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P07147

- TYRP1_MOUSE

UniProt

P07147 - TYRP1_MOUSE

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Protein
5,6-dihydroxyindole-2-carboxylic acid oxidase
Gene
Tyrp1, Tyrp-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.3 Publications

Cofactori

Binds 2 copper ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi192 – 1921Copper A By similarity
Metal bindingi215 – 2151Copper A By similarity
Metal bindingi224 – 2241Copper A By similarity
Metal bindingi377 – 3771Copper B By similarity
Metal bindingi381 – 3811Copper B By similarity
Metal bindingi404 – 4041Copper B By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Source: InterPro
  3. protein binding Source: UniProtKB
  4. protein heterodimerization activity Source: UniProtKB
  5. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. acetoacetic acid metabolic process Source: MGI
  2. melanin biosynthetic process from tyrosine Source: UniProtKB
  3. melanin metabolic process Source: MGI
  4. melanocyte differentiation Source: MGI
  5. melanosome organization Source: MGI
  6. pigmentation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15620.
UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Brown locus protein
Catalase B
Tyrosinase-related protein 1
Short name:
TRP
Short name:
TRP-1
Short name:
TRP1
Gene namesi
Name:Tyrp1
Synonyms:Tyrp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:98881. Tyrp1.

Subcellular locationi

Melanosome membrane; Single-pass type I membrane protein
Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 477453Lumenal, melanosome Reviewed prediction
Add
BLAST
Transmembranei478 – 50124Helical; Reviewed prediction
Add
BLAST
Topological domaini502 – 53736Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Ensembl
  2. endosome membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. melanosome Source: UniProtKB
  5. melanosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.

Keywords - Diseasei

Albinism, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424
Add
BLAST
Chaini25 – 5375135,6-dihydroxyindole-2-carboxylic acid oxidase
PRO_0000035890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi385 – 3851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP07147.
PRIDEiP07147.

PTM databases

PhosphoSiteiP07147.

Expressioni

Tissue specificityi

Pigment cells.

Gene expression databases

BgeeiP07147.
CleanExiMM_TYRP1.
GenevestigatoriP07147.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TyrP113442EBI-821614,EBI-821603

Protein-protein interaction databases

IntActiP07147. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07147.
SMRiP07147. Positions 128-466.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86242.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP07147.
KOiK00506.
OMAiVKKTFLG.
PhylomeDBiP07147.
TreeFamiTF315865.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 1 hit.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07147-1 [UniParc]FASTAAdd to Basket

« Hide

MKSYNVLPLA YISLFLMLFY QVWAQFPREC ANIEALRRGV CCPDLLPSSG    50
PGTDPCGSSS GRGRCVAVIA DSRPHSRHYP HDGKDDREAW PLRFFNRTCQ 100
CNDNFSGHNC GTCRPGWRGA ACNQKILTVR RNLLDLSPEE KSHFVRALDM 150
AKRTTHPQFV IATRRLEDIL GPDGNTPQFE NISVYNYFVW THYYSVKKTF 200
LGTGQESFGD VDFSHEGPAF LTWHRYHLLQ LERDMQEMLQ EPSFSLPYWN 250
FATGKNVCDV CTDDLMGSRS NFDSTLISPN SVFSQWRVVC ESLEEYDTLG 300
TLCNSTEGGP IRRNPAGNVG RPAVQRLPEP QDVTQCLEVR VFDTPPFYSN 350
STDSFRNTVE GYSAPTGKYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF 400
VLLHTFTDAV FDEWLRRYNA DISTFPLENA PIGHNRQYNM VPFWPPVTNT 450
EMFVTAPDNL GYAYEVQWPG QEFTVSEIIT IAVVAALLLV AAIFGVASCL 500
IRSRSTKNEA NQPLLTDHYQ RYAEDYEELP NPNHSMV 537
Length:537
Mass (Da):60,761
Last modified:April 1, 1988 - v1
Checksum:i86570998AA9EB0BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101C → Y in brown. 1 Publication
Natural varianti326 – 3261R → H in brown. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03687 mRNA. Translation: CAA27323.1.
BC076598 mRNA. Translation: AAH76598.1.
CCDSiCCDS18290.1.
PIRiA24933. YRMSB6.
RefSeqiNP_001268943.1. NM_001282014.1.
NP_001268944.1. NM_001282015.1.
NP_112479.1. NM_031202.3.
UniGeneiMm.30438.

Genome annotation databases

EnsembliENSMUST00000006151; ENSMUSP00000006151; ENSMUSG00000005994.
ENSMUST00000102831; ENSMUSP00000099895; ENSMUSG00000005994.
GeneIDi22178.
KEGGimmu:22178.
UCSCiuc008tjq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03687 mRNA. Translation: CAA27323.1 .
BC076598 mRNA. Translation: AAH76598.1 .
CCDSi CCDS18290.1.
PIRi A24933. YRMSB6.
RefSeqi NP_001268943.1. NM_001282014.1.
NP_001268944.1. NM_001282015.1.
NP_112479.1. NM_031202.3.
UniGenei Mm.30438.

3D structure databases

ProteinModelPortali P07147.
SMRi P07147. Positions 128-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07147. 1 interaction.

PTM databases

PhosphoSitei P07147.

Proteomic databases

MaxQBi P07147.
PRIDEi P07147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006151 ; ENSMUSP00000006151 ; ENSMUSG00000005994 .
ENSMUST00000102831 ; ENSMUSP00000099895 ; ENSMUSG00000005994 .
GeneIDi 22178.
KEGGi mmu:22178.
UCSCi uc008tjq.2. mouse.

Organism-specific databases

CTDi 7306.
MGIi MGI:98881. Tyrp1.

Phylogenomic databases

eggNOGi NOG86242.
HOGENOMi HOG000118376.
HOVERGENi HBG003553.
InParanoidi P07147.
KOi K00506.
OMAi VKKTFLG.
PhylomeDBi P07147.
TreeFami TF315865.

Enzyme and pathway databases

UniPathwayi UPA00785 .
BioCyci MetaCyc:MONOMER-15620.

Miscellaneous databases

ChiTaRSi TYRP1. mouse.
NextBioi 302135.
PROi P07147.
SOURCEi Search...

Gene expression databases

Bgeei P07147.
CleanExi MM_TYRP1.
Genevestigatori P07147.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
PANTHERi PTHR11474:SF3. PTHR11474:SF3. 1 hit.
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 2 hits.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  3. "A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse."
    Jackson I.J.
    Proc. Natl. Acad. Sci. U.S.A. 85:4392-4396(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROTEIN.
  4. "Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity."
    Halaban R., Moellmann G.
    Proc. Natl. Acad. Sci. U.S.A. 87:4809-4813(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  5. "The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts."
    Winder A.J., Wittbjer A., Rosengren E., Rorsman H.
    J. Cell Sci. 106:153-166(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  6. "Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis."
    Kobayashi T., Urabe K., Winder A., Jimenez-Cervantes C., Imokawa G., Brewington T., Solano F., Garcia-Borron J.C., Hearing V.J.
    EMBO J. 13:5818-5825(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."
    Setty S.R., Tenza D., Truschel S.T., Chou E., Sviderskaya E.V., Theos A.C., Lamoreux M.L., Di Pietro S.M., Starcevic M., Bennett D.C., Dell'Angelica E.C., Raposo G., Marks M.S.
    Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type."
    Zdarsky E., Favor J., Jackson I.J.
    Genetics 126:443-449(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS BROWN TYR-110 AND HIS-326.

Entry informationi

Entry nameiTYRP1_MOUSE
AccessioniPrimary (citable) accession number: P07147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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