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P07192

- MAL3_DROME

UniProt

P07192 - MAL3_DROME

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Protein
Maltase A3
Gene
Mal-A3, LvpL, CG8695
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201Nucleophile By similarity
Active sitei293 – 2931Proton donor By similarity
Sitei359 – 3591Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A3 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein L
Gene namesi
Name:Mal-A3
Synonyms:LvpL
ORF Names:CG8695
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002571. Mal-A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 574555Maltase A3
PRO_0000001448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07192.

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiP07192.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087837.

Structurei

3D structure databases

ProteinModelPortaliP07192.
SMRiP07192. Positions 20-574.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
GeneTreeiENSGT00530000063127.
InParanoidiP07192.
KOiK01187.
OMAiASYRDIE.
OrthoDBiEOG7B31NK.
PhylomeDBiP07192.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07192-1 [UniParc]FASTAAdd to Basket

« Hide

MFKLLVLSCL LALALPSLAE VGWWKTGQFY QIYPRSFKDS DGDGVGDLIG    50
ITQQLPYLKE IGITATWLSP IFTSPMADFG YDVADLKGID PIFGTMEDFE 100
ALLARAKELD IKIILDFVPN HTSDECDWFI RSAAGEEEYK DFYVWHTGKV 150
VNGIRQPPTN WVSVFRGSMW TWNEQRQAYY LHQFHAKQPD LNYRNPKVVE 200
AMKDVLRFWL RKGAYGFRID AVPHVYEIPA DADGNWPDEP RNEAVSDPED 250
YTYLQHIYTT DQPETLELVY AFRDVIEEID AELGGDDRVL LTEAYSPLEV 300
LMQYYGNGTH LGSQIPFNFE LLAKISYSSD AYHYSELIHN WLDNMPEGQV 350
ANWVFGNHDQ SRIGSRLGAD RIDACNMIIL GLPGVSVTYQ GEEMGMTDVW 400
ISWEDTVDPQ ACQSNEQEFE RLTRDPVRTP FQWSDEVNAG FSNASVTWLP 450
VASNYKLVNV KKERGIALSH LNVYKQLRAL RDEPTLKQGD VSVTAIGPNV 500
LAFKRSLAGY KSYITLININ DDVESINLDS VFTSITTQLQ YVVVNDKSVR 550
RKNDLTFANS VLLLPKEAVV LSTV 574
Length:574
Mass (Da):65,235
Last modified:June 21, 2005 - v2
Checksum:i6CDD5C92868DE098
GO

Sequence cautioni

The sequence CAA23493.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461H → P in CAA23493. 1 Publication
Sequence conflicti175 – 1751Q → E in CAA23493. 1 Publication
Sequence conflicti324 – 3241K → Q in CAA23493. 1 Publication
Sequence conflicti553 – 5531N → S in CAA23493. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00204 Genomic DNA. Translation: CAA23493.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF59087.2.
AY119654 mRNA. Translation: AAM50308.1.
PIRiS08598.
RefSeqiNP_476628.2. NM_057280.3.
UniGeneiDm.529.

Genome annotation databases

EnsemblMetazoaiFBtr0088758; FBpp0087837; FBgn0002571.
GeneIDi35826.
KEGGidme:Dmel_CG8695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00204 Genomic DNA. Translation: CAA23493.1 . Sequence problems.
AE013599 Genomic DNA. Translation: AAF59087.2 .
AY119654 mRNA. Translation: AAM50308.1 .
PIRi S08598.
RefSeqi NP_476628.2. NM_057280.3.
UniGenei Dm.529.

3D structure databases

ProteinModelPortali P07192.
SMRi P07192. Positions 20-574.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0087837.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Proteomic databases

PaxDbi P07192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088758 ; FBpp0087837 ; FBgn0002571 .
GeneIDi 35826.
KEGGi dme:Dmel_CG8695.

Organism-specific databases

CTDi 35826.
FlyBasei FBgn0002571. Mal-A3.

Phylogenomic databases

eggNOGi COG0366.
GeneTreei ENSGT00530000063127.
InParanoidi P07192.
KOi K01187.
OMAi ASYRDIE.
OrthoDBi EOG7B31NK.
PhylomeDBi P07192.

Miscellaneous databases

GenomeRNAii 35826.
NextBioi 795397.

Gene expression databases

Bgeei P07192.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two gene families clustered in a small region of the Drosophila genome."
    Snyder M., Davidson N.
    J. Mol. Biol. 166:101-118(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Characterization of maltase clusters in the genus Drosophila."
    Gabrisko M., Janecek S.
    J. Mol. Evol. 72:104-118(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMAL3_DROME
AccessioniPrimary (citable) accession number: P07192
Secondary accession number(s): Q9V4T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi