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P07146

- TRY2_MOUSE

UniProt

P07146 - TRY2_MOUSE

Protein

Anionic trypsin-2

Gene

Prss2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Charge relay systemBy similarity
    Metal bindingi75 – 751CalciumBy similarity
    Metal bindingi77 – 771Calcium; via carbonyl oxygenBy similarity
    Metal bindingi80 – 801Calcium; via carbonyl oxygenBy similarity
    Metal bindingi85 – 851CalciumBy similarity
    Active sitei107 – 1071Charge relay systemBy similarity
    Sitei194 – 1941Required for specificityBy similarity
    Active sitei200 – 2001Charge relay systemBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB
    2. digestion Source: UniProtKB-KW
    3. proteolysis Source: UniProtKB
    4. response to caffeine Source: Ensembl
    5. response to nicotine Source: Ensembl
    6. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anionic trypsin-2 (EC:3.4.21.4)
    Alternative name(s):
    Anionic trypsin II
    Pretrypsinogen II
    Serine protease 2
    Gene namesi
    Name:Prss2
    Synonyms:Try2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:102759. Prss2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Propeptidei16 – 238Activation peptidePRO_0000028203
    Chaini24 – 246223Anionic trypsin-2PRO_0000028204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 160PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi132 ↔ 233PROSITE-ProRule annotation
    Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
    Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
    Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    MaxQBiP07146.
    PaxDbiP07146.
    PRIDEiP07146.

    PTM databases

    PhosphoSiteiP07146.

    Expressioni

    Gene expression databases

    ArrayExpressiP07146.
    BgeeiP07146.
    CleanExiMM_PRSS2.
    GenevestigatoriP07146.

    Interactioni

    Protein-protein interaction databases

    BioGridi204335. 1 interaction.
    STRINGi10090.ENSMUSP00000065393.

    Structurei

    3D structure databases

    ProteinModelPortaliP07146.
    SMRiP07146. Positions 24-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP07146.
    KOiK01312.
    OMAiNWIEETI.
    OrthoDBiEOG75B84T.
    PhylomeDBiP07146.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSALLILALV GAAVAFPVDD DDKIVGGYTC RESSVPYQVS LNAGYHFCGG    50
    SLINDQWVVS AAHCYKYRIQ VRLGEHNINV LEGNEQFVDS AKIIRHPNYN 100
    SWTLDNDIML IKLASPVTLN ARVASVPLPS SCAPAGTQCL ISGWGNTLSN 150
    GVNNPDLLQC VDAPVLPQAD CEASYPGDIT NNMICVGFLE GGKDSCQGDS 200
    GGPVVCNGEL QGIVSWGYGC AQPDAPGVYT KVCNYVDWIQ NTIADN 246
    Length:246
    Mass (Da):26,204
    Last modified:April 1, 1988 - v1
    Checksum:iCEF8C97AAC2D07AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04574 mRNA. Translation: CAA28243.1.
    X04577 Genomic DNA. Translation: CAA28245.1.
    CCDSiCCDS20050.1.
    PIRiB25528.
    RefSeqiNP_033456.1. NM_009430.2.
    UniGeneiMm.276926.

    Genome annotation databases

    EnsembliENSMUST00000070380; ENSMUSP00000065393; ENSMUSG00000057163.
    GeneIDi22072.
    KEGGimmu:22072.
    UCSCiuc009boz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04574 mRNA. Translation: CAA28243.1 .
    X04577 Genomic DNA. Translation: CAA28245.1 .
    CCDSi CCDS20050.1.
    PIRi B25528.
    RefSeqi NP_033456.1. NM_009430.2.
    UniGenei Mm.276926.

    3D structure databases

    ProteinModelPortali P07146.
    SMRi P07146. Positions 24-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204335. 1 interaction.
    STRINGi 10090.ENSMUSP00000065393.

    Protein family/group databases

    MEROPSi S01.064.

    PTM databases

    PhosphoSitei P07146.

    Proteomic databases

    MaxQBi P07146.
    PaxDbi P07146.
    PRIDEi P07146.

    Protocols and materials databases

    DNASUi 22072.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070380 ; ENSMUSP00000065393 ; ENSMUSG00000057163 .
    GeneIDi 22072.
    KEGGi mmu:22072.
    UCSCi uc009boz.2. mouse.

    Organism-specific databases

    CTDi 5645.
    MGIi MGI:102759. Prss2.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P07146.
    KOi K01312.
    OMAi NWIEETI.
    OrthoDBi EOG75B84T.
    PhylomeDBi P07146.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 301902.
    PROi P07146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07146.
    Bgeei P07146.
    CleanExi MM_PRSS2.
    Genevestigatori P07146.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes."
      Stevenson B.J., Hagenbuechle O., Wellauer P.K.
      Nucleic Acids Res. 14:8307-8330(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: A/J.

    Entry informationi

    Entry nameiTRY2_MOUSE
    AccessioniPrimary (citable) accession number: P07146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3