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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi150 – 1501ZincBy similarity
Metal bindingi153 – 1531ZincBy similarity
Metal bindingi213 – 2131ZincBy similarity
Metal bindingi217 – 2171ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 267192By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Protein family/group databases

TCDBi1.C.110.1.2. the pore-forming pnc-27 peptide of 32 aas from the p53 tumor suppressor protein (pnc-27) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252168. tp53.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Cellular tumor antigen p53PRO_0000185726Add
BLAST

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Ubiquitous.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Interaction with DNABy similarity

Protein-protein interaction databases

IntActiP07193. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07193.
SMRiP07193. Positions 68-267, 301-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929Transcription activation (acidic)Add
BLAST
Regioni248 – 2558Interaction with DNABy similarity
Regioni300 – 33132OligomerizationAdd
BLAST
Regioni344 – 35613Basic (repression of DNA-binding)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi275 – 29218Bipartite nuclear localization signalBy similarityAdd
BLAST
Motifi314 – 32512Nuclear export signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

HOVERGENiHBG005201.
KOiK04451.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSSETGMD PPLSQETFED LWSLLPDPLQ TVTCRLDNLS EFPDYPLAAD
60 70 80 90 100
MTVLQEGLMG NAVPTVTSCA VPSTDDYAGK YGLQLDFQQN GTAKSVTCTY
110 120 130 140 150
SPELNKLFCQ LAKTCPLLVR VESPPPRGSI LRATAVYKKS EHVAEVVKRC
160 170 180 190 200
PHHERSVEPG EDAAPPSHLM RVEGNLQAYY MEDVNSGRHS VCVPYEGPQV
210 220 230 240 250
GTECTTVLYN YMCNSSCMGG MNRRPILTII TLETPQGLLL GRRCFEVRVC
260 270 280 290 300
ACPGRDRRTE EDNYTKKRGL KPSGKRELAH PPSSEPPLPK KRLVVVDDDE
310 320 330 340 350
EIFTLRIKGR SRYEMIKKLN DALELQESLD QQKVTIKCRK CRDEIKPKKG
360
KKLLVKDEQP DSE
Length:363
Mass (Da):40,693
Last modified:April 1, 1988 - v1
Checksum:iCE1F3E58F020D74D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521T → S in CAA54672 (PubMed:8302570).Curated
Sequence conflicti71 – 711Missing in CAA54672 (PubMed:8302570).Curated
Sequence conflicti296 – 2961Missing in CAA54672 (PubMed:8302570).Curated
Sequence conflicti296 – 2961Missing in AAC60746 (PubMed:8302570).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36962 mRNA. Translation: AAA49923.1.
X05191 mRNA. Translation: CAA28821.1.
X77546 mRNA. Translation: CAA54672.1.
S68353 mRNA. Translation: AAC60746.1.
PIRiA29376.
RefSeqiNP_001081567.1. NM_001088098.1.
UniGeneiXl.394.

Genome annotation databases

GeneIDi397926.
KEGGixla:397926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36962 mRNA. Translation: AAA49923.1.
X05191 mRNA. Translation: CAA28821.1.
X77546 mRNA. Translation: CAA54672.1.
S68353 mRNA. Translation: AAC60746.1.
PIRiA29376.
RefSeqiNP_001081567.1. NM_001088098.1.
UniGeneiXl.394.

3D structure databases

ProteinModelPortaliP07193.
SMRiP07193. Positions 68-267, 301-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07193. 1 interaction.

Protein family/group databases

TCDBi1.C.110.1.2. the pore-forming pnc-27 peptide of 32 aas from the p53 tumor suppressor protein (pnc-27) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397926.
KEGGixla:397926.

Organism-specific databases

CTDi7157.
XenbaseiXB-GENE-6252168. tp53.

Phylogenomic databases

HOVERGENiHBG005201.
KOiK04451.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP53_XENLA
AccessioniPrimary (citable) accession number: P07193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.