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Protein

Fatty acid synthase subunit beta

Gene

FAS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.

Catalytic activityi

Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+.
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.
An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei274For acetyltransferase activityBy similarity1
Active sitei1808For malonyltransferase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

  • long-chain fatty acid biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase, Oxidoreductase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:YKL182W-MONOMER.
YEAST:YKL182W-MONOMER.
SABIO-RKP07149.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid synthase subunit beta (EC:2.3.1.86)
Including the following 5 domains:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Enoyl-[acyl-carrier-protein] reductase [NADH] (EC:1.3.1.9)
[Acyl-carrier-protein] acetyltransferase (EC:2.3.1.38)
[Acyl-carrier-protein] malonyltransferase (EC:2.3.1.39)
S-acyl fatty acid synthase thioesterase (EC:3.1.2.14)
Gene namesi
Name:FAS1
Ordered Locus Names:YKL182W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL182W.
SGDiS000001665. FAS1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • fatty acid synthase complex Source: SGD
  • lipid particle Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001802821 – 2051Fatty acid synthase subunit betaAdd BLAST2051

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei733PhosphothreonineCombined sources1
Modified residuei1121PhosphoserineCombined sources1
Cross-linki1364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP07149.
PRIDEiP07149.

PTM databases

iPTMnetiP07149.

Interactioni

Subunit structurei

[Alpha6beta6] hexamers of two multifunctional subunits (alpha and beta).

Binary interactionsi

WithEntry#Exp.IntActNotes
FAS2P190973EBI-6795,EBI-6806

Protein-protein interaction databases

BioGridi33940. 66 interactors.
DIPiDIP-742N.
IntActiP07149. 79 interactors.
MINTiMINT-1325736.

