Reviewed, UniProtKB/Swiss-Prot P07162 (ADH_DROMA)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:

Adh

Organism

Drosophila mauritiana (Fruit fly)

Taxonomic identifier

7226 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 256	255	Alcohol dehydrogenase		PRO_0000054472
Regions
	Nucleotide binding	12 – 35	24	NAD By similarity
Sites
	Active site	153	1	Proton acceptor By similarity
	Binding site	140	1	Substrate By similarity
Experimental info
	Sequence conflict	246	1	I → V Ref.3
	Sequence conflict	246	1	I → V Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P07162-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 31DE52FB08656863	FASTA	256	27,761
	10 20 30 40 50 60 MAFTLTNKNV IFVAGLGGIG LDTSKELVKR DLKNLVILDR IENPAAIAEL QAINPKVTVT 70 80 90 100 110 120 FYPYDVTVPI AETTKLLKTI FAKLKTVDVL INGAGILDDH QIERTIAVNY TGLVNTTTAI 130 140 150 160 170 180 LDFWDKRKGG PGGIICNIGS VTGFNAIYQV PVYSGTKAAV VNFTSSLAKL APITGVTAYT 190 200 210 220 230 240 VNPGITRTTL VHKFNSWLDV EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL 250 STLEAIQWTK HWDSGI

References

[1]	"Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila." Bodmer M., Ashburner M. Nature 309:425-430(1984) [PubMed: 6427630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence comparison of the Adh gene in three drosophilids." Cohn V.H., Thompson M.A., Moore G.P. J. Mol. Evol. 20:31-37(1984) [PubMed: 6429340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Organization and evolution of the alcohol dehydrogenase gene in Drosophila." Cohn V.H., Moore G.P. Mol. Biol. Evol. 5:154-166(1988) [PubMed: 3367783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Evidence for interspecific transfer of the transposable element mariner between Drosophila and Zaprionus." Maruyama K., Hartl D.L. J. Mol. Evol. 33:514-524(1991) [PubMed: 1664000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z00033 Genomic DNA. Translation: CAA77334.1. M19264 Genomic DNA. Translation: AAA28332.1. X63953 Genomic DNA. Translation: CAA45374.1.
PIR	S09633.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	P07162. Positions 2-256.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012496. Dmau\Adh.
Enzyme and pathway databases
BRENDA	1.1.1.1. 294628.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
ProDom	PD000819. SRP54. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROMA

Accession

Primary (citable) accession number: P07162
Secondary accession number(s): Q24233

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project