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Protein

Beta-2-microglobulin

Gene

B2m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-RNO-1236974. ER-Phagosome pathway.
R-RNO-1236977. Endosomal/Vacuolar pathway.
R-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.
R-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2m
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2189. B2m.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 11999Beta-2-microglobulinPRO_0000018790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 100

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07151.
PRIDEiP07151.

PTM databases

iPTMnetiP07151.
PhosphoSiteiP07151.

Expressioni

Gene expression databases

GenevisibleiP07151. RN.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

Protein-protein interaction databases

BioGridi246411. 2 interactions.
IntActiP07151. 2 interactions.
MINTiMINT-253320.
STRINGi10116.ENSRNOP00000023017.

Structurei

Secondary structure

1
119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 338Combined sources
Beta strandi37 – 393Combined sources
Beta strandi41 – 5313Combined sources
Beta strandi56 – 616Combined sources
Beta strandi82 – 909Combined sources
Beta strandi98 – 1036Combined sources
Beta strandi111 – 1144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55B/E21-119[»]
1FRTX-ray4.50B21-119[»]
1I1AX-ray2.80B21-119[»]
1KJMX-ray2.35B21-119[»]
1KJVX-ray1.48B21-119[»]
2FRTmodel-B/D21-119[»]
3FRUX-ray2.20B/D/F21-119[»]
ProteinModelPortaliP07151.
SMRiP07151. Positions 21-119.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11490Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP07151.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
PhylomeDBiP07151.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSVTVIFL VLVSLAVVLA IQKTPQIQVY SRHPPENGKP NFLNCYVSQF
60 70 80 90 100
HPPQIEIELL KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC
110
RVKHVTLKEP KTVTWDRDM
Length:119
Mass (Da):13,720
Last modified:April 1, 1988 - v1
Checksum:i3BE0A869E236DDFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00441 mRNA. Translation: CAA68498.1.
Y08531 mRNA. Translation: CAA69847.1.
X16956 mRNA. Translation: CAA34830.1.
PIRiA26842.
RefSeqiNP_036644.1. NM_012512.2.
UniGeneiRn.1868.

Genome annotation databases

EnsembliENSRNOT00000023017; ENSRNOP00000023017; ENSRNOG00000017123.
GeneIDi24223.
KEGGirno:24223.
UCSCiRGD:2189. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00441 mRNA. Translation: CAA68498.1.
Y08531 mRNA. Translation: CAA69847.1.
X16956 mRNA. Translation: CAA34830.1.
PIRiA26842.
RefSeqiNP_036644.1. NM_012512.2.
UniGeneiRn.1868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55B/E21-119[»]
1FRTX-ray4.50B21-119[»]
1I1AX-ray2.80B21-119[»]
1KJMX-ray2.35B21-119[»]
1KJVX-ray1.48B21-119[»]
2FRTmodel-B/D21-119[»]
3FRUX-ray2.20B/D/F21-119[»]
ProteinModelPortaliP07151.
SMRiP07151. Positions 21-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246411. 2 interactions.
IntActiP07151. 2 interactions.
MINTiMINT-253320.
STRINGi10116.ENSRNOP00000023017.

PTM databases

iPTMnetiP07151.
PhosphoSiteiP07151.

Proteomic databases

PaxDbiP07151.
PRIDEiP07151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023017; ENSRNOP00000023017; ENSRNOG00000017123.
GeneIDi24223.
KEGGirno:24223.
UCSCiRGD:2189. rat.

Organism-specific databases

CTDi567.
RGDi2189. B2m.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP07151.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
PhylomeDBiP07151.
TreeFamiTF334167.

Enzyme and pathway databases

ReactomeiR-RNO-1236974. ER-Phagosome pathway.
R-RNO-1236977. Endosomal/Vacuolar pathway.
R-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.
R-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTraceiP07151.
PROiP07151.

Gene expression databases

GenevisibleiP07151. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of rat beta 2-microglobulin cDNA."
    Mauxion F., Kress M.
    Nucleic Acids Res. 15:7638-7638(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. le Rolle A.F., Butcher G.W., Joly E.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: RT10 stock.
    Tissue: Splenocyte.
  3. "An Fc receptor structurally related to MHC class I antigens."
    Simister N.E., Mostov K.E.
    Nature 337:184-187(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-39.
    Strain: Wistar.
  4. "The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain."
    Cole T., Dickson P.W., Esnard F., Averill F., Risbridger G., Gauthier F., Schreiber G.
    Eur. J. Biochem. 186:35-42(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-119.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  5. "Crystal structure of the complex of rat neonatal Fc receptor with Fc."
    Burmeister W.P., Huber A.H., Bjorkman P.J.
    Nature 372:379-383(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  6. "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor."
    Vaughn D.E., Bjorkman P.J.
    Structure 6:63-73(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  7. "Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-A(a)."
    Speir J.A., Stevens J., Joly E., Butcher G.W., Wilson I.A.
    Immunity 14:81-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS).

Entry informationi

Entry nameiB2MG_RAT
AccessioniPrimary (citable) accession number: P07151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 8, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.