Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P07201

- RIR2_SPISO

UniProt

P07201 - RIR2_SPISO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonucleoside-diphosphate reductase small chain

Gene
N/A
Organism
Spisula solidissima (Atlantic surf-clam)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
Metal bindingi161 – 1611Iron 1PROSITE-ProRule annotation
Metal bindingi161 – 1611Iron 2By similarity
Metal bindingi164 – 1641Iron 1PROSITE-ProRule annotation
Active sitei168 – 1681PROSITE-ProRule annotation
Metal bindingi224 – 2241Iron 2By similarity
Metal bindingi258 – 2581Iron 2By similarity
Metal bindingi261 – 2611Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
p41
OrganismiSpisula solidissima (Atlantic surf-clam)
Taxonomic identifieri6584 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaHeteroconchiaVeneroidaMactroideaMactridaeSpisula

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Ribonucleoside-diphosphate reductase small chainPRO_0000190453Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliP07201.
SMRiP07201. Positions 3-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07201-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSINTTRKE NELSGNLGKM KITEENKPKK VLGEITNFQR STQKTPLKQE
60 70 80 90 100
IKPVVKKSQQ VEPLLADNPR RFVVLPIQYH DIWKMYKKAE ASFWTAEEVD
110 120 130 140 150
LSKDMAHWES LKKEEKHFIS HVLAFFAASD GIVNENLVER FSKEVQVTEA
160 170 180 190 200
RCFYGFQIAM ENIHSEMYSL LIDTYIKDPQ ERDFLFNAIE TMPCVKEKAD
210 220 230 240 250
WAMRWINDDS SSYAERVVAF AAVEGIFFSG SFASIFWLKK RGIMPGLTFS
260 270 280 290 300
NELISRDEGL HCDFACLMFS HLVNKPSQER IHQIIDEAVK IEQVFLTEAL
310 320 330 340 350
PCRLIGMNCD LMRQYIEFVA DRLLLELKCD KLYNKENPFD FMEHISLEGK
360 370 380
TNFFEKRVGE YQKMGVMSGG NTGDSHAFTL DADF
Length:384
Mass (Da):44,447
Last modified:April 1, 1993 - v2
Checksum:i2F576F7BEA9297B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55125 mRNA. Translation: CAA38919.1.
X02471 mRNA. Translation: CAA26307.1.
PIRiA22259. RDSS2R.
S24585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55125 mRNA. Translation: CAA38919.1 .
X02471 mRNA. Translation: CAA26307.1 .
PIRi A22259. RDSS2R.
S24585.

3D structure databases

ProteinModelPortali P07201.
SMRi P07201. Positions 3-344.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region."
    Standart N.M., Dale M., Stewart E., Hunt T.
    Genes Dev. 4:2157-2168(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs."
    Standart N.M., Bray S.J., George E.L., Hunt T., Ruderman J.V.
    J. Cell Biol. 100:1968-1976(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-384.

Entry informationi

Entry nameiRIR2_SPISO
AccessioniPrimary (citable) accession number: P07201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

There is no sign of synthesis of a corresponding large subunit after fertilization. The authors suspect that the unfertilized oocytes contain a stockpile of large subunits ready for combination with newly made small subunits.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3