Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07194

- PENKB_XENLA

UniProt

P07194 - PENKB_XENLA

Protein

Proenkephalin-A-B

Gene

penk-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-A-B
    Cleaved into the following 4 chains:
    Alternative name(s):
    Opioid growth factor
    Short name:
    OGF
    Gene namesi
    Name:penk-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-942765. penk.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei‹1 – 47›47SynenkephalinPRO_0000008307Add
    BLAST
    Peptidei50 – 545Met-enkephalinPRO_0000008308
    Peptidei57 – 615Met-enkephalinPRO_0000008309
    Propeptidei64 – 8522PRO_0000008310Add
    BLAST
    Peptidei86 – 905Met-enkephalinPRO_0000008311
    Propeptidei93 – 13139PRO_0000008312Add
    BLAST
    Peptidei134 – 1418Met-enkephalin-Arg-Gly-TyrPRO_0000008313
    Propeptidei144 – 15512PRO_0000008314Add
    BLAST
    Peptidei158 – 1625Met-enkephalinPRO_0000008315
    Propeptidei165 – 17511PRO_0000008316Add
    BLAST
    Peptidei178 – 1825Met-enkephalinPRO_0000008317
    Propeptidei183 – 20725PRO_0000008318Add
    BLAST
    Peptidei210 – 2167Met-enkephalin-Arg-PhePRO_0000008319

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP07194.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG000063.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07194-1 [UniParc]FASTAAdd to Basket

    « Hide

    ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY    50
    GGFMKRYGGF MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA 100
    SDLLRELLAT SGDPESAIYH DNNSETPGEM NKRYGGFMRG YRRSTDLEDE 150
    TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG FMTRFTDSFL PSDEDGESYS 200
    KENPDMEKRY GGFMRF 216
    Length:216
    Mass (Da):24,979
    Last modified:April 1, 1988 - v1
    Checksum:iBB48865419AC4131
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00853 Genomic DNA. Translation: CAA25406.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00853 Genomic DNA. Translation: CAA25406.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P07194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-942765. penk.

    Phylogenomic databases

    HOVERGENi HBG000063.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
      Martens G.J.M., Herbert E.
      Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPENKB_XENLA
    AccessioniPrimary (citable) accession number: P07194
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3