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Protein

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Catalytic activityi

2 iodide + H2O2 + 2 H+ = 2 iodine + 2 H2O.
[Thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O.
[Thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.
2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O.
[Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei238 – 2381Heme (covalent; via 2 links)By similarity
Active sitei239 – 2391Proton acceptorPROSITE-ProRule annotation
Metal bindingi240 – 2401CalciumPROSITE-ProRule annotation
Metal bindingi321 – 3211CalciumPROSITE-ProRule annotation
Metal bindingi323 – 3231Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi325 – 3251CalciumPROSITE-ProRule annotation
Metal bindingi327 – 3271CalciumPROSITE-ProRule annotation
Sitei396 – 3961Transition state stabilizerPROSITE-ProRule annotation
Binding sitei399 – 3991Heme (covalent; via 2 links)By similarity
Metal bindingi494 – 4941Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide, Thyroid hormones biosynthesis

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.52. 2681.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.
UniPathwayiUPA00194.

Protein family/group databases

PeroxiBasei3318. HsTPO01.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid peroxidase (EC:1.11.1.8)
Short name:
TPO
Gene namesi
Name:TPO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12015. TPO.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 846828ExtracellularSequence analysisAdd
BLAST
Transmembranei847 – 87125HelicalSequence analysisAdd
BLAST
Topological domaini872 – 93362CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • mitochondrion Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.

Thyroid dyshormonogenesis 2A (TDH2A)16 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
See also OMIM:274500
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → P in TDH2A. 1 Publication
VAR_021622
Natural varianti240 – 2401D → N in TDH2A; loss of activity. 1 Publication
VAR_021623
Natural varianti307 – 3071N → T in TDH2A. 1 Publication
VAR_021624
Natural varianti326 – 3261A → T in TDH2A. 1 Publication
Corresponds to variant rs371367459 [ dbSNP | Ensembl ].
VAR_021625
Natural varianti378 – 3781E → K in TDH2A. 1 Publication
VAR_025784
Natural varianti433 – 4331V → M in TDH2A. 1 Publication
VAR_021626
Natural varianti447 – 4471I → F in TDH2A. 2 Publications
Corresponds to variant rs104893669 [ dbSNP | Ensembl ].
VAR_015375
Natural varianti453 – 4531Y → D in TDH2A. 3 Publications
Corresponds to variant rs121908083 [ dbSNP | Ensembl ].
VAR_006060
Natural varianti458 – 4581L → P in TDH2A. 1 Publication
VAR_021627
Natural varianti491 – 4911R → H in TDH2A. 1 Publication
Corresponds to variant rs201165648 [ dbSNP | Ensembl ].
VAR_021628
Natural varianti493 – 4931G → S in TDH2A. 1 Publication
Corresponds to variant rs778515113 [ dbSNP | Ensembl ].
VAR_021629
Natural varianti499 – 4991P → L in TDH2A. 1 Publication
VAR_021630
Natural varianti527 – 5271W → C in TDH2A. 1 Publication
Corresponds to variant rs779434941 [ dbSNP | Ensembl ].
VAR_021631
Natural varianti533 – 5331G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication
VAR_027229
Natural varianti574 – 5752Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme.
VAR_027230
Natural varianti590 – 5901G → S in TDH2A. 1 Publication
Corresponds to variant rs121908084 [ dbSNP | Ensembl ].
VAR_027231
Natural varianti648 – 6481R → Q in TDH2A. 1 Publication
Corresponds to variant rs121908086 [ dbSNP | Ensembl ].
VAR_013138
Natural varianti660 – 6601Q → E in TDH2A. 1 Publication
Corresponds to variant rs121908088 [ dbSNP | Ensembl ].
VAR_021632
Natural varianti665 – 6651R → W in TDH2A; fails to localize to the plasma membrane. 1 Publication
Corresponds to variant rs776742629 [ dbSNP | Ensembl ].
VAR_021633
Natural varianti693 – 6931R → W in TDH2A. 2 Publications
Corresponds to variant rs121908087 [ dbSNP | Ensembl ].
VAR_021634
Natural varianti771 – 7711G → R in TDH2A; fails to localize to the plasma membrane. 1 Publication
Corresponds to variant rs138931129 [ dbSNP | Ensembl ].
VAR_021635
Natural varianti796 – 7961D → Y in TDH2A. 1 Publication
VAR_021636
Natural varianti799 – 7991E → K in TDH2A. 3 Publications
Corresponds to variant rs121908085 [ dbSNP | Ensembl ].
VAR_006062
Natural varianti808 – 8081C → R in TDH2A. 1 Publication
VAR_021637
Natural varianti839 – 8391V → I in TDH2A. 1 Publication
Corresponds to variant rs146351101 [ dbSNP | Ensembl ].
VAR_027235

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

MalaCardsiTPO.
MIMi274500. phenotype.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA36694.

Protein family/group databases

Allergomei9554. Hom s TPO.

Chemistry

ChEMBLiCHEMBL1839.
DrugBankiDB00389. Carbimazole.
DB00509. Dextrothyroxine.
DB00763. Methimazole.
DB00550. Propylthiouracil.

Polymorphism and mutation databases

BioMutaiTPO.
DMDMi160281455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 933915Thyroid peroxidasePRO_0000023662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi142 ↔ 158By similarity
Disulfide bondi259 ↔ 269By similarity
Disulfide bondi263 ↔ 286By similarity
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi598 ↔ 655By similarity
Disulfide bondi696 ↔ 721By similarity
Disulfide bondi800 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Disulfide bondi825 ↔ 838By similarity

Post-translational modificationi

Glycosylated.
Heme is covalently bound through a H2O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07202.
PeptideAtlasiP07202.
PRIDEiP07202.

PTM databases

iPTMnetiP07202.
PhosphoSiteiP07202.

Expressioni

Gene expression databases

BgeeiENSG00000115705.
ExpressionAtlasiP07202. baseline and differential.
GenevisibleiP07202. HS.

Organism-specific databases

HPAiCAB009587.
HPA007987.

Interactioni

Subunit structurei

Interacts with DUOX1, DUOX2 and CYBA.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000318820.

Structurei

3D structure databases

ProteinModelPortaliP07202.
SMRiP07202. Positions 149-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini740 – 79556SushiPROSITE-ProRule annotationAdd
BLAST
Domaini796 – 83944EGF-like; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
GeneTreeiENSGT00550000074325.
HOVERGENiHBG000071.
InParanoidiP07202.
KOiK00431.
OMAiCDSIPGM.
OrthoDBiEOG091G0236.
PhylomeDBiP07202.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP_dom.
IPR029589. TPO.
[Graphical view]
PANTHERiPTHR11475:SF60. PTHR11475:SF60. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P07202-1) [UniParc]FASTAAdd to basket
Also known as: TPO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,963
Last modified:November 13, 2007 - v4
Checksum:iF67C5F1A4AEE0B29
GO
Isoform 2 (identifier: P07202-2) [UniParc]FASTAAdd to basket
Also known as: TPO2

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.

Note: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive.
Show »
Length:876
Mass (Da):96,699
Checksum:iF4CF0D050608F808
GO
Isoform 3 (identifier: P07202-3) [UniParc]FASTAAdd to basket
Also known as: TPO3, Graves' disease, TPOzaninelli

The sequence of this isoform differs from the canonical sequence as follows:
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active.
Show »
Length:929
Mass (Da):102,771
Checksum:i423AC29EEB27277B
GO
Isoform 4 (identifier: P07202-4) [UniParc]FASTAAdd to basket
Also known as: TPO4

The sequence of this isoform differs from the canonical sequence as follows:
     796-839: Missing.

Note: Lacks exon 14. Active.
Show »
Length:889
Mass (Da):98,327
Checksum:iF9C575FC93A450C8
GO
Isoform 5 (identifier: P07202-5) [UniParc]FASTAAdd to basket
Also known as: TPO5

The sequence of this isoform differs from the canonical sequence as follows:
     274-446: Missing.

Note: Lacks exon 8. Does not fold correctly. Does not reach the cell surface.
Show »
Length:760
Mass (Da):84,581
Checksum:i3C6150EA7E602B78
GO
Isoform 6 (identifier: P07202-6) [UniParc]FASTAAdd to basket
Also known as: TPO6

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     669-933: Missing.

Note: Lacks exons 10, 12, 13, 14 and 16.
Show »
Length:611
Mass (Da):67,293
Checksum:i7AD0B6FA3206066A
GO
Isoform 2-3 (identifier: P07202-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exons 10 and 16.
Show »
Length:872
Mass (Da):96,507
Checksum:i3EDC31BFE86C24E2
GO
Isoform 2-4 (identifier: P07202-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     796-839: Missing.

Note: Lacks exons 10 and 14.
Show »
Length:832
Mass (Da):92,063
Checksum:i7C6D17A3B62C1D7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701P → G in AAA61217 (Ref. 5) Curated
Sequence conflicti354 – 3541A → G (Ref. 5) Curated
Sequence conflicti354 – 3541A → G (PubMed:3654979).Curated
Sequence conflicti371 – 3711A → R in AAA61215 (PubMed:3475693).Curated
Sequence conflicti371 – 3711A → R in AAA61216 (PubMed:3475693).Curated
Sequence conflicti381 – 3811I → N (Ref. 5) Curated
Sequence conflicti381 – 3811I → N (PubMed:3654979).Curated
Sequence conflicti574 – 5741D → N in CAA68467 (PubMed:3453124).Curated
Sequence conflicti732 – 7321W → C in AAN11302 (PubMed:12454013).Curated
Sequence conflicti748 – 7481V → M (PubMed:3453124).Curated
Sequence conflicti748 – 7481V → M (PubMed:12454013).Curated
Sequence conflicti816 – 8161N → S in AAL74416 (Ref. 6) Curated
Sequence conflicti872 – 8721R → K (PubMed:3453124).Curated
Sequence conflicti872 – 8721R → K (PubMed:12454013).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → P in TDH2A. 1 Publication
VAR_021622
Natural varianti240 – 2401D → N in TDH2A; loss of activity. 1 Publication
VAR_021623
Natural varianti257 – 2571A → S.3 Publications
Corresponds to variant rs4927611 [ dbSNP | Ensembl ].
VAR_006057
Natural varianti307 – 3071N → T in TDH2A. 1 Publication
VAR_021624
Natural varianti326 – 3261A → T in TDH2A. 1 Publication
Corresponds to variant rs371367459 [ dbSNP | Ensembl ].
VAR_021625
Natural varianti373 – 3731A → S.1 Publication
Corresponds to variant rs2280132 [ dbSNP | Ensembl ].
VAR_006058
Natural varianti378 – 3781E → K in TDH2A. 1 Publication
VAR_025784
Natural varianti398 – 3981S → T.1 Publication
Corresponds to variant rs2175977 [ dbSNP | Ensembl ].
VAR_006059
Natural varianti433 – 4331V → M in TDH2A. 1 Publication
VAR_021626
Natural varianti447 – 4471I → F in TDH2A. 2 Publications
Corresponds to variant rs104893669 [ dbSNP | Ensembl ].
VAR_015375
Natural varianti453 – 4531Y → D in TDH2A. 3 Publications
Corresponds to variant rs121908083 [ dbSNP | Ensembl ].
VAR_006060
Natural varianti458 – 4581L → P in TDH2A. 1 Publication
VAR_021627
Natural varianti491 – 4911R → H in TDH2A. 1 Publication
Corresponds to variant rs201165648 [ dbSNP | Ensembl ].
VAR_021628
Natural varianti493 – 4931G → S in TDH2A. 1 Publication
Corresponds to variant rs778515113 [ dbSNP | Ensembl ].
VAR_021629
Natural varianti499 – 4991P → L in TDH2A. 1 Publication
VAR_021630
Natural varianti527 – 5271W → C in TDH2A. 1 Publication
Corresponds to variant rs779434941 [ dbSNP | Ensembl ].
VAR_021631
Natural varianti533 – 5331G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication
VAR_027229
Natural varianti574 – 5752Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme.
VAR_027230
Natural varianti590 – 5901G → S in TDH2A. 1 Publication
Corresponds to variant rs121908084 [ dbSNP | Ensembl ].
VAR_027231
Natural varianti618 – 6181V → M.
Corresponds to variant rs10189135 [ dbSNP | Ensembl ].
VAR_027232
Natural varianti648 – 6481R → Q in TDH2A. 1 Publication
Corresponds to variant rs121908086 [ dbSNP | Ensembl ].
VAR_013138
Natural varianti660 – 6601Q → E in TDH2A. 1 Publication
Corresponds to variant rs121908088 [ dbSNP | Ensembl ].
VAR_021632
Natural varianti665 – 6651R → W in TDH2A; fails to localize to the plasma membrane. 1 Publication
Corresponds to variant rs776742629 [ dbSNP | Ensembl ].
VAR_021633
Natural varianti693 – 6931R → W in TDH2A. 2 Publications
Corresponds to variant rs121908087 [ dbSNP | Ensembl ].
VAR_021634
Natural varianti706 – 7061M → V.
Corresponds to variant rs13431173 [ dbSNP | Ensembl ].
VAR_027233
Natural varianti725 – 7251T → P.5 Publications
Corresponds to variant rs732609 [ dbSNP | Ensembl ].
VAR_006061
Natural varianti771 – 7711G → R in TDH2A; fails to localize to the plasma membrane. 1 Publication
Corresponds to variant rs138931129 [ dbSNP | Ensembl ].
VAR_021635
Natural varianti793 – 7931L → P.
Corresponds to variant rs28991293 [ dbSNP | Ensembl ].
VAR_027234
Natural varianti796 – 7961D → Y in TDH2A. 1 Publication
VAR_021636
Natural varianti799 – 7991E → K in TDH2A. 3 Publications
Corresponds to variant rs121908085 [ dbSNP | Ensembl ].
VAR_006062
Natural varianti808 – 8081C → R in TDH2A. 1 Publication
VAR_021637
Natural varianti839 – 8391V → I in TDH2A. 1 Publication
Corresponds to variant rs146351101 [ dbSNP | Ensembl ].
VAR_027235
Natural varianti846 – 8461R → W.
Corresponds to variant rs28913014 [ dbSNP | Ensembl ].
VAR_027236
Natural varianti847 – 8471V → A.4 Publications
Corresponds to variant rs1126799 [ dbSNP | Ensembl ].
VAR_027237

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei274 – 446173Missing in isoform 5. 1 PublicationVSP_007268Add
BLAST
Alternative sequencei534 – 59057Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsVSP_004665Add
BLAST
Alternative sequencei669 – 933265Missing in isoform 6. CuratedVSP_007270Add
BLAST
Alternative sequencei796 – 83944Missing in isoform 4 and isoform 2-4. CuratedVSP_007269Add
BLAST
Alternative sequencei874 – 93360TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationVSP_004666Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1.
J02970 mRNA. Translation: AAA61216.1.
Y00406 mRNA. Translation: CAA68467.1.
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA. Translation: AAA97517.1.
X17358 mRNA. Translation: CAA35235.1.
M17755 mRNA. Translation: AAA61217.2.
AF439430 mRNA. Translation: AAL74416.1.
AF533528 mRNA. Translation: AAN04471.1.
AY136822 mRNA. Translation: AAN11302.1.
AF533529 mRNA. Translation: AAN04472.1.
AF533530 mRNA. Translation: AAN04473.1.
AF533531 mRNA. Translation: AAN04474.1.
M55702 mRNA. Translation: AAA61219.1.
M55702 mRNA. Translation: AAA61218.1.
CCDSiCCDS1643.1. [P07202-1]
CCDS1644.1. [P07202-2]
CCDS1646.1. [P07202-5]
PIRiA32413. OPHUIT.
RefSeqiNP_000538.3. NM_000547.5. [P07202-1]
NP_001193673.1. NM_001206744.1. [P07202-1]
NP_001193674.1. NM_001206745.1. [P07202-2]
NP_783650.1. NM_175719.3. [P07202-2]
NP_783652.1. NM_175721.3. [P07202-4]
NP_783653.1. NM_175722.3. [P07202-5]
XP_011508683.1. XM_011510381.2. [P07202-8]
UniGeneiHs.467554.

