Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P07194

- PENKB_XENLA

UniProt

P07194 - PENKB_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proenkephalin-A-B

Gene

penk-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A-B
Cleaved into the following 4 chains:
Alternative name(s):
Opioid growth factor
Short name:
OGF
Gene namesi
Name:penk-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942765. penk.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei‹1 – 47›47SynenkephalinPRO_0000008307Add
BLAST
Peptidei50 – 545Met-enkephalinPRO_0000008308
Peptidei57 – 615Met-enkephalinPRO_0000008309
Propeptidei64 – 8522PRO_0000008310Add
BLAST
Peptidei86 – 905Met-enkephalinPRO_0000008311
Propeptidei93 – 13139PRO_0000008312Add
BLAST
Peptidei134 – 1418Met-enkephalin-Arg-Gly-TyrPRO_0000008313
Propeptidei144 – 15512PRO_0000008314Add
BLAST
Peptidei158 – 1625Met-enkephalinPRO_0000008315
Propeptidei165 – 17511PRO_0000008316Add
BLAST
Peptidei178 – 1825Met-enkephalinPRO_0000008317
Propeptidei183 – 20725PRO_0000008318Add
BLAST
Peptidei210 – 2167Met-enkephalin-Arg-PhePRO_0000008319

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP07194.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07194-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY
60 70 80 90 100
GGFMKRYGGF MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA
110 120 130 140 150
SDLLRELLAT SGDPESAIYH DNNSETPGEM NKRYGGFMRG YRRSTDLEDE
160 170 180 190 200
TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG FMTRFTDSFL PSDEDGESYS
210
KENPDMEKRY GGFMRF
Length:216
Mass (Da):24,979
Last modified:April 1, 1988 - v1
Checksum:iBB48865419AC4131
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P07194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-942765. penk.

Phylogenomic databases

HOVERGENi HBG000063.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
ProtoNeti Search...

Publicationsi

  1. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
    Martens G.J.M., Herbert E.
    Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPENKB_XENLA
AccessioniPrimary (citable) accession number: P07194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3