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P07194 (PENKB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-A-B

Cleaved into the following 4 chains:

  1. Synenkephalin
  2. Met-enkephalin
    Alternative name(s):
    Opioid growth factor
    Short name=OGF
  3. Met-enkephalin-Arg-Gly-Tyr
  4. Met-enkephalin-Arg-Phe
Gene names
Name:penk-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length216 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionEndorphin
Neuropeptide
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide‹1 – 47›47Synenkephalin
PRO_0000008307
Peptide50 – 545Met-enkephalin
PRO_0000008308
Peptide57 – 615Met-enkephalin
PRO_0000008309
Propeptide64 – 8522
PRO_0000008310
Peptide86 – 905Met-enkephalin
PRO_0000008311
Propeptide93 – 13139
PRO_0000008312
Peptide134 – 1418Met-enkephalin-Arg-Gly-Tyr
PRO_0000008313
Propeptide144 – 15512
PRO_0000008314
Peptide158 – 1625Met-enkephalin
PRO_0000008315
Propeptide165 – 17511
PRO_0000008316
Peptide178 – 1825Met-enkephalin
PRO_0000008317
Propeptide183 – 20725
PRO_0000008318
Peptide210 – 2167Met-enkephalin-Arg-Phe
PRO_0000008319

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P07194 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: BB48865419AC4131

FASTA21624,979
        10         20         30         40         50         60 
ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY GGFMKRYGGF 

        70         80         90        100        110        120 
MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA SDLLRELLAT SGDPESAIYH 

       130        140        150        160        170        180 
DNNSETPGEM NKRYGGFMRG YRRSTDLEDE TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG 

       190        200        210 
FMTRFTDSFL PSDEDGESYS KENPDMEKRY GGFMRF 

« Hide

References

[1]"Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
Martens G.J.M., Herbert E.
Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00853 Genomic DNA. Translation: CAA25406.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP07194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-942765. penk.

Phylogenomic databases

HOVERGENHBG000063.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
ProtoNetSearch...

Entry information

Entry namePENKB_XENLA
AccessionPrimary (citable) accession number: P07194
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families