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Protein

Histidine transport ATP-binding protein HisP

Gene

hisP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:HISP-MONOMER.
ECOL316407:JW2303-MONOMER.
MetaCyc:HISP-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport ATP-binding protein HisP
Gene namesi
Name:hisP
Ordered Locus Names:b2306, JW2303
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10452. hisP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Histidine transport ATP-binding protein HisPPRO_0000092341Add
BLAST

Proteomic databases

EPDiP07109.
PaxDbiP07109.
PRIDEiP07109.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4263202. 11 interactions.
IntActiP07109. 5 interactions.
STRINGi511145.b2306.

Structurei

3D structure databases

ProteinModelPortaliP07109.
SMRiP07109. Positions 4-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 252247ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
InParanoidiP07109.
KOiK10017.
OMAiKPDQIFD.
OrthoDBiEOG6T7N3V.
PhylomeDBiP07109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC
60 70 80 90 100
INFLEKPSEG SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH
110 120 130 140 150
FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG IDERAQGKYP
160 170 180 190 200
VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE
210 220 230 240 250
EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR

FLKGSLK
Length:257
Mass (Da):28,653
Last modified:November 1, 1997 - v2
Checksum:i5D2F598F2F757291
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171E → G AA sequence (PubMed:2246240).Curated
Sequence conflicti191 – 1911V → L in CAA68511 (PubMed:3313284).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00455 Genomic DNA. Translation: CAA68511.1.
U00096 Genomic DNA. Translation: AAC75366.1.
AP009048 Genomic DNA. Translation: BAA16143.1.
PIRiH65002.
RefSeqiNP_416809.1. NC_000913.3.
WP_001293613.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75366; AAC75366; b2306.
BAA16143; BAA16143; BAA16143.
GeneIDi946789.
KEGGiecj:JW2303.
eco:b2306.
PATRICi32119983. VBIEscCol129921_2401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00455 Genomic DNA. Translation: CAA68511.1.
U00096 Genomic DNA. Translation: AAC75366.1.
AP009048 Genomic DNA. Translation: BAA16143.1.
PIRiH65002.
RefSeqiNP_416809.1. NC_000913.3.
WP_001293613.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP07109.
SMRiP07109. Positions 4-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263202. 11 interactions.
IntActiP07109. 5 interactions.
STRINGi511145.b2306.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP07109.
PaxDbiP07109.
PRIDEiP07109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75366; AAC75366; b2306.
BAA16143; BAA16143; BAA16143.
GeneIDi946789.
KEGGiecj:JW2303.
eco:b2306.
PATRICi32119983. VBIEscCol129921_2401.

Organism-specific databases

EchoBASEiEB0447.
EcoGeneiEG10452. hisP.

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
InParanoidiP07109.
KOiK10017.
OMAiKPDQIFD.
OrthoDBiEOG6T7N3V.
PhylomeDBiP07109.

Enzyme and pathway databases

BioCyciEcoCyc:HISP-MONOMER.
ECOL316407:JW2303-MONOMER.
MetaCyc:HISP-MONOMER.

Miscellaneous databases

PROiP07109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium."
    Kraft R., Leinwand L.A.
    Nucleic Acids Res. 15:8568-8568(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The nucleotide-binding site of HisP, a membrane protein of the histidine permease. Identification of amino acid residues photoaffinity labeled by 8-azido-ATP."
    Mimura C.S., Admon A., Hurt K.A., Ames G.F.-L.
    J. Biol. Chem. 265:19535-19542(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 15-22 AND 30-44.
  6. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiHISP_ECOLI
AccessioniPrimary (citable) accession number: P07109
Secondary accession number(s): P77299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: March 16, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.