Structurei

Secondary structure

12051
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Beta strandi16 – 19Combined sources4
Turni24 – 26Combined sources3
Helixi27 – 40Combined sources14
Turni46 – 48Combined sources3
Beta strandi50 – 53Combined sources4
Helixi57 – 69Combined sources13
Beta strandi74 – 76Combined sources3
Helixi81 – 95Combined sources15
Helixi101 – 110Combined sources10
Helixi116 – 132Combined sources17
Helixi144 – 151Combined sources8
Beta strandi156 – 160Combined sources5
Helixi169 – 179Combined sources11
Helixi181 – 201Combined sources21
Beta strandi202 – 204Combined sources3
Helixi205 – 208Combined sources4
Helixi215 – 220Combined sources6
Helixi222 – 224Combined sources3
Helixi228 – 232Combined sources5
Helixi234 – 256Combined sources23
Helixi260 – 265Combined sources6
Beta strandi267 – 273Combined sources7
Helixi274 – 276Combined sources3
Helixi277 – 284Combined sources8
Helixi289 – 313Combined sources25
Helixi321 – 329Combined sources9
Beta strandi337 – 344Combined sources8
Helixi346 – 358Combined sources13
Helixi362 – 364Combined sources3
Beta strandi367 – 370Combined sources4
Beta strandi373 – 375Combined sources3
Beta strandi377 – 381Combined sources5
Helixi383 – 396Combined sources14
Helixi404 – 406Combined sources3
Helixi409 – 411Combined sources3
Beta strandi417 – 420Combined sources4
Turni430 – 432Combined sources3
Helixi433 – 444Combined sources12
Beta strandi445 – 447Combined sources3
Turni452 – 454Combined sources3
Turni462 – 464Combined sources3
Beta strandi466 – 470Combined sources5
Helixi475 – 484Combined sources10
Helixi490 – 493Combined sources4
Beta strandi499 – 503Combined sources5
Beta strandi505 – 507Combined sources3
Helixi508 – 510Combined sources3
Helixi512 – 520Combined sources9
Beta strandi526 – 529Combined sources4
Beta strandi540 – 542Combined sources3
Turni544 – 548Combined sources5
Helixi552 – 554Combined sources3
Helixi561 – 564Combined sources4
Beta strandi568 – 571Combined sources4
Beta strandi577 – 580Combined sources4
Helixi582 – 587Combined sources6
Beta strandi591 – 594Combined sources4
Helixi598 – 601Combined sources4
Helixi604 – 612Combined sources9
Beta strandi616 – 620Combined sources5
Helixi621 – 623Combined sources3
Helixi627 – 640Combined sources14
Beta strandi647 – 652Combined sources6
Helixi658 – 671Combined sources14
Beta strandi675 – 684Combined sources10
Helixi688 – 697Combined sources10
Beta strandi703 – 705Combined sources3
Helixi710 – 722Combined sources13
Beta strandi728 – 732Combined sources5
Beta strandi738 – 740Combined sources3
Helixi748 – 757Combined sources10
Beta strandi766 – 770Combined sources5
Helixi774 – 777Combined sources4
Helixi778 – 780Combined sources3
Turni781 – 783Combined sources3
Helixi785 – 787Combined sources3
Turni788 – 790Combined sources3
Helixi803 – 805Combined sources3
Helixi815 – 822Combined sources8
Helixi829 – 836Combined sources8
Beta strandi841 – 847Combined sources7
Beta strandi853 – 857Combined sources5
Helixi860 – 870Combined sources11
Turni871 – 874Combined sources4
Turni877 – 879Combined sources3
Helixi880 – 885Combined sources6
Helixi888 – 898Combined sources11
Helixi914 – 916Combined sources3
Helixi919 – 930Combined sources12
Turni933 – 936Combined sources4
Beta strandi937 – 939Combined sources3
Helixi941 – 958Combined sources18
Helixi970 – 974Combined sources5
Helixi976 – 986Combined sources11
Helixi988 – 991Combined sources4
Helixi997 – 1006Combined sources10
Beta strandi1010 – 1012Combined sources3
Beta strandi1016 – 1018Combined sources3
Helixi1025 – 1030Combined sources6
Helixi1035 – 1038Combined sources4
Helixi1040 – 1042Combined sources3
Helixi1048 – 1050Combined sources3
