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P07142

- CY1_NEUCR

UniProt

P07142 - CY1_NEUCR

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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

cyt-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Heme (covalent)
Binding sitei113 – 1131Heme (covalent)
Metal bindingi114 – 1141Iron (heme axial ligand)
Metal bindingi234 – 2341Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity Source: EnsemblFungi
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:cyt-1
ORF Names:NCU09816
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei282 – 29615Helical; Note=Anchors to the membraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. mitochondrial respiratory chain complex III Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7070MitochondrionAdd
BLAST
Chaini71 – 332262Cytochrome c1, heme protein, mitochondrialPRO_0000006556Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi5141.NCU09816.1.

Structurei

3D structure databases

ProteinModelPortaliP07142.
SMRiP07142. Positions 71-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 250154Cytochrome cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c family.Curated
Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2857.
HOGENOMiHOG000003867.
InParanoidiP07142.
KOiK00413.
OrthoDBiEOG7M0P2N.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07142-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARTCLRST RTFASAKNGA FKFAKRSAST QSSGAAAESP LRLNIAAAAA
60 70 80 90 100
TAVAAGSIAW YYHLYGFASA MTPAEEGLHA TKYPWVHEQW LKTFDHQALR
110 120 130 140 150
RGFQVYREVC ASCHSLSRVP YRALVGTILT VDEAKALAEE NEYDTEPNDQ
160 170 180 190 200
GEIEKRPGKL SDYLPDPYKN DEAARFANNG ALPPDLSLIV KARHGGCDYI
210 220 230 240 250
FSLLTGYPDE PPAGASVGAG LNFNPYFPGT GIAMARVLYD GLVDYEDGTP
260 270 280 290 300
ASTSQMAKDV VEFLNWAAEP EMDDRKRMGM KVLVVTSVLF ALSVYVKRYK
310 320 330
WAWLKSRKIV YDPPKSPPPA TNLALPQQRA KS
Length:332
Mass (Da):36,456
Last modified:April 1, 1988 - v1
Checksum:i3AAFCCE896E8D4DB
GO

Sequence cautioni

The sequence EAA34520.1 differs from that shown. Reason: Frameshift at position 316. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05235 mRNA. Translation: CAA28860.1.
CM002236 Genomic DNA. Translation: EAA34520.1. Frameshift.
PIRiA27187.
RefSeqiXP_963756.1. XM_958663.2.
UniGeneiNcr.13832.

Genome annotation databases

EnsemblFungiiEFNCRT00000009576; EFNCRP00000009558; EFNCRG00000009557.
GeneIDi3879905.
KEGGincr:NCU09816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05235 mRNA. Translation: CAA28860.1 .
CM002236 Genomic DNA. Translation: EAA34520.1 . Frameshift.
PIRi A27187.
RefSeqi XP_963756.1. XM_958663.2.
UniGenei Ncr.13832.

3D structure databases

ProteinModelPortali P07142.
SMRi P07142. Positions 71-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09816.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000009576 ; EFNCRP00000009558 ; EFNCRG00000009557 .
GeneIDi 3879905.
KEGGi ncr:NCU09816.

Phylogenomic databases

eggNOGi COG2857.
HOGENOMi HOG000003867.
InParanoidi P07142.
KOi K00413.
OrthoDBi EOG7M0P2N.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view ]
PANTHERi PTHR10266. PTHR10266. 1 hit.
Pfami PF02167. Cytochrom_C1. 1 hit.
[Graphical view ]
PRINTSi PR00603. CYTOCHROMEC1.
SUPFAMi SSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of cytochrome c1 from Neurospora crassa."
    Roemisch J., Tropschug M., Sebald W., Weiss H.
    Eur. J. Biochem. 164:111-115(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiCY1_NEUCR
AccessioniPrimary (citable) accession number: P07142
Secondary accession number(s): Q7SCQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3