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Protein

PAP fimbrial minor pilin protein

Gene

papH

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.
PapH seems to anchor the pilus to the bacterial cell. In addition the stoichiometric relationship between PapH and PapA determines the pilus length.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PAP fimbrial minor pilin protein
Gene namesi
Name:papH
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Fimbrium, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 195173PAP fimbrial minor pilin proteinPRO_0000009198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 971 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP07111.

Interactioni

Protein-protein interaction databases

DIPiDIP-44596N.
IntActiP07111. 1 interaction.
MINTiMINT-4055117.
STRINGi199310.c5187.

Structurei

Secondary structure

1
195
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 613Combined sources
Beta strandi68 – 703Combined sources
Helixi76 – 805Combined sources
Beta strandi88 – 9710Combined sources
Turni106 – 1105Combined sources
Beta strandi111 – 1188Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi134 – 1429Combined sources
Beta strandi165 – 17410Combined sources
Beta strandi187 – 1948Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J2ZX-ray2.30B23-195[»]
2XG4X-ray2.40B23-195[»]
2XG5X-ray2.00B23-195[»]
ProteinModelPortaliP07111.
SMRiP07111. Positions 46-195.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07111.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108ZJG. Bacteria.
ENOG4111UXZ. LUCA.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRFSVPLF FFGCVFVHGV FAGPFPPPGM SLPEYWGEEH VWWDGRAAFH
60 70 80 90 100
GEVVRPACTL AMEDAWQIID MGETPVRDLQ NGFSGPERKF SLRLRNCEFN
110 120 130 140 150
SQGGNLFSDS RIRVTFDGVR GETPDKFNLS GQAKGINLQI ADVRGNIARA
160 170 180 190
GKVMPAIPLT GNEEALDYTL RIVRNGKKLE AGNYFAVLGF RVDYE
Length:195
Mass (Da):21,835
Last modified:April 1, 1988 - v1
Checksum:iD2120FC5DA063169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00529 Genomic DNA. Translation: CAA68587.1.
M16202 Genomic DNA. Translation: AAA24286.1.
X61239 Genomic DNA. Translation: CAA43563.1.
PIRiA27021. YQECPH.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00529 Genomic DNA. Translation: CAA68587.1.
M16202 Genomic DNA. Translation: AAA24286.1.
X61239 Genomic DNA. Translation: CAA43563.1.
PIRiA27021. YQECPH.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J2ZX-ray2.30B23-195[»]
2XG4X-ray2.40B23-195[»]
2XG5X-ray2.00B23-195[»]
ProteinModelPortaliP07111.
SMRiP07111. Positions 46-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-44596N.
IntActiP07111. 1 interaction.
MINTiMINT-4055117.
STRINGi199310.c5187.

Proteomic databases

PRIDEiP07111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108ZJG. Bacteria.
ENOG4111UXZ. LUCA.

Miscellaneous databases

EvolutionaryTraceiP07111.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAPH_ECOLX
AccessioniPrimary (citable) accession number: P07111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 11, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Strains of E.coli that cause infection of the human urinary tract produce pap-pili which are hair-like appendages consisting of about 1000 helically arranged subunits of the protein PapA. These pili mediate binding to digalactoside-containing glycolipids present on the epithelial cells which line the urinary tract.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.