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Protein

Maltase A3

Gene

Mal-A3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220NucleophileBy similarity1
Active sitei293Proton donorBy similarity1
Sitei359Transition state stabilizerBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-352230 Amino acid transport across the plasma membrane

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A3 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein L
Gene namesi
Name:Mal-A3
Synonyms:LvpL
ORF Names:CG8695
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002571 Mal-A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000144820 – 574Maltase A3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07192
PRIDEiP07192

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiFBgn0002571
GenevisibleiP07192 DM

Interactioni

Protein-protein interaction databases

IntActiP07192, 1 interactor
STRINGi7227.FBpp0087837

Structurei

3D structure databases

ProteinModelPortaliP07192
SMRiP07192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0471 Eukaryota
COG0366 LUCA
GeneTreeiENSGT00900000140965
InParanoidiP07192
KOiK01187
OMAiMNNHDVP
OrthoDBiEOG091G03FE
PhylomeDBiP07192

Family and domain databases

InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKLLVLSCL LALALPSLAE VGWWKTGQFY QIYPRSFKDS DGDGVGDLIG
60 70 80 90 100
ITQQLPYLKE IGITATWLSP IFTSPMADFG YDVADLKGID PIFGTMEDFE
110 120 130 140 150
ALLARAKELD IKIILDFVPN HTSDECDWFI RSAAGEEEYK DFYVWHTGKV
160 170 180 190 200
VNGIRQPPTN WVSVFRGSMW TWNEQRQAYY LHQFHAKQPD LNYRNPKVVE
210 220 230 240 250
AMKDVLRFWL RKGAYGFRID AVPHVYEIPA DADGNWPDEP RNEAVSDPED
260 270 280 290 300
YTYLQHIYTT DQPETLELVY AFRDVIEEID AELGGDDRVL LTEAYSPLEV
310 320 330 340 350
LMQYYGNGTH LGSQIPFNFE LLAKISYSSD AYHYSELIHN WLDNMPEGQV
360 370 380 390 400
ANWVFGNHDQ SRIGSRLGAD RIDACNMIIL GLPGVSVTYQ GEEMGMTDVW
410 420 430 440 450
ISWEDTVDPQ ACQSNEQEFE RLTRDPVRTP FQWSDEVNAG FSNASVTWLP
460 470 480 490 500
VASNYKLVNV KKERGIALSH LNVYKQLRAL RDEPTLKQGD VSVTAIGPNV
510 520 530 540 550
LAFKRSLAGY KSYITLININ DDVESINLDS VFTSITTQLQ YVVVNDKSVR
560 570
RKNDLTFANS VLLLPKEAVV LSTV
Length:574
Mass (Da):65,235
Last modified:June 21, 2005 - v2
Checksum:i6CDD5C92868DE098
GO

Sequence cautioni

The sequence CAA23493 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146H → P in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti175Q → E in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti324K → Q in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti553N → S in CAA23493 (PubMed:6854639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00204 Genomic DNA Translation: CAA23493.1 Sequence problems.
AE013599 Genomic DNA Translation: AAF59087.2
AY119654 mRNA Translation: AAM50308.1
PIRiS08598
RefSeqiNP_476628.2, NM_057280.4
UniGeneiDm.529

Genome annotation databases

EnsemblMetazoaiFBtr0088758; FBpp0087837; FBgn0002571
GeneIDi35826
KEGGidme:Dmel_CG8695

Similar proteinsi

Entry informationi

Entry nameiMAL3_DROME
AccessioniPrimary (citable) accession number: P07192
Secondary accession number(s): Q9V4T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health