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P07190

- MAL1_DROME

UniProt

P07190 - MAL1_DROME

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Protein

Maltase A1

Gene
Mal-A1, LvpH, CG8696
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei221 – 2211Nucleophile By similarity
Active sitei297 – 2971Proton donor By similarity
Sitei363 – 3631Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase A1 (EC:3.2.1.20)
Alternative name(s):
Larval visceral protein H
Gene namesi
Name:Mal-A1
Synonyms:LvpH
ORF Names:CG8696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002570. Mal-A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 577558Maltase A1PRO_0000001447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07190.
PRIDEiP07190.

Expressioni

Developmental stagei

One of the proteins expressed by the 44D cuticle gene cluster. Expressed in first, second and early 3rd instar larvae and in adults, but not in embryos or pupae.1 Publication

Gene expression databases

BgeeiP07190.

Interactioni

Protein-protein interaction databases

BioGridi61676. 5 interactions.
MINTiMINT-1599685.
STRINGi7227.FBpp0087838.

Structurei

3D structure databases

ProteinModelPortaliP07190.
SMRiP07190. Positions 19-577.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
GeneTreeiENSGT00530000063127.
InParanoidiP07190.
KOiK01187.
OMAiMMDIVAN.
OrthoDBiEOG7B31NK.
PhylomeDBiP07190.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07190-1 [UniParc]FASTAAdd to Basket

« Hide

MRPQSAACLL LAIVGFVGAT EWWESGNYYQ IYPRSFRDSD GDGIGDLNGV    50
TEKLQYLKDI GFTGTWLSPI FKSPMVDFGY DISDFYQIHP EYGTMEDFER 100
MIAKAKEVGI KIILDFVPNH SSTENEWFTK SVDSDPVYKD FYIWHDGKIN 150
NETGEREPPS NWNSEFRYSA WEWNEVRQQY YLHQFAIQQA DLNYRNPAVV 200
NEMKNVIRFW LGKGVSGFRI DAVPYLFEVD LDRYNQYPDE PLTNDSVNCP 250
DPDDHCYTQH IYTQDMPETI DMVYQWRELV DEFHVENGGD KRLLMTEAYT 300
SFENIMTYYG NGVRNGSHIP FNFDFLTSIN NASKAGEYVE HIKKWMDAMP 350
EGVYANWVLG NHDNKRVASR FGVQRTDLIN ILLQTLPGHA VTYNGEELGM 400
TDVWISWEDT VDPNACNSDP DNYYARSRDP ARSPYQWDAS SKAGFTSADH 450
TWLPVADDYK TNNALQQLRA PRSHLQIFKK LVRVRKEPSF RQGELNIQAI 500
DDDVIIYSRQ KTGSDLYVIV LNLGSTSKTL DLTKYYELGT QAEVITTSLS 550
SQYIDGDVIK STEFVANPYV GTVLVAV 577
Length:577
Mass (Da):66,386
Last modified:February 2, 2004 - v2
Checksum:iE005AE05F98ABE0F
GO

Sequence cautioni

The sequence AAL48097.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00204 Genomic DNA. Translation: CAA23491.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF59089.3.
AY070626 mRNA. Translation: AAL48097.2. Different initiation.
PIRiS07253.
RefSeqiNP_476627.3. NM_057279.4.
UniGeneiDm.1825.

Genome annotation databases

EnsemblMetazoaiFBtr0088759; FBpp0087838; FBgn0002570.
GeneIDi35824.
KEGGidme:Dmel_CG8696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00204 Genomic DNA. Translation: CAA23491.1 . Sequence problems.
AE013599 Genomic DNA. Translation: AAF59089.3 .
AY070626 mRNA. Translation: AAL48097.2 . Different initiation.
PIRi S07253.
RefSeqi NP_476627.3. NM_057279.4.
UniGenei Dm.1825.

3D structure databases

ProteinModelPortali P07190.
SMRi P07190. Positions 19-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61676. 5 interactions.
MINTi MINT-1599685.
STRINGi 7227.FBpp0087838.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Proteomic databases

PaxDbi P07190.
PRIDEi P07190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088759 ; FBpp0087838 ; FBgn0002570 .
GeneIDi 35824.
KEGGi dme:Dmel_CG8696.

Organism-specific databases

CTDi 35824.
FlyBasei FBgn0002570. Mal-A1.

Phylogenomic databases

eggNOGi COG0366.
GeneTreei ENSGT00530000063127.
InParanoidi P07190.
KOi K01187.
OMAi MMDIVAN.
OrthoDBi EOG7B31NK.
PhylomeDBi P07190.

Miscellaneous databases

GenomeRNAii 35824.
NextBioi 795387.

Gene expression databases

Bgeei P07190.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two gene families clustered in a small region of the Drosophila genome."
    Snyder M., Davidson N.
    J. Mol. Biol. 166:101-118(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiMAL1_DROME
AccessioniPrimary (citable) accession number: P07190
Secondary accession number(s): Q9V4T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: February 2, 2004
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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