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P07191

- MAL2_DROME

UniProt

P07191 - MAL2_DROME

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Protein

Maltase A2

Gene

Mal-A2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261NucleophileBy similarity
Active sitei298 – 2981Proton donorBy similarity
Sitei364 – 3641Transition state stabilizerBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_254974. Amino acid transport across the plasma membrane.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A2 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein D
Gene namesi
Name:Mal-A2
Synonyms:LvpD
ORF Names:CG8694
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002569. Mal-A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 567544Maltase A2PRO_0000001446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07191.

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiP07191.

Interactioni

Protein-protein interaction databases

BioGridi61677. 5 interactions.
MINTiMINT-851985.
STRINGi7227.FBpp0087826.

Structurei

3D structure databases

ProteinModelPortaliP07191.
SMRiP07191. Positions 22-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
GeneTreeiENSGT00530000063127.
InParanoidiP07191.
KOiK01187.
OMAiDAVPHIY.
OrthoDBiEOG7B31NK.
PhylomeDBiP07191.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKWAHLGLA ALLLISTTQE GTADIDWWEN ASLYQIYPRS FQDSDGDGIG
60 70 80 90 100
DLKGITSRLG YLKEIGITAT WLSPIFTSPM SDFGYDISNF YDIDPIFGTL
110 120 130 140 150
EDFDDLIVEA KSLGVKIILD FVPNHSSDEN VWFEKSVNRE DGYDDFYVWD
160 170 180 190 200
DGKLNEETGA RDPPSNWVSV FSGPMWTWNE KRQQYFLHQF QVKQPDLNFT
210 220 230 240 250
NPMVREHMLD VLKFWLDRGV DGFRIDAVPH IYEHRNADGS YPDEPVSGWG
260 270 280 290 300
SDPNAYDYHD HIYTKDQPAT VDLMYEWREF LDNYRAQNGG DSRVLLAEAY
310 320 330 340 350
SSVETLSAYF GNSTHQGTQL PMNFQLMYLS GYSTAKDVVG SIDYWMNTMW
360 370 380 390 400
KEHQTANWVV GNHDTNRVAD RMGAHKVDLL NVIVNALPGA SVTYYGEEIG
410 420 430 440 450
MSNVDVECTG DSCEDRDGER TPMQWTAGKN ADFSDGESTW LPLSPEYQRY
460 470 480 490 500
NVQTERGVSR SSLNIFKGLQ ELKSSSAFLA FKEDGGFSYE AVTEQVLQII
510 520 530 540 550
RTNKISEEYR ILVNMGNGME ILDGLAPKTY EYVLATAYST HYSGQKADLS
560
QRIILMPYEA VVLRWLA
Length:567
Mass (Da):64,542
Last modified:July 5, 2005 - v2
Checksum:i51242BA9F185213D
GO

Sequence cautioni

The sequence CAA23492.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti527 – 5271P → T in CAA23492. (PubMed:6854639)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00204 Genomic DNA. Translation: CAA23492.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF59088.1.
AY071566 mRNA. Translation: AAL49188.1.
PIRiS08597.
RefSeqiNP_476625.2. NM_057277.3.
UniGeneiDm.5267.

Genome annotation databases

EnsemblMetazoaiFBtr0088747; FBpp0087826; FBgn0002569.
GeneIDi35825.
KEGGidme:Dmel_CG8694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00204 Genomic DNA. Translation: CAA23492.1 . Sequence problems.
AE013599 Genomic DNA. Translation: AAF59088.1 .
AY071566 mRNA. Translation: AAL49188.1 .
PIRi S08597.
RefSeqi NP_476625.2. NM_057277.3.
UniGenei Dm.5267.

3D structure databases

ProteinModelPortali P07191.
SMRi P07191. Positions 22-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61677. 5 interactions.
MINTi MINT-851985.
STRINGi 7227.FBpp0087826.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Proteomic databases

PaxDbi P07191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088747 ; FBpp0087826 ; FBgn0002569 .
GeneIDi 35825.
KEGGi dme:Dmel_CG8694.

Organism-specific databases

CTDi 35825.
FlyBasei FBgn0002569. Mal-A2.

Phylogenomic databases

eggNOGi COG0366.
GeneTreei ENSGT00530000063127.
InParanoidi P07191.
KOi K01187.
OMAi DAVPHIY.
OrthoDBi EOG7B31NK.
PhylomeDBi P07191.

Enzyme and pathway databases

Reactomei REACT_254974. Amino acid transport across the plasma membrane.

Miscellaneous databases

GenomeRNAii 35825.
NextBioi 795392.

Gene expression databases

Bgeei P07191.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two gene families clustered in a small region of the Drosophila genome."
    Snyder M., Davidson N.
    J. Mol. Biol. 166:101-118(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiMAL2_DROME
AccessioniPrimary (citable) accession number: P07191
Secondary accession number(s): Q9V4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3