Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P07202

- PERT_HUMAN

UniProt

P07202 - PERT_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Catalytic activityi

2 iodide + H2O2 + 2 H+ = 2 iodine + 2 H2O.
[Thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O.
[Thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.
2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O.
[Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca(2+) ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei238 – 2381Heme (covalent; via 2 links)By similarity
Active sitei239 – 2391Proton acceptorPROSITE-ProRule annotation
Metal bindingi240 – 2401CalciumPROSITE-ProRule annotation
Metal bindingi321 – 3211CalciumPROSITE-ProRule annotation
Metal bindingi323 – 3231Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi325 – 3251CalciumPROSITE-ProRule annotation
Metal bindingi327 – 3271CalciumPROSITE-ProRule annotation
Sitei396 – 3961Transition state stabilizerPROSITE-ProRule annotation
Binding sitei399 – 3991Heme (covalent; via 2 links)By similarity
Metal bindingi494 – 4941Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heme binding Source: InterPro
  3. iodide peroxidase activity Source: UniProtKB-EC
  4. peroxidase activity Source: ProtInc

GO - Biological processi

  1. cellular nitrogen compound metabolic process Source: Reactome
  2. embryonic hemopoiesis Source: DFLAT
  3. hormone biosynthetic process Source: UniProtKB-KW
  4. hydrogen peroxide catabolic process Source: UniProtKB-KW
  5. small molecule metabolic process Source: Reactome
  6. thyroid hormone generation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide, Thyroid hormones biosynthesis

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_15292. Thyroxine biosynthesis.
UniPathwayiUPA00194.

Protein family/group databases

PeroxiBasei3318. HsTPO01.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid peroxidase (EC:1.11.1.8)
Short name:
TPO
Gene namesi
Name:TPO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:12015. TPO.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 846828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei847 – 87125HelicalSequence AnalysisAdd
BLAST
Topological domaini872 – 93362CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. mitochondrion Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]: A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.16 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → P in TDH2A. 1 Publication
VAR_021622
Natural varianti240 – 2401D → N in TDH2A; loss of activity. 1 Publication
VAR_021623
Natural varianti307 – 3071N → T in TDH2A. 1 Publication
VAR_021624
Natural varianti326 – 3261A → T in TDH2A. 1 Publication
VAR_021625
Natural varianti378 – 3781E → K in TDH2A. 1 Publication
VAR_025784
Natural varianti433 – 4331V → M in TDH2A. 1 Publication
VAR_021626
Natural varianti447 – 4471I → F in TDH2A. 2 Publications
VAR_015375
Natural varianti453 – 4531Y → D in TDH2A. 3 Publications
VAR_006060
Natural varianti458 – 4581L → P in TDH2A. 1 Publication
VAR_021627
Natural varianti491 – 4911R → H in TDH2A. 1 Publication
Corresponds to variant rs201165648 [ dbSNP | Ensembl ].
VAR_021628
Natural varianti493 – 4931G → S in TDH2A. 1 Publication
VAR_021629
Natural varianti499 – 4991P → L in TDH2A. 1 Publication
VAR_021630
Natural varianti527 – 5271W → C in TDH2A. 1 Publication
VAR_021631
Natural varianti533 – 5331G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication
VAR_027229
Natural varianti574 – 5752Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme.
VAR_027230
Natural varianti590 – 5901G → S in TDH2A. 1 Publication
VAR_027231
Natural varianti648 – 6481R → Q in TDH2A. 1 Publication
VAR_013138
Natural varianti660 – 6601Q → E in TDH2A. 1 Publication
Corresponds to variant rs121908088 [ dbSNP | Ensembl ].
VAR_021632
Natural varianti665 – 6651R → W in TDH2A; fails to localize to the plasma membrane. 1 Publication
VAR_021633
Natural varianti693 – 6931R → W in TDH2A. 2 Publications
VAR_021634
Natural varianti771 – 7711G → R in TDH2A; fails to localize to the plasma membrane. 1 Publication
VAR_021635
Natural varianti796 – 7961D → Y in TDH2A. 1 Publication
VAR_021636
Natural varianti799 – 7991E → K in TDH2A. 3 Publications
Corresponds to variant rs121908085 [ dbSNP | Ensembl ].
VAR_006062
Natural varianti808 – 8081C → R in TDH2A. 1 Publication
VAR_021637
Natural varianti839 – 8391V → I in TDH2A. 1 Publication
VAR_027235

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

MIMi274500. phenotype.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA36694.

Protein family/group databases

Allergomei9554. Hom s TPO.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 933915Thyroid peroxidasePRO_0000023662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 158By similarity
Disulfide bondi259 ↔ 269By similarity
Disulfide bondi263 ↔ 286By similarity
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi598 ↔ 655By similarity
Disulfide bondi696 ↔ 721By similarity
Disulfide bondi800 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Disulfide bondi825 ↔ 838By similarity

Post-translational modificationi

Glycosylated.
Heme is covalently bound through a H2O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07202.
PRIDEiP07202.

PTM databases

PhosphoSiteiP07202.

Expressioni

Gene expression databases

BgeeiP07202.
ExpressionAtlasiP07202. baseline.
GenevestigatoriP07202.

Organism-specific databases

HPAiCAB009587.
HPA007987.

Interactioni

Subunit structurei

Interacts with DUOX1, DUOX2 and CYBA.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP07202.
SMRiP07202. Positions 149-732, 738-843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini740 – 79556SushiPROSITE-ProRule annotationAdd
BLAST
Domaini796 – 83944EGF-like; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262194.
GeneTreeiENSGT00550000074325.
HOVERGENiHBG000071.
InParanoidiP07202.
KOiK00431.
OMAiIMETSIQ.
OrthoDBiEOG7D2FD6.
PhylomeDBiP07202.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP.
IPR029589. TPO.
[Graphical view]
PANTHERiPTHR11475:SF60. PTHR11475:SF60. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00032. CCP. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P07202-1) [UniParc]FASTAAdd to Basket

Also known as: TPO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,963
Last modified:November 13, 2007 - v4
Checksum:iF67C5F1A4AEE0B29
GO
Isoform 2 (identifier: P07202-2) [UniParc]FASTAAdd to Basket

Also known as: TPO2

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.

Note: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive.

Show »
Length:876
Mass (Da):96,699
Checksum:iF4CF0D050608F808
GO
Isoform 3 (identifier: P07202-3) [UniParc]FASTAAdd to Basket

Also known as: TPO3, Graves' disease, TPOzaninelli

The sequence of this isoform differs from the canonical sequence as follows:
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active.

Show »
Length:929
Mass (Da):102,771
Checksum:i423AC29EEB27277B
GO
Isoform 4 (identifier: P07202-4) [UniParc]FASTAAdd to Basket

Also known as: TPO4

The sequence of this isoform differs from the canonical sequence as follows:
     796-839: Missing.

Note: Lacks exon 14. Active.

Show »
Length:889
Mass (Da):98,327
Checksum:iF9C575FC93A450C8
GO
Isoform 5 (identifier: P07202-5) [UniParc]FASTAAdd to Basket

Also known as: TPO5

The sequence of this isoform differs from the canonical sequence as follows:
     274-446: Missing.

Note: Lacks exon 8. Does not fold correctly. Does not reach the cell surface.

Show »
Length:760
Mass (Da):84,581
Checksum:i3C6150EA7E602B78
GO
Isoform 6 (identifier: P07202-6) [UniParc]FASTAAdd to Basket

Also known as: TPO6

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     669-933: Missing.

Note: Lacks exons 10, 12, 13, 14 and 16.

Show »
Length:611
Mass (Da):67,293
Checksum:i7AD0B6FA3206066A
GO
Isoform 2-3 (identifier: P07202-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exons 10 and 16.

Show »
Length:872
Mass (Da):96,507
Checksum:i3EDC31BFE86C24E2
GO
Isoform 2-4 (identifier: P07202-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     796-839: Missing.

Note: Lacks exons 10 and 14.

Show »
Length:832
Mass (Da):92,063
Checksum:i7C6D17A3B62C1D7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701P → G in AAA61217. 1 PublicationCurated
Sequence conflicti354 – 3541A → G1 PublicationCurated
Sequence conflicti354 – 3541A → G(PubMed:3654979)Curated
Sequence conflicti371 – 3711A → R in AAA61215. (PubMed:3475693)Curated
Sequence conflicti371 – 3711A → R in AAA61216. (PubMed:3475693)Curated
Sequence conflicti381 – 3811I → N1 PublicationCurated
Sequence conflicti381 – 3811I → N(PubMed:3654979)Curated
Sequence conflicti574 – 5741D → N in CAA68467. (PubMed:3453124)Curated
Sequence conflicti732 – 7321W → C in AAN11302. (PubMed:12454013)Curated
Sequence conflicti748 – 7481V → M(PubMed:3453124)Curated
Sequence conflicti748 – 7481V → M(PubMed:12454013)Curated
Sequence conflicti816 – 8161N → S in AAL74416. 1 PublicationCurated
Sequence conflicti872 – 8721R → K(PubMed:3453124)Curated
Sequence conflicti872 – 8721R → K(PubMed:12454013)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → P in TDH2A. 1 Publication
VAR_021622
Natural varianti240 – 2401D → N in TDH2A; loss of activity. 1 Publication
VAR_021623
Natural varianti257 – 2571A → S.3 Publications
Corresponds to variant rs4927611 [ dbSNP | Ensembl ].
VAR_006057
Natural varianti307 – 3071N → T in TDH2A. 1 Publication
VAR_021624
Natural varianti326 – 3261A → T in TDH2A. 1 Publication
VAR_021625
Natural varianti373 – 3731A → S.1 Publication
Corresponds to variant rs2280132 [ dbSNP | Ensembl ].
VAR_006058
Natural varianti378 – 3781E → K in TDH2A. 1 Publication
VAR_025784
Natural varianti398 – 3981S → T.1 Publication
Corresponds to variant rs2175977 [ dbSNP | Ensembl ].
VAR_006059
Natural varianti433 – 4331V → M in TDH2A. 1 Publication
VAR_021626
Natural varianti447 – 4471I → F in TDH2A. 2 Publications
VAR_015375
Natural varianti453 – 4531Y → D in TDH2A. 3 Publications
VAR_006060
Natural varianti458 – 4581L → P in TDH2A. 1 Publication
VAR_021627
Natural varianti491 – 4911R → H in TDH2A. 1 Publication
Corresponds to variant rs201165648 [ dbSNP | Ensembl ].
VAR_021628
Natural varianti493 – 4931G → S in TDH2A. 1 Publication
VAR_021629
Natural varianti499 – 4991P → L in TDH2A. 1 Publication
VAR_021630
Natural varianti527 – 5271W → C in TDH2A. 1 Publication
VAR_021631
Natural varianti533 – 5331G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication
VAR_027229
Natural varianti574 – 5752Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme.
VAR_027230
Natural varianti590 – 5901G → S in TDH2A. 1 Publication
VAR_027231
Natural varianti618 – 6181V → M.
Corresponds to variant rs10189135 [ dbSNP | Ensembl ].
VAR_027232
Natural varianti648 – 6481R → Q in TDH2A. 1 Publication
VAR_013138
Natural varianti660 – 6601Q → E in TDH2A. 1 Publication
Corresponds to variant rs121908088 [ dbSNP | Ensembl ].
VAR_021632
Natural varianti665 – 6651R → W in TDH2A; fails to localize to the plasma membrane. 1 Publication
VAR_021633
Natural varianti693 – 6931R → W in TDH2A. 2 Publications
VAR_021634
Natural varianti706 – 7061M → V.
Corresponds to variant rs13431173 [ dbSNP | Ensembl ].
VAR_027233
Natural varianti725 – 7251T → P.5 Publications
Corresponds to variant rs732609 [ dbSNP | Ensembl ].
VAR_006061
Natural varianti771 – 7711G → R in TDH2A; fails to localize to the plasma membrane. 1 Publication
VAR_021635
Natural varianti793 – 7931L → P.
Corresponds to variant rs28991293 [ dbSNP | Ensembl ].
VAR_027234
Natural varianti796 – 7961D → Y in TDH2A. 1 Publication
VAR_021636
Natural varianti799 – 7991E → K in TDH2A. 3 Publications
Corresponds to variant rs121908085 [ dbSNP | Ensembl ].
VAR_006062
Natural varianti808 – 8081C → R in TDH2A. 1 Publication
VAR_021637
Natural varianti839 – 8391V → I in TDH2A. 1 Publication
VAR_027235
Natural varianti846 – 8461R → W.
Corresponds to variant rs28913014 [ dbSNP | Ensembl ].
VAR_027236
Natural varianti847 – 8471V → A.4 Publications
Corresponds to variant rs1126799 [ dbSNP | Ensembl ].
VAR_027237

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei274 – 446173Missing in isoform 5. 1 PublicationVSP_007268Add
BLAST
Alternative sequencei534 – 59057Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsVSP_004665Add
BLAST
Alternative sequencei669 – 933265Missing in isoform 6. CuratedVSP_007270Add
BLAST
Alternative sequencei796 – 83944Missing in isoform 4 and isoform 2-4. CuratedVSP_007269Add
BLAST
Alternative sequencei874 – 93360TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationVSP_004666Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1.
J02970 mRNA. Translation: AAA61216.1.
Y00406 mRNA. Translation: CAA68467.1.
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA. Translation: AAA97517.1.
X17358 mRNA. Translation: CAA35235.1.
M17755 mRNA. Translation: AAA61217.2.
AF439430 mRNA. Translation: AAL74416.1.
AF533528 mRNA. Translation: AAN04471.1.
AY136822 mRNA. Translation: AAN11302.1.
AF533529 mRNA. Translation: AAN04472.1.
AF533530 mRNA. Translation: AAN04473.1.
AF533531 mRNA. Translation: AAN04474.1.
M55702 mRNA. Translation: AAA61219.1.
M55702 mRNA. Translation: AAA61218.1.
CCDSiCCDS1643.1. [P07202-1]
CCDS1644.1. [P07202-2]
CCDS1646.1. [P07202-5]
PIRiA32413. OPHUIT.
RefSeqiNP_000538.3. NM_000547.5. [P07202-1]
NP_001193673.1. NM_001206744.1. [P07202-1]
NP_001193674.1. NM_001206745.1. [P07202-2]
NP_783650.1. NM_175719.3. [P07202-2]
NP_783652.1. NM_175721.3. [P07202-4]
NP_783653.1. NM_175722.3. [P07202-5]
UniGeneiHs.467554.

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705. [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705. [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705. [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705. [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705. [P07202-2]
GeneIDi7173.
KEGGihsa:7173.
UCSCiuc002qwr.3. human. [P07202-1]
uc002qwu.3. human. [P07202-2]
uc010yio.2. human. [P07202-5]
uc010yip.2. human. [P07202-4]

Polymorphism databases

DMDMi160281455.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Thyroid peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA. Translation: AAA61215.1 .
J02970 mRNA. Translation: AAA61216.1 .
Y00406 mRNA. Translation: CAA68467.1 .
M25715
, M25702 , M25703 , M25704 , M25705 , M25706 , M25707 , M25708 , M25709 , M25710 , M25711 , M25712 , M25713 , M25714 Genomic DNA. Translation: AAA97517.1 .
X17358 mRNA. Translation: CAA35235.1 .
M17755 mRNA. Translation: AAA61217.2 .
AF439430 mRNA. Translation: AAL74416.1 .
AF533528 mRNA. Translation: AAN04471.1 .
AY136822 mRNA. Translation: AAN11302.1 .
AF533529 mRNA. Translation: AAN04472.1 .
AF533530 mRNA. Translation: AAN04473.1 .
AF533531 mRNA. Translation: AAN04474.1 .
M55702 mRNA. Translation: AAA61219.1 .
M55702 mRNA. Translation: AAA61218.1 .
CCDSi CCDS1643.1. [P07202-1 ]
CCDS1644.1. [P07202-2 ]
CCDS1646.1. [P07202-5 ]
PIRi A32413. OPHUIT.
RefSeqi NP_000538.3. NM_000547.5. [P07202-1 ]
NP_001193673.1. NM_001206744.1. [P07202-1 ]
NP_001193674.1. NM_001206745.1. [P07202-2 ]
NP_783650.1. NM_175719.3. [P07202-2 ]
NP_783652.1. NM_175721.3. [P07202-4 ]
NP_783653.1. NM_175722.3. [P07202-5 ]
UniGenei Hs.467554.

3D structure databases

ProteinModelPortali P07202.
SMRi P07202. Positions 149-732, 738-843.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1839.
DrugBanki DB00389. Carbimazole.
DB00509. Dextrothyroxine.
DB00763. Methimazole.
DB00550. Propylthiouracil.
GuidetoPHARMACOLOGYi 2526.

Protein family/group databases

Allergomei 9554. Hom s TPO.
PeroxiBasei 3318. HsTPO01.

PTM databases

PhosphoSitei P07202.

Polymorphism databases

DMDMi 160281455.

Proteomic databases

PaxDbi P07202.
PRIDEi P07202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329066 ; ENSP00000329869 ; ENSG00000115705 . [P07202-1 ]
ENST00000345913 ; ENSP00000318820 ; ENSG00000115705 . [P07202-1 ]
ENST00000346956 ; ENSP00000263886 ; ENSG00000115705 . [P07202-4 ]
ENST00000382198 ; ENSP00000371633 ; ENSG00000115705 . [P07202-5 ]
ENST00000382201 ; ENSP00000371636 ; ENSG00000115705 . [P07202-2 ]
GeneIDi 7173.
KEGGi hsa:7173.
UCSCi uc002qwr.3. human. [P07202-1 ]
uc002qwu.3. human. [P07202-2 ]
uc010yio.2. human. [P07202-5 ]
uc010yip.2. human. [P07202-4 ]

Organism-specific databases

CTDi 7173.
GeneCardsi GC02P001396.
H-InvDB HIX0029848.
HGNCi HGNC:12015. TPO.
HPAi CAB009587.
HPA007987.
MIMi 274500. phenotype.
606765. gene.
neXtProti NX_P07202.
Orphaneti 95716. Familial thyroid dyshormonogenesis.
PharmGKBi PA36694.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262194.
GeneTreei ENSGT00550000074325.
HOVERGENi HBG000071.
InParanoidi P07202.
KOi K00431.
OMAi IMETSIQ.
OrthoDBi EOG7D2FD6.
PhylomeDBi P07202.
TreeFami TF314316.

Enzyme and pathway databases

UniPathwayi UPA00194 .
Reactomei REACT_15292. Thyroxine biosynthesis.

Miscellaneous databases

ChiTaRSi TPO. human.
GenomeRNAii 7173.
NextBioi 28112.
PROi P07202.
SOURCEi Search...

Gene expression databases

Bgeei P07202.
ExpressionAtlasi P07202. baseline.
Genevestigatori P07202.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP.
IPR029589. TPO.
[Graphical view ]
PANTHERi PTHR11475:SF60. PTHR11475:SF60. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00032. CCP. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs."
    Kimura S., Kotani T., McBride O.W., Umeki K., Hirai K., Nakayama T., Ohtaki S.
    Proc. Natl. Acad. Sci. U.S.A. 84:5555-5559(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-725 AND ALA-847.
  2. "Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA."
    Libert F., Ruel J., Ludgate M., Swillens S., Alexander N., Vassart G., Dinsart C.
    Nucleic Acids Res. 15:6735-6735(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS PRO-725 AND ALA-847.
    Tissue: Thyroid.
  3. "Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene."
    Kimura S., Hong Y.S., Kotani T., Ohtaki S., Kikkawa F.
    Biochemistry 28:4481-4489(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2."
    Barnett P.S., Banga J.P., Watkins J., Huang G.C., Gluckman D.R.B., Page M.J., McGregor A.M.
    Nucleic Acids Res. 18:670-670(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Thyroid.
  5. Rapoport B.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-257.
    Tissue: Thyroid.
  6. "Homo sapiens thyroid peroxidase (TPO) variant mRNA, alternatively spliced sequence."
    Hennen G.P., Igout A., Melen L.B.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANTS SER-257; PRO-725 AND ALA-847.
    Tissue: Thyroid.
  7. "Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs."
    Ferrand M., Le Fourn V., Franc J.-L.
    J. Biol. Chem. 278:3793-3800(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6; 2-3 AND 2-4), VARIANTS PRO-725 AND ALA-847.
    Tissue: Thyroid.
  8. "Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase."
    Seto P., Hirayu H., Magnusson R.P., Gestautas J., Portmann L., Degroot L.J., Rapoport B.
    J. Clin. Invest. 80:1205-1208(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-496.
  9. "Evidence for an alternate splicing in the thyroperoxidase messenger from patients with Graves' disease."
    Zanelli E., Henry M., Charvet B., Malthiery Y.
    Biochem. Biophys. Res. Commun. 170:735-741(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 670-933 (ISOFORM 3), ALTERNATIVE SPLICING IN GRAVES' DISEASE.
    Tissue: Thyroid.
  10. "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
    Wang D., De Deken X., Milenkovic M., Song Y., Pirson I., Dumont J.E., Miot F.
    J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DUOX1; DUOX2 AND CYBA.
  11. "Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis."
    Bikker H., Vulsma T., Baas F., de Vijlder J.J.M.
    Hum. Mutat. 6:9-16(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A ASP-453; SER-590 AND LYS-799, VARIANTS SER-257; SER-373; THR-398 AND PRO-725.
  12. "Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects."
    Bikker H., Baas F., De Vijlder J.J.M.
    J. Clin. Endocrinol. Metab. 82:649-653(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A PHE-447.
  13. "A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect."
    Santos C.L.S., Bikker H., Rego K.G.M., Nascimento A.C., Tambascia M., De Vijlder J.J.M., Medeiros-Neto G.
    Clin. Endocrinol. (Oxf.) 51:165-172(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A GLU-660.
  14. "Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping."
    Pannain S., Weiss R.E., Jackson C.E., Dian D., Beck J.C., Sheffield V.C., Cox N., Refetoff S.
    J. Clin. Endocrinol. Metab. 84:1061-1071(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A GLN-648 AND LYS-799.
  15. "A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect."
    Kotani T., Umeki K., Yamamoto I., Maesaka H., Tachibana K., Ohtaki S.
    J. Endocrinol. 160:267-273(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A ASN-240, CHARACTERIZATION OF VARIANT TDH2A ASN-240.
  16. "Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update)."
    Bakker B., Bikker H., Vulsma T., de Randamie J.S.E., Wiedijk B.M., De Vijlder J.J.M.
    J. Clin. Endocrinol. Metab. 85:3708-3712(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A THR-326; PHE-447; ASP-453; CYS-527; TRP-693 AND LYS-799.
  17. "Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism."
    Ambrugger P., Stoeva I., Biebermann H., Torresani T., Leitner C., Grueters A.
    Eur. J. Endocrinol. 145:19-24(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A PRO-458 AND HIS-491.
  18. "Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism."
    Umeki K., Kotani T., Kawano J., Suganuma T., Yamamoto I., Aratake Y., Furujo M., Ichiba Y.
    Eur. J. Endocrinol. 146:491-498(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A TRP-665 AND ARG-771, CHARACTERIZATION OF VARIANTS TDH2A TRP-665 AND ARG-771.
  19. "High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect."
    Niu D.-M., Hwang B., Chu Y.-K., Liao C.-J., Wang P.-L., Lin C.-Y.
    J. Clin. Endocrinol. Metab. 87:4208-4212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A PRO-53.
  20. "Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations."
    Wu J.-Y., Shu S.-G., Yang C.-F., Lee C.-C., Tsai F.-J.
    J. Endocrinol. 172:627-635(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A SER-493 AND TYR-796.
  21. "Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach."
    Calaciura F., Miscio G., Coco A., Leonardi D., Cisternino C., Regalbuto C., Bozzali M., Maiorana R., Ranieri A., Carta A., Buscema M., Trischitta V., Sava L., Tassi V.
    Thyroid 12:945-951(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A ILE-839.
  22. "Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings."
    Kotani T., Umeki K., Kawano J., Suganuma T., Hishinuma A., Ieiri T., Harada S.
    Clin. Endocrinol. (Oxf.) 59:198-206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A CYS-533 AND ASP-574-575-LEU DEL, CHARACTERIZATION OF VARIANTS TDH2A CYS-533 AND ASP-574-575-LEU DEL.
  23. "Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect."
    Rivolta C.M., Esperante S.A., Gruneiro-Papendieck L., Chiesa A., Moya C.M., Domene S., Varela V., Targovnik H.M.
    Hum. Mutat. 22:259-259(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TDH2A THR-307; MET-433; LEU-499 AND ARG-808.
  24. "Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect."
    Fugazzola L., Cerutti N., Mannavola D., Vannucchi G., Fallini C., Persani L., Beck-Peccoz P.
    J. Clin. Endocrinol. Metab. 88:3264-3271(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A TRP-693.
  25. "Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism."
    Tajima T., Tsubaki J., Fujieda K.
    Endocr. J. 52:643-645(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A LYS-378.
  26. "Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes."
    Pfarr N., Borck G., Turk A., Napiontek U., Keilmann A., Mueller-Forell W., Kopp P., Pohlenz J.
    J. Clin. Endocrinol. Metab. 91:2678-2681(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH2A ASP-453.

Entry informationi

Entry nameiPERT_HUMAN
AccessioniPrimary (citable) accession number: P07202
Secondary accession number(s): P09934
, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 192 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3