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P07194

- PENKB_XENLA

UniProt

P07194 - PENKB_XENLA

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Protein

Proenkephalin-A-B

Gene
penk-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A-B
Cleaved into the following 4 chains:
Alternative name(s):
Opioid growth factor
Short name:
OGF
Gene namesi
Name:penk-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942765. penk.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei‹1 – 47›47SynenkephalinPRO_0000008307Add
BLAST
Peptidei50 – 545Met-enkephalinPRO_0000008308
Peptidei57 – 615Met-enkephalinPRO_0000008309
Propeptidei64 – 8522PRO_0000008310Add
BLAST
Peptidei86 – 905Met-enkephalinPRO_0000008311
Propeptidei93 – 13139PRO_0000008312Add
BLAST
Peptidei134 – 1418Met-enkephalin-Arg-Gly-TyrPRO_0000008313
Propeptidei144 – 15512PRO_0000008314Add
BLAST
Peptidei158 – 1625Met-enkephalinPRO_0000008315
Propeptidei165 – 17511PRO_0000008316Add
BLAST
Peptidei178 – 1825Met-enkephalinPRO_0000008317
Propeptidei183 – 20725PRO_0000008318Add
BLAST
Peptidei210 – 2167Met-enkephalin-Arg-PhePRO_0000008319

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP07194.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07194-1 [UniParc]FASTAAdd to Basket

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ACTLECEGKL PSAKAWGTCK ELLQLTKLDG VQDGEKYQDN NDSHYIAKKY    50
GGFMKRYGGF MKKMDELYHA EPEEDDAGGE ILAKNYGGFM KKEYDSNRDA 100
SDLLRELLAT SGDPESAIYH DNNSETPGEM NKRYGGFMRG YRRSTDLEDE 150
TRGIQKRYGG FMRRVGRPEW WQDYQKRYGG FMTRFTDSFL PSDEDGESYS 200
KENPDMEKRY GGFMRF 216
Length:216
Mass (Da):24,979
Last modified:April 1, 1988 - v1
Checksum:iBB48865419AC4131
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00853 Genomic DNA. Translation: CAA25406.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P07194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-942765. penk.

Phylogenomic databases

HOVERGENi HBG000063.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
ProtoNeti Search...

Publicationsi

  1. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
    Martens G.J.M., Herbert E.
    Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPENKB_XENLA
AccessioniPrimary (citable) accession number: P07194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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