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Protein

Outer membrane usher protein PapC

Gene

papC

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export and assembly of pili subunits across the outer membrane. Forms a hexameric ring-shaped pore in the outer bacterial membrane. The 2 nanometer-diameter pore allows the passage of the thin tip fibrillum. As for the rod, it probably unwinds into linear fibers which would therefore be narrow enough to pass through the pore.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Fimbrium biogenesis, Transport

Protein family/group databases

TCDBi1.B.11.2.1. the outer membrane fimbrial usher porin (fup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane usher protein PapC
Gene namesi
Name:papC
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000000932325 – 836Outer membrane usher protein PapCAdd BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi814 ↔ 832Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP07110.

Interactioni

Protein-protein interaction databases

DIPiDIP-60749N.
STRINGi199310.c5186.

Structurei

Secondary structure

1836
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi174 – 185Combined sources12
Beta strandi192 – 203Combined sources12
Beta strandi208 – 215Combined sources8
Beta strandi218 – 221Combined sources4
Beta strandi228 – 231Combined sources4
Beta strandi234 – 244Combined sources11
Turni245 – 248Combined sources4
Beta strandi249 – 257Combined sources9
Beta strandi261 – 263Combined sources3
Beta strandi267 – 275Combined sources9
Helixi282 – 284Combined sources3
Beta strandi293 – 298Combined sources6
Beta strandi300 – 305Combined sources6
Beta strandi308 – 314Combined sources7
Beta strandi317 – 320Combined sources4
Beta strandi331 – 338Combined sources8
Beta strandi347 – 350Combined sources4
Beta strandi363 – 371Combined sources9
Beta strandi383 – 392Combined sources10
Beta strandi395 – 406Combined sources12
Beta strandi409 – 419Combined sources11
Beta strandi421 – 423Combined sources3
Beta strandi425 – 436Combined sources12
Turni438 – 440Combined sources3
Beta strandi442 – 452Combined sources11
Beta strandi464 – 471Combined sources8
Helixi478 – 485Combined sources8
Beta strandi494 – 505Combined sources12
Turni507 – 510Combined sources4
Beta strandi512 – 525Combined sources14
Beta strandi528 – 537Combined sources10
Beta strandi548 – 554Combined sources7
Beta strandi565 – 572Combined sources8
Beta strandi579 – 584Combined sources6
Beta strandi590 – 599Combined sources10
Helixi601 – 603Combined sources3
Beta strandi606 – 615Combined sources10
Beta strandi622 – 632Combined sources11
Beta strandi634 – 645Combined sources12
Beta strandi648 – 661Combined sources14
Beta strandi758 – 764Combined sources7
Beta strandi775 – 777Combined sources3
Beta strandi783 – 787Combined sources5
Beta strandi792 – 796Combined sources5
Beta strandi806 – 810Combined sources5
Beta strandi814 – 818Combined sources5
Beta strandi824 – 834Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KT6NMR-A752-836[»]
2VQIX-ray3.20A/B157-667[»]
3FIPX-ray3.15A/B171-650[»]
ProteinModelPortaliP07110.
SMRiP07110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07110.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4106PG1. Bacteria.
COG3188. LUCA.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRIPFAVN NITCVILLSL FCNAASAVEF NTDVLDAADK KNIDFTRFSE
60 70 80 90 100
AGYVLPGQYL LDVIVNGQSI SPASLQISFV EPALSGDKAE KKLPQACLTS
110 120 130 140 150
DMVRLMGLTA ESLDKVVYWH DGQCADFHGL PGVDIRPDTG AGVLRINMPQ
160 170 180 190 200
AWLEYSDATW LPPSRWDDGI PGLMLDYNLN GTVSRNYQGG DSHQFSYNGT
210 220 230 240 250
VGGNLGPWRL RADYQGSQEQ SRYNGEKTTN RNFTWSRFYL FRAIPRWRAN
260 270 280 290 300
LTLGENNINS DIFRSWSYTG ASLESDDRML PPRLRGYAPQ ITGIAETNAR
310 320 330 340 350
VVVSQQGRVL YDSMVPAGPF SIQDLDSSVR GRLDVEVIEQ NGRKKTFQVD
360 370 380 390 400
TASVPYLTRP GQVRYKLVSG RSRGYGHETE GPVFATGEAS WGLSNQWSLY
410 420 430 440 450
GGAVLAGDYN ALAAGAGWDL GVPGTLSADI TQSVARIEGE RTFQGKSWRL
460 470 480 490 500
SYSKRFDNAD ADITFAGYRF SERNYMTMEQ YLNARYRNDY SSREKEMYTV
510 520 530 540 550
TLNKNVADWN TSFNLQYSRQ TYWDIRKTDY YTVSVNRYFN VFGLQGVAVG
560 570 580 590 600
LSASRSKYLG RDNDSAYLRI SVPLGTGTAS YSGSMSNDRY VNMAGYTDTF
610 620 630 640 650
NDGLDSYSLN AGLNSGGGLT SQRQINAYYS HRSPLANLSA NIASLQKGYT
660 670 680 690 700
SFGVSASGGA TITGKGAALH AGGMSGGTRL LVDTDGVGGV PVDGGQVVTN
710 720 730 740 750
RWGTGVVTDI SSYYRNTTSV DLKRLPDDVE ATRSVVESAL TEGAIGYRKF
760 770 780 790 800
SVLKGKRLFA ILRLADGSQP PFGASVTSEK GRELGMVADE GLAWLSGVTP
810 820 830
GETLSVNWDG KIQCQVNVPE TAISDQQLLL PCTPQK
Length:836
Mass (Da):91,509
Last modified:November 28, 2002 - v2
Checksum:i9343D35DC7B1E4C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti517 – 543YSRQT…FNVFG → SENIKVAVDAHRIIVRFPYV PVCLTAV (PubMed:2897064).CuratedAdd BLAST27
Sequence conflicti517 – 543YSRQT…FNVFG → SENIKVAVDAHRIIVRFPYV PVCLTAV (PubMed:1357526).CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00529 Genomic DNA. Translation: CAA68588.1.
X61239 Genomic DNA. Translation: CAA43564.1.
AF481883 Genomic DNA. Translation: AAL89688.1.
PIRiS25218.
RefSeqiWP_000654936.1. NZ_LVTC01000148.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00529 Genomic DNA. Translation: CAA68588.1.
X61239 Genomic DNA. Translation: CAA43564.1.
AF481883 Genomic DNA. Translation: AAL89688.1.
PIRiS25218.
RefSeqiWP_000654936.1. NZ_LVTC01000148.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KT6NMR-A752-836[»]
2VQIX-ray3.20A/B157-667[»]
3FIPX-ray3.15A/B171-650[»]
ProteinModelPortaliP07110.
SMRiP07110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60749N.
STRINGi199310.c5186.

Protein family/group databases

TCDBi1.B.11.2.1. the outer membrane fimbrial usher porin (fup) family.

Proteomic databases

PRIDEiP07110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4106PG1. Bacteria.
COG3188. LUCA.

Miscellaneous databases

EvolutionaryTraceiP07110.

Family and domain databases

InterProiIPR000015. Fimb_usher.
IPR018030. Fimbrial_membr_usher_CS.
IPR025949. PapC-like_C.
IPR025885. PapC_N.
[Graphical view]
PANTHERiPTHR30451. PTHR30451. 1 hit.
PfamiPF13953. PapC_C. 1 hit.
PF13954. PapC_N. 1 hit.
PF00577. Usher. 1 hit.
[Graphical view]
PROSITEiPS01151. FIMBRIAL_USHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAPC_ECOLX
AccessioniPrimary (citable) accession number: P07110
Secondary accession number(s): Q8RNL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 28, 2002
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.