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705. [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705. [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705. [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705. [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705. [P07202-2]
GeneIDi7173.
KEGGihsa:7173.
UCSCiuc002qwr.4. human. [P07202-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Thyroid peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1.
J02970 mRNA. Translation: AAA61216.1.
Y00406 mRNA. Translation: CAA68467.1.
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA. Translation: AAA97517.1.
X17358 mRNA. Translation: CAA35235.1.
M17755 mRNA. Translation: AAA61217.2.
AF439430 mRNA. Translation: AAL74416.1.
AF533528 mRNA. Translation: AAN04471.1.
AY136822 mRNA. Translation: AAN11302.1.
AF533529 mRNA. Translation: AAN04472.1.
AF533530 mRNA. Translation: AAN04473.1.
AF533531 mRNA. Translation: AAN04474.1.
M55702 mRNA. Translation: AAA61219.1.
M55702 mRNA. Translation: AAA61218.1.
CCDSiCCDS1643.1. [P07202-1]
CCDS1644.1. [P07202-2]
CCDS1646.1. [P07202-5]
PIRiA32413. OPHUIT.
RefSeqiNP_000538.3. NM_000547.5. [P07202-1]
NP_001193673.1. NM_001206744.1. [P07202-1]
NP_001193674.1. NM_001206745.1. [P07202-2]
NP_783650.1. NM_175719.3. [P07202-2]
NP_783652.1. NM_175721.3. [P07202-4]
NP_783653.1. NM_175722.3. [P07202-5]
XP_011508683.1. XM_011510381.2. [P07202-8]
UniGeneiHs.467554.

3D structure databases

ProteinModelPortaliP07202.
SMRiP07202. Positions 149-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318820.

Chemistry

ChEMBLiCHEMBL1839.
DrugBankiDB00389. Carbimazole.
DB00509. Dextrothyroxine.
DB00763. Methimazole.
DB00550. Propylthiouracil.

Protein family/group databases

Allergomei9554. Hom s TPO.
PeroxiBasei3318. HsTPO01.

PTM databases

iPTMnetiP07202.
PhosphoSiteiP07202.

Polymorphism and mutation databases

BioMutaiTPO.
DMDMi160281455.

Proteomic databases

PaxDbiP07202.
PeptideAtlasiP07202.
PRIDEiP07202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705. [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705. [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705. [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705. [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705. [P07202-2]
GeneIDi7173.
KEGGihsa:7173.
UCSCiuc002qwr.4. human. [P07202-1]

Organism-specific databases

CTDi7173.
GeneCardsiTPO.
H-InvDBHIX0029848.
HGNCiHGNC:12015. TPO.
HPAiCAB009587.
HPA007987.
MalaCardsiTPO.
MIMi274500. phenotype.
606765. gene.
neXtProtiNX_P07202.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA36694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
GeneTreeiENSGT00550000074325.
HOVERGENiHBG000071.
InParanoidiP07202.
KOiK00431.
OMAiCDSIPGM.
OrthoDBiEOG091G0236.
PhylomeDBiP07202.
TreeFamiTF314316.

Enzyme and pathway databases

UniPathwayiUPA00194.
BRENDAi3.6.1.52. 2681.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.

Miscellaneous databases

ChiTaRSiTPO. human.
GenomeRNAii7173.
PROiP07202.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115705.
ExpressionAtlasiP07202. baseline and differential.
GenevisibleiP07202. HS.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP_dom.
IPR029589. TPO.
[Graphical view]
PANTHERiPTHR11475:SF60. PTHR11475:SF60. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPERT_HUMAN
AccessioniPrimary (citable) accession number: P07202
Secondary accession number(s): P09934
, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 209 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.