P07194 (PENKB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proenkephalin-A-B

Cleaved into the following 4 chains:

1. Synenkephalin
2. Met-enkephalin
   Alternative name(s):
   Opioid growth factor
   Short name=OGF
3. Met-enkephalin-Arg-Gly-Tyr
4. Met-enkephalin-Arg-Phe

Gene names

Name:

penk-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	216 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Secreted.
Post-translational modification	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence similarities	Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Endorphin Neuropeptide Opioid peptide
PTM	Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	‹1 – 47	›47	Synenkephalin		PRO_0000008307
	Peptide	50 – 54	5	Met-enkephalin		PRO_0000008308
	Peptide	57 – 61	5	Met-enkephalin		PRO_0000008309
	Propeptide	64 – 85	22			PRO_0000008310
	Peptide	86 – 90	5	Met-enkephalin		PRO_0000008311
	Propeptide	93 – 131	39			PRO_0000008312
	Peptide	134 – 141	8	Met-enkephalin-Arg-Gly-Tyr		PRO_0000008313
	Propeptide	144 – 155	12			PRO_0000008314
	Peptide	158 – 162	5	Met-enkephalin		PRO_0000008315
	Propeptide	165 – 175	11			PRO_0000008316
	Peptide	178 – 182	5	Met-enkephalin		PRO_0000008317
	Propeptide	183 – 207	25			PRO_0000008318
	Peptide	210 – 216	7	Met-enkephalin-Arg-Phe		PRO_0000008319
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P07194 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: BB48865419AC4131	FASTA	216	24,979
	10 20 30 40 50 60 ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY GGFMKRYGGF 70 80 90 100 110 120 MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA SDLLRELLAT SGDPESAIYH 130 140 150 160 170 180 DNNSETPGEM NKRYGGFMRG YRRSTDLEDE TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG 190 200 210 FMTRFTDSFL PSDEDGESYS KENPDMEKRY GGFMRF

References

[1]	"Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis." Martens G.J.M., Herbert E. Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00853 Genomic DNA. Translation: CAA25406.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P07194.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-942765. penk.
Phylogenomic databases
HOVERGEN	HBG000063.
Family and domain databases
InterPro	IPR006024. Opioid_neupept. IPR000703. Proenkphlin_A. [Graphical view]
PANTHER	PTHR11438. PTHR11438. 1 hit. PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfam	PF01160. Opiods_neuropep. 1 hit. [Graphical view]
PRINTS	PR01028. OPIOIDPRCRSR. PR01029. PENKAPRCRSR.
PROSITE	PS01252. OPIOIDS_PRECURSOR. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PENKB_XENLA

Accession

Primary (citable) accession number: P07194

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program