1

Gene

ITGB1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi156 – 1561MagnesiumBy similarity
    Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi160 – 1601Calcium 1By similarity
    Metal bindingi161 – 1611Calcium 1By similarity
    Metal bindingi193 – 1931Calcium 2By similarity
    Metal bindingi248 – 2481Calcium 2By similarity
    Metal bindingi250 – 2501Calcium 2By similarity
    Metal bindingi252 – 2521Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi253 – 2531Calcium 2By similarity
    Metal bindingi253 – 2531MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. receptor activity Source: InterPro

    GO - Biological processi

    1. cell-matrix adhesion Source: InterPro
    2. integrin-mediated signaling pathway Source: UniProtKB-KW
    3. multicellular organismal development Source: InterPro

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin beta-1
    Alternative name(s):
    CSAT antigen
    JG22 antigen
    RGD-receptor
    Gene namesi
    Name:ITGB1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Melanosome By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity

    GO - Cellular componenti

    1. integrin complex Source: InterPro
    2. lamellipodium Source: UniProtKB-SubCell
    3. melanosome Source: UniProtKB-SubCell
    4. plasma membrane Source: Reactome
    5. ruffle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 803779Integrin beta-1PRO_0000016337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Blocked amino end (Gln)
    Disulfide bondi31 ↔ 49By similarity
    Disulfide bondi39 ↔ 469By similarity
    Disulfide bondi42 ↔ 79By similarity
    Disulfide bondi52 ↔ 68By similarity
    Disulfide bondi211 ↔ 217By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi265 ↔ 305By similarity
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi405 ↔ 419By similarity
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi439 ↔ 467By similarity
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi471 ↔ 696By similarity
    Disulfide bondi482 ↔ 494By similarity
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi491 ↔ 530By similarity
    Disulfide bondi496 ↔ 505By similarity
    Disulfide bondi507 ↔ 521By similarity
    Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi536 ↔ 541By similarity
    Disulfide bondi538 ↔ 573By similarity
    Disulfide bondi543 ↔ 558By similarity
    Disulfide bondi560 ↔ 565By similarity
    Disulfide bondi579 ↔ 584By similarity
    Disulfide bondi581 ↔ 612By similarity
    Disulfide bondi586 ↔ 595By similarity
    Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi597 ↔ 604By similarity
    Disulfide bondi618 ↔ 623By similarity
    Disulfide bondi620 ↔ 666By similarity
    Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi625 ↔ 635By similarity
    Disulfide bondi638 ↔ 641By similarity
    Disulfide bondi645 ↔ 654By similarity
    Disulfide bondi651 ↔ 728By similarity
    Disulfide bondi670 ↔ 704By similarity
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
    Modified residuei788 – 7881Phosphotyrosine; by Tyr-kinasesSequence Analysis

    Post-translational modificationi

    The cysteine residues are involved in intrachain disulfide bonds.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP07228.
    PRIDEiP07228.

    Expressioni

    Tissue specificityi

    Expressed on surface of embryonic fibroblasts (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACTN1P050944EBI-5606437,EBI-5847257
    FLNAP213332EBI-5606437,EBI-350432From a different organism.

    Protein-protein interaction databases

    IntActiP07228. 3 interactions.
    MINTiMINT-197077.
    STRINGi9031.ENSGALP00000011559.

    Structurei

    3D structure databases

    ProteinModelPortaliP07228.
    SMRiP07228. Positions 726-802.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 733709ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini757 – 80347CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei734 – 75623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini144 – 382239VWFAAdd
    BLAST
    Repeati471 – 52050IAdd
    BLAST
    Repeati521 – 56444IIAdd
    BLAST
    Repeati565 – 60339IIIAdd
    BLAST
    Repeati604 – 64037IVAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni471 – 640170Cysteine-rich tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the integrin beta chain family.Curated
    Contains 1 VWFA domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287997.
    HOGENOMiHOG000252936.
    HOVERGENiHBG006190.
    InParanoidiP07228.
    PhylomeDBiP07228.

    Family and domain databases

    Gene3Di1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProiIPR013111. EGF_extracell.
    IPR027071. Integrin_beta-1.
    IPR015812. Integrin_bsu.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF28. PTHR10082:SF28. 1 hit.
    PfamiPF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002512. Integrin_B. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00022. EGF_1. 2 hits.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07228-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETNLTLLT WAGILCCLIW SGSAQQGGSD CIKANAKSCG ECIQAGPNCG    50
    WCKKTDFLQE GEPTSARCDD LAALKSKGCP EQDIENPRGS KRVLEDREVT 100
    NRKIGAAEKL KPEAITQIQP QKLVLQLRVG EPQTFSLKFK RAEDYPIDLY 150
    YLMDLSYSMK DDLENVKSLG TALMREMEKI TSDFRIGFGS FVEKTVMPYI 200
    STTPAKLRNP CTGDQNCTSP FSYKNVLSLT SEGNKFNELV GKQHISGNLD 250
    SPEGGFDAIM QVAVCGDQIG WRNVTRLLVF STDAGFHFAG DGKLGGIVLP 300
    NDGKCHLENN MYTMSHYYDY PSIAHLVQKL SENNIQTIFA VTEEFQAVYK 350
    ELKNLIPKSA VGTLSSNSSN VIQLIIDAYN SLSSEVILEN SKLPKEVTIS 400
    YKSYCKNGVN DTQEDGRKCS NISIGDEVRF EINVTANECP KKGQNETIKI 450
    KPLGFTEEVE IHLQFICDCL CQSEGEPNSP ACHDGNGTFE CGACRCNEGR 500
    IGRLCECSTD EVNSEDMDAY CRRENSTEIC SNNGECICGQ CVCKKRENTN 550
    EVYSGKYCEC DNFNCDRSNG LICGGNGICK CRVCECFPNF TGSACDCSLD 600
    TTPCMAGNGQ ICNGRGTCEC GTCNCTDPKF QGPTCEMCQT CLGVCAEHKD 650
    CVQCRAFEKG EKKETCSQEC MHFNMTRVES RGKLPQPVHP DPLSHCKEKD 700
    VGDCWFYFTY SVNSNGEASV HVVETPECPS GPDIIPIVAG VVAGIVLIGL 750
    ALLLIWKLLM IIHDRREFAK FEKEKMNAKW DTGENPIYKS AVTTVVNPKY 800
    EGK 803
    Length:803
    Mass (Da):88,554
    Last modified:April 1, 1988 - v1
    Checksum:i2F6FEFCDF2C80457
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14049 mRNA. Translation: AAA48926.1.
    PIRiA23947. IJCH3.
    UniGeneiGga.111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14049 mRNA. Translation: AAA48926.1 .
    PIRi A23947. IJCH3.
    UniGenei Gga.111.

    3D structure databases

    ProteinModelPortali P07228.
    SMRi P07228. Positions 726-802.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P07228. 3 interactions.
    MINTi MINT-197077.
    STRINGi 9031.ENSGALP00000011559.

    Proteomic databases

    PaxDbi P07228.
    PRIDEi P07228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG287997.
    HOGENOMi HOG000252936.
    HOVERGENi HBG006190.
    InParanoidi P07228.
    PhylomeDBi P07228.

    Miscellaneous databases

    NextBioi 20813580.
    PROi P07228.

    Family and domain databases

    Gene3Di 1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProi IPR013111. EGF_extracell.
    IPR027071. Integrin_beta-1.
    IPR015812. Integrin_bsu.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF28. PTHR10082:SF28. 1 hit.
    Pfami PF07974. EGF_2. 1 hit.
    PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002512. Integrin_B. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00022. EGF_1. 2 hits.
    PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin."
      Tamkun J.W., Desimone D.W., Fonda D., Patel R.S., Buck C., Horwitz A.F., Hynes R.O.
      Cell 46:271-282(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiITB1_CHICK
    AccessioniPrimary (citable) accession number: P07228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3