P07109 (HISP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidine transport ATP-binding protein HisP

Gene names

Name:	hisP
Ordered Locus Names:	b2306, JW2303

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system.
Subcellular location	Cell inner membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC histidine biosynthetic process Inferred from mutant phenotype PubMed 4920090. Source: EcoliWiki histidine transport Inferred from mutant phenotype PubMed 4920090. Source: EcoliWiki
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Histidine transport ATP-binding protein HisP		PRO_0000092341
Regions
	Domain	6 – 252	247	ABC transporter
	Nucleotide binding	38 – 45	8	ATP By similarity
Experimental info
	Sequence conflict	17	1	E → G AA sequence Ref.5
	Sequence conflict	191	1	V → L in CAA68511. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P07109 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 5D2F598F2F757291	FASTA	257	28,653
	10 20 30 40 50 60 MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG 70 80 90 100 110 120 SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV 130 140 150 160 170 180 LGLSKQEARE RAVKYLAKVG IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT 190 200 210 220 230 240 SALDPELVGE VLRIMQQLAE EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF 250 GNPQSPRLQR FLKGSLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium." Kraft R., Leinwand L.A. Nucleic Acids Res. 15:8568-8568(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"The nucleotide-binding site of HisP, a membrane protein of the histidine permease. Identification of amino acid residues photoaffinity labeled by 8-azido-ATP." Mimura C.S., Admon A., Hurt K.A., Ames G.F.-L. J. Biol. Chem. 265:19535-19542(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 15-22 AND 30-44.
[6]	"Escherichia coli proteome analysis using the gene-protein database." VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C. Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY 2D-GEL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y00455 Genomic DNA. Translation: CAA68511.1. U00096 Genomic DNA. Translation: AAC75366.1. AP009048 Genomic DNA. Translation: BAA16143.1.
PIR	H65002.
RefSeq	NP_416809.1. NC_000913.2. YP_490548.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P07109.
SMR	P07109. Positions 4-257.
ModBase	Search...
Protein-protein interaction databases
IntAct	P07109. 3 interactions.
STRING	511145.b2306.
Proteomic databases
PaxDb	P07109.
PRIDE	P07109.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75366; AAC75366; b2306. BAA16143; BAA16143; BAA16143.
GeneID	12934208. 946789.
KEGG	ecj:Y75_p2272. eco:b2306.
PATRIC	32119983. VBIEscCol129921_2401.
Organism-specific databases
EchoBASE	EB0447.
EcoGene	EG10452. hisP.
Phylogenomic databases
eggNOG	COG4598.
KO	K10017.
OMA	SMKAKAG.
ProtClustDB	PRK10619.
Enzyme and pathway databases
BioCyc	EcoCyc:HISP-MONOMER. ECOL316407:JW2303-MONOMER.
Gene expression databases
Genevestigator	P07109.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISP_ECOLI

Accession

Primary (citable) accession number: P07109
Secondary accession number(s): P77299

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program