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Protein

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.By similarity

Catalytic activityi

2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O.By similarity
[Thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O.By similarity
[Thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.By similarity
2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O.By similarity
[Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei238Heme (covalent; via 2 links)By similarity1
Active sitei239Proton acceptorPROSITE-ProRule annotation1
Metal bindingi240CalciumPROSITE-ProRule annotation1
Metal bindingi321CalciumPROSITE-ProRule annotation1
Metal bindingi323Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi325CalciumPROSITE-ProRule annotation1
Metal bindingi327CalciumPROSITE-ProRule annotation1
Sitei396Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei399Heme (covalent; via 2 links)By similarity1
Metal bindingi494Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide, Thyroid hormones biosynthesis

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS03930-MONOMER.
BRENDAi3.6.1.52. 2681.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.
UniPathwayiUPA00194.

Protein family/group databases

PeroxiBasei3318. HsTPO01.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid peroxidase (EC:1.11.1.8By similarity)
Short name:
TPO
Gene namesi
Name:TPO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12015. TPO.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 846ExtracellularSequence analysisAdd BLAST828
Transmembranei847 – 871HelicalSequence analysisAdd BLAST25
Topological domaini872 – 933CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • mitochondrion Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.

Thyroid dyshormonogenesis 2A (TDH2A)16 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
See also OMIM:274500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 Publication1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant rs371367459dbSNPEnsembl.1
Natural variantiVAR_025784378E → K in TDH2A. 1 Publication1
Natural variantiVAR_021626433V → M in TDH2A. 1 Publication1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant rs104893669dbSNPEnsembl.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant rs121908083dbSNPEnsembl.1
Natural variantiVAR_021627458L → P in TDH2A. 1 Publication1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant rs201165648dbSNPEnsembl.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant rs778515113dbSNPEnsembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 Publication1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant rs779434941dbSNPEnsembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant rs121908084dbSNPEnsembl.1
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant rs121908086dbSNPEnsembl.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant rs121908088dbSNPEnsembl.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant rs776742629dbSNPEnsembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant rs121908087dbSNPEnsembl.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant rs138931129dbSNPEnsembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant rs121908085dbSNPEnsembl.1
Natural variantiVAR_021637808C → R in TDH2A. 1 Publication1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant rs146351101dbSNPEnsembl.1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi7173.
MalaCardsiTPO.
MIMi274500. phenotype.
OpenTargetsiENSG00000115705.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA36694.

Protein family/group databases

Allergomei9554. Hom s TPO.

Chemistry databases

ChEMBLiCHEMBL1839.
DrugBankiDB00389. Carbimazole.
DB00509. Dextrothyroxine.
DB00763. Methimazole.
DB00550. Propylthiouracil.

Polymorphism and mutation databases

BioMutaiTPO.
DMDMi160281455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002366219 – 933Thyroid peroxidaseAdd BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi142 ↔ 158By similarity
Disulfide bondi259 ↔ 269By similarity
Disulfide bondi263 ↔ 286By similarity
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi569N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi598 ↔ 655By similarity
Disulfide bondi696 ↔ 721By similarity
Disulfide bondi800 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Disulfide bondi825 ↔ 838By similarity

Post-translational modificationi

Glycosylated.
Heme is covalently bound through a H2O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07202.
PeptideAtlasiP07202.
PRIDEiP07202.

PTM databases

iPTMnetiP07202.
PhosphoSitePlusiP07202.

Expressioni

Gene expression databases

BgeeiENSG00000115705.
ExpressionAtlasiP07202. baseline and differential.
GenevisibleiP07202. HS.

Organism-specific databases

HPAiCAB009587.
HPA007987.

Interactioni

Subunit structurei

Interacts with DUOX1, DUOX2 and CYBA.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000318820.

Structurei

3D structure databases

ProteinModelPortaliP07202.
SMRiP07202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini740 – 795SushiPROSITE-ProRule annotationAdd BLAST56
Domaini796 – 839EGF-like; calcium-bindingPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
GeneTreeiENSGT00550000074325.
HOVERGENiHBG000071.
InParanoidiP07202.
KOiK00431.
OMAiCDSIPGM.
OrthoDBiEOG091G0236.
PhylomeDBiP07202.
TreeFamiTF314316.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di1.10.640.10. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP_dom.
IPR029589. TPO.
[Graphical view]
PANTHERiPTHR11475:SF60. PTHR11475:SF60. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P07202-1) [UniParc]FASTAAdd to basket
Also known as: TPO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,963
Last modified:November 13, 2007 - v4
Checksum:iF67C5F1A4AEE0B29
GO
Isoform 2 (identifier: P07202-2) [UniParc]FASTAAdd to basket
Also known as: TPO2

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.

Note: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive.
Show »
Length:876
Mass (Da):96,699
Checksum:iF4CF0D050608F808
GO
Isoform 3 (identifier: P07202-3) [UniParc]FASTAAdd to basket
Also known as: TPO3, Graves' disease, TPOzaninelli

The sequence of this isoform differs from the canonical sequence as follows:
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active.
Show »
Length:929
Mass (Da):102,771
Checksum:i423AC29EEB27277B
GO
Isoform 4 (identifier: P07202-4) [UniParc]FASTAAdd to basket
Also known as: TPO4

The sequence of this isoform differs from the canonical sequence as follows:
     796-839: Missing.

Note: Lacks exon 14. Active.
Show »
Length:889
Mass (Da):98,327
Checksum:iF9C575FC93A450C8
GO
Isoform 5 (identifier: P07202-5) [UniParc]FASTAAdd to basket
Also known as: TPO5

The sequence of this isoform differs from the canonical sequence as follows:
     274-446: Missing.

Note: Lacks exon 8. Does not fold correctly. Does not reach the cell surface.
Show »
Length:760
Mass (Da):84,581
Checksum:i3C6150EA7E602B78
GO
Isoform 6 (identifier: P07202-6) [UniParc]FASTAAdd to basket
Also known as: TPO6

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     669-933: Missing.

Note: Lacks exons 10, 12, 13, 14 and 16.
Show »
Length:611
Mass (Da):67,293
Checksum:i7AD0B6FA3206066A
GO
Isoform 2-3 (identifier: P07202-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exons 10 and 16.
Show »
Length:872
Mass (Da):96,507
Checksum:i3EDC31BFE86C24E2
GO
Isoform 2-4 (identifier: P07202-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     796-839: Missing.

Note: Lacks exons 10 and 14.
Show »
Length:832
Mass (Da):92,063
Checksum:i7C6D17A3B62C1D7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70P → G in AAA61217 (Ref. 5) Curated1
Sequence conflicti354A → G (Ref. 5) Curated1
Sequence conflicti354A → G (PubMed:3654979).Curated1
Sequence conflicti371A → R in AAA61215 (PubMed:3475693).Curated1
Sequence conflicti371A → R in AAA61216 (PubMed:3475693).Curated1
Sequence conflicti381I → N (Ref. 5) Curated1
Sequence conflicti381I → N (PubMed:3654979).Curated1
Sequence conflicti574D → N in CAA68467 (PubMed:3453124).Curated1
Sequence conflicti732W → C in AAN11302 (PubMed:12454013).Curated1
Sequence conflicti748V → M (PubMed:3453124).Curated1
Sequence conflicti748V → M (PubMed:12454013).Curated1
Sequence conflicti816N → S in AAL74416 (Ref. 6) Curated1
Sequence conflicti872R → K (PubMed:3453124).Curated1
Sequence conflicti872R → K (PubMed:12454013).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 Publication1
Natural variantiVAR_006057257A → S.3 PublicationsCorresponds to variant rs4927611dbSNPEnsembl.1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant rs371367459dbSNPEnsembl.1
Natural variantiVAR_006058373A → S.1 PublicationCorresponds to variant rs2280132dbSNPEnsembl.1
Natural variantiVAR_025784378E → K in TDH2A. 1 Publication1
Natural variantiVAR_006059398S → T.1 PublicationCorresponds to variant rs2175977dbSNPEnsembl.1
Natural variantiVAR_021626433V → M in TDH2A. 1 Publication1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant rs104893669dbSNPEnsembl.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant rs121908083dbSNPEnsembl.1
Natural variantiVAR_021627458L → P in TDH2A. 1 Publication1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant rs201165648dbSNPEnsembl.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant rs778515113dbSNPEnsembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 Publication1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant rs779434941dbSNPEnsembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant rs121908084dbSNPEnsembl.1
Natural variantiVAR_027232618V → M.Corresponds to variant rs10189135dbSNPEnsembl.1
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant rs121908086dbSNPEnsembl.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant rs121908088dbSNPEnsembl.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant rs776742629dbSNPEnsembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant rs121908087dbSNPEnsembl.1
Natural variantiVAR_027233706M → V.Corresponds to variant rs13431173dbSNPEnsembl.1
Natural variantiVAR_006061725T → P.5 PublicationsCorresponds to variant rs732609dbSNPEnsembl.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant rs138931129dbSNPEnsembl.1
Natural variantiVAR_027234793L → P.Corresponds to variant rs28991293dbSNPEnsembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant rs121908085dbSNPEnsembl.1
Natural variantiVAR_021637808C → R in TDH2A. 1 Publication1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant rs146351101dbSNPEnsembl.1
Natural variantiVAR_027236846R → W.Corresponds to variant rs28913014dbSNPEnsembl.1
Natural variantiVAR_027237847V → A.4 PublicationsCorresponds to variant rs1126799dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007268274 – 446Missing in isoform 5. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_004665534 – 590Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_007270669 – 933Missing in isoform 6. CuratedAdd BLAST265
Alternative sequenceiVSP_007269796 – 839Missing in isoform 4 and isoform 2-4. CuratedAdd BLAST44
Alternative sequenceiVSP_004666874 – 933TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1.
J02970 mRNA. Translation: AAA61216.1.
Y00406 mRNA. Translation: CAA68467.1.
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA. Translation: AAA97517.1.
X17358 mRNA. Translation: CAA35235.1.
M17755 mRNA. Translation: AAA61217.2.
AF439430 mRNA. Translation: AAL74416.1.
AF533528 mRNA. Translation: AAN04471.1.
AY136822 mRNA. Translation: AAN11302.1.
AF533529 mRNA. Translation: AAN04472.1.
AF533530 mRNA. Translation: AAN04473.1.
AF533531 mRNA. Translation: AAN04474.1.
M55702 mRNA. Translation: AAA61219.1.
M55702 mRNA. Translation: AAA61218.1.
CCDSiCCDS1643.1. [P07202-1]
CCDS1644.1. [P07202-2]
CCDS1646.1. [P07202-5]
PIRiA32413. OPHUIT.
RefSeqiNP_000538.3. NM_000547.5. [P07202-1]
NP_001193673.1. NM_001206744.1. [P07202-1]
NP_001193674.1. NM_001206745.1. [P07202-2]
NP_783650.1. NM_175719.3. [P07202-2]
NP_783652.1. NM_175721.3. [P07202-4]
NP_783653.1. NM_175722.3. [P07202-5]
XP_011508683.1. XM_011510381.2. [P07202-8]
UniGeneiHs.467554.

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705. [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705. [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705. [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705. [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705. [P07202-2]
GeneIDi7173.
KEGGihsa:7173.
UCSCiuc002qwr.4. human. [P07202-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Thyroid peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1.
J02970 mRNA. Translation: AAA61216.1.
Y00406 mRNA. Translation: CAA68467.1.
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA. Translation: AAA97517.1.
X17358 mRNA. Translation: CAA35235.1.
M17755 mRNA. Translation: AAA61217.2.
AF439430 mRNA. Translation: AAL74416.1.
AF533528 mRNA. Translation: AAN04471.1.
AY136822 mRNA. Translation: AAN11302.1.
AF533529 mRNA. Translation: AAN04472.1.
AF533530 mRNA. Translation: AAN04473.1.
AF533531 mRNA. Translation: AAN04474.1.
M55702 mRNA. Translation: AAA61219.1.
M55702 mRNA. Translation: AAA61218.1.
CCDSiCCDS1643.1. [P07202-1]
CCDS1644.1. [P07202-2]
CCDS1646.1. [P07202-5]
PIRiA32413. OPHUIT.
RefSeqiNP_000538.3. NM_000547.5. [P07202-1]
NP_001193673.1. NM_001206744.1. [P07202-1]
NP_001193674.1. NM_001206745.1. [P07202-2]
NP_783650.1. NM_175719.3. [P07202-2]
NP_783652.1. NM_175721.3. [P07202-4]
NP_783653.1. NM_175722.3. [P07202-5]
XP_011508683.1. XM_011510381.2. [P07202-8]
UniGeneiHs.467554.

3D structure databases

ProteinModelPortaliP07202.
SMRiP07202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318820.

Chemistry databases

ChEMBLiCHEMBL1839.
DrugBankiDB00389. Carbimazole.
DB00509. Dextrothyroxine.
DB00763. Methimazole.
DB00550. Propylthiouracil.

Protein family/group databases

Allergomei9554. Hom s TPO.
PeroxiBasei3318. HsTPO01.

PTM databases

iPTMnetiP07202.
PhosphoSitePlusiP07202.

Polymorphism and mutation databases

BioMutaiTPO.
DMDMi160281455.

Proteomic databases

PaxDbiP07202.
PeptideAtlasiP07202.
PRIDEiP07202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705. [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705. [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705. [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705. [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705. [P07202-2]
GeneIDi7173.
KEGGihsa:7173.
UCSCiuc002qwr.4. human. [P07202-1]

Organism-specific databases

CTDi7173.
DisGeNETi7173.
GeneCardsiTPO.
H-InvDBHIX0029848.
HGNCiHGNC:12015. TPO.
HPAiCAB009587.
HPA007987.
MalaCardsiTPO.
MIMi274500. phenotype.
606765. gene.
neXtProtiNX_P07202.
OpenTargetsiENSG00000115705.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA36694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
GeneTreeiENSGT00550000074325.
HOVERGENiHBG000071.
InParanoidiP07202.
KOiK00431.
OMAiCDSIPGM.
OrthoDBiEOG091G0236.
PhylomeDBiP07202.
TreeFamiTF314316.

Enzyme and pathway databases

UniPathwayiUPA00194.
BioCyciZFISH:HS03930-MONOMER.
BRENDAi3.6.1.52. 2681.
ReactomeiR-HSA-209968. Thyroxine biosynthesis.

Miscellaneous databases

ChiTaRSiTPO. human.
GenomeRNAii7173.
PROiP07202.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115705.
ExpressionAtlasiP07202. baseline and differential.
GenevisibleiP07202. HS.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di1.10.640.10. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP_dom.
IPR029589. TPO.
[Graphical view]
PANTHERiPTHR11475:SF60. PTHR11475:SF60. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00084. Sushi. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPERT_HUMAN
AccessioniPrimary (citable) accession number: P07202
Secondary accession number(s): P09934
, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 212 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.