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P07146 (TRY2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anionic trypsin-2

EC=3.4.21.4
Alternative name(s):
Anionic trypsin II
Pretrypsinogen II
Serine protease 2
Gene names
Name:Prss2
Synonyms:Try2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Propeptide16 – 238Activation peptide
PRO_0000028203
Chain24 – 246223Anionic trypsin-2
PRO_0000028204

Regions

Domain24 – 244221Peptidase S1

Sites

Active site631Charge relay system By similarity
Active site1071Charge relay system By similarity
Active site2001Charge relay system By similarity
Metal binding751Calcium By similarity
Metal binding771Calcium; via carbonyl oxygen By similarity
Metal binding801Calcium; via carbonyl oxygen By similarity
Metal binding851Calcium By similarity
Site1941Required for specificity By similarity

Amino acid modifications

Disulfide bond30 ↔ 160 By similarity
Disulfide bond48 ↔ 64 By similarity
Disulfide bond132 ↔ 233 By similarity
Disulfide bond139 ↔ 206 By similarity
Disulfide bond171 ↔ 185 By similarity
Disulfide bond196 ↔ 220 By similarity

Sequences

Sequence LengthMass (Da)Tools
P07146 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: CEF8C97AAC2D07AD

FASTA24626,204
        10         20         30         40         50         60 
MSALLILALV GAAVAFPVDD DDKIVGGYTC RESSVPYQVS LNAGYHFCGG SLINDQWVVS 

        70         80         90        100        110        120 
AAHCYKYRIQ VRLGEHNINV LEGNEQFVDS AKIIRHPNYN SWTLDNDIML IKLASPVTLN 

       130        140        150        160        170        180 
ARVASVPLPS SCAPAGTQCL ISGWGNTLSN GVNNPDLLQC VDAPVLPQAD CEASYPGDIT 

       190        200        210        220        230        240 
NNMICVGFLE GGKDSCQGDS GGPVVCNGEL QGIVSWGYGC AQPDAPGVYT KVCNYVDWIQ 


NTIADN 

« Hide

References

[1]"Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes."
Stevenson B.J., Hagenbuechle O., Wellauer P.K.
Nucleic Acids Res. 14:8307-8330(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: A/J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04574 mRNA. Translation: CAA28243.1.
X04577 Genomic DNA. Translation: CAA28245.1.
CCDSCCDS20050.1.
PIRB25528.
RefSeqNP_033456.1. NM_009430.2.
UniGeneMm.276926.

3D structure databases

ProteinModelPortalP07146.
SMRP07146. Positions 24-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204335. 1 interaction.
STRING10090.ENSMUSP00000065393.

Protein family/group databases

MEROPSS01.064.

PTM databases

PhosphoSiteP07146.

Proteomic databases

MaxQBP07146.
PaxDbP07146.
PRIDEP07146.

Protocols and materials databases

DNASU22072.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070380; ENSMUSP00000065393; ENSMUSG00000057163.
GeneID22072.
KEGGmmu:22072.
UCSCuc009boz.2. mouse.

Organism-specific databases

CTD5645.
MGIMGI:102759. Prss2.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP07146.
KOK01312.
OMANWIEETI.
OrthoDBEOG75B84T.
PhylomeDBP07146.
TreeFamTF331065.

Gene expression databases

ArrayExpressP07146.
BgeeP07146.
CleanExMM_PRSS2.
GenevestigatorP07146.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301902.
PROP07146.
SOURCESearch...

Entry information

Entry nameTRY2_MOUSE
AccessionPrimary (citable) accession number: P07146
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot