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Protein

Histidinol-phosphate aminotransferase

Gene

HIS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (HIS1)
  2. Histidine biosynthesis trifunctional protein (HIS4)
  3. Histidine biosynthesis trifunctional protein (HIS4)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (HIS6)
  5. Imidazole glycerol phosphate synthase hisHF (HIS7)
  6. Imidazoleglycerol-phosphate dehydratase (HIS3)
  7. Histidinol-phosphate aminotransferase (HIS5)
  8. Histidinol-phosphatase (HIS2)
  9. Histidine biosynthesis trifunctional protein (HIS4)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • histidinol-phosphate transaminase activity Source: SGD
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • histidine biosynthetic process Source: SGD

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:YIL116W-MONOMER
UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:HIS5
Ordered Locus Names:YIL116W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL116W
SGDiS000001378 HIS5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001535091 – 385Histidinol-phosphate aminotransferaseAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-(pyridoxal phosphate)lysineCurated1

Proteomic databases

MaxQBiP07172
PaxDbiP07172
PRIDEiP07172
TopDownProteomicsiP07172

Interactioni

Protein-protein interaction databases

BioGridi34875, 13 interactors
STRINGi4932.YIL116W

Structurei

3D structure databases

ProteinModelPortaliP07172
SMRiP07172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000288512
InParanoidiP07172
KOiK00817
OMAiTYGMYKV
OrthoDBiEOG092C2LVP

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN
60 70 80 90 100
LHRYPDPHQL EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI
110 120 130 140 150
DAIIRACCVP GKEKILVLPP TYSMYSVCAN INDIEVVQCP LTVSDGSFQM
160 170 180 190 200
DTEAVLTILK NDSLIKLMFV TSPGNPTGAK IKTSLIEKVL QNWDNGLVVV
210 220 230 240 250
DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG MTYATAELAR
260 270 280 290 300
ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT
310 320 330 340 350
ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN
360 370 380
ELGCSGCLRI TVGTHEENTH LIKYFKETLY KLANE
Length:385
Mass (Da):42,646
Last modified:February 1, 1995 - v2
Checksum:iE026E09DB0443C45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110 – 112PGK → RE in CAA29139 (PubMed:3302607).Curated3
Sequence conflicti125Y → S in CAA29139 (PubMed:3302607).Curated1
Sequence conflicti142T → I in CAA29139 (PubMed:3302607).Curated1
Sequence conflicti294R → L in CAA29139 (PubMed:3302607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA Translation: CAA86264.1
X05650 Genomic DNA Translation: CAA29139.1
M38613 Genomic DNA Translation: AAA34675.1
BK006942 Genomic DNA Translation: DAA08437.1
PIRiS48456
RefSeqiNP_012150.1, NM_001179464.1

Genome annotation databases

EnsemblFungiiYIL116W; YIL116W; YIL116W
GeneIDi854690
KEGGisce:YIL116W

Similar proteinsi

Entry informationi

Entry nameiHIS8_YEAST
AccessioniPrimary (citable) accession number: P07172
Secondary accession number(s): D6VVH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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