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Protein

Histidine transport ATP-binding protein HisP

Gene

hisP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • histidine transport Source: EcoliWiki
  • L-histidine import across plasma membrane Source: EcoCyc
  • L-histidine transmembrane transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:HISP-MONOMER

Protein family/group databases

TCDBi3.A.1.3.29 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport ATP-binding protein HisP
Gene namesi
Name:hisP
Ordered Locus Names:b2306, JW2303
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10452 hisP

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923411 – 257Histidine transport ATP-binding protein HisPAdd BLAST257

Proteomic databases

EPDiP07109
PaxDbiP07109
PRIDEiP07109

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi426320213 interactors.
IntActiP07109 5 interactors.
STRINGi316385.ECDH10B_2468

Structurei

3D structure databases

ProteinModelPortaliP07109
SMRiP07109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 252ABC transporterPROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108JEH Bacteria
COG4598 LUCA
InParanoidiP07109
KOiK10017
OMAiLFFKLRD
PhylomeDBiP07109

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR030679 ABC_ATPase_HisP-typ
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PIRSFiPIRSF039085 ABC_ATPase_HisP, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC
60 70 80 90 100
INFLEKPSEG SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH
110 120 130 140 150
FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG IDERAQGKYP
160 170 180 190 200
VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE
210 220 230 240 250
EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR

FLKGSLK
Length:257
Mass (Da):28,653
Last modified:November 1, 1997 - v2
Checksum:i5D2F598F2F757291
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → G AA sequence (PubMed:2246240).Curated1
Sequence conflicti191V → L in CAA68511 (PubMed:3313284).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00455 Genomic DNA Translation: CAA68511.1
U00096 Genomic DNA Translation: AAC75366.1
AP009048 Genomic DNA Translation: BAA16143.1
PIRiH65002
RefSeqiNP_416809.1, NC_000913.3
WP_001293613.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75366; AAC75366; b2306
BAA16143; BAA16143; BAA16143
GeneIDi946789
KEGGiecj:JW2303
eco:b2306
PATRICifig|1411691.4.peg.4428

Similar proteinsi

Entry informationi

Entry nameiHISP_ECOLI
AccessioniPrimary (citable) accession number: P07109
Secondary accession number(s): P77299
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome