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P07142 (CY1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name=Cytochrome c-1
Gene names
Name:cyt-1
ORF Names:NCU09816
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Subunit structure

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer By similarity.

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Contains 1 cytochrome c domain.

Sequence caution

The sequence EAA34520.1 differs from that shown. Reason: Frameshift at position 316.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 7070Mitochondrion
Chain71 – 332262Cytochrome c1, heme protein, mitochondrial
PRO_0000006556

Regions

Transmembrane282 – 29615Helical; Note=Anchors to the membrane; Potential
Domain97 – 250154Cytochrome c

Sites

Metal binding1141Iron (heme axial ligand)
Metal binding2341Iron (heme axial ligand) By similarity
Binding site1101Heme (covalent)
Binding site1131Heme (covalent)

Sequences

Sequence LengthMass (Da)Tools
P07142 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 3AAFCCE896E8D4DB

FASTA33236,456
        10         20         30         40         50         60 
MLARTCLRST RTFASAKNGA FKFAKRSAST QSSGAAAESP LRLNIAAAAA TAVAAGSIAW 

        70         80         90        100        110        120 
YYHLYGFASA MTPAEEGLHA TKYPWVHEQW LKTFDHQALR RGFQVYREVC ASCHSLSRVP 

       130        140        150        160        170        180 
YRALVGTILT VDEAKALAEE NEYDTEPNDQ GEIEKRPGKL SDYLPDPYKN DEAARFANNG 

       190        200        210        220        230        240 
ALPPDLSLIV KARHGGCDYI FSLLTGYPDE PPAGASVGAG LNFNPYFPGT GIAMARVLYD 

       250        260        270        280        290        300 
GLVDYEDGTP ASTSQMAKDV VEFLNWAAEP EMDDRKRMGM KVLVVTSVLF ALSVYVKRYK 

       310        320        330 
WAWLKSRKIV YDPPKSPPPA TNLALPQQRA KS 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of cytochrome c1 from Neurospora crassa."
Roemisch J., Tropschug M., Sebald W., Weiss H.
Eur. J. Biochem. 164:111-115(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05235 mRNA. Translation: CAA28860.1.
CM002236 Genomic DNA. Translation: EAA34520.1. Frameshift.
PIRA27187.
RefSeqXP_963756.1. XM_958663.2.
UniGeneNcr.13832.

3D structure databases

ProteinModelPortalP07142.
SMRP07142. Positions 71-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU09816.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000009576; EFNCRP00000009558; EFNCRG00000009557.
GeneID3879905.
KEGGncr:NCU09816.

Phylogenomic databases

eggNOGCOG2857.
HOGENOMHOG000003867.
KOK00413.
OrthoDBEOG7M0P2N.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERPTHR10266. PTHR10266. 1 hit.
PfamPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSPR00603. CYTOCHROMEC1.
SUPFAMSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCY1_NEUCR
AccessionPrimary (citable) accession number: P07142
Secondary accession number(s): Q7SCQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families