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Reviewed, UniProtKB/Swiss-Prot P07148 (FABPL_HUMAN)

Last modified June 16, 2009. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fatty acid-binding protein, liver
Alternative name(s):
    L-FABP
Gene names
Name: FABP1
Synonyms: FABPL
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.

Subcellular location

Cytoplasm.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   LigandLipid-binding
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processorgan morphogenesis

Traceable author statement. Source: ProtInc

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Fatty acid-binding protein, liver
PRO_0000067334

Amino acid modifications

Modified residue11N-acetylmethionine
Modified residue561Phosphoserine By similarity

Natural variations

Natural variant541A → T: dbSNP rs1801273.
VAR_014662
Natural variant941T → A: dbSNP rs2241883. Ref.2
VAR_022093

Secondary structure

1 ........................... 127
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P07148-1 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 065DCEFB08DAB6B6

FASTA12714,208
        10         20         30         40         50         60 
MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 

        70         80         90        100        110        120 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 


KRISKRI

« Hide

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References

« Hide 'large scale' references
[1]"Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications."
Chan L., Wei C.-F., Li W.-H., Yang C.-Y., Ratner P., Pownall H., Gotto A.M. Jr., Smith L.C.
J. Biol. Chem. 260:2629-2632(1985) [PubMed: 3838309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins."
Lowe J.B., Boguski M.S., Sweetser D.A., Elshourbagy N.A., Taylor J.M., Gordon J.I.
J. Biol. Chem. 260:3413-3417(1985) [PubMed: 3838313] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-94.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Kidney and Stomach.
[4]"Rapid data collection for protein structure determination by NMR spectroscopy."
Xu Y., Long D., Yang D.
J. Am. Chem. Soc. 129:7722-7723(2007) [PubMed: 17536800] [Abstract]
Cited for: STRUCTURE BY NMR.
[5]"Crystal structure of human FABP1."
Structural genomics consortium (SGC)
Submitted (DEC-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

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Cross-references

Sequence databases

M10617 mRNA. Translation: AAA52419.1.
M10050 mRNA. Translation: AAA52418.1.
BC032801 mRNA. Translation: AAH32801.1.
IPIIPI00010290.
PIRFZHUL. A22289.
RefSeqNP_001434.1.
UniGeneHs.380135

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2F73X-ray2.50A/B/C/D/E/F/G/H1-127[»]
2PY1NMR-A1-127[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP07148. 1 interaction.

PTM databases

PhosphoSiteP07148.

2-D gel databases

SWISS-2DPAGEP07148.
PMMA-2DPAGEP07148.
Siena-2DPAGEP07148.

Proteomic databases

PRIDEP07148.

Genome annotation databases

EnsemblENSG00000163586. Homo sapiens. [Contig view]
GeneID2168.
KEGGhsa:2168.

Organism-specific databases

GeneCardsGC02M088261.
H-InvDBHIX0002246.
HGNCHGNC:3555. FABP1.
HPACAB002305.
MIM134650. gene.
PharmGKBPA27956.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP07148.
HOVERGENP07148.
OMAP07148. QNEFTLG.

Gene expression databases

ArrayExpressP07148.
BgeeP07148.
CleanExHS_FABP1.
GermOnlineENSG00000163586. Homo sapiens.

Family and domain databases

InterProIPR012674. Calycin.
IPR000463. Fatty_acid_bd.
IPR000566. Lipocln_cytFABP.
[Graphical view]
Gene3DG3DSA:2.40.128.20. Calycin. 1 hit.
PANTHERPTHR11955. Fatty_acid_bd. 1 hit.
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio8755.
SOURCESearch...

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Entry information

Entry nameFABPL_HUMAN
AccessionPrimary (citable) accession number: P07148
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 16, 2009
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents