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P07146

- TRY2_MOUSE

UniProt

P07146 - TRY2_MOUSE

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Protein

Anionic trypsin-2

Gene

Prss2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay systemBy similarity
Metal bindingi75 – 751CalciumBy similarity
Metal bindingi77 – 771Calcium; via carbonyl oxygenBy similarity
Metal bindingi80 – 801Calcium; via carbonyl oxygenBy similarity
Metal bindingi85 – 851CalciumBy similarity
Active sitei107 – 1071Charge relay systemBy similarity
Sitei194 – 1941Required for specificityBy similarity
Active sitei200 – 2001Charge relay systemBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB
  2. digestion Source: UniProtKB-KW
  3. proteolysis Source: UniProtKB
  4. response to caffeine Source: Ensembl
  5. response to nicotine Source: Ensembl
  6. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.064.

Names & Taxonomyi

Protein namesi
Recommended name:
Anionic trypsin-2 (EC:3.4.21.4)
Alternative name(s):
Anionic trypsin II
Pretrypsinogen II
Serine protease 2
Gene namesi
Name:Prss2
Synonyms:Try2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:102759. Prss2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Propeptidei16 – 238Activation peptidePRO_0000028203
Chaini24 – 246223Anionic trypsin-2PRO_0000028204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 160PROSITE-ProRule annotation
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Disulfide bondi132 ↔ 233PROSITE-ProRule annotation
Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiP07146.
PaxDbiP07146.
PRIDEiP07146.

PTM databases

PhosphoSiteiP07146.

Expressioni

Gene expression databases

BgeeiP07146.
CleanExiMM_PRSS2.
ExpressionAtlasiP07146. baseline and differential.
GenevestigatoriP07146.

Interactioni

Protein-protein interaction databases

BioGridi204335. 1 interaction.
STRINGi10090.ENSMUSP00000065393.

Structurei

3D structure databases

ProteinModelPortaliP07146.
SMRiP07146. Positions 24-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP07146.
KOiK01312.
OMAiNWIEETI.
OrthoDBiEOG75B84T.
PhylomeDBiP07146.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07146 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSALLILALV GAAVAFPVDD DDKIVGGYTC RESSVPYQVS LNAGYHFCGG
60 70 80 90 100
SLINDQWVVS AAHCYKYRIQ VRLGEHNINV LEGNEQFVDS AKIIRHPNYN
110 120 130 140 150
SWTLDNDIML IKLASPVTLN ARVASVPLPS SCAPAGTQCL ISGWGNTLSN
160 170 180 190 200
GVNNPDLLQC VDAPVLPQAD CEASYPGDIT NNMICVGFLE GGKDSCQGDS
210 220 230 240
GGPVVCNGEL QGIVSWGYGC AQPDAPGVYT KVCNYVDWIQ NTIADN
Length:246
Mass (Da):26,204
Last modified:April 1, 1988 - v1
Checksum:iCEF8C97AAC2D07AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04574 mRNA. Translation: CAA28243.1.
X04577 Genomic DNA. Translation: CAA28245.1.
CCDSiCCDS20050.1.
PIRiB25528.
RefSeqiNP_033456.1. NM_009430.2.
UniGeneiMm.276926.

Genome annotation databases

EnsembliENSMUST00000070380; ENSMUSP00000065393; ENSMUSG00000057163.
GeneIDi22072.
KEGGimmu:22072.
UCSCiuc009boz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04574 mRNA. Translation: CAA28243.1 .
X04577 Genomic DNA. Translation: CAA28245.1 .
CCDSi CCDS20050.1.
PIRi B25528.
RefSeqi NP_033456.1. NM_009430.2.
UniGenei Mm.276926.

3D structure databases

ProteinModelPortali P07146.
SMRi P07146. Positions 24-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204335. 1 interaction.
STRINGi 10090.ENSMUSP00000065393.

Protein family/group databases

MEROPSi S01.064.

PTM databases

PhosphoSitei P07146.

Proteomic databases

MaxQBi P07146.
PaxDbi P07146.
PRIDEi P07146.

Protocols and materials databases

DNASUi 22072.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070380 ; ENSMUSP00000065393 ; ENSMUSG00000057163 .
GeneIDi 22072.
KEGGi mmu:22072.
UCSCi uc009boz.2. mouse.

Organism-specific databases

CTDi 5645.
MGIi MGI:102759. Prss2.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P07146.
KOi K01312.
OMAi NWIEETI.
OrthoDBi EOG75B84T.
PhylomeDBi P07146.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 301902.
PROi P07146.
SOURCEi Search...

Gene expression databases

Bgeei P07146.
CleanExi MM_PRSS2.
ExpressionAtlasi P07146. baseline and differential.
Genevestigatori P07146.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes."
    Stevenson B.J., Hagenbuechle O., Wellauer P.K.
    Nucleic Acids Res. 14:8307-8330(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: A/J.

Entry informationi

Entry nameiTRY2_MOUSE
AccessioniPrimary (citable) accession number: P07146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3