Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidine transport ATP-binding protein HisP

Gene

hisP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:HISP-MONOMER.
ECOL316407:JW2303-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport ATP-binding protein HisP
Gene namesi
Name:hisP
Ordered Locus Names:b2306, JW2303
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10452. hisP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923411 – 257Histidine transport ATP-binding protein HisPAdd BLAST257

Proteomic databases

EPDiP07109.
PaxDbiP07109.
PRIDEiP07109.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4263202. 11 interactors.
IntActiP07109. 5 interactors.
STRINGi511145.b2306.

Structurei

3D structure databases

ProteinModelPortaliP07109.
SMRiP07109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 252ABC transporterPROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
InParanoidiP07109.
KOiK10017.
OMAiKPDQIFD.
PhylomeDBiP07109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC
60 70 80 90 100
INFLEKPSEG SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH
110 120 130 140 150
FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG IDERAQGKYP
160 170 180 190 200
VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE
210 220 230 240 250
EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR

FLKGSLK
Length:257
Mass (Da):28,653
Last modified:November 1, 1997 - v2
Checksum:i5D2F598F2F757291
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → G AA sequence (PubMed:2246240).Curated1
Sequence conflicti191V → L in CAA68511 (PubMed:3313284).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00455 Genomic DNA. Translation: CAA68511.1.
U00096 Genomic DNA. Translation: AAC75366.1.
AP009048 Genomic DNA. Translation: BAA16143.1.
PIRiH65002.
RefSeqiNP_416809.1. NC_000913.3.
WP_001293613.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75366; AAC75366; b2306.
BAA16143; BAA16143; BAA16143.
GeneIDi946789.
KEGGiecj:JW2303.
eco:b2306.
PATRICi32119983. VBIEscCol129921_2401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00455 Genomic DNA. Translation: CAA68511.1.
U00096 Genomic DNA. Translation: AAC75366.1.
AP009048 Genomic DNA. Translation: BAA16143.1.
PIRiH65002.
RefSeqiNP_416809.1. NC_000913.3.
WP_001293613.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP07109.
SMRiP07109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263202. 11 interactors.
IntActiP07109. 5 interactors.
STRINGi511145.b2306.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP07109.
PaxDbiP07109.
PRIDEiP07109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75366; AAC75366; b2306.
BAA16143; BAA16143; BAA16143.
GeneIDi946789.
KEGGiecj:JW2303.
eco:b2306.
PATRICi32119983. VBIEscCol129921_2401.

Organism-specific databases

EchoBASEiEB0447.
EcoGeneiEG10452. hisP.

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
InParanoidiP07109.
KOiK10017.
OMAiKPDQIFD.
PhylomeDBiP07109.

Enzyme and pathway databases

BioCyciEcoCyc:HISP-MONOMER.
ECOL316407:JW2303-MONOMER.

Miscellaneous databases

PROiP07109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISP_ECOLI
AccessioniPrimary (citable) accession number: P07109
Secondary accession number(s): P77299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.