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Protein

Maltase A3

Gene

Mal-A3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220NucleophileBy similarity1
Active sitei293Proton donorBy similarity1
Sitei359Transition state stabilizerBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A3 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein L
Gene namesi
Name:Mal-A3
Synonyms:LvpL
ORF Names:CG8695
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002571. Mal-A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000144820 – 574Maltase A3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07192.
PRIDEiP07192.

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiFBgn0002571.
GenevisibleiP07192. DM.

Interactioni

Protein-protein interaction databases

IntActiP07192. 1 interactor.
STRINGi7227.FBpp0087837.

Structurei

3D structure databases

ProteinModelPortaliP07192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
GeneTreeiENSGT00900000140965.
InParanoidiP07192.
KOiK01187.
OMAiAEAWVEP.
OrthoDBiEOG091G03FE.
PhylomeDBiP07192.

Family and domain databases

InterProiView protein in InterPro
IPR006047. Glyco_hydro_13_cat_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKLLVLSCL LALALPSLAE VGWWKTGQFY QIYPRSFKDS DGDGVGDLIG
60 70 80 90 100
ITQQLPYLKE IGITATWLSP IFTSPMADFG YDVADLKGID PIFGTMEDFE
110 120 130 140 150
ALLARAKELD IKIILDFVPN HTSDECDWFI RSAAGEEEYK DFYVWHTGKV
160 170 180 190 200
VNGIRQPPTN WVSVFRGSMW TWNEQRQAYY LHQFHAKQPD LNYRNPKVVE
210 220 230 240 250
AMKDVLRFWL RKGAYGFRID AVPHVYEIPA DADGNWPDEP RNEAVSDPED
260 270 280 290 300
YTYLQHIYTT DQPETLELVY AFRDVIEEID AELGGDDRVL LTEAYSPLEV
310 320 330 340 350
LMQYYGNGTH LGSQIPFNFE LLAKISYSSD AYHYSELIHN WLDNMPEGQV
360 370 380 390 400
ANWVFGNHDQ SRIGSRLGAD RIDACNMIIL GLPGVSVTYQ GEEMGMTDVW
410 420 430 440 450
ISWEDTVDPQ ACQSNEQEFE RLTRDPVRTP FQWSDEVNAG FSNASVTWLP
460 470 480 490 500
VASNYKLVNV KKERGIALSH LNVYKQLRAL RDEPTLKQGD VSVTAIGPNV
510 520 530 540 550
LAFKRSLAGY KSYITLININ DDVESINLDS VFTSITTQLQ YVVVNDKSVR
560 570
RKNDLTFANS VLLLPKEAVV LSTV
Length:574
Mass (Da):65,235
Last modified:June 21, 2005 - v2
Checksum:i6CDD5C92868DE098
GO

Sequence cautioni

The sequence CAA23493 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146H → P in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti175Q → E in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti324K → Q in CAA23493 (PubMed:6854639).Curated1
Sequence conflicti553N → S in CAA23493 (PubMed:6854639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00204 Genomic DNA. Translation: CAA23493.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF59087.2.
AY119654 mRNA. Translation: AAM50308.1.
PIRiS08598.
RefSeqiNP_476628.2. NM_057280.4.
UniGeneiDm.529.

Genome annotation databases

EnsemblMetazoaiFBtr0088758; FBpp0087837; FBgn0002571.
GeneIDi35826.
KEGGidme:Dmel_CG8695.

Similar proteinsi

Entry informationi

Entry nameiMAL3_DROME
AccessioniPrimary (citable) accession number: P07192
Secondary accession number(s): Q9V4T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 21, 2005
Last modified: October 25, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families