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P07142

- CY1_NEUCR

UniProt

P07142 - CY1_NEUCR

Protein

Cytochrome c1, heme protein, mitochondrial

Gene

cyt-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101Heme (covalent)
    Binding sitei113 – 1131Heme (covalent)
    Metal bindingi114 – 1141Iron (heme axial ligand)
    Metal bindingi234 – 2341Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity Source: EnsemblFungi
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c1, heme protein, mitochondrial
    Alternative name(s):
    Complex III subunit 4
    Complex III subunit IV
    Cytochrome b-c1 complex subunit 4
    Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
    Short name:
    Cytochrome c-1
    Gene namesi
    Name:cyt-1
    ORF Names:NCU09816
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex III Source: EnsemblFungi

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 7070MitochondrionAdd
    BLAST
    Chaini71 – 332262Cytochrome c1, heme protein, mitochondrialPRO_0000006556Add
    BLAST

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Interactioni

    Subunit structurei

    Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi5141.NCU09816.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP07142.
    SMRiP07142. Positions 71-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei282 – 29615Helical; Note=Anchors to the membraneSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 250154Cytochrome cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated
    Contains 1 cytochrome c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2857.
    HOGENOMiHOG000003867.
    KOiK00413.
    OrthoDBiEOG7M0P2N.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002326. Cyt_c1.
    IPR021157. Cyt_c1_TM_anchor_C.
    [Graphical view]
    PANTHERiPTHR10266. PTHR10266. 1 hit.
    PfamiPF02167. Cytochrom_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00603. CYTOCHROMEC1.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    SSF81496. SSF81496. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07142-1 [UniParc]FASTAAdd to Basket

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    MLARTCLRST RTFASAKNGA FKFAKRSAST QSSGAAAESP LRLNIAAAAA    50
    TAVAAGSIAW YYHLYGFASA MTPAEEGLHA TKYPWVHEQW LKTFDHQALR 100
    RGFQVYREVC ASCHSLSRVP YRALVGTILT VDEAKALAEE NEYDTEPNDQ 150
    GEIEKRPGKL SDYLPDPYKN DEAARFANNG ALPPDLSLIV KARHGGCDYI 200
    FSLLTGYPDE PPAGASVGAG LNFNPYFPGT GIAMARVLYD GLVDYEDGTP 250
    ASTSQMAKDV VEFLNWAAEP EMDDRKRMGM KVLVVTSVLF ALSVYVKRYK 300
    WAWLKSRKIV YDPPKSPPPA TNLALPQQRA KS 332
    Length:332
    Mass (Da):36,456
    Last modified:April 1, 1988 - v1
    Checksum:i3AAFCCE896E8D4DB
    GO

    Sequence cautioni

    The sequence EAA34520.1 differs from that shown. Reason: Frameshift at position 316.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05235 mRNA. Translation: CAA28860.1.
    CM002236 Genomic DNA. Translation: EAA34520.1. Frameshift.
    PIRiA27187.
    RefSeqiXP_963756.1. XM_958663.2.
    UniGeneiNcr.13832.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000009576; EFNCRP00000009558; EFNCRG00000009557.
    GeneIDi3879905.
    KEGGincr:NCU09816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05235 mRNA. Translation: CAA28860.1 .
    CM002236 Genomic DNA. Translation: EAA34520.1 . Frameshift.
    PIRi A27187.
    RefSeqi XP_963756.1. XM_958663.2.
    UniGenei Ncr.13832.

    3D structure databases

    ProteinModelPortali P07142.
    SMRi P07142. Positions 71-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU09816.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000009576 ; EFNCRP00000009558 ; EFNCRG00000009557 .
    GeneIDi 3879905.
    KEGGi ncr:NCU09816.

    Phylogenomic databases

    eggNOGi COG2857.
    HOGENOMi HOG000003867.
    KOi K00413.
    OrthoDBi EOG7M0P2N.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002326. Cyt_c1.
    IPR021157. Cyt_c1_TM_anchor_C.
    [Graphical view ]
    PANTHERi PTHR10266. PTHR10266. 1 hit.
    Pfami PF02167. Cytochrom_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00603. CYTOCHROMEC1.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    SSF81496. SSF81496. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of cytochrome c1 from Neurospora crassa."
      Roemisch J., Tropschug M., Sebald W., Weiss H.
      Eur. J. Biochem. 164:111-115(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiCY1_NEUCR
    AccessioniPrimary (citable) accession number: P07142
    Secondary accession number(s): Q7SCQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3