Turni1057 – 1062Combined sources6
Helixi1070 – 1090Combined sources21
Helixi1094 – 1096Combined sources3
Beta strandi1125 – 1128Combined sources4
Helixi1135 – 1143Combined sources9
Helixi1149 – 1155Combined sources7
Beta strandi1158 – 1161Combined sources4
Beta strandi1164 – 1167Combined sources4
Helixi1169 – 1174Combined sources6
Beta strandi1181 – 1186Combined sources6
Helixi1190 – 1192Combined sources3
Beta strandi1194 – 1201Combined sources8
Beta strandi1204 – 1214Combined sources11
Turni1215 – 1217Combined sources3
Beta strandi1218 – 1225Combined sources8
Beta strandi1229 – 1232Combined sources4
Beta strandi1234 – 1241Combined sources8
Helixi1258 – 1270Combined sources13
Helixi1294 – 1304Combined sources11
Helixi1323 – 1325Combined sources3
Helixi1326 – 1335Combined sources10
Helixi1336 – 1338Combined sources3
Helixi1341 – 1343Combined sources3
Helixi1347 – 1349Combined sources3
Beta strandi1350 – 1359Combined sources10
Beta strandi1367 – 1369Combined sources3
Beta strandi1375 – 1383Combined sources9
Beta strandi1385 – 1398Combined sources14
Beta strandi1401 – 1414Combined sources14
Helixi1419 – 1421Combined sources3
Beta strandi1423 – 1434Combined sources12
Helixi1438 – 1446Combined sources9
Beta strandi1450 – 1454Combined sources5
Beta strandi1463 – 1474Combined sources12
Beta strandi1476 – 1478Combined sources3
Beta strandi1480 – 1492Combined sources13
Beta strandi1498 – 1510Combined sources13
Helixi1515 – 1522Combined sources8
Beta strandi1524 – 1527Combined sources4
Beta strandi1529 – 1545Combined sources17
Helixi1551 – 1557Combined sources7
Helixi1562 – 1564Combined sources3
Helixi1567 – 1572Combined sources6
Beta strandi1576 – 1578Combined sources3
Helixi1582 – 1597Combined sources16
Helixi1602 – 1604Combined sources3
Beta strandi1605 – 1612Combined sources8
Beta strandi1621 – 1632Combined sources12
Beta strandi1635 – 1643Combined sources9
Beta strandi1649 – 1658Combined sources10
Beta strandi1662 – 1666Combined sources5
Turni1674 – 1677Combined sources4
Helixi1678 – 1683Combined sources6
Helixi1685 – 1702Combined sources18
Helixi1706 – 1711Combined sources6
Beta strandi1715 – 1720Combined sources6
Helixi1724 – 1734Combined sources11
Beta strandi1749 – 1754Combined sources6
Beta strandi1761 – 1765Combined sources5
Helixi1770 – 1772Combined sources3
Helixi1774 – 1794Combined sources21
Beta strandi1803 – 1806Combined sources4
Helixi1810 – 1819Combined sources10
Helixi1824 – 1840Combined sources17
Beta strandi1850 – 1857Combined sources8
Helixi1859 – 1862Combined sources4
Helixi1868 – 1882Combined sources15
Beta strandi1886 – 1893Combined sources8
Turni1894 – 1896Combined sources3
Beta strandi1897 – 1903Combined sources7
Helixi1904 – 1919Combined sources16
Helixi1924 – 1930Combined sources7
Helixi1933 – 1952Combined sources20
Beta strandi1964 – 1968Combined sources5
Helixi1979 – 1981Combined sources3
Helixi1988 – 1993Combined sources6
Helixi1998 – 2000Combined sources3
Helixi2003 – 2006Combined sources4
Turni2007 – 2009Combined sources3
Beta strandi2013 – 2015Combined sources3
Helixi2023 – 2033Combined sources11
Helixi2036 – 2043Combined sources8
Turni2044 – 2048Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFFX-ray4.00B/E/H1-545[»]
B/E/H1669-1940[»]
2UV8X-ray3.10G/H/I1-2051[»]
2VKZX-ray4.00G/H/I1-2051[»]
3HMJX-ray4.00G/H/I1-2051[»]
ProteinModelPortaliP07149.
SMRiP07149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1523 – 1648MaoC-likeAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 468AcetyltransferaseAdd BLAST468
Regioni480 – 868Enoyl reductaseAdd BLAST389
Regioni1144 – 1626DehydrataseAdd BLAST483
Regioni1627 – 1845Malonyl/palmitoyl transferaseAdd BLAST219

Sequence similaritiesi

Contains 1 MaoC-like domain.Curated

Phylogenomic databases

HOGENOMiHOG000177963.
InParanoidiP07149.
KOiK00668.
OMAiKLQHVGM.
OrthoDBiEOG092C010Q.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.40.366.10. 5 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR020801. PKS_acyl_transferase.
IPR032088. SAT.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF16073. SAT. 1 hit.
[Graphical view]
PIRSFiPIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSiPR01483. FASYNTHASE.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.

Sequencei

Sequence statusi: Complete.

P07149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAYSTRPLT LSHGSLEHVL LVPTASFFIA SQLQEQFNKI LPEPTEGFAA
60 70 80 90 100
DDEPTTPAEL VGKFLGYVSS LVEPSKVGQF DQVLNLCLTE FENCYLEGND
110 120 130 140 150
IHALAAKLLQ ENDTTLVKTK ELIKNYITAR IMAKRPFDKK SNSALFRAVG
160 170 180 190 200
EGNAQLVAIF GGQGNTDDYF EELRDLYQTY HVLVGDLIKF SAETLSELIR
210 220 230 240 250
TTLDAEKVFT QGLNILEWLE NPSNTPDKDY LLSIPISCPL IGVIQLAHYV
260 270 280 290 300
VTAKLLGFTP GELRSYLKGA TGHSQGLVTA VAIAETDSWE SFFVSVRKAI
310 320 330 340 350
TVLFFIGVRC YEAYPNTSLP PSILEDSLEN NEGVPSPMLS ISNLTQEQVQ
360 370 380 390 400
DYVNKTNSHL PAGKQVEISL VNGAKNLVVS GPPQSLYGLN LTLRKAKAPS
410 420 430 440 450
GLDQSRIPFS ERKLKFSNRF LPVASPFHSH LLVPASDLIN KDLVKNNVSF
460 470 480 490 500
NAKDIQIPVY DTFDGSDLRV LSGSISERIV DCIIRLPVKW ETTTQFKATH
510 520 530 540 550
ILDFGPGGAS GLGVLTHRNK DGTGVRVIVA GTLDINPDDD YGFKQEIFDV
560 570 580 590 600
TSNGLKKNPN WLEEYHPKLI KNKSGKIFVE TKFSKLIGRP PLLVPGMTPC
610 620 630 640 650
TVSPDFVAAT TNAGYTIELA GGGYFSAAGM TAAIDSVVSQ IEKGSTFGIN
660 670 680 690 700
LIYVNPFMLQ WGIPLIKELR SKGYPIQFLT IGAGVPSLEV ASEYIETLGL
710 720 730 740 750
KYLGLKPGSI DAISQVINIA KAHPNFPIAL QWTGGRGGGH HSFEDAHTPM
760 770 780 790 800
LQMYSKIRRH PNIMLIFGSG FGSADDTYPY LTGEWSTKFD YPPMPFDGFL
810 820 830 840 850
FGSRVMIAKE VKTSPDAKKC IAACTGVPDD KWEQTYKKPT GGIVTVRSEM
860 870 880 890 900
GEPIHKIATR GVMLWKEFDE TIFNLPKNKL VPTLEAKRDY IISRLNADFQ
910 920 930 940 950
KPWFATVNGQ ARDLATMTYE EVAKRLVELM FIRSTNSWFD VTWRTFTGDF
960 970 980 990 1000
LRRVEERFTK SKTLSLIQSY SLLDKPDEAI EKVFNAYPAA REQFLNAQDI
1010 1020 1030 1040 1050
DHFLSMCQNP MQKPVPFVPV LDRRFEIFFK KDSLWQSEHL EAVVDQDVQR
1060 1070 1080 1090 1100
TCILHGPVAA QFTKVIDEPI KSIMDGIHDG HIKKLLHQYY GDDESKIPAV
1110 1120 1130 1140 1150
EYFGGESPVD VQSQVDSSSV SEDSAVFKAT SSTDEESWFK ALAGSEINWR
1160 1170 1180 1190 1200
HASFLCSFIT QDKMFVSNPI RKVFKPSQGM VVEISNGNTS SKTVVTLSEP
1210 1220 1230 1240 1250
VQGELKPTVI LKLLKENIIQ MEMIENRTMD GKPVSLPLLY NFNPDNGFAP
1260 1270 1280 1290 1300
ISEVMEDRNQ RIKEMYWKLW IDEPFNLDFD PRDVIKGKDF EITAKEVYDF
1310 1320 1330 1340 1350
THAVGNNCED FVSRPDRTML APMDFAIVVG WRAIIKAIFP NTVDGDLLKL
1360 1370 1380 1390 1400
VHLSNGYKMI PGAKPLQVGD VVSTTAVIES VVNQPTGKIV DVVGTLSRNG
1410 1420 1430 1440 1450
KPVMEVTSSF FYRGNYTDFE NTFQKTVEPV YQMHIKTSKD IAVLRSKEWF
1460 1470 1480 1490 1500
QLDDEDFDLL NKTLTFETET EVTFKNANIF SSVKCFGPIK VELPTKETVE
1510 1520 1530 1540 1550
IGIVDYEAGA SHGNPVVDFL KRNGSTLEQK VNLENPIPIA VLDSYTPSTN
1560 1570 1580 1590 1600
EPYARVSGDL NPIHVSRHFA SYANLPGTIT HGMFSSASVR ALIENWAADS
1610 1620 1630 1640 1650
VSSRVRGYTC QFVDMVLPNT ALKTSIQHVG MINGRKLIKF ETRNEDDVVV
1660 1670 1680 1690 1700
LTGEAEIEQP VTTFVFTGQG SQEQGMGMDL YKTSKAAQDV WNRADNHFKD
1710 1720 1730 1740 1750
TYGFSILDIV INNPVNLTIH FGGEKGKRIR ENYSAMIFET IVDGKLKTEK
1760 1770 1780 1790 1800
IFKEINEHST SYTFRSEKGL LSATQFTQPA LTLMEKAAFE DLKSKGLIPA
1810 1820 1830 1840 1850
DATFAGHSLG EYAALASLAD VMSIESLVEV VFYRGMTMQV AVPRDELGRS
1860 1870 1880 1890 1900
NYGMIAINPG RVAASFSQEA LQYVVERVGK RTGWLVEIVN YNVENQQYVA
1910 1920 1930 1940 1950
AGDLRALDTV TNVLNFIKLQ KIDIIELQKS LSLEEVEGHL FEIIDEASKK
1960 1970 1980 1990 2000
SAVKPRPLKL ERGFACIPLV GISVPFHSTY LMNGVKPFKS FLKKNIIKEN
2010 2020 2030 2040 2050
VKVARLAGKY IPNLTAKPFQ VTKEYFQDVY DLTGSEPIKE IIDNWEKYEQ

