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Protein

Maltase A2

Gene

Mal-A2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei226NucleophileBy similarity1
Active sitei298Proton donorBy similarity1
Sitei364Transition state stabilizerBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-352230 Amino acid transport across the plasma membrane

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A2 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein D
Gene namesi
Name:Mal-A2
Synonyms:LvpD
ORF Names:CG8694
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002569 Mal-A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000144624 – 567Maltase A2Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07191
PRIDEiP07191

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiFBgn0002569
GenevisibleiP07191 DM

Interactioni

Protein-protein interaction databases

BioGridi61677, 5 interactors
IntActiP07191, 3 interactors
STRINGi7227.FBpp0087826

Structurei

3D structure databases

ProteinModelPortaliP07191
SMRiP07191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0471 Eukaryota
COG0366 LUCA
GeneTreeiENSGT00900000140965
InParanoidiP07191
KOiK01187
OMAiEHQTANW
OrthoDBiEOG091G03FE
PhylomeDBiP07191

Family and domain databases

InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKWAHLGLA ALLLISTTQE GTADIDWWEN ASLYQIYPRS FQDSDGDGIG
60 70 80 90 100
DLKGITSRLG YLKEIGITAT WLSPIFTSPM SDFGYDISNF YDIDPIFGTL
110 120 130 140 150
EDFDDLIVEA KSLGVKIILD FVPNHSSDEN VWFEKSVNRE DGYDDFYVWD
160 170 180 190 200
DGKLNEETGA RDPPSNWVSV FSGPMWTWNE KRQQYFLHQF QVKQPDLNFT
210 220 230 240 250
NPMVREHMLD VLKFWLDRGV DGFRIDAVPH IYEHRNADGS YPDEPVSGWG
260 270 280 290 300
SDPNAYDYHD HIYTKDQPAT VDLMYEWREF LDNYRAQNGG DSRVLLAEAY
310 320 330 340 350
SSVETLSAYF GNSTHQGTQL PMNFQLMYLS GYSTAKDVVG SIDYWMNTMW
360 370 380 390 400
KEHQTANWVV GNHDTNRVAD RMGAHKVDLL NVIVNALPGA SVTYYGEEIG
410 420 430 440 450
MSNVDVECTG DSCEDRDGER TPMQWTAGKN ADFSDGESTW LPLSPEYQRY
460 470 480 490 500
NVQTERGVSR SSLNIFKGLQ ELKSSSAFLA FKEDGGFSYE AVTEQVLQII
510 520 530 540 550
RTNKISEEYR ILVNMGNGME ILDGLAPKTY EYVLATAYST HYSGQKADLS
560
QRIILMPYEA VVLRWLA
Length:567
Mass (Da):64,542
Last modified:July 5, 2005 - v2
Checksum:i51242BA9F185213D
GO

Sequence cautioni

The sequence CAA23492 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527P → T in CAA23492 (PubMed:6854639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00204 Genomic DNA Translation: CAA23492.1 Sequence problems.
AE013599 Genomic DNA Translation: AAF59088.1
AY071566 mRNA Translation: AAL49188.1
PIRiS08597
RefSeqiNP_476625.2, NM_057277.3
UniGeneiDm.5267

Genome annotation databases

EnsemblMetazoaiFBtr0088747; FBpp0087826; FBgn0002569
GeneIDi35825
KEGGidme:Dmel_CG8694

Similar proteinsi

Entry informationi

Entry nameiMAL2_DROME
AccessioniPrimary (citable) accession number: P07191
Secondary accession number(s): Q9V4T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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