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P07203

- GPX1_HUMAN

UniProt

P07203 - GPX1_HUMAN

Protein

Glutathione peroxidase 1

Gene

GPX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 172 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Protects the hemoglobin in erythrocytes from oxidative breakdown.

    Catalytic activityi

    2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491
    Sitei49 – 491Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity

    GO - Molecular functioni

    1. glutathione binding Source: Ensembl
    2. glutathione peroxidase activity Source: BHF-UCL
    3. phospholipid-hydroperoxide glutathione peroxidase activity Source: Ensembl
    4. selenium binding Source: Ensembl
    5. SH3 domain binding Source: BHF-UCL

    GO - Biological processi

    1. aging Source: Ensembl
    2. angiogenesis involved in wound healing Source: Ensembl
    3. arachidonic acid metabolic process Source: Reactome
    4. blood vessel endothelial cell migration Source: Ensembl
    5. cell redox homeostasis Source: BHF-UCL
    6. endothelial cell development Source: Ensembl
    7. fat cell differentiation Source: Ensembl
    8. glutathione metabolic process Source: BHF-UCL
    9. heart contraction Source: BHF-UCL
    10. hydrogen peroxide catabolic process Source: BHF-UCL
    11. interaction with symbiont Source: Ensembl
    12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
    13. lipoxygenase pathway Source: Reactome
    14. myoblast proliferation Source: Ensembl
    15. negative regulation of apoptotic process Source: Ensembl
    16. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
    17. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    18. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
    19. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    20. negative regulation of release of cytochrome c from mitochondria Source: BHF-UCL
    21. nucleobase-containing small molecule metabolic process Source: Reactome
    22. positive regulation of protein kinase B signaling Source: Ensembl
    23. protein oxidation Source: Ensembl
    24. purine nucleobase metabolic process Source: Reactome
    25. purine nucleotide catabolic process Source: Reactome
    26. regulation of gene expression, epigenetic Source: BHF-UCL
    27. regulation of mammary gland epithelial cell proliferation Source: BHF-UCL
    28. regulation of neuron apoptotic process Source: Ensembl
    29. regulation of proteasomal protein catabolic process Source: BHF-UCL
    30. response to estradiol Source: Ensembl
    31. response to folic acid Source: Ensembl
    32. response to gamma radiation Source: Ensembl
    33. response to glucose Source: Ensembl
    34. response to hydrogen peroxide Source: BHF-UCL
    35. response to lipid hydroperoxide Source: Ensembl
    36. response to nicotine Source: Ensembl
    37. response to selenium ion Source: BHF-UCL
    38. response to symbiotic bacterium Source: Ensembl
    39. response to toxic substance Source: Ensembl
    40. response to xenobiotic stimulus Source: Ensembl
    41. sensory perception of sound Source: Ensembl
    42. skeletal muscle fiber development Source: Ensembl
    43. skeletal muscle tissue regeneration Source: Ensembl
    44. small molecule metabolic process Source: Reactome
    45. temperature homeostasis Source: Ensembl
    46. triglyceride metabolic process Source: Ensembl
    47. UV protection Source: BHF-UCL
    48. vasodilation Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00019-MONOMER.
    ReactomeiREACT_150201. Synthesis of 12-eicosatetraenoic acid derivatives.
    REACT_150209. Synthesis of 5-eicosatetraenoic acids.
    REACT_150422. Synthesis of 15-eicosatetraenoic acid derivatives.
    REACT_172715. Detoxification of Reactive Oxygen Species.
    REACT_2086. Purine catabolism.

    Protein family/group databases

    PeroxiBasei3600. HsGPx01-A.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione peroxidase 1 (EC:1.11.1.9)
    Short name:
    GPx-1
    Short name:
    GSHPx-1
    Alternative name(s):
    Cellular glutathione peroxidase
    Gene namesi
    Name:GPX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4553. GPX1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. mitochondrial matrix Source: Reactome
    5. mitochondrion Source: BHF-UCL
    6. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    MIMi138320. gene+phenotype.
    PharmGKBiPA28949.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Glutathione peroxidase 1PRO_0000066610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei88 – 881N6-acetyllysine; alternateBy similarity
    Modified residuei88 – 881N6-succinyllysine; alternateBy similarity
    Modified residuei114 – 1141N6-acetyllysine; alternateBy similarity
    Modified residuei114 – 1141N6-succinyllysine; alternateBy similarity
    Modified residuei148 – 1481N6-acetyllysine; alternateBy similarity
    Modified residuei148 – 1481N6-succinyllysine; alternateBy similarity

    Post-translational modificationi

    During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP07203.
    PaxDbiP07203.
    PRIDEiP07203.

    2D gel databases

    OGPiP07203.
    SWISS-2DPAGEP07203.

    PTM databases

    PhosphoSiteiP07203.

    Expressioni

    Gene expression databases

    BgeeiP07203.
    CleanExiHS_GPX1.
    GenevestigatoriP07203.

    Organism-specific databases

    HPAiCAB011582.
    HPA044758.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with MIEN1.

    Protein-protein interaction databases

    BioGridi109134. 7 interactions.
    IntActiP07203. 1 interaction.
    STRINGi9606.ENSP00000407375.

    Structurei

    Secondary structure

    1
    203
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 183
    Helixi32 – 354
    Beta strandi38 – 458
    Beta strandi47 – 493
    Helixi52 – 6615
    Helixi67 – 693
    Beta strandi71 – 777
    Turni82 – 854
    Helixi89 – 913
    Helixi92 – 987
    Beta strandi108 – 1125
    Helixi124 – 1329
    Helixi147 – 1493
    Beta strandi152 – 1543
    Beta strandi166 – 1694
    Beta strandi175 – 1795
    Helixi185 – 1884
    Helixi189 – 1968

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2F8AX-ray1.50A/B14-198[»]
    ProteinModelPortaliP07203.
    SMRiP07203. Positions 14-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07203.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG0386.
    HOGENOMiHOG000277055.
    HOVERGENiHBG004333.
    InParanoidiP07203.
    KOiK00432.
    OMAiGHQENTK.
    OrthoDBiEOG7KQ23C.
    PhylomeDBiP07203.
    TreeFamiTF105318.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P07203-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG    50
    TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR 100
    PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI 150
    TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP 200
    SCA 203
    Length:203
    Mass (Da):22,088
    Last modified:November 2, 2010 - v4
    Checksum:i5DB11579C66FE8E5
    GO
    Isoform 2 (identifier: P07203-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-98: ENAKNEEILNSLKY → VRRAERGGAGADVQ
         99-203: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:98
    Mass (Da):10,289
    Checksum:i9AD713E53537E4A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931L → Q in CAA31992. (PubMed:2955287)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51R → P.1 Publication
    Corresponds to variant rs8179169 [ dbSNP | Ensembl ].
    VAR_020912
    Natural varianti7 – 82Missing.4 Publications
    VAR_020913
    Natural varianti8 – 81Missing.3 Publications
    VAR_020914
    Natural varianti194 – 1941A → T.1 Publication
    Corresponds to variant rs6446261 [ dbSNP | Ensembl ].
    VAR_020915
    Natural varianti200 – 2001P → L Frequent polymorphism. 4 Publications
    Corresponds to variant rs1050450 [ dbSNP | Ensembl ].
    VAR_007904

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei85 – 9814ENAKN…NSLKY → VRRAERGGAGADVQ in isoform 2. CuratedVSP_047369Add
    BLAST
    Alternative sequencei99 – 203105Missing in isoform 2. CuratedVSP_047370Add
    BLAST

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei49 – 491Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00433 mRNA. Translation: CAA68491.1.
    Y00483 Genomic DNA. Translation: CAB37833.1.
    X13709 mRNA. Translation: CAA31992.1.
    X13710 mRNA. Translation: CAA31993.1.
    M21304 mRNA. Translation: AAA75389.2.
    M83094 Genomic DNA. Translation: AAA67540.2.
    AY327818 Genomic DNA. Translation: AAP80181.1.
    AC121247 Genomic DNA. No translation available.
    BC000742 mRNA. Translation: AAH00742.3.
    CCDSiCCDS43091.1. [P07203-1]
    CCDS54582.1. [P07203-2]
    PIRiA42152. OPHUE.
    RefSeqiNP_000572.2. NM_000581.2. [P07203-1]
    NP_958799.1. NM_201397.1. [P07203-2]
    UniGeneiHs.76686.

    Genome annotation databases

    EnsembliENST00000419349; ENSP00000391316; ENSG00000233276. [P07203-2]
    ENST00000419783; ENSP00000407375; ENSG00000233276. [P07203-1]
    GeneIDi2876.
    KEGGihsa:2876.
    UCSCiuc021wxw.1. human. [P07203-1]

    Polymorphism databases

    DMDMi311033481.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism, Selenocysteine

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Wikipedia

    Glutathione peroxidase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00433 mRNA. Translation: CAA68491.1 .
    Y00483 Genomic DNA. Translation: CAB37833.1 .
    X13709 mRNA. Translation: CAA31992.1 .
    X13710 mRNA. Translation: CAA31993.1 .
    M21304 mRNA. Translation: AAA75389.2 .
    M83094 Genomic DNA. Translation: AAA67540.2 .
    AY327818 Genomic DNA. Translation: AAP80181.1 .
    AC121247 Genomic DNA. No translation available.
    BC000742 mRNA. Translation: AAH00742.3 .
    CCDSi CCDS43091.1. [P07203-1 ]
    CCDS54582.1. [P07203-2 ]
    PIRi A42152. OPHUE.
    RefSeqi NP_000572.2. NM_000581.2. [P07203-1 ]
    NP_958799.1. NM_201397.1. [P07203-2 ]
    UniGenei Hs.76686.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2F8A X-ray 1.50 A/B 14-198 [» ]
    ProteinModelPortali P07203.
    SMRi P07203. Positions 14-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109134. 7 interactions.
    IntActi P07203. 1 interaction.
    STRINGi 9606.ENSP00000407375.

    Chemistry

    ChEMBLi CHEMBL2163186.
    DrugBanki DB00143. Glutathione.

    Protein family/group databases

    PeroxiBasei 3600. HsGPx01-A.

    PTM databases

    PhosphoSitei P07203.

    Polymorphism databases

    DMDMi 311033481.

    2D gel databases

    OGPi P07203.
    SWISS-2DPAGE P07203.

    Proteomic databases

    MaxQBi P07203.
    PaxDbi P07203.
    PRIDEi P07203.

    Protocols and materials databases

    DNASUi 2876.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000419349 ; ENSP00000391316 ; ENSG00000233276 . [P07203-2 ]
    ENST00000419783 ; ENSP00000407375 ; ENSG00000233276 . [P07203-1 ]
    GeneIDi 2876.
    KEGGi hsa:2876.
    UCSCi uc021wxw.1. human. [P07203-1 ]

    Organism-specific databases

    CTDi 2876.
    GeneCardsi GC03M049369.
    H-InvDB HIX0003298.
    HGNCi HGNC:4553. GPX1.
    HPAi CAB011582.
    HPA044758.
    MIMi 138320. gene+phenotype.
    neXtProti NX_P07203.
    PharmGKBi PA28949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0386.
    HOGENOMi HOG000277055.
    HOVERGENi HBG004333.
    InParanoidi P07203.
    KOi K00432.
    OMAi GHQENTK.
    OrthoDBi EOG7KQ23C.
    PhylomeDBi P07203.
    TreeFami TF105318.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS00019-MONOMER.
    Reactomei REACT_150201. Synthesis of 12-eicosatetraenoic acid derivatives.
    REACT_150209. Synthesis of 5-eicosatetraenoic acids.
    REACT_150422. Synthesis of 15-eicosatetraenoic acid derivatives.
    REACT_172715. Detoxification of Reactive Oxygen Species.
    REACT_2086. Purine catabolism.

    Miscellaneous databases

    ChiTaRSi GPX1. human.
    EvolutionaryTracei P07203.
    GeneWikii GPX1.
    GenomeRNAii 2876.
    NextBioi 11353.
    PROi P07203.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07203.
    CleanExi HS_GPX1.
    Genevestigatori P07203.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence coding for human glutathione peroxidase."
      Sukenaga Y., Ishida K., Takeda T., Takagi K.
      Nucleic Acids Res. 15:7178-7178(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT 7-ALA-ALA-8 DEL.
    2. "Nucleotide sequence of a human gene for glutathione peroxidase."
      Ishida K., Morino T., Takagi K., Sukenaga Y.
      Nucleic Acids Res. 15:10051-10051(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT 7-ALA-ALA-8 DEL.
    3. "Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine."
      Mullenbach G.T., Tabrizi A., Irvine B.D., Bell G.I., Hallewell R.A.
      Nucleic Acids Res. 15:5484-5484(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT 7-ALA-ALA-8 DEL.
      Tissue: Kidney.
    4. "Isolation and chromosomal localization of the human glutathione peroxidase gene."
      Chada S., le Beau M.M., Casey L., Newburger P.E.
      Genomics 6:268-271(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT 7-ALA-ALA-8 DEL.
    5. "Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1)."
      Moscow J.A., Morrow C.S., He R., Mullenbach G.T., Cowan K.H.
      J. Biol. Chem. 267:5949-5958(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ALA-8 DEL.
    6. NIEHS SNPs program
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS PRO-5; THR-194 AND LEU-200.
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 14-198.
    11. "Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1."
      Forsberg L., de Faire U., Morgenstern R.
      Hum. Mutat. 13:294-300(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-200.
    12. "Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer."
      Kote-Jarai Z., Durocher F., Edwards S.M., Hamoudi R., Jackson R.A., Ardern-Jones A., Murkin A., Dearnaley D.P., Kirby R., Houlston R., Easton D.F., Eeles R.
      Prostate Cancer Prostatic Dis. 5:189-192(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-8 DEL AND 7-ALA-ALA-8 DEL.
    13. "Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients."
      Hamanishi T., Furuta H., Kato H., Doi A., Tamai M., Shimomura H., Sakagashira S., Nishi M., Sasaki H., Sanke T., Nanjo K.
      Diabetes 53:2455-2460(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ALA-8 DEL AND LEU-200.
    14. "Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant."
      Ichimura Y., Habuchi T., Tsuchiya N., Wang L., Oyama C., Sato K., Nishiyama H., Ogawa O., Kato T.
      J. Urol. 172:728-732(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-200.

    Entry informationi

    Entry nameiGPX1_HUMAN
    AccessioniPrimary (citable) accession number: P07203
    Secondary accession number(s): E9PAS1, Q7Z5H1, Q9BW12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 172 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3