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P07207

- NOTCH_DROME

UniProt

P07207 - NOTCH_DROME

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Protein
Neurogenic locus Notch protein
Gene
N, CG3936
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Essential for proper differentiation of ectoderm. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. Rumi acts in the endoplasmic reticulum to glucosylate the EGF modules in N, this is required for correct folding and cleavage of N.2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. chromatin binding Source: FlyBase
  3. protein binding Source: UniProtKB
  4. receptor activity Source: FlyBase
  5. transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  1. I-kappaB phosphorylation Source: FlyBase
  2. Malpighian tubule tip cell differentiation Source: FlyBase
  3. Notch signaling pathway Source: UniProtKB-KW
  4. R1/R6 cell differentiation Source: FlyBase
  5. R3/R4 cell fate commitment Source: FlyBase
  6. R7 cell differentiation Source: FlyBase
  7. R8 cell development Source: FlyBase
  8. R8 cell differentiation Source: FlyBase
  9. R8 cell fate commitment Source: FlyBase
  10. actin filament organization Source: FlyBase
  11. anterior/posterior pattern specification Source: FlyBase
  12. asymmetric cell division Source: FlyBase
  13. axon guidance Source: FlyBase
  14. border follicle cell migration Source: FlyBase
  15. cell adhesion Source: FlyBase
  16. cell fate specification Source: FlyBase
  17. chaeta development Source: FlyBase
  18. chaeta morphogenesis Source: FlyBase
  19. compound eye cone cell fate commitment Source: FlyBase
  20. compound eye development Source: FlyBase
  21. compound eye morphogenesis Source: FlyBase
  22. compound eye retinal cell programmed cell death Source: FlyBase
  23. crystal cell differentiation Source: FlyBase
  24. determination of adult lifespan Source: FlyBase
  25. dorsal appendage formation Source: FlyBase
  26. dorsal closure Source: FlyBase
  27. dorsal/ventral lineage restriction, imaginal disc Source: FlyBase
  28. dorsal/ventral pattern formation, imaginal disc Source: FlyBase
  29. ectoderm development Source: FlyBase
  30. embryonic crystal cell differentiation Source: FlyBase
  31. embryonic hemopoiesis Source: FlyBase
  32. epithelial cell proliferation involved in Malpighian tubule morphogenesis Source: FlyBase
  33. epithelial cell type specification, open tracheal system Source: FlyBase
  34. establishment of ommatidial planar polarity Source: FlyBase
  35. eye-antennal disc development Source: FlyBase
  36. foregut morphogenesis Source: FlyBase
  37. formation of a compartment boundary Source: FlyBase
  38. germ-line stem cell maintenance Source: FlyBase
  39. germarium-derived egg chamber formation Source: FlyBase
  40. germarium-derived female germ-line cyst encapsulation Source: FlyBase
  41. glial cell differentiation Source: FlyBase
  42. glial cell fate determination Source: FlyBase
  43. glial cell migration Source: FlyBase
  44. hemocyte proliferation Source: FlyBase
  45. heterophilic cell-cell adhesion Source: FlyBase
  46. imaginal disc growth Source: FlyBase
  47. imaginal disc pattern formation Source: FlyBase
  48. imaginal disc-derived leg joint morphogenesis Source: FlyBase
  49. imaginal disc-derived leg segmentation Source: FlyBase
  50. imaginal disc-derived male genitalia morphogenesis Source: FlyBase
  51. imaginal disc-derived wing margin morphogenesis Source: FlyBase
  52. imaginal disc-derived wing morphogenesis Source: FlyBase
  53. imaginal disc-derived wing vein specification Source: FlyBase
  54. intestinal stem cell homeostasis Source: FlyBase
  55. lamellocyte differentiation Source: FlyBase
  56. larval lymph gland hemopoiesis Source: FlyBase
  57. lateral inhibition Source: FlyBase
  58. leg disc morphogenesis Source: FlyBase
  59. long-term memory Source: FlyBase
  60. lymph gland crystal cell differentiation Source: FlyBase
  61. lymph gland development Source: FlyBase
  62. mesoderm development Source: FlyBase
  63. morphogenesis of follicular epithelium Source: FlyBase
  64. motor neuron axon guidance Source: FlyBase
  65. muscle cell fate determination Source: FlyBase
  66. negative regulation of JNK cascade Source: FlyBase
  67. negative regulation of compound eye photoreceptor development Source: FlyBase
  68. negative regulation of fusion cell fate specification Source: FlyBase
  69. negative regulation of gene expression Source: FlyBase
  70. negative regulation of neurogenesis Source: FlyBase
  71. negative regulation of terminal cell fate specification, open tracheal system Source: FlyBase
  72. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  73. neuroblast fate determination Source: FlyBase
  74. neurological system process Source: FlyBase
  75. neuron development Source: FlyBase
  76. oocyte anterior/posterior axis specification Source: FlyBase
  77. oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  78. oogenesis Source: FlyBase
  79. open tracheal system development Source: FlyBase
  80. ovarian follicle cell development Source: FlyBase
  81. ovarian follicle cell migration Source: FlyBase
  82. ovarian follicle cell stalk formation Source: FlyBase
  83. peripheral nervous system development Source: FlyBase
  84. positive regulation of G1/S transition of mitotic cell cycle Source: FlyBase
  85. positive regulation of Notch signaling pathway Source: FlyBase
  86. positive regulation of cell proliferation Source: FlyBase
  87. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  88. regulation of R8 cell spacing in compound eye Source: FlyBase
  89. regulation of cardioblast cell fate specification Source: FlyBase
  90. regulation of cell differentiation Source: FlyBase
  91. regulation of crystal cell differentiation Source: FlyBase
  92. regulation of filopodium assembly Source: FlyBase
  93. regulation of growth Source: FlyBase
  94. regulation of mitotic cell cycle Source: FlyBase
  95. regulation of neurogenesis Source: FlyBase
  96. response to symbiont Source: FlyBase
  97. retinal cell programmed cell death Source: FlyBase
  98. second mitotic wave involved in compound eye morphogenesis Source: FlyBase
  99. sensory organ development Source: FlyBase
  100. skeletal muscle tissue development Source: FlyBase
  101. stem cell differentiation Source: FlyBase
  102. transcription, DNA-templated Source: UniProtKB-KW
  103. ventral cord development Source: FlyBase
  104. wing disc dorsal/ventral pattern formation Source: FlyBase
  105. wing disc pattern formation Source: FlyBase
  106. wing disc proximal/distal pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Neurogenesis, Notch signaling pathway, Oogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_180761. Pre-NOTCH Processing in the Endoplasmic Reticulum.
REACT_180769. Pre-NOTCH Processing in Golgi.
REACT_180784. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_184296. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_184298. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_184380. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
REACT_184382. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_184383. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_212548. Signaling by NOTCH4.
REACT_218930. Signaling by NOTCH3.
REACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinkiP07207.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic locus Notch protein
Cleaved into the following chain:
Gene namesi
Name:N
ORF Names:CG3936
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004647. N.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endosome
Note: Transported to early endosomes by O-fut1.1 Publication
Chain Processed neurogenic locus Notch protein : Nucleus
Note: Upon activation and S3 cleavage, it is released from the cell membrane and enters into the nucleus in conjunction with Su(H).1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini53 – 17451693Extracellular Reviewed prediction
Add
BLAST
Transmembranei1746 – 176621Helical; Reviewed prediction
Add
BLAST
Topological domaini1767 – 2703937Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. adherens junction Source: FlyBase
  3. cell surface Source: FlyBase
  4. cytoplasm Source: FlyBase
  5. cytosol Source: Reactome
  6. endocytic vesicle Source: FlyBase
  7. endoplasmic reticulum lumen Source: Reactome
  8. endosome Source: FlyBase
  9. integral component of membrane Source: FlyBase
  10. intracellular Source: FlyBase
  11. nucleoplasm Source: Reactome
  12. nucleus Source: FlyBase
  13. plasma membrane Source: FlyBase
  14. protein complex Source: FlyBase
  15. subapical complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi739 – 7391C → Y in mcd5; induces loss of microchaetae sensory precursors.
Mutagenesisi2060 – 20601A → V in su42c; deltex-like mutation that induces outstreched wings and variability-fused ocelli.
Mutagenesisi2328 – 23281Y → F: Abolishes interaction with Nedd4 and reduces ubiquitination. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 2703Processed neurogenic locus Notch proteinPRO_0000296234
Signal peptidei1 – 5252 Reviewed prediction
Add
BLAST
Chaini53 – 27032651Neurogenic locus Notch protein
PRO_0000007673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 73 By similarity
Disulfide bondi67 ↔ 83 By similarity
Disulfide bondi85 ↔ 94 By similarity
Disulfide bondi100 ↔ 111 By similarity
Disulfide bondi105 ↔ 124 By similarity
Disulfide bondi126 ↔ 135 By similarity
Disulfide bondi143 ↔ 154 By similarity
Disulfide bondi148 ↔ 164 By similarity
Disulfide bondi166 ↔ 175 By similarity
Disulfide bondi181 ↔ 192 By similarity
Disulfide bondi186 ↔ 203 By similarity
Disulfide bondi205 ↔ 214 By similarity
Disulfide bondi221 ↔ 232 By similarity
Disulfide bondi226 ↔ 241 By similarity
Disulfide bondi243 ↔ 252 By similarity
Disulfide bondi259 ↔ 270 By similarity
Disulfide bondi264 ↔ 279 By similarity
Disulfide bondi281 ↔ 290 By similarity
Disulfide bondi297 ↔ 308 By similarity
Disulfide bondi302 ↔ 317 By similarity
Disulfide bondi319 ↔ 328 By similarity
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi335 ↔ 349 By similarity
Disulfide bondi343 ↔ 358 By similarity
Disulfide bondi360 ↔ 369 By similarity
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi376 ↔ 387 By similarity
Disulfide bondi381 ↔ 396 By similarity
Disulfide bondi398 ↔ 407 By similarity
Disulfide bondi413 ↔ 424 By similarity
Disulfide bondi418 ↔ 435 By similarity
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi437 ↔ 446 By similarity
Disulfide bondi453 ↔ 465 By similarity
Disulfide bondi459 ↔ 474 By similarity
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi476 ↔ 485 By similarity
Disulfide bondi492 ↔ 503 By similarity
Disulfide bondi497 ↔ 512 By similarity
Disulfide bondi514 ↔ 523 By similarity
Disulfide bondi530 ↔ 541 By similarity
Disulfide bondi535 ↔ 550 By similarity
Disulfide bondi552 ↔ 561 By similarity
Disulfide bondi568 ↔ 579 By similarity
Disulfide bondi573 ↔ 588 By similarity
Disulfide bondi590 ↔ 599 By similarity
Disulfide bondi606 ↔ 616 By similarity
Disulfide bondi611 ↔ 625 By similarity
Disulfide bondi627 ↔ 636 By similarity
Disulfide bondi643 ↔ 654 By similarity
Disulfide bondi648 ↔ 663 By similarity
Disulfide bondi665 ↔ 674 By similarity
Disulfide bondi681 ↔ 692 By similarity
Disulfide bondi686 ↔ 701 By similarity
Disulfide bondi703 ↔ 712 By similarity
Disulfide bondi719 ↔ 730 By similarity
Disulfide bondi724 ↔ 739 By similarity
Disulfide bondi741 ↔ 750 By similarity
Disulfide bondi757 ↔ 768 By similarity
Disulfide bondi762 ↔ 777 By similarity
Disulfide bondi779 ↔ 788 By similarity
Disulfide bondi795 ↔ 806 By similarity
Disulfide bondi800 ↔ 815 By similarity
Disulfide bondi817 ↔ 826 By similarity
Disulfide bondi833 ↔ 844 By similarity
Disulfide bondi838 ↔ 853 By similarity
Disulfide bondi855 ↔ 864 By similarity
Disulfide bondi871 ↔ 882 By similarity
Disulfide bondi876 ↔ 893 By similarity
Disulfide bondi895 ↔ 904 By similarity
Disulfide bondi911 ↔ 923 By similarity
Disulfide bondi917 ↔ 932 By similarity
Disulfide bondi934 ↔ 943 By similarity
Disulfide bondi950 ↔ 961 By similarity
Disulfide bondi955 ↔ 970 By similarity
Disulfide bondi972 ↔ 981 By similarity
Disulfide bondi988 ↔ 999 By similarity
Disulfide bondi993 ↔ 1008 By similarity
Disulfide bondi1010 ↔ 1019 By similarity
Disulfide bondi1026 ↔ 1037 By similarity
Disulfide bondi1031 ↔ 1046 By similarity
Glycosylationi1045 – 10451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1048 ↔ 1057 By similarity
Disulfide bondi1064 ↔ 1075 By similarity
Disulfide bondi1069 ↔ 1084 By similarity
Disulfide bondi1086 ↔ 1095 By similarity
Disulfide bondi1102 ↔ 1113 By similarity
Disulfide bondi1107 ↔ 1122 By similarity
Disulfide bondi1124 ↔ 1133 By similarity
Disulfide bondi1140 ↔ 1160 By similarity
Disulfide bondi1155 ↔ 1169 By similarity
Glycosylationi1157 – 11571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1171 ↔ 1180 By similarity
Disulfide bondi1187 ↔ 1198 By similarity
Disulfide bondi1192 ↔ 1207 By similarity
Disulfide bondi1209 ↔ 1218 By similarity
Disulfide bondi1225 ↔ 1236 By similarity
Disulfide bondi1230 ↔ 1245 By similarity
Glycosylationi1242 – 12421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1247 ↔ 1256 By similarity
Disulfide bondi1263 ↔ 1274 By similarity
Disulfide bondi1268 ↔ 1283 By similarity
Glycosylationi1271 – 12711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1285 ↔ 1294 By similarity
Disulfide bondi1301 ↔ 1314 By similarity
Disulfide bondi1306 ↔ 1323 By similarity
Disulfide bondi1325 ↔ 1334 By similarity
Disulfide bondi1341 ↔ 1352 By similarity
Disulfide bondi1346 ↔ 1361 By similarity
Disulfide bondi1363 ↔ 1372 By similarity
Disulfide bondi1379 ↔ 1389 By similarity
Disulfide bondi1384 ↔ 1400 By similarity
Disulfide bondi1402 ↔ 1411 By similarity
Disulfide bondi1419 ↔ 1430 By similarity
Disulfide bondi1424 ↔ 1439 By similarity
Disulfide bondi1441 ↔ 1450 By similarity
Disulfide bondi1482 ↔ 1505 By similarity
Disulfide bondi1487 ↔ 1500 By similarity
Disulfide bondi1496 ↔ 1512 By similarity
Glycosylationi1521 – 15211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1522 ↔ 1545 By similarity
Disulfide bondi1527 ↔ 1540 By similarity
Disulfide bondi1536 ↔ 1552 By similarity
Disulfide bondi1559 ↔ 1585 By similarity
Disulfide bondi1567 ↔ 1580 By similarity
Disulfide bondi1576 ↔ 1592 By similarity
Glycosylationi1594 – 15941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1627 – 16271N-linked (GlcNAc...) Reviewed prediction
Modified residuei2447 – 24471Phosphoserine1 Publication

Post-translational modificationi

Upon binding its ligands such as Delta or Serrate, it is cleaved (S2 cleavage) in its extracellular domain, close to the transmembrane domain. S2 cleavage is probably mediated by Kuz. It is then cleaved (S3 cleavage) downstream of its transmembrane domain, releasing it from the cell membrane. S3 cleavage requires Psn.3 Publications
O-glycosylated. O-fucosylated by O-fut1 in the EGF repeat doamin which inhibits both Serrate/Ser- and Delta/Dl-binding.1 Publication
Ubiquitinated by Nedd4; which promotes ligand-independent endocytosis and proteasomal degradation. May also be ubiquitinated by Su(dx).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP07207.
PRIDEiP07207.

Expressioni

Gene expression databases

BgeeiP07207.

Interactioni

Subunit structurei

Homomer. Interacts with Su(H) when activated. Interacts with Dx via its ANK repeats. Interacts with Dl via the EGF repeats and the Dl EGF repeats. Interacts with Nedd4 and Su(dx). Interacts with O-fut1; the interaction glycosylates N and transports N to early endosomes.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
cnoQ242793EBI-103438,EBI-868783
DlP100412EBI-103438,EBI-115346
Su(H)P281594EBI-103438,EBI-92180

Protein-protein interaction databases

BioGridi57823. 138 interactions.
DIPiDIP-5N.
IntActiP07207. 8 interactions.
MINTiMINT-133064.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1930 – 195021
Helixi1954 – 19607
Helixi1964 – 19729
Helixi1987 – 19937
Helixi1997 – 20048
Helixi2021 – 20277
Helixi2033 – 20397
Helixi2054 – 20607
Helixi2064 – 20729
Helixi2087 – 20937
Helixi2097 – 21059
Helixi2120 – 21267
Helixi2130 – 21367

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OT8X-ray2.00A/B/C1902-2139[»]
2JMFNMR-B2318-2333[»]
ProteinModelPortaliP07207.
SMRiP07207. Positions 46-1452, 1482-1726, 1862-2198.

Miscellaneous databases

EvolutionaryTraceiP07207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 9538EGF-like 1
Add
BLAST
Domaini96 – 13641EGF-like 2
Add
BLAST
Domaini139 – 17638EGF-like 3
Add
BLAST
Domaini177 – 21539EGF-like 4
Add
BLAST
Domaini217 – 25337EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini255 – 29137EGF-like 6
Add
BLAST
Domaini293 – 32937EGF-like 7; calcium-binding Reviewed prediction
Add
BLAST
Domaini331 – 37040EGF-like 8; calcium-binding Reviewed prediction
Add
BLAST
Domaini372 – 40837EGF-like 9; calcium-binding Reviewed prediction
Add
BLAST
Domaini409 – 44739EGF-like 10
Add
BLAST
Domaini449 – 48638EGF-like 11; calcium-binding Reviewed prediction
Add
BLAST
Domaini488 – 52437EGF-like 12; calcium-binding Reviewed prediction
Add
BLAST
Domaini526 – 56237EGF-like 13; calcium-binding Reviewed prediction
Add
BLAST
Domaini564 – 60037EGF-like 14; calcium-binding Reviewed prediction
Add
BLAST
Domaini602 – 63736EGF-like 15; calcium-binding Reviewed prediction
Add
BLAST
Domaini639 – 67537EGF-like 16; calcium-binding Reviewed prediction
Add
BLAST
Domaini677 – 71337EGF-like 17; calcium-binding Reviewed prediction
Add
BLAST
Domaini715 – 75137EGF-like 18; calcium-binding Reviewed prediction
Add
BLAST
Domaini753 – 78937EGF-like 19; calcium-binding Reviewed prediction
Add
BLAST
Domaini791 – 82737EGF-like 20; calcium-binding Reviewed prediction
Add
BLAST
Domaini829 – 86537EGF-like 21; calcium-binding Reviewed prediction
Add
BLAST
Domaini867 – 90539EGF-like 22
Add
BLAST
Domaini907 – 94438EGF-like 23; calcium-binding Reviewed prediction
Add
BLAST
Domaini946 – 98237EGF-like 24; calcium-binding Reviewed prediction
Add
BLAST
Domaini984 – 102037EGF-like 25
Add
BLAST
Domaini1022 – 105837EGF-like 26; calcium-binding Reviewed prediction
Add
BLAST
Domaini1060 – 109637EGF-like 27
Add
BLAST
Domaini1098 – 113437EGF-like 28
Add
BLAST
Domaini1136 – 118146EGF-like 29
Add
BLAST
Domaini1183 – 121937EGF-like 30; calcium-binding Reviewed prediction
Add
BLAST
Domaini1221 – 125737EGF-like 31; calcium-binding Reviewed prediction
Add
BLAST
Domaini1259 – 129537EGF-like 32; calcium-binding Reviewed prediction
Add
BLAST
Domaini1297 – 133539EGF-like 33
Add
BLAST
Domaini1337 – 137337EGF-like 34
Add
BLAST
Domaini1375 – 141238EGF-like 35
Add
BLAST
Domaini1415 – 145137EGF-like 36
Add
BLAST
Repeati1482 – 152140LNR 1
Add
BLAST
Repeati1522 – 155736LNR 2
Add
BLAST
Repeati1559 – 159941LNR 3
Add
BLAST
Repeati1901 – 194545ANK 1
Add
BLAST
Repeati1950 – 197930ANK 2
Add
BLAST
Repeati1983 – 201331ANK 3
Add
BLAST
Repeati2017 – 204630ANK 4
Add
BLAST
Repeati2050 – 207930ANK 5
Add
BLAST
Repeati2083 – 211230ANK 6
Add
BLAST
Repeati2116 – 213924ANK 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2325 – 23284Interaction with Nedd4

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2486 – 249813Poly-Gly
Add
BLAST
Compositional biasi2538 – 256831Poly-Gln (OPA repeat)
Add
BLAST
Compositional biasi2664 – 26674Poly-Ser

Domaini

Crystal structure of the ANK repeat domain shows that there are 7 repeats and the stabilizing C-terminal repeat enhances the protein stability by extending the ankyrin domain.1 Publication

Sequence similaritiesi

Belongs to the NOTCH family.
Contains 7 ANK repeats.
Contains 36 EGF-like domains.

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110611.
InParanoidiP07207.
KOiK02599.
OMAiGHYICSC.
OrthoDBiEOG7992RD.
PhylomeDBiP07207.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF00023. Ank. 5 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 24 hits.
PF07645. EGF_CA. 4 hits.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PIRSFiPIRSF002279. Notch. 1 hit.
PRINTSiPR01452. LNOTCHREPEAT.
SMARTiSM00248. ANK. 7 hits.
SM00181. EGF. 12 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 22 hits.
PS00022. EGF_1. 34 hits.
PS01186. EGF_2. 28 hits.
PS50026. EGF_3. 36 hits.
PS01187. EGF_CA. 21 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07207-1 [UniParc]FASTAAdd to Basket

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MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV     50
RGTDTALVAA SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC 100
NSMRCQNGGT CQVTFRNGRP GISCKCPLGF DESLCEIAVP NACDHVTCLN 150
GGTCQLKTLE EYTCACANGY TGERCETKNL CASSPCRNGA TCTALAGSSS 200
FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ CMCPTGYTGK 250
DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH 300
LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT 350
NTHGSYSCIC VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK 400
GKTGLLCHLD DACTSNPCHA DAICDTSPIN GSYACSCATG YKGVDCSEDI 450
DECDQGSPCE HNGICVNTPG SYRCNCSQGF TGPRCETNIN ECESHPCQNE 500
GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT CHDKINGFKC 550
SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE 600
ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF 650
DGHCQDRVGS YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK 700
CQCVPGFTGQ HCEKNVDECI SSPCANNGVC IDQVNGYKCE CPRGFYDAHC 750
LSDVDECASN PCVNEGRCED GINEFICHCP PGYTGKRCEL DIDECSSNPC 800
QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN GGTCIDKVNG 850
YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT 900
GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC 950
ASFPCQNGGT CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS 1000
QYVNSYTCTC PLGFSGINCQ TNDEDCTESS CLNGGSCIDG INGYNCSCLA 1050
GYSGANCQYK LNKCDSNPCL NGATCHEQNN EYTCHCPSGF TGKQCSEYVD 1100
WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC QDAADRKGLS 1150
LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD 1200
LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG 1250
TMGIICEINK DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE 1300
CLSNPCSNAG TLDCVQLVNN YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG 1350
NCNIRQSGHH CICNNGFYGK NCELSGQDCD SNPCRVGNCV VADEGFGYRC 1400
ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL CPSKWKGKRC 1450
DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC 1500
NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH 1550
DCERKLKSCD SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV 1600
LAEGAMSVVM LMNVEAFREI QAQFLRNMSH MLRTTVRLKK DALGHDIIIN 1650
WKDNVRVPEI EDTDFARKNK ILYTQQVHQT GIQIYLEIDN RKCTECFTHA 1700
VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP ANVKYVITGI 1750
ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM 1800
RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY 1850
ASDHTMVSEY EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP 1900
CGLTPLMIAA VRGGGLDTGE DIENNEDSTA QVISDLLAQG AELNATMDKT 1950
GETSLHLAAR FARADAAKRL LDAGADANCQ DNTGRTPLHA AVAADAMGVF 2000
QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA DADINAADNS 2050
GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC 2100
KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT 2150
PQAMIGSPPP GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA 2200
AKKAKLIEGS PDNGLDATGS LRRKASSKKT SAASKKAANL NGLNPGQLTG 2250
GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH ELEGSPVGVG MGGNLPSPYD 2300
TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS LQGNGLDMIK 2350
LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG 2400
AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT 2450
SPTHIQAMRH ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ 2500
NSPVSLGIIS PTGSDMGIML APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ 2550
HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD LNGFCGSPDS FHSGQMNPPS 2600
IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH TPQHLVQTLD 2650
SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA 2700
IYI 2703
Length:2,703
Mass (Da):288,853
Last modified:November 2, 2001 - v3
Checksum:i0EAE23F426FECD7B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti578 – 5781I → T.
Natural varianti2044 – 20441I → R.
Natural varianti2265 – 22651A → V.
Natural varianti2407 – 24071H → R.
Natural varianti2445 – 24451R → L.
Natural varianti2568 – 25681Q → QQQQQ.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91R → G in CAB37610. 1 Publication
Sequence conflicti84 – 841A → G in CAB37610. 1 Publication
Sequence conflicti103 – 1031M → I in AAB59220. 1 Publication
Sequence conflicti119 – 1191R → H in AAA28725. 1 Publication
Sequence conflicti231 – 2311T → I in AAB59220. 1 Publication
Sequence conflicti240 – 2401Q → R in CAB37610. 1 Publication
Sequence conflicti267 – 2671G → A in AAB59220. 1 Publication
Sequence conflicti1561 – 15611S → T in AAB59220. 1 Publication
Sequence conflicti1561 – 15611S → T in AAA28725. 1 Publication
Sequence conflicti2257 – 22571G → S in AAA28725. 1 Publication
Sequence conflicti2577 – 25771A → E in AAA74496. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16152
, M16153, M16149, M16150, M16151 Genomic DNA. Translation: AAB59220.1.
K03508, M13689, K03507 Genomic DNA. Translation: AAA28725.1.
AE014298 Genomic DNA. Translation: AAF45848.2.
AL035436, AL035395 Genomic DNA. Translation: CAB37610.1.
M16025 Genomic DNA. Translation: AAA28726.1.
M12175 Genomic DNA. Translation: AAA74496.1.
PIRiA24420.
RefSeqiNP_001245510.1. NM_001258581.1.
NP_476859.2. NM_057511.3.
UniGeneiDm.4702.

Genome annotation databases

EnsemblMetazoaiFBtr0070507; FBpp0070483; FBgn0004647.
FBtr0304659; FBpp0293201; FBgn0004647.
GeneIDi31293.
KEGGidme:Dmel_CG3936.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16152
, M16153 , M16149 , M16150 , M16151 Genomic DNA. Translation: AAB59220.1 .
K03508 , M13689 , K03507 Genomic DNA. Translation: AAA28725.1 .
AE014298 Genomic DNA. Translation: AAF45848.2 .
AL035436 , AL035395 Genomic DNA. Translation: CAB37610.1 .
M16025 Genomic DNA. Translation: AAA28726.1 .
M12175 Genomic DNA. Translation: AAA74496.1 .
PIRi A24420.
RefSeqi NP_001245510.1. NM_001258581.1.
NP_476859.2. NM_057511.3.
UniGenei Dm.4702.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OT8 X-ray 2.00 A/B/C 1902-2139 [» ]
2JMF NMR - B 2318-2333 [» ]
ProteinModelPortali P07207.
SMRi P07207. Positions 46-1452, 1482-1726, 1862-2198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 57823. 138 interactions.
DIPi DIP-5N.
IntActi P07207. 8 interactions.
MINTi MINT-133064.

Proteomic databases

PaxDbi P07207.
PRIDEi P07207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0070507 ; FBpp0070483 ; FBgn0004647 .
FBtr0304659 ; FBpp0293201 ; FBgn0004647 .
GeneIDi 31293.
KEGGi dme:Dmel_CG3936.

Organism-specific databases

CTDi 109544.
FlyBasei FBgn0004647. N.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00730000110611.
InParanoidi P07207.
KOi K02599.
OMAi GHYICSC.
OrthoDBi EOG7992RD.
PhylomeDBi P07207.

Enzyme and pathway databases

Reactomei REACT_180761. Pre-NOTCH Processing in the Endoplasmic Reticulum.
REACT_180769. Pre-NOTCH Processing in Golgi.
REACT_180784. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_184296. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_184298. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_184380. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
REACT_184382. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_184383. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_212548. Signaling by NOTCH4.
REACT_218930. Signaling by NOTCH3.
REACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinki P07207.

Miscellaneous databases

EvolutionaryTracei P07207.
GenomeRNAii 31293.
NextBioi 772898.
PROi P07207.

Gene expression databases

Bgeei P07207.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view ]
Pfami PF00023. Ank. 5 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 24 hits.
PF07645. EGF_CA. 4 hits.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view ]
PIRSFi PIRSF002279. Notch. 1 hit.
PRINTSi PR01452. LNOTCHREPEAT.
SMARTi SM00248. ANK. 7 hits.
SM00181. EGF. 12 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 22 hits.
PS00022. EGF_1. 34 hits.
PS01186. EGF_2. 28 hits.
PS50026. EGF_3. 36 hits.
PS01187. EGF_CA. 21 hits.
PS50258. LNR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats."
    Wharton K.A., Johansen K.M., Xu T., Artavanis-Tsakonas S.
    Cell 43:567-581(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors."
    Kidd S., Kelley M.R., Young M.W.
    Mol. Cell. Biol. 6:3094-3108(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S and Oregon-R.
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oregon-R.
  6. "Restriction of P-element insertions at the Notch locus of Drosophila melanogaster."
    Kelley M.R., Kidd S., Berg R.L., Young M.W.
    Mol. Cell. Biol. 7:1545-1548(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
  7. "opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster."
    Wharton K.A., Yedvobnick B., Finnerty V.G., Artavanis-Tsakonas S.
    Cell 40:55-62(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2505-2611.
    Strain: Oregon-R.
    Tissue: Embryo.
  8. "Hypervariability of simple sequences as a general source for polymorphic DNA markers."
    Tautz D.
    Nucleic Acids Res. 17:6463-6471(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2505-2604.
  9. "Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway."
    Diederich R.J., Matsuno K., Hing H., Artavanis-Tsakonas S.
    Development 120:473-481(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DX, MUTANT SU42C.
  10. "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats."
    Matsuno K., Diederich R.J., Go M.J., Blaumueller C.M., Artavanis-Tsakonas S.
    Development 121:2633-2644(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DX.
  11. "Presenilin is required for activity and nuclear access of Notch in Drosophila."
    Struhl G., Greenwald I.
    Nature 398:522-525(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: S3 CLEAVAGE BY PSN.
  12. "Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants."
    Ye Y., Lukinova N., Fortini M.E.
    Nature 398:525-529(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: S3 CLEAVAGE BY PSN.
  13. "Glycosyltransferase activity of Fringe modulates Notch-Delta interactions."
    Bruckner K., Perez L., Clausen H., Cohen S.
    Nature 406:411-415(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DL.
  14. "Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate."
    Ramain P., Khechumian K., Seugnet L., Arbogast N., Ackermann C., Heitzler P.
    Curr. Biol. 11:1729-1738(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTANT MCD5.
  15. "Kuzbanian-mediated cleavage of Drosophila Notch."
    Lieber T., Kidd S., Young M.W.
    Genes Dev. 16:209-221(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: S2 CLEAVAGE BY KUZ.
  16. "General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review."
    Portin P.
    Hereditas 136:89-96(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  17. "Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe."
    Okajima T., Xu A., Irvine K.D.
    J. Biol. Chem. 278:42340-42345(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, LIGAND-BINDING.
  18. "Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation."
    Sakata T., Sakaguchi H., Tsuda L., Higashitani A., Aigaki T., Matsuno K., Hayashi S.
    Curr. Biol. 14:2228-2236(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEDD4, UBIQUITINATION, MUTAGENESIS OF TYR-2328.
  19. "Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins."
    Wilkin M.B., Carbery A.-M., Fostier M., Aslam H., Mazaleyrat S.L., Higgs J., Myat A., Evans D.A.P., Cornell M., Baron M.
    Curr. Biol. 14:2237-2244(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SU(DX).
  20. "The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila."
    Sasamura T., Ishikawa H.O., Sasaki N., Higashi S., Kanai M., Nakao S., Ayukawa T., Aigaki T., Noda K., Miyoshi E., Taniguchi N., Matsuno K.
    Development 134:1347-1356(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH O-FUT1.
  21. "Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling."
    Acar M., Jafar-Nejad H., Takeuchi H., Rajan A., Ibrani D., Rana N.A., Pan H., Haltiwanger R.S., Bellen H.J.
    Cell 132:247-258(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2447, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.
  23. "Structure and stability of the ankyrin domain of the Drosophila Notch receptor."
    Zweifel M.E., Leahy D.J., Hughson F.M., Barrick D.
    Protein Sci. 12:2622-2632(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1901-2139, DOMAIN ANK REPEATS, SUBUNIT.

Entry informationi

Entry nameiNOTCH_DROME
AccessioniPrimary (citable) accession number: P07207
Secondary accession number(s): O97458, P04154, Q9W4T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 2, 2001
Last modified: September 3, 2014
This is version 187 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi