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P07173

- CYCR_BLAVI

UniProt

P07173 - CYCR_BLAVI

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Protein
Photosynthetic reaction center cytochrome c subunit
Gene
pufC, cytC
Organism
Blastochloris viridis (Rhodopseudomonas viridis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei21 – 211Not N-palmitoylated
Metal bindingi94 – 941Iron (heme 1 axial ligand)
Binding sitei107 – 1071Heme 1 (covalent)
Binding sitei110 – 1101Heme 1 (covalent)
Metal bindingi111 – 1111Iron (heme 1 axial ligand)
Metal bindingi130 – 1301Iron (heme 2 axial ligand)
Metal bindingi144 – 1441Iron (heme 4 axial ligand)
Binding sitei152 – 1521Heme 2 (covalent)
Binding sitei155 – 1551Heme 2 (covalent)
Metal bindingi156 – 1561Iron (heme 2 axial ligand)
Metal bindingi253 – 2531Iron (heme 3 axial ligand)
Binding sitei264 – 2641Heme 3 (covalent)
Binding sitei267 – 2671Heme 3 (covalent)
Metal bindingi268 – 2681Iron (heme 3 axial ligand)
Binding sitei325 – 3251Heme 4 (covalent)
Binding sitei328 – 3281Heme 4 (covalent)
Metal bindingi329 – 3291Iron (heme 4 axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
  2. photosynthesis, light reaction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Photosynthesis, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Photosynthetic reaction center cytochrome c subunit
Alternative name(s):
Cytochrome c558/c559
Gene namesi
Name:pufC
Synonyms:cytC
OrganismiBlastochloris viridis (Rhodopseudomonas viridis)
Taxonomic identifieri1079 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeBlastochloris

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
  2. plasma membrane light-harvesting complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Reaction center

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 356336Photosynthetic reaction center cytochrome c subunit
PRO_0000006551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi21 – 211S-diacylglycerol cysteine

Post-translational modificationi

Binds 4 heme groups per subunit.
After the signal sequence is removed, the N-terminal cysteine is modified to form a diacylglyceride thioether, but the alpha-amino group is free and is not N-palmitoylated.

Keywords - PTMi

Lipoprotein

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 5511
Beta strandi69 – 713
Helixi72 – 754
Beta strandi76 – 783
Beta strandi80 – 823
Helixi87 – 10115
Turni103 – 1053
Helixi106 – 1094
Helixi122 – 14019
Helixi142 – 1454
Turni146 – 1483
Helixi152 – 1565
Beta strandi159 – 1613
Beta strandi172 – 1754
Turni182 – 1843
Helixi189 – 1913
Helixi192 – 1976
Turni198 – 2025
Helixi209 – 2135
Beta strandi215 – 2173
Beta strandi226 – 2294
Beta strandi234 – 2363
Helixi237 – 2393
Helixi244 – 26017
Helixi264 – 2663
Helixi270 – 2723
Helixi282 – 30019
Helixi303 – 3075
Helixi311 – 3133
Helixi325 – 3295
Beta strandi332 – 3343
Helixi335 – 3384
Helixi342 – 3443
Helixi346 – 3483

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DXRX-ray2.00C21-352[»]
1PRCX-ray2.30C21-356[»]
1R2CX-ray2.86C21-356[»]
1VRNX-ray2.20C21-352[»]
2I5NX-ray1.96C21-356[»]
2JBLX-ray2.40C1-356[»]
2PRCX-ray2.45C21-356[»]
2WJMX-ray1.95C21-356[»]
2WJNX-ray1.86C21-356[»]
2X5UX-ray3.00C21-356[»]
2X5VX-ray3.00C21-356[»]
3D38X-ray3.21C21-356[»]
3G7FX-ray2.50C21-356[»]
3PRCX-ray2.40C21-356[»]
3T6DX-ray1.95C1-356[»]
3T6EX-ray1.92C1-356[»]
4AC5X-ray8.20C21-356[»]
4CASX-ray3.50A1-356[»]
5PRCX-ray2.35C21-356[»]
6PRCX-ray2.30C21-356[»]
7PRCX-ray2.65C21-356[»]
ProteinModelPortaliP07173.
SMRiP07173. Positions 21-352.

Miscellaneous databases

EvolutionaryTraceiP07173.

Family & Domainsi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di1.10.468.10. 2 hits.
InterProiIPR011031. Multihaem_cyt.
IPR023119. Multihaem_cyt_PRC_cyt_su-like.
IPR003158. Photosyn_RC_cyt_c-su.
[Graphical view]
PfamiPF02276. CytoC_RC. 1 hit.
[Graphical view]
PIRSFiPIRSF000017. RC_cytochrome. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07173-1 [UniParc]FASTAAdd to Basket

« Hide

MKQLIVNSVA TVALASLVAG CFEPPPATTT QTGFRGLSMG EVLHPATVKA    50
KKERDAQYPP ALAAVKAEGP PVSQVYKNVK VLGNLTEAEF LRTMTAITEW 100
VSPQEGCTYC HDENNLASEA KYPYVVARRM LEMTRAINTN WTQHVAQTGV 150
TCYTCHRGTP LPPYVRYLEP TLPLNNRETP THVERVETRS GYVVRLAKYT 200
AYSALNYDPF TMFLANDKRQ VRVVPQTALP LVGVSRGKER RPLSDAYATF 250
ALMMSISDSL GTNCTFCHNA QTFESWGKKS TPQRAIAWWG IRMVRDLNMN 300
YLAPLNASLP ASRLGRQGEA PQADCRTCHQ GVTKPLFGAS RLKDYPELGP 350
IKAAAK 356
Length:356
Mass (Da):39,371
Last modified:April 1, 1988 - v1
Checksum:iECE3D64F1BB0877A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05768 Genomic DNA. Translation: CAA29223.1.
M16317 Genomic DNA. Translation: AAA26093.1.
PIRiS00139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05768 Genomic DNA. Translation: CAA29223.1 .
M16317 Genomic DNA. Translation: AAA26093.1 .
PIRi S00139.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DXR X-ray 2.00 C 21-352 [» ]
1PRC X-ray 2.30 C 21-356 [» ]
1R2C X-ray 2.86 C 21-356 [» ]
1VRN X-ray 2.20 C 21-352 [» ]
2I5N X-ray 1.96 C 21-356 [» ]
2JBL X-ray 2.40 C 1-356 [» ]
2PRC X-ray 2.45 C 21-356 [» ]
2WJM X-ray 1.95 C 21-356 [» ]
2WJN X-ray 1.86 C 21-356 [» ]
2X5U X-ray 3.00 C 21-356 [» ]
2X5V X-ray 3.00 C 21-356 [» ]
3D38 X-ray 3.21 C 21-356 [» ]
3G7F X-ray 2.50 C 21-356 [» ]
3PRC X-ray 2.40 C 21-356 [» ]
3T6D X-ray 1.95 C 1-356 [» ]
3T6E X-ray 1.92 C 1-356 [» ]
4AC5 X-ray 8.20 C 21-356 [» ]
4CAS X-ray 3.50 A 1-356 [» ]
5PRC X-ray 2.35 C 21-356 [» ]
6PRC X-ray 2.30 C 21-356 [» ]
7PRC X-ray 2.65 C 21-356 [» ]
ProteinModelPortali P07173.
SMRi P07173. Positions 21-352.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P07173.

Family and domain databases

Gene3Di 1.10.468.10. 2 hits.
InterProi IPR011031. Multihaem_cyt.
IPR023119. Multihaem_cyt_PRC_cyt_su-like.
IPR003158. Photosyn_RC_cyt_c-su.
[Graphical view ]
Pfami PF02276. CytoC_RC. 1 hit.
[Graphical view ]
PIRSFi PIRSF000017. RC_cytochrome. 1 hit.
PROSITEi PS51008. MULTIHEME_CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of the cytochrome subunit of the photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis."
    Weyer K.A., Lottspeich F., Lang F., Oesterhelt D., Michel H.
    EMBO J. 6:2197-2202(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE.
    Strain: ATCC 19567 / DSM 133 / F.
  2. "The cytochrome subunit of the photosynthetic reaction center from Rhodopseudomonas viridis is a lipoprotein."
    Weyer K.A., Schaefer W., Lottspeich F., Michel H.
    Biochemistry 26:2909-2914(1987)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46, DIACYLGLYCEROL AT CYS-21.
  3. "Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3-A resolution."
    Deisenhofer J., Epp O., Miki K., Huber R., Michel H.
    Nature 318:618-624(1985)
    Cited for: X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS).
  4. "X-ray structure analysis of a membrane protein complex. Electron density map at 3-A resolution and a model of the chromophores of the photosynthetic reaction center from Rhodopseudomonas viridis."
    Deisenhofer J., Epp O., Miki K., Huber R., Michel H.
    J. Mol. Biol. 180:385-398(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS).
  5. "The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB."
    Lancaster C.R.D., Michel H.
    Structure 5:1339-1359(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).
    Strain: ATCC 19567 / DSM 133 / F.
  6. "Refined crystal structures of reaction centres from Rhodopseudomonas viridis in complexes with the herbicide atrazine and two chiral atrazine derivatives also lead to a new model of the bound carotenoid."
    Lancaster C.R.D., Michel H.
    J. Mol. Biol. 286:883-898(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
    Strain: ATCC 19567 / DSM 133 / F.

Entry informationi

Entry nameiCYCR_BLAVI
AccessioniPrimary (citable) accession number: P07173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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