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Protein

Larval cuticle protein 3

Gene

Lcp3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the larval cuticle.

GO - Molecular functioni

  • structural constituent of chitin-based larval cuticle Source: FlyBase

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • larval chitin-based cuticle development Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Larval cuticle protein 3
Alternative name(s):
Larval cuticle protein III
Gene namesi
Name:Lcp3
ORF Names:CG2043
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002534 Lcp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000000639117 – 112Larval cuticle protein 3Add BLAST96

Proteomic databases

PaxDbiP07188
PRIDEiP07188

Expressioni

Gene expression databases

BgeeiFBgn0002534
ExpressionAtlasiP07188 differential
GenevisibleiP07188 DM

Interactioni

Protein-protein interaction databases

BioGridi61672, 2 interactors
DIPiDIP-22311N
IntActiP07188, 1 interactor
STRINGi7227.FBpp0305732

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 95Pro-rich7

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000106082
InParanoidiP07188
OMAiATGDIHG
OrthoDBiEOG091G16M9
PhylomeDBiP07188

Family and domain databases

InterProiView protein in InterPro
IPR031311 CHIT_BIND_RR_consensus
IPR000618 Insect_cuticle
PfamiView protein in Pfam
PF00379 Chitin_bind_4, 1 hit
PROSITEiView protein in PROSITE
PS00233 CHIT_BIND_RR_1, 1 hit
PS51155 CHIT_BIND_RR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKILLVCSL AALVAANANV EVKELVNDVQ PDGFVSKLVL DDGSASSATG
60 70 80 90 100
DIHGNIDGVF EWISPEGVHV RVSYKADENG YQPQSDLLPT PPPIPAAILK
110
AIAYIEANPS KN
Length:112
Mass (Da):11,857
Last modified:April 1, 1988 - v1
Checksum:i2C6AC731B77291A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00203 Genomic DNA Translation: CAA23489.1
AE013599 Genomic DNA Translation: AAF59094.1
BT011538 mRNA Translation: AAS15674.1
PIRiC25299
RefSeqiNP_001260803.1, NM_001273874.1
NP_476621.1, NM_057273.4
UniGeneiDm.4832

Genome annotation databases

EnsemblMetazoaiFBtr0088743; FBpp0087822; FBgn0002534
FBtr0333554; FBpp0305732; FBgn0002534
GeneIDi35819
KEGGidme:Dmel_CG2043

Similar proteinsi

Entry informationi

Entry nameiLCP3_DROME
AccessioniPrimary (citable) accession number: P07188
Secondary accession number(s): Q53XF1, Q9V4T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health