Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proenkephalin-A-B

Gene

penk-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A-B
Cleaved into the following 4 chains:
Alternative name(s):
Opioid growth factor
Short name:
OGF
Gene namesi
Name:penk-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942765. penk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_0000008307‹1 – 47SynenkephalinAdd BLAST›47
PeptideiPRO_000000830850 – 54Met-enkephalin5
PeptideiPRO_000000830957 – 61Met-enkephalin5
PropeptideiPRO_000000831064 – 85Add BLAST22
PeptideiPRO_000000831186 – 90Met-enkephalin5
PropeptideiPRO_000000831293 – 131Add BLAST39
PeptideiPRO_0000008313134 – 141Met-enkephalin-Arg-Gly-Tyr8
PropeptideiPRO_0000008314144 – 155Add BLAST12
PeptideiPRO_0000008315158 – 162Met-enkephalin5
PropeptideiPRO_0000008316165 – 175Add BLAST11
PeptideiPRO_0000008317178 – 182Met-enkephalin5
PropeptideiPRO_0000008318183 – 207Add BLAST25
PeptideiPRO_0000008319210 – 216Met-enkephalin-Arg-Phe7

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP07194.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY
60 70 80 90 100
GGFMKRYGGF MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA
110 120 130 140 150
SDLLRELLAT SGDPESAIYH DNNSETPGEM NKRYGGFMRG YRRSTDLEDE
160 170 180 190 200
TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG FMTRFTDSFL PSDEDGESYS
210
KENPDMEKRY GGFMRF
Length:216
Mass (Da):24,979
Last modified:April 1, 1988 - v1
Checksum:iBB48865419AC4131
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP07194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-942765. penk.

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
ProtoNetiSearch...

Entry informationi

Entry nameiPENKB_XENLA
AccessioniPrimary (citable) accession number: P07194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.