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Protein

Ribonucleoside-diphosphate reductase small chain

Gene
N/A
Organism
Spisula solidissima (Atlantic surf-clam)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Iron 1PROSITE-ProRule annotation1
Metal bindingi161Iron 1PROSITE-ProRule annotation1
Metal bindingi161Iron 2By similarity1
Metal bindingi164Iron 1PROSITE-ProRule annotation1
Active sitei168PROSITE-ProRule annotation1
Metal bindingi224Iron 2By similarity1
Metal bindingi258Iron 2By similarity1
Metal bindingi261Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
p41
OrganismiSpisula solidissima (Atlantic surf-clam)
Taxonomic identifieri6584 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaHeteroconchiaEuheterodontaVeneroidaMactroideaMactridaeSpisula

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904531 – 384Ribonucleoside-diphosphate reductase small chainAdd BLAST384

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliP07201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSINTTRKE NELSGNLGKM KITEENKPKK VLGEITNFQR STQKTPLKQE
60 70 80 90 100
IKPVVKKSQQ VEPLLADNPR RFVVLPIQYH DIWKMYKKAE ASFWTAEEVD
110 120 130 140 150
LSKDMAHWES LKKEEKHFIS HVLAFFAASD GIVNENLVER FSKEVQVTEA
160 170 180 190 200
RCFYGFQIAM ENIHSEMYSL LIDTYIKDPQ ERDFLFNAIE TMPCVKEKAD
210 220 230 240 250
WAMRWINDDS SSYAERVVAF AAVEGIFFSG SFASIFWLKK RGIMPGLTFS
260 270 280 290 300
NELISRDEGL HCDFACLMFS HLVNKPSQER IHQIIDEAVK IEQVFLTEAL
310 320 330 340 350
PCRLIGMNCD LMRQYIEFVA DRLLLELKCD KLYNKENPFD FMEHISLEGK
360 370 380
TNFFEKRVGE YQKMGVMSGG NTGDSHAFTL DADF
Length:384
Mass (Da):44,447
Last modified:April 1, 1993 - v2
Checksum:i2F576F7BEA9297B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55125 mRNA. Translation: CAA38919.1.
X02471 mRNA. Translation: CAA26307.1.
PIRiA22259. RDSS2R.
S24585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55125 mRNA. Translation: CAA38919.1.
X02471 mRNA. Translation: CAA26307.1.
PIRiA22259. RDSS2R.
S24585.

3D structure databases

ProteinModelPortaliP07201.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_SPISO
AccessioniPrimary (citable) accession number: P07201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

There is no sign of synthesis of a corresponding large subunit after fertilization. The authors suspect that the unfertilized oocytes contain a stockpile of large subunits ready for combination with newly made small subunits.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.