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Protein

Homoserine kinase

Gene

thrB

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi95 – 105ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10757-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:thrB
Ordered Locus Names:Cgl1184, cg1338
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001565652 – 309Homoserine kinaseAdd BLAST308

Proteomic databases

PRIDEiP07128.

2D gel databases

World-2DPAGEi0001:P07128.

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1338.

Structurei

3D structure databases

ProteinModelPortaliP07128.
SMRiP07128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5I. Bacteria.
COG0083. LUCA.
HOGENOMiHOG000247199.
KOiK00872.
OMAiPDNVAPC.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiView protein in InterPro
IPR013750. GHMP_kinase_C_dom.
IPR036554. GHMP_kinase_C_sf.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERiPTHR20861:SF1. PTHR20861:SF1. 1 hit.
PfamiView protein in Pfam
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiView protein in PROSITE
PS00627. GHMP_KINASES_ATP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIELNVGRK VTVTVPGSSA NLGPGFDTLG LALSVYDTVE VEIIPSGLEV
60 70 80 90 100
EVFGEGQGEV PLDGSHLVVK AIRAGLKAAD AEVPGLRVVC HNNIPQSRGL
110 120 130 140 150
GSSAAAAVAG VAAANGLADF PLTQEQIVQL SSAFEGHPDN AAASVLGGAV
160 170 180 190 200
VSWTNLSIDG KSQPQYAAVP LEVQDNIRAT ALVPNFHAST EAVRRVLPTE
210 220 230 240 250
VTHIDARFNV SRVAVMIVAL QQRPDLLWEG TRDRLHQPYR AEVLPITSEW
260 270 280 290 300
VNRLRNRGYA AYLSGAGPTA MVLSTEPIPD KVLEDARESG IKVLELEVAG

PVKVEVNQP
Length:309
Mass (Da):32,620
Last modified:January 23, 2007 - v4
Checksum:i89C807BC983A60E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246I → V in CAA68332 (PubMed:3035505).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00546 Genomic DNA. Translation: CAA68615.1.
Y00140 Genomic DNA. Translation: CAA68332.1.
BA000036 Genomic DNA. Translation: BAB98577.1.
BX927151 Genomic DNA. Translation: CAF19888.1.
PIRiS00866. KIFKMG.
RefSeqiNP_600410.1. NC_003450.3.
WP_011014183.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98577; BAB98577; BAB98577.
CAF19888; CAF19888; cg1338.
GeneIDi1019167.
KEGGicgb:cg1338.
cgl:NCgl1137.
PATRICifig|196627.13.peg.1163.

Similar proteinsi

Entry informationi

Entry nameiKHSE_CORGL
AccessioniPrimary (citable) accession number: P07128
Secondary accession number(s): P08210
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 139 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families