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Reviewed, UniProtKB/Swiss-Prot P07191 (MAL1_DROME)

Last modified January 19, 2010. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable maltase D
    EC=3.2.1.20
Alternative name(s):
    Larval visceral protein D
Gene names
Name: LvpD
ORF Names: CG8694
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Developmental stage

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Sequence caution

The sequence CAA23492.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionalpha-glucosidase activity

Inferred from electronic annotation. Source: EC

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 567544Probable maltase D
PRO_0000001446

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5271P → T Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P07191-1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 51242BA9F185213D

FASTA56764,542
        10         20         30         40         50         60 
MPKWAHLGLA ALLLISTTQE GTADIDWWEN ASLYQIYPRS FQDSDGDGIG DLKGITSRLG 

        70         80         90        100        110        120 
YLKEIGITAT WLSPIFTSPM SDFGYDISNF YDIDPIFGTL EDFDDLIVEA KSLGVKIILD 

       130        140        150        160        170        180 
FVPNHSSDEN VWFEKSVNRE DGYDDFYVWD DGKLNEETGA RDPPSNWVSV FSGPMWTWNE 

       190        200        210        220        230        240 
KRQQYFLHQF QVKQPDLNFT NPMVREHMLD VLKFWLDRGV DGFRIDAVPH IYEHRNADGS 

       250        260        270        280        290        300 
YPDEPVSGWG SDPNAYDYHD HIYTKDQPAT VDLMYEWREF LDNYRAQNGG DSRVLLAEAY 

       310        320        330        340        350        360 
SSVETLSAYF GNSTHQGTQL PMNFQLMYLS GYSTAKDVVG SIDYWMNTMW KEHQTANWVV 

       370        380        390        400        410        420 
GNHDTNRVAD RMGAHKVDLL NVIVNALPGA SVTYYGEEIG MSNVDVECTG DSCEDRDGER 

       430        440        450        460        470        480 
TPMQWTAGKN ADFSDGESTW LPLSPEYQRY NVQTERGVSR SSLNIFKGLQ ELKSSSAFLA 

       490        500        510        520        530        540 
FKEDGGFSYE AVTEQVLQII RTNKISEEYR ILVNMGNGME ILDGLAPKTY EYVLATAYST 

       550        560 
HYSGQKADLS QRIILMPYEA VVLRWLA

« Hide

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References

« Hide 'large scale' references
[1]"Two gene families clustered in a small region of the Drosophila genome."
Snyder M., Davidson N.
J. Mol. Biol. 166:101-118(1983) [PubMed: 6854639] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Detection of protein similarities using nucleotide sequence databases."
Henikoff S., Wallace J.C.
Nucleic Acids Res. 16:6191-6204(1988) [PubMed: 3135536] [Abstract]
Cited for: POSSIBLE FUNCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		V00204 Genomic DNA. Translation: CAA23492.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF59088.1.
AY071566 mRNA. Translation: AAL49188.1.
PIRS08597.
RefSeqNP_476625.2.
UniGeneDm.5267

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP07191. 6 interactions.
STRINGP07191.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

Genome annotation databases

EnsemblFBtr0088747; FBpp0087826; FBgn0002569; Drosophila melanogaster. [Genome view]
GeneID35825.
KEGGdme:Dmel_CG8694.
NMPDRfig|7227.3.peg.3879.

Organism-specific databases

CTD35825.
FlyBaseFBgn0002569. LvpD.

Phylogenomic databases

eggNOGinNOG05255.
InParanoidP07191.
OMAWENASLY.
OrthoDBEOG95X82H.
PhylomeDBP07191.

Enzyme and pathway databases

BRENDA3.2.1.20. 48.

Gene expression databases

GermOnlineCG8694. Drosophila melanogaster.

Family and domain databases

InterProIPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR017853. Glyco_hydro_catalytic_core.
IPR013781. Glyco_hydro_sg_catalytic.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio795392.

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Entry information

Entry nameMAL1_DROME
AccessionPrimary (citable) accession number: P07191
Secondary accession number(s): Q9V4T7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 5, 2005
Last modified: January 19, 2010
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents