P07148 (FABPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acid-binding protein, liver

Alternative name(s):
Fatty acid-binding protein 1
Liver-type fatty acid-binding protein
Short name=L-FABP

Gene names

Name:	FABP1
Synonyms:	FABPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
Subcellular location	Cytoplasm.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Lipid-binding
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Traceable author statement. Source: Reactome cellular response to hydrogen peroxide Inferred from direct assay PubMed 16175609. Source: UniProtKB cellular response to hypoxia Inferred from direct assay PubMed 16175609. Source: UniProtKB intestinal absorption Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from direct assay PubMed 16175609. Source: UniProtKB negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay PubMed 16175609. Source: UniProtKB positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara positive regulation of hydrolase activity Inferred from electronic annotation. Source: Compara small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	apical cortex Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara nucleoplasm Traceable author statement. Source: Reactome peroxisomal matrix Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	antioxidant activity Inferred from direct assay PubMed 16175609. Source: UniProtKB bile acid binding Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara drug binding Inferred from electronic annotation. Source: Compara fatty acid binding Inferred from electronic annotation. Source: Compara long-chain fatty acid transporter activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 127

127

Fatty acid-binding protein, liver

PRO_0000067334

Amino acid modifications

Modified residue

1

1

N-acetylmethionine

Modified residue

56

1

Phosphoserine By similarity

Natural variations

Natural variant

54

1

A → T.
Corresponds to variant rs1801273 [ dbSNP | Ensembl ].

VAR_014662

Natural variant

94

1

T → A. Ref.2
Corresponds to variant rs2241883 [ dbSNP | Ensembl ].

VAR_022093

Secondary structure

1

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127

Helix Strand Turn

Details...

Beta strand

5 – 14

10

Helix

15 – 21

7

Helix

26 – 32

7

Beta strand

38 – 44

7

Beta strand

47 – 54

8

Beta strand

57 – 64

8

Beta strand

67 – 72

6

Beta strand

74 – 76

3

Beta strand

78 – 82

5

Beta strand

84 – 87

4

Beta strand

90 – 95

6

Beta strand

98 – 105

8

Beta strand

108 – 115

8

Beta strand

118 – 126

9

Sequences

	Sequence		Length	Mass (Da)
	P07148 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: 065DCEFB08DAB6B6	FASTA	127	14,208
	10 20 30 40 50 60 MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 70 80 90 100 110 120 NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF KRISKRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications." Chan L., Wei C.-F., Li W.-H., Yang C.-Y., Ratner P., Pownall H., Gotto A.M. Jr., Smith L.C. J. Biol. Chem. 260:2629-2632(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins." Lowe J.B., Boguski M.S., Sweetser D.A., Elshourbagy N.A., Taylor J.M., Gordon J.I. J. Biol. Chem. 260:3413-3417(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-94.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"Rapid data collection for protein structure determination by NMR spectroscopy." Xu Y., Long D., Yang D. J. Am. Chem. Soc. 129:7722-7723(2007) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
[6]	"Crystal structure of human FABP1." Structural genomics consortium (SGC) Submitted (DEC-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M10617 mRNA. Translation: AAA52419.1.
M10050 mRNA. Translation: AAA52418.1.
BC032801 mRNA. Translation: AAH32801.1.

IPI

IPI00010290.

PIR

FZHUL. A22289.

RefSeq

NP_001434.1. NM_001443.2.

UniGene

Hs.380135.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F73	X-ray	2.50	A/B/C/D/E/F/G/H	1-127	[»]
2L67	NMR	-	A	2-127	[»]
2L68	NMR	-	A	2-127	[»]
2LKK	NMR	-	A	2-127	[»]
2PY1	NMR	-	A	1-127	[»]
3B2H	X-ray	1.55	A	2-127	[»]
3B2I	X-ray	1.86	A	2-127	[»]
3B2J	X-ray	2.00	A	2-127	[»]
3B2K	X-ray	1.73	A	2-127	[»]
3B2L	X-ray	2.25	A	2-127	[»]
3STK	X-ray	1.55	A	2-127	[»]
3STM	X-ray	2.22	X	2-127	[»]
3STN	X-ray	2.60	A	2-127	[»]
3VG2	X-ray	2.40	A	2-127	[»]
3VG3	X-ray	2.22	A	2-127	[»]
3VG4	X-ray	2.50	A	2-127	[»]
3VG5	X-ray	2.00	A	2-127	[»]
3VG6	X-ray	2.22	A	2-127	[»]
3VG7	X-ray	1.44	A	2-127	[»]

ProteinModelPortal

P07148.

ModBase

Search...

Protein-protein interaction databases

IntAct

P07148. 1 interaction.

STRING

9606.ENSP00000295834.

PTM databases

PhosphoSite

P07148.

Polymorphism databases

DMDM

119808.

2D gel databases

SWISS-2DPAGE

P07148.

Proteomic databases

PaxDb

P07148.

PRIDE

P07148.

Protocols and materials databases

DNASU

2168.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000295834; ENSP00000295834; ENSG00000163586.

GeneID

2168.

KEGG

hsa:2168.

UCSC

uc002sst.2. human.

Organism-specific databases

CTD

2168.

GeneCards

GC02M088422.

HGNC

HGNC:3555. FABP1.

HPA

CAB002305.
HPA028275.

MIM

134650. gene.

neXtProt

NX_P07148.

PharmGKB

PA27956.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG317209.

HOVERGEN

HBG005633.

InParanoid

P07148.

KO

K08750.

OMA

QNEFTLG.

OrthoDB

EOG40CHJJ.

PhylomeDB

P07148.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

P07148.

Bgee

P07148.

CleanEx

HS_FABP1.

Genevestigator

P07148.

GermOnline

ENSG00000163586. Homo sapiens.

Family and domain databases

Gene3D

2.40.128.20. 1 hit.

InterPro

IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]

Pfam

PF00061. Lipocalin. 1 hit.
[Graphical view]

PRINTS

PR00178. FATTYACIDBP.

SUPFAM

SSF50814. Calycin. 1 hit.

PROSITE

PS00214. FABP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P07148.

ChEMBL

CHEMBL5421.

ChiTaRS

FABP1. human.

EvolutionaryTrace

P07148.

GenomeRNAi

2168.

NextBio

8755.

SOURCE

Search...

Entry information

Entry name

FABPL_HUMAN

Accession

Primary (citable) accession number: P07148

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.