S
Length:2,051
Mass (Da):228,691
Last modified:February 1, 1994 - v2
Checksum:i43AA85A6071D8EAA
GO

Sequence cautioni

The sequence CAA27616 differs from that shown. Reason: Frameshift at positions 1845, 1948 and 2017.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → F in AAB59310 (PubMed:2034224).Curated1
Sequence conflicti191S → F in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti212G → D in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti403D → G in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1039H → Q in AAB59310 (PubMed:2034224).Curated1
Sequence conflicti1039H → Q in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti1149W → R in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1184I → F in AAB59310 (PubMed:2034224).Curated1
Sequence conflicti1184I → F in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti1290 – 1292FEI → SET in AAA34602 (PubMed:3031066).Curated3
Sequence conflicti1331 – 1333WRA → LRG in AAB59310 (PubMed:2034224).Curated3
Sequence conflicti1331 – 1333WRA → LRG in CAA27616 (PubMed:3528750).Curated3
Sequence conflicti1407 – 1411TSSFF → IFLFL in AAA34602 (PubMed:3031066).Curated5
Sequence conflicti1559D → H in AAB59310 (PubMed:2034224).Curated1
Sequence conflicti1559D → H in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti1576P → L in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1587A → T in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1631M → T in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1647D → H in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti1661V → G in AAB59310 (PubMed:2034224).Curated1
Sequence conflicti1661V → G in CAA27616 (PubMed:3528750).Curated1
Sequence conflicti1876E → K in AAA34602 (PubMed:3031066).Curated1
Sequence conflicti1980Y → T in AAA34602 (PubMed:3031066).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30162 Genomic DNA. Translation: AAB59310.1.
X74151 Genomic DNA. Translation: CAA52256.1.
Z28182 Genomic DNA. Translation: CAA82025.1.
X03977 Genomic DNA. Translation: CAA27616.1. Frameshift.
M31034 Genomic DNA. Translation: AAA34602.1.
X70069 Genomic DNA. Translation: CAA49673.1.
BK006944 Genomic DNA. Translation: DAA08985.1.
PIRiS34688.
RefSeqiNP_012739.1. NM_001179748.1.

Genome annotation databases

EnsemblFungiiYKL182W; YKL182W; YKL182W.
GeneIDi853653.
KEGGisce:YKL182W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30162 Genomic DNA. Translation: AAB59310.1.
X74151 Genomic DNA. Translation: CAA52256.1.
Z28182 Genomic DNA. Translation: CAA82025.1.
X03977 Genomic DNA. Translation: CAA27616.1. Frameshift.
M31034 Genomic DNA. Translation: AAA34602.1.
X70069 Genomic DNA. Translation: CAA49673.1.
BK006944 Genomic DNA. Translation: DAA08985.1.
PIRiS34688.
RefSeqiNP_012739.1. NM_001179748.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFFX-ray4.00B/E/H1-545[»]
B/E/H1669-1940[»]
2UV8X-ray3.10G/H/I1-2051[»]
2VKZX-ray4.00G/H/I1-2051[»]
3HMJX-ray4.00G/H/I1-2051[»]
ProteinModelPortaliP07149.
SMRiP07149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33940. 66 interactors.
DIPiDIP-742N.
IntActiP07149. 79 interactors.
MINTiMINT-1325736.

PTM databases

iPTMnetiP07149.

Proteomic databases

MaxQBiP07149.
PRIDEiP07149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL182W; YKL182W; YKL182W.
GeneIDi853653.
KEGGisce:YKL182W.

Organism-specific databases

EuPathDBiFungiDB:YKL182W.
SGDiS000001665. FAS1.

Phylogenomic databases

HOGENOMiHOG000177963.
InParanoidiP07149.
KOiK00668.
OMAiKLQHVGM.
OrthoDBiEOG092C010Q.

Enzyme and pathway databases

BioCyciMetaCyc:YKL182W-MONOMER.
YEAST:YKL182W-MONOMER.
SABIO-RKP07149.

Miscellaneous databases

EvolutionaryTraceiP07149.
PROiP07149.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.40.366.10. 5 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR020801. PKS_acyl_transferase.
IPR032088. SAT.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF16073. SAT. 1 hit.
[Graphical view]
PIRSFiPIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSiPR01483. FASYNTHASE.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFAS1_YEAST
AccessioniPrimary (citable) accession number: P07149
Secondary accession number(s): D6VX19, Q05747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 172 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 91800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.