Reviewed,
UniProtKB/Swiss-Prot P07146 (TRY2_MOUSE)
Last modified
May 5, 2009.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Anionic trypsin-2 EC=3.4.21.4 Alternative name(s): Anionic trypsin II Pretrypsinogen II Serine protease 2 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 246 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Digestion |
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | Calcium Metal-binding |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Zymogen |
| Gene Ontology (GO) | |
| Biological process | collagen catabolic process Inferred from sequence or structural similarity. Source: UniProtKB digestionInferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | extracellular space Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB protein bindingInferred from sequence or structural similarity. Source: UniProtKB serine-type endopeptidase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 15 | 15 | |||||||||
| Propeptide | 16 – 23 | 8 | Activation peptide | PRO_0000028203 | |||||||
| Chain | 24 – 246 | 223 | Anionic trypsin-2 | PRO_0000028204 | |||||||
Regions | |||||||||||
| Domain | 24 – 244 | 221 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 63 | 1 | Charge relay system By similarity | ||||||||
| Active site | 107 | 1 | Charge relay system By similarity | ||||||||
| Active site | 200 | 1 | Charge relay system By similarity | ||||||||
| Metal binding | 75 | 1 | Calcium By similarity | ||||||||
| Metal binding | 77 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 80 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 85 | 1 | Calcium By similarity | ||||||||
| Site | 194 | 1 | Required for specificity By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 30 ↔ 160 | By similarity | |||||||||
| Disulfide bond | 48 ↔ 64 | By similarity | |||||||||
| Disulfide bond | 132 ↔ 233 | By similarity | |||||||||
| Disulfide bond | 139 ↔ 206 | By similarity | |||||||||
| Disulfide bond | 171 ↔ 185 | By similarity | |||||||||
| Disulfide bond | 196 ↔ 220 | By similarity | |||||||||
Sequences
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References
| [1] | "Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes." Stevenson B.J., Hagenbuechle O., Wellauer P.K. Nucleic Acids Res. 14:8307-8330(1986) [PubMed: 3641189] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: A/J. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X04574 mRNA. Translation: CAA28243.1. X04577 Genomic DNA. Translation: CAA28245.1. | |
| IPI | IPI00403650. |
| PIR | B25528. |
| RefSeq | NP_033456.1. |
| UniGene | Mm.276926 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EZX based on UniProtKB P00760. |
| SMR | P07146. Positions 24-246. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.064. |
PTM databases | |
| PhosphoSite | P07146. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000057163. Mus musculus. [Contig view] |
| GeneID | 22072. |
| KEGG | mmu:22072. |
Organism-specific databases | |
| MGI | MGI:102759. Prss2. |
Phylogenomic databases | |
| HOGENOM | P07146. |
| HOVERGEN | P07146. |
| OMA | P07146. LLQCVDA. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.4. 244. |
Gene expression databases | |
| ArrayExpress | P07146. |
| Bgee | P07146. |
| CleanEx | MM_PRSS2. |
| GermOnline | ENSMUSG00000057163. Mus musculus. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 301902. |
| SOURCE | Search... |
Entry information
| Entry name | TRY2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P07146 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


