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Protein

Beta-2-microglobulin

Gene

B2m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-RNO-1236974 ER-Phagosome pathway
R-RNO-1236977 Endosomal/Vacuolar pathway
R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-2172127 DAP12 interactions
R-RNO-2424491 DAP12 signaling
R-RNO-6798695 Neutrophil degranulation
R-RNO-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2m
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2189 B2m

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001879021 – 119Beta-2-microglobulinAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 100

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP07151
PRIDEiP07151

PTM databases

iPTMnetiP07151
PhosphoSitePlusiP07151

Expressioni

Gene expression databases

BgeeiENSRNOG00000017123
GenevisibleiP07151 RN

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246411, 2 interactors
IntActiP07151, 3 interactors
MINTiP07151
STRINGi10116.ENSRNOP00000023017

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi37 – 39Combined sources3
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi82 – 90Combined sources9
Beta strandi98 – 103Combined sources6
Beta strandi111 – 114Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55B/E21-119[»]
1FRTX-ray4.50B21-119[»]
1I1AX-ray2.80B21-119[»]
1KJMX-ray2.35B21-119[»]
1KJVX-ray1.48B21-119[»]
2FRTmodel-B/D21-119[»]
3FRUX-ray2.20B/D/F21-119[»]
ProteinModelPortaliP07151
SMRiP07151
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07151

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 114Ig-like C1-typeAdd BLAST90

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A Eukaryota
ENOG410YTDG LUCA
GeneTreeiENSGT00690000102227
HOGENOMiHOG000043084
HOVERGENiHBG006197
InParanoidiP07151
KOiK08055
OMAiPNFLNCY
OrthoDBiEOG091G0ZOW
PhylomeDBiP07151
TreeFamiTF334167

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSVTVIFL VLVSLAVVLA IQKTPQIQVY SRHPPENGKP NFLNCYVSQF
60 70 80 90 100
HPPQIEIELL KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC
110
RVKHVTLKEP KTVTWDRDM
Length:119
Mass (Da):13,720
Last modified:April 1, 1988 - v1
Checksum:i3BE0A869E236DDFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00441 mRNA Translation: CAA68498.1
Y08531 mRNA Translation: CAA69847.1
X16956 mRNA Translation: CAA34830.1
PIRiA26842
RefSeqiNP_036644.1, NM_012512.2
UniGeneiRn.1868

Genome annotation databases

EnsembliENSRNOT00000023017; ENSRNOP00000023017; ENSRNOG00000017123
GeneIDi24223
KEGGirno:24223
UCSCiRGD:2189 rat

Similar proteinsi

Entry informationi

Entry nameiB2MG_RAT
AccessioniPrimary (citable) accession number: P07151
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health